CN111588747A - Pharmaceutical composition for treating allergic rhinitis and preparation method thereof - Google Patents

Pharmaceutical composition for treating allergic rhinitis and preparation method thereof Download PDF

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Publication number
CN111588747A
CN111588747A CN202010669586.6A CN202010669586A CN111588747A CN 111588747 A CN111588747 A CN 111588747A CN 202010669586 A CN202010669586 A CN 202010669586A CN 111588747 A CN111588747 A CN 111588747A
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pharmaceutical composition
allergic rhinitis
catechu
treating allergic
filtering
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CN202010669586.6A
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Chinese (zh)
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彭爱辉
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to the technical field of medicines, and provides a pharmaceutical composition for treating allergic rhinitis and a preparation method thereof, wherein in the pharmaceutical composition, the weight ratio of cocklebur fruit: and (3) sesame oil: and (3) honey of sophora flower: the preferable mass ratio of the catechu is respectively 4: 6: 1: 1, the external use has excellent effect of treating allergic rhinitis (particularly cold air allergic rhinitis), the nasal cavity is unobstructed when the external use is carried out for three days, sneezing and rhinorrhea are avoided, and the external use is stable and does not attack seven days.

Description

Pharmaceutical composition for treating allergic rhinitis and preparation method thereof
Technical Field
The invention belongs to the technical field of medicines, and provides a pharmaceutical composition for treating allergic rhinitis and a preparation method thereof.
Background
The nasal cavity is positioned at the foremost end of the respiratory tract, has the functions of moistening, heating and filtering inhaled air, is the first defense line of a respiratory system, is one of the most easily infected organs, and is the necessary way for inflammation to enter a human body and spread to the lower respiratory tract and adjacent organs. Rhinitis is a common nasal mucosal inflammation disease, and is divided into two types, namely acute rhinitis and chronic rhinitis according to the time of onset.
In recent years, the incidence of rhinitis has been on the rise due to various causes such as air pollution, global warming, sudden changes in air temperature, bacterial and viral infection, exposure to allergens, and a decrease in the body resistance. Rhinitis obstructs breathing and causes symptoms such as headache and brain distension, the work and rest are affected, the state of an illness is painful, various treatment methods and medicine effects for the rhinitis in the prior art are not obvious, side effects such as drug-induced rhinitis are easy to cause in some cases after long-term use, drug resistance is easy to generate, the rhinitis cannot be effectively treated well, in addition, the prices of a plurality of existing rhinitis medicines are high, and a patient suffering from rhinitis needs to spend high medical expenses on the premise that the good treatment effect cannot be guaranteed, so that the development of a new rhinitis medicine is one of important scientific research directions for people all the time.
The prior art CN106491929A provides a rhinitis spray, which is characterized by comprising the following substances in parts by weight: 2-5 parts of magnolia flower; 5-10 parts of cocklebur fruit; 10-20 parts of luffa stem; 8-17 parts of sophora flower honey; 1-8 parts of sesame oil; 4-15 parts of fistular onion stalk; 3-10 parts of mint; 10-15 parts of wild chrysanthemum; the balance of water and alcohol. Not only has complex prescription, but also needs to improve the treatment effect.
The prior art CN107260882A provides a compound treatment liquid for rhinitis and pharyngitis, which is prepared from the following components in parts by weight: 10-300 g of holy basil, 10-300 g of biond magnolia flower, 10-300 g of cocklebur fruit, 10-300 g of weeping forsythia, 5-50 g of asarum, 10-300 g of centipeda minima, 5-50 g of divaricate saposhnikovia root, 10-300 g of catechu, 5-50 g of liquorice, 5-50 g of Chinese honeylocust fruit, 10-300 g of figwort root, 10-300 g of sophora flower, 10-300 g of loquat flower, 10-300 g of angelica root, 1-20 g of bear gall powder, 1-10 g of borneol, 1-10 g of menthol and 50-300 g of honey. Not only has complex prescription, but also needs to improve the treatment effect.
Disclosure of Invention
In view of the problems in the prior art, the invention provides a pharmaceutical composition for treating allergic rhinitis and a preparation method thereof.
The invention is realized by the following technical scheme that the pharmaceutical composition for treating allergic rhinitis contains cocklebur fruit, sesame oil, Japanese pagodatree flower seed and catechu.
The fructus Xanthii is dried mature fruit with involucre of Xanthium Sibiricum Patr of Compositae. Harvesting in autumn when the fruit is mature, drying, and removing impurities such as stems, leaves and the like.
The Catechu is dried soft extract of branches and stems of Acacia catechu (L.f.) of Leguminosae. Harvesting in winter, drying, removing outer skin, cutting into large blocks, decocting in water, concentrating, and drying.
The sesame oil and the sophora japonica honey are edible or medicinal substances and can be obtained by the market.
The preferable technical proposal of the invention comprises 400 g of 200-400 g of siberian cocklour fruit, 600 g of sesame oil, 50-100 g of Japanese pagodatree flower bud and 50-100 g of catechu.
The more preferable technical scheme is as follows: fructus xanthil: and (3) sesame oil: and (3) honey of sophora flower: the mass ratio of the catechu is respectively 4: 6: 1: 1.
