CN111700977B - Traditional Chinese medicine composition for promoting fracture healing and preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for promoting fracture healing and preparation method and application thereof Download PDF

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CN111700977B
CN111700977B CN202010799001.2A CN202010799001A CN111700977B CN 111700977 B CN111700977 B CN 111700977B CN 202010799001 A CN202010799001 A CN 202010799001A CN 111700977 B CN111700977 B CN 111700977B
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traditional chinese
chinese medicine
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fracture healing
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CN111700977A (en
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蓝国生
蓝冠宇
蓝天蔚
张皓
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
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Abstract

The invention discloses a Chinese medicinal composition for promoting fracture healing, which takes notopterygium root, heracleum hemsleyanum michaux, safflower, Chinese angelica, myrrh, frankincense, peach kernel, ground beeltle, pseudo-ginseng, dragon's blood, earthworm, erythrina bark, pinkeye fish, Chinese ivy, orientvine, climbing entada, beautiful millettia root, common scouring rush herb, sweet wormwood herb, spreading hedyotis herb, gypsum, tall gastrodia tuber, barbed skullcap herb, obscured homalomena rhizome and other Chinese medicaments or medicaments with homology of medicine and food as raw materials, and has good recovery effect on fracture; the traditional Chinese medicine composition provided by the invention adopts the matching use of the traditional Chinese medicine raw materials, has a synergistic effect, can effectively improve the callus formation effect, is beneficial to promoting callus formation, greatly reduces fracture healing time, and has a wide market application prospect.

Description

Traditional Chinese medicine composition for promoting fracture healing and preparation method and application thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for promoting fracture healing and a preparation method and application thereof.
Background
With the rapid development of market economy, the pace of life of people is faster and faster, the pace of urban traffic and work is also expanded at a high speed, and the occurrence of fractures is more and more common. At present, a patient after fracture generally adopts a splinting plate, plaster fixation, operation traction and the like, after good reduction and fixation, the fracture can be cured after 3-4 months or even more than half a year, and a great deal of inconvenience is brought to the work and life of the patient, so that a traditional Chinese medicine for rapidly promoting fracture healing is urgently needed to promote fracture healing, and the pain time of the patient is shortened.
At present, chemical synthetic pharmacy and traditional Chinese medicines such as paste, pills, decoction and the like can be adopted for treating the fracture, the chemical synthetic pharmacy generally has certain toxic and side effects, and can not promote the formation of callus well, so that the healing time of the fracture is prolonged, and the damage is brought to the liver and kidney functions of a patient; however, the traditional Chinese medicine compound for treating fracture, such as Yunnan Baiyao, traumatic pill and the like, has low purity, long curative effect, complex components and large administration dosage, is a great challenge for liver and kidney functions of patients, is not beneficial to timely rehabilitation of patients, and is easy to cause a series of sequelae, so that the research and development of a traditional Chinese medicine composition which has no toxic or side effect, does not damage liver and kidney functions of patients and promotes fracture healing is urgently needed.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a traditional Chinese medicine composition for promoting fracture healing and a preparation method and application thereof.
In order to achieve the purpose, the invention is realized by the following technical scheme:
a traditional Chinese medicine composition for promoting fracture healing comprises the following raw materials in parts by weight: 5-15 parts of notopterygium root, 7-18 parts of radix angelicae pubescentis, 8-13 parts of safflower, 4-15 parts of angelica sinensis, 5-15 parts of myrrh, 8-20 parts of frankincense, 5-12 parts of peach kernel, 8-12 parts of ground beetle, 7-11 parts of pseudo-ginseng, 9-14 parts of dragon's blood, 6-13 parts of earthworm, 7-11 parts of radix clematidis, 8-14 parts of leech, 7-15 parts of lycopodium clavatum, 6-16 parts of gentiana macrophylla, 7-12 parts of uncaria, 8-18 parts of Chinese starjasmine stem, 7-18 parts of erythrina bark, 6-14 parts of redeye fish, 7-14 parts of caulis sinomenii, 7-16 parts of caulis sinomenii, 6-15 parts of climbing dragon, 5-18 parts of beautiful millettia root, 7-13 parts of horsetail, 8-18 parts of sweet wormwood, 7-14 parts of oldenlandia diffusa, 7-16 parts of gypsum, 6-15 parts of gastrodia elata, 6-16 parts of barbat skullcap and 7-18 parts of homalomena.
