CN111514188A - Medicinal oil for treating nasal diseases and preparation method and application thereof - Google Patents
Medicinal oil for treating nasal diseases and preparation method and application thereof Download PDFInfo
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- CN111514188A CN111514188A CN202010523125.8A CN202010523125A CN111514188A CN 111514188 A CN111514188 A CN 111514188A CN 202010523125 A CN202010523125 A CN 202010523125A CN 111514188 A CN111514188 A CN 111514188A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
The invention is suitable for the technical field of medicaments, and provides medicinal oil for treating nasal diseases, a preparation method and application thereof, wherein the medicinal oil comprises the following components: radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, periostracum Cicadae, and oleum Sesami Niger. The medicinal oil provided by the invention is an oily external medicament, has low cost, convenient use and no toxic or side effect, has the effects of expelling wind and removing cold, clearing heat and removing toxicity, eliminating turbid pathogen with aromatics, freeing nasal orifices and the like by compounding a plurality of Chinese herbal medicines without any additive and preservative, and can be effectively used for treating nasal diseases such as acute and chronic rhinitis, allergic rhinitis, rhinocnesmus, nasal polyp, nasal obstruction, nasosinusitis and the like.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to medicinal oil for treating nasal diseases, and a preparation method and application thereof.
Background
Nasal diseases refer to diseases of external nose, nasal vestibule, nasal cavity and nasal sinuses, and mainly include symptoms of acute and chronic rhinitis, allergic rhinitis, nasal itching, nasal polyp, nasal obstruction, nasosinusitis, and the like.
The existing methods for treating nasal diseases mainly comprise radiotherapy, chemical drug therapy and the like, and have the problems of high treatment cost, inconvenience in treatment, large side effect and the like; although there are also cases where drugs in external preparations such as nasal sprays are used to treat nasal diseases in the prior art, there is a problem that the therapeutic effect is general.
Disclosure of Invention
The embodiment of the invention aims to provide medicinal oil for treating nasal diseases, and aims to solve the problems in the background art.
The embodiment of the invention is realized in such a way that the medicinal oil for treating the nasal diseases comprises the following components in parts by weight: 1-8 parts of divaricate saposhnikovia root, 5-20 parts of schizonepeta, 5-20 parts of cocklebur fruit, 2-10 parts of ligusticum wallichii, 1-8 parts of cicada slough and 300-1200 parts of black sesame oil.
As a preferable scheme of the embodiment of the invention, the medicinal oil comprises the following components in parts by weight: 3-6 parts of divaricate saposhnikovia root, 10-15 parts of schizonepeta, 10-15 parts of cocklebur fruit, 3-9 parts of ligusticum wallichii, 3-6 parts of cicada slough and 500-1000 parts of black sesame oil.
As another preferable scheme of the embodiment of the invention, the medicinal oil comprises the following components in parts by weight: 4-5 parts of divaricate saposhnikovia root, 12-13 parts of schizonepeta, 12-13 parts of cocklebur fruit, 5-7 parts of ligusticum wallichii, 4-5 parts of cicada slough and 700-800 parts of black sesame oil.
Another object of the embodiments of the present invention is to provide a method for preparing the above medicinal oil, which comprises the following steps:
weighing radix sileris, herba schizonepetae, cocklebur fruit, rhizoma ligustici wallichii, periostracum cicadae and black sesame oil according to the weight parts of the components for later use;
cutting radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain mixture;
and adding the mixture into black sesame oil, soaking, decocting, filtering, and filtering to remove residues to obtain the medicinal oil.
As another preferable scheme of the embodiment of the invention, in the step, the soaking time is 60-84 h.
As another preferable scheme of the embodiment of the invention, in the step, the decoction time is 0.4-0.6 h.
The embodiment of the invention also aims to provide the medicinal oil prepared by the preparation method.
As another preferable mode of the embodiment of the present invention, the medicinal oil is in a form for external use.
Another object of the embodiments of the present invention is to provide a use of the above medicinal oil in the preparation of a medicament for treating nasal diseases.
As another preferred embodiment of the present invention, the nasal disease includes at least one of acute and chronic rhinitis, allergic rhinitis, nasal itching, nasal polyps, nasal obstruction, and sinusitis.