according to the invention, through a large number of researches and comparisons, the pharmaceutical composition has the advantages that when the formula is adjusted, or the proportion and the dosage are not in the selected range, the treatment effect is obviously reduced, and the effect is not good. Fully indicates that the pharmaceutical composition of the invention has synergistic effect when being used for allergic rhinitis.
As a preferred embodiment of the present invention, the pharmaceutical composition is used by external application; it is not swallowable.
The invention further provides a pharmaceutical composition, which is obtained by the following method: oven drying Catechu, and grinding into powder; cleaning fructus Xanthii, oven drying, grinding, soaking in oleum Sesami for 8 hr, parching with strong fire at 90 deg.C for 9 min, pouring out, filtering, adding filtered oil juice in stainless steel container, adding flos Sophorae Immaturus and Catechu powder at a certain proportion at a temperature below 30 deg.C, stirring, and filtering to remove impurities to obtain filtrate; and (5) packaging the container.
Through a large number of researches and comparisons, the invention discovers that the medicinal chemical components can be effectively obtained from the medicinal composition obtained by the preparation method, the medicinal chemical components have obvious effect on ensuring the medicinal effect, and the repeatability of the medicinal effect of the medicament after use is good.
The invention also aims to provide a preparation process of the pharmaceutical composition for treating allergic rhinitis, which comprises the steps of drying and grinding the catechu into powder; cleaning fructus Xanthii, oven drying, grinding, soaking in oleum Sesami for 8 hr, parching with strong fire at 90 deg.C for 9 min, pouring out, filtering, adding filtered oil juice in stainless steel container, adding flos Sophorae Immaturus and Catechu powder at a certain proportion at a temperature below 30 deg.C, stirring, and filtering to remove impurities to obtain filtrate; and (5) packaging the container.
The invention also aims to provide application of the pharmaceutical composition for treating allergic rhinitis in preparing a medicament for treating allergic rhinitis. Specifically, the medicinal oil can be dipped by cotton swab and applied to the inner wall of nasal cavity after opening the package and container, or applied by spraying with sprayer to the inner wall of nasal cavity once in the morning and evening. The medicine has the advantages of simple application and sanitary treatment method.
The beneficial effects of the invention compared with the prior art comprise:
the pharmaceutical composition has excellent effect of treating allergic rhinitis (particularly cold air allergic rhinitis) by external use, has smooth nasal cavity, does not sneeze and run nose after being used for three days, and is stable and does not attack after being used for seven days.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the invention are not limited thereto.
Example 1
A pharmaceutical composition for treating allergic rhinitis comprises 200 g of cocklebur fruit, 300g of sesame oil, 50g of Japanese pagodatree flower seed and 50g of catechu.
Obtained by the following method: oven drying Catechu, and grinding into powder; cleaning fructus Xanthii, oven drying, grinding, soaking in oleum Sesami for 8 hr, parching with strong fire at 90 deg.C for 9 min, pouring out, filtering, adding filtered oil juice in stainless steel container, adding flos Sophorae Immaturus and Catechu powder at a certain proportion at a temperature below 30 deg.C, stirring, and filtering to remove impurities to obtain filtrate; and (5) packaging the container.
Example 2
A pharmaceutical composition for treating allergic rhinitis comprises 400 g of cocklebur fruit, 600 g of sesame oil, 100 g of sophora japonica honey and 100 g of catechu.
Obtained by the following method: oven drying Catechu, and grinding into powder; cleaning fructus Xanthii, oven drying, grinding, soaking in oleum Sesami for 8 hr, parching with strong fire at 90 deg.C for 9 min, pouring out, filtering, adding filtered oil juice in stainless steel container, adding flos Sophorae Immaturus and Catechu powder at a certain proportion at a temperature below 30 deg.C, stirring, and filtering to remove impurities to obtain filtrate; and (5) packaging the container.
Example 3
A pharmaceutical composition for treating allergic rhinitis comprises 300g of cocklebur fruit, 450 g of sesame oil, 75 g of sophora flower honey and 75 g of catechu.
Obtained by the following method: oven drying Catechu, and grinding into powder; cleaning fructus Xanthii, oven drying, grinding, soaking in oleum Sesami for 8 hr, parching with strong fire at 90 deg.C for 9 min, pouring out, filtering, adding filtered oil juice in stainless steel container, adding flos Sophorae Immaturus and Catechu powder at a certain proportion at a temperature below 30 deg.C, stirring, and filtering to remove impurities to obtain filtrate; and (5) packaging the container.
Example 4
Typical cases are:
mr. Huang, man, 32 years old, research and development engineers, because often working in air-conditioned environment, cold air allergic rhinitis outbreaks, used the medicament of embodiment 3 of the invention to spray on the nasal cavity intima, spraying 1-2 times on the first day relieved, used three days basically without sneezing, the symptom of runny nose outbreak, basically cured in a week.
Miss, women, age 36, office staff, who have allergic rhinitis for years, use a variety of therapeutic drugs, the effect is not ideal, after trying the medicament of the embodiment 3 of the invention for one day, the effect is remarkable, and the patient basically cures after insisting on spraying for one week.
In conclusion, the pharmaceutical composition of the invention can treat allergic rhinitis (particularly cold air allergic rhinitis); the nasal cavity is smooth, sneezing and nasal discharge are avoided after three days of use, and the nasal cavity is stable and does not attack after seven days of use.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (7)