Preferably, the feed consists of the following raw materials in parts by weight: 9-12 parts of notopterygium root, 8-12 parts of radix angelicae pubescentis, 9-12 parts of safflower, 9-12 parts of angelica sinensis, 7-11 parts of myrrh, 8-12 parts of frankincense, 9-11 parts of peach kernel, 9-11 parts of ground beetle, 8-10 parts of pseudo-ginseng, 9-12 parts of dragon's blood, 9-12 parts of earthworm, 8-10 parts of radix clematidis, 9-12 parts of leech, 10-12 parts of lycopodium clavatum, 8-14 parts of gentiana macrophylla, 8-11 parts of uncaria, 9-14 parts of Chinese starjasmine stem, 8-14 parts of erythrina bark, 7-11 parts of redeye fish, 9-12 parts of caulis sinomenii, 8-11 parts of climbing fern, 8-11 parts of beautiful millettia root, 8-12 parts of common scouring rush herb, 9-12 parts of sweet wormwood herb, 8-12 parts of spreading hedyotis herb, 10-14 parts of gypsum, 8-13 parts of gastrodia elata, 8-14 parts of barbat skullcap herb and 8-13 parts of homalomena rhizome.
Preferably, the feed consists of the following raw materials in parts by weight: 10 parts of notopterygium root, 10 parts of radix angelicae pubescentis, 10 parts of safflower, 9 parts of angelica, 8 parts of myrrh, 10 parts of frankincense, 10 parts of peach kernel, 10 parts of ground beeltle, 9 parts of pseudo-ginseng, 11 parts of dragon's blood, 11 parts of earthworm, 9 parts of radix clematidis, 10 parts of leech, 11 parts of lycopodium clavatum, 12 parts of gentiana macrophylla, 9 parts of uncaria, 12 parts of Chinese starjasmine stem, 12 parts of erythrina bark, 10 parts of redeye fish, 10 parts of caulis sinomenii, 9 parts of climbing fern, 10 parts of beautiful millettia root, 11 parts of equisetum, 10 parts of sweet wormwood, 10 parts of spreading hedyotis herb, 12 parts of gypsum, 10 parts of gastrodia elata, 12 parts of barbed skullcap herb and 12 parts of homalomena rhizome.
The invention also comprises a preparation method of the traditional Chinese medicine composition for promoting fracture healing, which comprises the following steps:
firstly, taking traditional Chinese medicine raw materials, removing moldy traditional Chinese medicine materials, cleaning the traditional Chinese medicine materials, drying, and keeping the traditional Chinese medicine materials for later use;
secondly, adding the dried traditional Chinese medicine raw materials into a grinder respectively, grinding for 10-30 minutes, sieving by using a 120-150-mesh filter screen, and grinding the filtered unqualified powder again after gathering; the glass is respectively put into different clean glass vessels and sealed, so that the air is prevented from being contacted, and the storage time is prolonged; standby;
mixing 8-12 parts of ground beetle and 6-14 parts of pinkeye fish in parts by weight, adding an ethanol water solution with the weight being 20-30 times of the total weight, mixing for 20-30 minutes under ultrasound, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to 5-10% of the total volume to obtain a concentrated extract for later use;
fourthly, mixing 5 to 15 parts of notopterygium root, 7 to 18 parts of pubescent angelica root, 8 to 13 parts of safflower, 4 to 15 parts of angelica, 5 to 15 parts of myrrh, 8 to 20 parts of frankincense, 5 to 12 parts of peach kernel, 8 to 12 parts of ground beetle, 7 to 11 parts of pseudo-ginseng, 9 to 14 parts of dragon's blood, 6 to 13 parts of earthworm, 7 to 11 parts of clematis root, 8 to 14 parts of leech, 7 to 15 parts of lycopodium clavatum, 6 to 16 parts of gentiana macrophylla, 7 to 12 parts of uncaria, 8 to 18 parts of Chinese starjasmine stem, 7 to 18 parts of erythrina bark, 6 to 14 parts of red-eye fish, 7 to 14 parts of celastrus angulatus, 7 to 16 parts of ivy, 6 to 15 parts of climbing fern, 5 to 18 parts of beautiful millettia root, 7 to 13 parts of common scouring rush herb, 8 to 18 parts of sweet wormwood herb, 7 to 14 parts of spreading hedyotis herb, 7 to 16 parts of gypsum, 6 to 15 parts of gastrodia elata, 6 to 16 parts of barbed skullcap herb and 7 to 18 parts of homalomena rhizome by weight, adding water or 2 times of ethanol for decoction for 1 hour to obtain a mixture, filtering to obtain a first filtrate and a first filter residue; and (3) repeating the decocting step on the first filter residue, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate to obtain a mixed filtrate, distilling the mixed filtrate under reduced pressure to 5-10% of the total volume to obtain an extract, cooling to room temperature, adding the concentrated extract obtained in the third step, stirring and mixing uniformly to obtain a mixture, namely the traditional Chinese medicine composition for promoting fracture healing.