The medicinal oil for treating nasal diseases is an oily external medicament, is low in cost, convenient to use and free of toxic and side effects, is prepared by compounding multiple Chinese herbal medicines, does not contain any additive or preservative, has the effects of dispelling wind and cold, clearing heat and removing toxicity, eliminating turbid pathogen by aroma, freeing nasal orifices and the like, and can be effectively used for treating nasal diseases such as acute and chronic rhinitis, allergic rhinitis, nasal itching, nasal polyp, nasal obstruction, nasosinusitis and the like.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
The embodiment provides medicinal oil for treating nasal diseases, which is oily external preparation type medicine, and specifically, the preparation method of the medicinal oil comprises the following steps:
s1, weighing 1g of radix sileris, 5g of herba schizonepetae, 20g of cocklebur fruit, 2g of rhizoma ligustici wallichii, 8g of cicada slough and 300g of black sesame oil for later use. Wherein, the ledebouriella root, schizonepeta, cocklebur fruit, chuanxiong rhizome and cicada slough are cleaned and dried in the sun before being weighed.
S2, cutting the above weighed radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain a mixture.
S3, adding the mixture into black sesame oil, placing the mixture into a pot for decocting for 0.4h after soaking for 60h under natural conditions, cooling and filtering, and filtering out dregs of a decoction to obtain oily liquid medicinal oil.
Example 2
The embodiment provides medicinal oil for treating nasal diseases, which is oily external preparation type medicine, and specifically, the preparation method of the medicinal oil comprises the following steps:
s1, weighing 8g of radix sileris, 20g of herba schizonepetae, 5g of cocklebur fruit, 10g of rhizoma ligustici wallichii, 1g of cicada slough and 1200g of black sesame oil for later use. Wherein, the ledebouriella root, schizonepeta, cocklebur fruit, chuanxiong rhizome and cicada slough are cleaned and dried in the sun before being weighed.
S2, cutting the above weighed radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain a mixture.
S3, adding the mixture into black sesame oil, placing the mixture into a pot to be decocted for 0.6h after soaking for 84h under natural conditions, cooling and filtering, and filtering out dregs of a decoction to obtain oily liquid medicinal oil.
Example 3
The embodiment provides medicinal oil for treating nasal diseases, which is oily external preparation type medicine, and specifically, the preparation method of the medicinal oil comprises the following steps:
s1, weighing 2g of radix sileris, 18g of herba schizonepetae, 18g of cocklebur fruit, 3g of rhizoma ligustici wallichii, 2g of cicada slough and 1100g of black sesame oil for later use. Wherein, the ledebouriella root, schizonepeta, cocklebur fruit, chuanxiong rhizome and cicada slough are cleaned and dried in the sun before being weighed.
S2, cutting the above weighed radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain a mixture.
S3, adding the mixture into black sesame oil, placing the mixture into a pot for decocting for 0.5h after soaking for 70h under natural conditions, cooling and filtering, and filtering out dregs of a decoction to obtain oily liquid medicinal oil.
Example 4
The embodiment provides medicinal oil for treating nasal diseases, which is oily external preparation type medicine, and specifically, the preparation method of the medicinal oil comprises the following steps:
s1, weighing 7g of radix sileris, 7g of herba schizonepetae, 7g of cocklebur fruit, 7g of rhizoma ligustici wallichii, 7g of cicada slough and 700g of black sesame oil for later use. Wherein, the ledebouriella root, schizonepeta, cocklebur fruit, chuanxiong rhizome and cicada slough are cleaned and dried in the sun before being weighed.
S2, cutting the above weighed radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain a mixture.
S3, adding the mixture into black sesame oil, placing the mixture into a pot for decocting for 0.5h after soaking for 80h under natural conditions, cooling and filtering, and filtering out dregs of a decoction to obtain oily liquid medicinal oil.
Example 5
The embodiment provides medicinal oil for treating nasal diseases, which is oily external preparation type medicine, and specifically, the preparation method of the medicinal oil comprises the following steps:
s1, weighing 3g of radix sileris, 10g of herba schizonepetae, 10g of cocklebur fruit, 3g of rhizoma ligustici wallichii, 3g of cicada slough and 1000g of black sesame oil for later use. Wherein, the ledebouriella root, schizonepeta, cocklebur fruit, chuanxiong rhizome and cicada slough are cleaned and dried in the sun before being weighed.
S2, cutting the above weighed radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain a mixture.
