CN111601798B - 双酰胺肌节活化化合物及其用途 - Google Patents

双酰胺肌节活化化合物及其用途 Download PDF

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Publication number
CN111601798B
CN111601798B CN201880072907.5A CN201880072907A CN111601798B CN 111601798 B CN111601798 B CN 111601798B CN 201880072907 A CN201880072907 A CN 201880072907A CN 111601798 B CN111601798 B CN 111601798B
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carbonyl
methyl
trifluoromethyl
sulfonyl
azetidinyl
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CN111601798A (zh
Inventor
L.阿什克拉夫特
A.贝齐奥
J.巴特勒
A.钱德拉
C.闯
S.E.科利比
M.德贝内德托
V.迪马萨
R.格雷斯法
J.马利诺夫斯基
D.梅比乌斯
B.P.摩根
J.佩耶特
A.罗梅罗
D.小圣简
R.瓦加斯
J.耶奥曼
H.张
A.成
F.冈萨雷斯洛佩斯德图里索
M.G.约翰逊
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Amgen Inc
Cytokinetics Inc
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Amgen Inc
Cytokinetics Inc
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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  • Pyrrole Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880072907.5A 2017-09-13 2018-09-13 双酰胺肌节活化化合物及其用途 Active CN111601798B (zh)

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US201762557846P 2017-09-13 2017-09-13
US62/557846 2017-09-13
PCT/US2018/050793 WO2019055590A1 (en) 2017-09-13 2018-09-13 SARCOMERIC BISAMIDE ACTIVATOR COMPOUNDS AND USES THEREOF

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