Preferably, the ethanol water solution accounts for 70-95% by mass.
Preferably, the mixture obtained in the step (iv) is further subjected to the following post-treatment steps: drying the obtained mixture, pulverizing into fine powder, sealing, and packaging.
Preferably, when in use, the auxiliary agent with the weight 0.5-1.5 times of the weight of the raw material is added and stirred into a paste; the auxiliary agent is rice wine, cassava wine or tea oil.
Preferably, the addition amount of the auxiliary agent is 1.0 time of the weight of the mixture.
Preferably, the raw materials are decocted for 0.5 to 1 hour at 40 to 50 ℃ in the stirring process, and the mixture is used after being cooled.
A Chinese medicinal composition for promoting fracture healing is applied to fracture.
Compared with the prior art, the invention has the following advantages:
the traditional Chinese medicine composition for promoting fracture healing has a good recovery effect on fracture, and is prepared from traditional Chinese medicines or medicine-food homologous medicines such as notopterygium root, radix angelicae pubescentis, safflower, Chinese angelica, myrrh, frankincense, peach kernel, ground beeltle, pseudo-ginseng, dragon's blood, earthworm, erythrina bark, pinkeye, caulis sinomenii, climbing groundsel herb, beautiful millettia root and rhizome, on one hand, the traditional Chinese medicine composition has no toxic or side effect on a human body, can promote blood circulation to remove nodules, promote blood stagnation, relieve swelling and pain, regulate qi and open orifices, can quickly relieve swelling and pain of nodule parts, promote callus formation, and promote the force of the fracture part to strengthen the reunion of bones; on the other hand, the Chinese medicinal composition can promote the massive proliferation of osteoblasts, promote the growth of callus fast and mature, and has the effects of diminishing inflammation and easing pain, so that the fracture healing time is shortened by more than half.
The traditional Chinese medicine composition for promoting fracture healing provided by the invention adopts the matching use of the traditional Chinese medicine raw materials, has the synergistic effect, can effectively improve the callus formation effect, is beneficial to promoting callus formation, greatly reduces fracture healing time, and has wide market application prospect.
The traditional Chinese medicine composition for promoting fracture healing is prepared by carrying out ultrasonic treatment on ground beetle and red-eye fish in ethanol water to effectively purify active substances in the ground beetle and red-eye fish to obtain concentrated extract; decocting the rest materials with ethanol or water, concentrating under reduced pressure, and mixing with the above concentrated extract to obtain Chinese medicinal composition for promoting fracture healing; the preparation process and equipment are simple, the extraction solvent is cheap and easy to recover, the solvent can be recycled, the environment is not polluted, and the method has a very good market prospect.
Detailed Description
The invention aims to provide a traditional Chinese medicine composition for promoting fracture healing and a preparation method and application thereof, and the traditional Chinese medicine composition is realized by the following technical scheme:
a traditional Chinese medicine composition for promoting fracture healing comprises the following raw materials in parts by weight: 5-15 parts of notopterygium root, 7-18 parts of radix angelicae pubescentis, 8-13 parts of safflower, 4-15 parts of angelica sinensis, 5-15 parts of myrrh, 8-20 parts of frankincense, 5-12 parts of peach kernel, 8-12 parts of ground beetle, 7-11 parts of pseudo-ginseng, 9-14 parts of dragon's blood, 6-13 parts of earthworm, 7-11 parts of radix clematidis, 8-14 parts of leech, 7-15 parts of lycopodium clavatum, 6-16 parts of gentiana macrophylla, 7-12 parts of uncaria, 8-18 parts of Chinese starjasmine stem, 7-18 parts of erythrina bark, 6-14 parts of redeye fish, 7-14 parts of caulis sinomenii, 7-16 parts of caulis sinomenii, 6-15 parts of climbing dragon, 5-18 parts of beautiful millettia root, 7-13 parts of horsetail, 8-18 parts of sweet wormwood, 7-14 parts of oldenlandia diffusa, 7-16 parts of gypsum, 6-15 parts of gastrodia elata, 6-16 parts of barbat skullcap and 7-18 parts of homalomena.