1. A pharmaceutical composition for treating allergic rhinitis is characterized by comprising cocklebur fruit, sesame oil, Japanese pagodatree flower seed and catechu.
2. The pharmaceutical composition for treating allergic rhinitis according to claim 1, which comprises 200-400 g of fructus xanthil, 300-600 g of sesame oil, 50-100 g of Japanese pagodatree flower bud and 50-100 g of catechu.
3. The pharmaceutical composition for treating allergic rhinitis according to claim 1 or 2, wherein the ratio of cocklebur fruit: and (3) sesame oil: and (3) honey of sophora flower: the mass ratio of the catechu is respectively 4: 6: 1: 1.
4. the pharmaceutical composition for treating allergic rhinitis according to claim 1 or 2, wherein the pharmaceutical composition is administered by external application.
5. The pharmaceutical composition for the treatment of allergic rhinitis according to claim 1 or 2, wherein said pharmaceutical composition is obtained by the following method: oven drying Catechu, and grinding into powder; cleaning fructus Xanthii, oven drying, grinding, soaking in oleum Sesami for 8 hr, parching with strong fire at 90 deg.C for 9 min, pouring out, filtering, adding filtered oil juice in stainless steel container, adding flos Sophorae Immaturus and Catechu powder at a certain proportion at a temperature below 30 deg.C, stirring, and filtering to remove impurities to obtain filtrate; and (5) packaging the container.
6. The process for preparing a pharmaceutical composition for the treatment of allergic rhinitis according to any one of claims 1-5, wherein Catechu is oven dried and ground; cleaning fructus Xanthii, oven drying, grinding, soaking in oleum Sesami for 8 hr, parching with strong fire at 90 deg.C for 9 min, pouring out, filtering, adding filtered oil juice in stainless steel container, adding flos Sophorae Immaturus and Catechu powder at a certain proportion at a temperature below 30 deg.C, stirring, and filtering to remove impurities to obtain filtrate; and (5) packaging the container.
7. The use of a pharmaceutical composition for the treatment of allergic rhinitis in the manufacture of a medicament for the treatment of allergic rhinitis according to any one of claims 1 to 5, wherein the pharmaceutical composition is formulated into a medicinal oil, and the medicinal oil is applied to the inner wall of the nasal cavity once in the morning and once in the evening.
CN202010669586.6A 2020-07-13 2020-07-13 Pharmaceutical composition for treating allergic rhinitis and preparation method thereof Pending CN111588747A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105362220A (en) * 2014-08-08 2016-03-02 深圳君圣泰生物技术有限公司 Preparation, preparation method and uses thereof
CN105560372A (en) * 2016-03-22 2016-05-11 泰山医学院 Traditional Chinese medicine spray for treating rhinitis and preparation method thereof
CN106491929A (en) * 2016-12-13 2017-03-15 广西民族大学 A kind of spray for treating rhinitis
CN107998207A (en) * 2017-12-26 2018-05-08 闫传涛 It is a kind of to be used to treat Chinese medicine composition of rhinitis and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105362220A (en) * 2014-08-08 2016-03-02 深圳君圣泰生物技术有限公司 Preparation, preparation method and uses thereof
CN105560372A (en) * 2016-03-22 2016-05-11 泰山医学院 Traditional Chinese medicine spray for treating rhinitis and preparation method thereof
CN106491929A (en) * 2016-12-13 2017-03-15 广西民族大学 A kind of spray for treating rhinitis
CN107998207A (en) * 2017-12-26 2018-05-08 闫传涛 It is a kind of to be used to treat Chinese medicine composition of rhinitis and preparation method thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
王建国等: "《专家与你面对面—过敏性鼻炎》", 31 January 2016, 中国医药科技出版社 *
程爵棠等: "《单方验方治百病》", 31 December 2015, 人民军医出版社 *
阎荣军，李明娟，何幼民，季军捷: "鹅不食草苍耳子浸液滴鼻治疗鼻炎54例", 《山东中医杂志》 *
陆小鸿: ""鼻渊头痛要药"辛夷", 《广西林业》 *

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