S3, adding the mixture into black sesame oil, placing the mixture into a pot for decocting for 0.4h after soaking for 60h under natural conditions, cooling and filtering, and filtering out dregs of a decoction to obtain oily liquid medicinal oil.
Example 6
The embodiment provides medicinal oil for treating nasal diseases, which is oily external preparation type medicine, and specifically, the preparation method of the medicinal oil comprises the following steps:
s1, weighing 6g of radix sileris, 15g of herba schizonepetae, 15g of cocklebur fruit, 9g of rhizoma ligustici wallichii, 6g of cicada slough and 500g of black sesame oil for later use. Wherein, the ledebouriella root, schizonepeta, cocklebur fruit, chuanxiong rhizome and cicada slough are cleaned and dried in the sun before being weighed.
S2, cutting the above weighed radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain a mixture.
S3, adding the mixture into black sesame oil, placing the mixture into a pot for decocting for 0.5h after soaking for 72h under natural conditions, cooling and filtering, and filtering out dregs of a decoction to obtain oily liquid medicinal oil.
Example 7
The embodiment provides medicinal oil for treating nasal diseases, which is oily external preparation type medicine, and specifically, the preparation method of the medicinal oil comprises the following steps:
s1, weighing 4g of divaricate saposhnikovia root, 12g of schizonepeta, 12g of cocklebur fruit, 5g of szechuan lovage rhizome, 4g of cicada slough and 800g of black sesame oil for later use. Wherein, the ledebouriella root, schizonepeta, cocklebur fruit, chuanxiong rhizome and cicada slough are cleaned and dried in the sun before being weighed.
S2, cutting the above weighed radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain a mixture.
S3, adding the mixture into black sesame oil, placing the mixture into a pot for decocting for 0.5h after soaking for 72h under natural conditions, cooling and filtering, and filtering out dregs of a decoction to obtain oily liquid medicinal oil.
Example 8
The embodiment provides medicinal oil for treating nasal diseases, which is oily external preparation type medicine, and specifically, the preparation method of the medicinal oil comprises the following steps:
s1, weighing 5g of divaricate saposhnikovia root, 13g of schizonepeta, 13g of cocklebur fruit, 7g of szechuan lovage rhizome, 5g of cicada slough and 700g of black sesame oil for later use. Wherein, the ledebouriella root, schizonepeta, cocklebur fruit, chuanxiong rhizome and cicada slough are cleaned and dried in the sun before being weighed.
S2, cutting the above weighed radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain a mixture.
S3, adding the mixture into black sesame oil, placing the mixture into a pot for decocting for 0.5h after soaking for 72h under natural conditions, cooling and filtering, and filtering out dregs of a decoction to obtain oily liquid medicinal oil.
Example 9
The embodiment provides medicinal oil for treating nasal diseases, which is oily external preparation type medicine, and specifically, the preparation method of the medicinal oil comprises the following steps:
s1, weighing 5g of divaricate saposhnikovia root, 12g of fineleaf schizonepeta herb, 13g of siberian cocklebur fruit, 7g of szechuan lovage rhizome, 4g of cicada slough and 780g of black sesame oil for later use. Wherein, the ledebouriella root, schizonepeta, cocklebur fruit, chuanxiong rhizome and cicada slough are cleaned and dried in the sun before being weighed.
S2, cutting the above weighed radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain a mixture.
S3, adding the mixture into black sesame oil, placing the mixture into a pot for decocting for 0.5h after soaking for 72h under natural conditions, cooling and filtering, and filtering out dregs of a decoction to obtain oily liquid medicinal oil.
Example 10
The embodiment provides medicinal oil for treating nasal diseases, which is oily external preparation type medicine, and specifically, the preparation method of the medicinal oil comprises the following steps:
s1, weighing 4.5g of divaricate saposhnikovia root, 12.5g of schizonepeta, 12.5g of cocklebur fruit, 6g of szechuan lovage rhizome, 4.5g of cicada slough and 750g of black sesame oil for later use. Wherein, the ledebouriella root, schizonepeta, cocklebur fruit, chuanxiong rhizome and cicada slough are cleaned and dried in the sun before being weighed.
S2, cutting the above weighed radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain a mixture.