Preferably, the feed consists of the following raw materials in parts by weight: 9-12 parts of notopterygium root, 8-12 parts of radix angelicae pubescentis, 9-12 parts of safflower, 9-12 parts of angelica sinensis, 7-11 parts of myrrh, 8-12 parts of frankincense, 9-11 parts of peach kernel, 9-11 parts of ground beetle, 8-10 parts of pseudo-ginseng, 9-12 parts of dragon's blood, 9-12 parts of earthworm, 8-10 parts of radix clematidis, 9-12 parts of leech, 10-12 parts of lycopodium clavatum, 8-14 parts of gentiana macrophylla, 8-11 parts of uncaria, 9-14 parts of Chinese starjasmine stem, 8-14 parts of erythrina bark, 7-11 parts of redeye fish, 9-12 parts of caulis sinomenii, 8-11 parts of climbing fern, 8-11 parts of beautiful millettia root, 8-12 parts of common scouring rush herb, 9-12 parts of sweet wormwood herb, 8-12 parts of spreading hedyotis herb, 10-14.
Preferably, the feed consists of the following raw materials in parts by weight: 10 parts of notopterygium root, 10 parts of radix angelicae pubescentis, 10 parts of safflower, 9 parts of angelica, 8 parts of myrrh, 10 parts of frankincense, 10 parts of peach kernel, 10 parts of ground beeltle, 9 parts of pseudo-ginseng, 11 parts of dragon's blood, 11 parts of earthworm, 9 parts of radix clematidis, 10 parts of leech, 11 parts of lycopodium clavatum, 12 parts of gentiana macrophylla, 9 parts of uncaria, 12 parts of Chinese starjasmine stem, 12 parts of erythrina bark, 10 parts of redeye fish, 10 parts of caulis sinomenii, 9 parts of climbing fern, 10 parts of beautiful millettia root, 11 parts of equisetum, 10 parts of sweet wormwood, 10 parts of spreading hedyotis herb, 12 parts of gypsum, 10 parts of gastrodia elata, 12 parts of barbed skullcap herb and 12 parts of homalomena rhizome.
The invention also comprises a preparation method of the traditional Chinese medicine composition for promoting fracture healing, which comprises the following steps:
firstly, taking traditional Chinese medicine raw materials, removing moldy traditional Chinese medicine materials, cleaning the traditional Chinese medicine materials, drying, and keeping the traditional Chinese medicine materials for later use;
secondly, adding the dried traditional Chinese medicine raw materials into a grinder respectively, grinding for 10-30 minutes, sieving by using a 120-150-mesh filter screen, and grinding the filtered unqualified powder again after gathering; the glass is respectively put into different clean glass vessels and sealed, so that the air is prevented from being contacted, and the storage time is prolonged; standby;
mixing 8-12 parts of ground beetle and 6-14 parts of pinkeye fish in parts by weight, adding an ethanol water solution with the weight being 20-30 times of the total weight, mixing for 20-30 minutes under ultrasound, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to 5-10% of the total volume to obtain a concentrated extract for later use;
fourthly, mixing 5 to 15 parts of notopterygium root, 7 to 18 parts of pubescent angelica root, 8 to 13 parts of safflower, 4 to 15 parts of angelica, 5 to 15 parts of myrrh, 8 to 20 parts of frankincense, 5 to 12 parts of peach kernel, 8 to 12 parts of ground beetle, 7 to 11 parts of pseudo-ginseng, 9 to 14 parts of dragon's blood, 6 to 13 parts of earthworm, 7 to 11 parts of clematis root, 8 to 14 parts of leech, 7 to 15 parts of lycopodium clavatum, 6 to 16 parts of gentiana macrophylla, 7 to 12 parts of uncaria, 8 to 18 parts of Chinese starjasmine stem, 7 to 18 parts of erythrina bark, 6 to 14 parts of red-eye fish, 7 to 14 parts of celastrus angulatus, 7 to 16 parts of ivy, 6 to 15 parts of climbing fern, 5 to 18 parts of beautiful millettia root, 7 to 13 parts of common scouring rush herb, 8 to 18 parts of sweet wormwood herb, 7 to 14 parts of spreading hedyotis herb, 7 to 16 parts of gypsum, 6 to 15 parts of gastrodia elata, 6 to 16 parts of barbed skullcap herb and 7 to 18 parts of homalomena rhizome by weight, adding water or 2 times of ethanol for decoction for 1 hour to obtain a mixture, filtering to obtain a first filtrate and a first filter residue; and (3) repeating the decocting step on the first filter residue, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate to obtain a mixed filtrate, distilling the mixed filtrate under reduced pressure to 5-10% of the total volume to obtain an extract, cooling to room temperature, adding the concentrated extract obtained in the third step, stirring and mixing uniformly to obtain a mixture, namely the traditional Chinese medicine composition for promoting fracture healing.