S3, adding the mixture into black sesame oil, placing the mixture into a pot for decocting for 0.5h after soaking for 72h under natural conditions, cooling and filtering, and filtering out dregs of a decoction to obtain oily liquid medicinal oil.
The medicinal oil provided by the embodiment is light brown oily liquid in appearance, has sesame fragrance and a shelf life of 10 years (stored in a dry place), and the using method comprises the following steps: before use, the nostrils are cleaned by normal saline, and then the cotton swab is dipped with the medicinal oil and is directly placed in the nostrils for 10-30 minutes, 2-5 times per day.
In addition, the typical case of the practical application of the medicinal oil provided in the above example 10 is as follows:
1. wu XX, male, 38 years old, clinical diagnosis at 7 month and 8 days 2019: nasal obstruction, sinusitis, headache. The patient had no symptoms after using 80mL of the medicinal oil provided in example 10.
2. Yellow XX, female, 40 years old, clinical diagnosis 4 months and 10 days 2020: stuffy nose, running clear nasal discharge. The patient had no symptoms after using 40mL of the medicinal oil provided in example 10 above.
3. Many XX, female, 65 years old, clinical diagnosis at 11 months and 2 days 2019: nasal obstruction, headache. The patient had no symptoms after using 40mL of the medicinal oil provided in example 10 above.
4. Forest XX, male, 32 years old, 3 months and 10 days in 2020 clinical diagnosis: wind-cold, rhinitis, which is caused by cold weather, sneeze and thin nasal discharge. The patient had a significant reduction in the above symptoms after using the medicated oil 40m L provided in example 10 above.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. The medicinal oil for treating nasal diseases is characterized by comprising the following components in parts by weight: 1-8 parts of divaricate saposhnikovia root, 5-20 parts of schizonepeta, 5-20 parts of cocklebur fruit, 2-10 parts of ligusticum wallichii, 1-8 parts of cicada slough and 300-1200 parts of black sesame oil.
2. The medicinal oil for treating the nasal diseases according to claim 1, which comprises the following components in parts by weight: 3-6 parts of divaricate saposhnikovia root, 10-15 parts of schizonepeta, 10-15 parts of cocklebur fruit, 3-9 parts of ligusticum wallichii, 3-6 parts of cicada slough and 500-1000 parts of black sesame oil.
3. The medicinal oil for treating the nasal diseases according to claim 2, which comprises the following components in parts by weight: 4-5 parts of divaricate saposhnikovia root, 12-13 parts of schizonepeta, 12-13 parts of cocklebur fruit, 5-7 parts of ligusticum wallichii, 4-5 parts of cicada slough and 700-800 parts of black sesame oil.
4. A method of preparing a medicinal oil according to any one of claims 1 to 3, comprising the steps of:
weighing radix sileris, herba schizonepetae, cocklebur fruit, rhizoma ligustici wallichii, periostracum cicadae and black sesame oil according to the weight parts of the components for later use;
cutting radix Saposhnikoviae, herba Schizonepetae, fructus Xanthii, rhizoma Ligustici Chuanxiong, and periostracum Cicadae, and mixing to obtain mixture;
and adding the mixture into black sesame oil, soaking, decocting, filtering, and filtering to remove residues to obtain the medicinal oil.
5. The method for preparing medicinal oil according to claim 4, wherein in the step, the soaking time is 60-84 h.
6. The method for preparing medicinal oil according to claim 4, wherein the decocting time is 0.4-0.6 h.
7. A medicinal oil prepared by the preparation method of any one of claims 4 to 6.
8. The medicinal oil of claim 7, wherein the medicinal oil is in a form for external use.
9. Use of a medicinal oil according to any one of claims 1 to 3 and 7 to 8 in the manufacture of a medicament for the treatment of nasal disorders.
10. A use as claimed in claim 9, wherein the nasal disorder comprises at least one of acute and chronic rhinitis, allergic rhinitis, nasal itching, nasal polyps, nasal congestion and sinusitis.
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| CN202010523125.8A CN111514188A (en) | 2020-06-10 | 2020-06-10 | Medicinal oil for treating nasal diseases and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113827638A (en) * | 2021-10-21 | 2021-12-24 | 柴秀成 | Rhinitis medicinal oil and preparation method thereof |
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| CN113827638A (en) * | 2021-10-21 | 2021-12-24 | 柴秀成 | Rhinitis medicinal oil and preparation method thereof |
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Application publication date: 20200811 |
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