Preferably, the ethanol water solution accounts for 70-95% by mass.
Preferably, the mixture obtained in step (iv) may be subjected to the following post-treatment steps if long-term storage or long-distance transport is required: drying the obtained mixture, pulverizing into fine powder, sealing, packaging, and making into commodity for sale or transportation.
Preferably, when in use, the auxiliary agent with the weight 0.5-1.5 times of the weight of the raw material is added and stirred into a paste; the auxiliary agent is rice wine, cassava wine or tea oil; the selected auxiliary agent is compatible with the traditional Chinese medicine composition of the invention, has moderate hardness and moderate adhesive force, avoids the stimulation of the sensitive skin-adhered traditional Chinese medicine composition to the skin, and plays a role in isolation and lubrication; secondly, the effective components in the traditional Chinese medicine composition are easier to dissolve out, the efficacy of the traditional Chinese medicine composition is improved, and the traditional Chinese medicine composition finally has the efficacy of promoting blood circulation and removing blood stasis, and greatly promotes the blood circulation of fractured ends, thereby accelerating fracture healing and reducing infection.
Preferably, the addition amount of the auxiliary agent is 1.0 time of the weight of the mixture.
Preferably, decocting for 0.5-1 hour at 40-50 ℃ in the stirring process, and cooling for use; the optimal preparation method can ensure that the mutual permeation effect of all the components of the traditional Chinese medicine composition is better, and the effective components are easier to dissolve out after heating and decocting, thereby being beneficial to improving the treatment effect of the medicine.
A Chinese medicinal composition for promoting fracture healing is applied to fracture.
The invention is further described with reference to specific examples.
Example 1
A traditional Chinese medicine composition for promoting fracture healing comprises the following raw materials: 5g of notopterygium root, 7g of radix angelicae pubescentis, 8g of safflower, 4g of angelica, 5g of myrrh, 8g of frankincense, 5g of peach kernel, 8g of ground beeltle, 7g of pseudo-ginseng, 9g of dragon's blood, 6g of earthworm, 7g of radix clematidis, 8g of leech, 7g of lycopodium clavatum, 6g of gentiana macrophylla, 7g of uncaria, 8g of Chinese starjasmine stem, 7g of erythrina bark, 6g of redeye fish, 7g of caulis sinomenii, 6g of dioscoreae nipponicae, 5g of beautiful millettia root, 7g of equisetum, 8g of sweet wormwood, 7g of oldenlandia, 7g of gypsum, 6g of gastrodia elata, 6g of barbed skullcap herb and 7g of homalomena rhizome.
Example 2
A traditional Chinese medicine composition for promoting fracture healing comprises the following raw materials: 15g of notopterygium root, 18g of radix angelicae pubescentis, 13g of safflower, 15g of angelica, 15g of myrrh, 20g of frankincense, 12g of peach kernel, 12g of ground beeltle, 11g of pseudo-ginseng, 14g of dragon's blood, 13g of earthworm, 11g of radix clematidis, 14g of leech, 15g of lycopodium clavatum, 16g of gentiana macrophylla, 12g of uncaria, 18g of Chinese starjasmine stem, 18g of erythrina bark, 14g of redeye fish, 14g of caulis sinomenii, 16g of caulis sinomenii, 15g of dioscoreae nipponicae, 18g of beautiful millettia root, 13g of equisetum, 18g of sweet wormwood, 14g of oldenlandia, 16g of gypsum, 15g of gastrodia elata, 16g of barbed skullcap and 18g of homalomena rhizome.
Example 3
A traditional Chinese medicine composition for promoting fracture healing comprises the following raw materials: 9g of notopterygium root, 8g of radix angelicae pubescentis, 9g of safflower, 9g of angelica sinensis, 7g of myrrh, 8g of frankincense, 9g of peach kernel, 9g of ground beeltle, 8g of pseudo-ginseng, 9g of dragon's blood, 9g of earthworm, 8g of radix clematidis, 9g of leech, 10g of lycopodium clavatum, 8g of gentiana macrophylla, 8g of uncaria, 9g of Chinese starjasmine stem, 8g of erythrina bark, 7g of redeye fish, 9g of caulis sinomenii, 8g of dioscoreae nipponicae, 8g of beautiful millettia root, 9-12 g of equisetum, 9g of sweet wormwood, 8g of oldenlandia, 10g of gypsum, 8g of gastrodia elata, 8g of barbed skullcap herb and 8g of homalomena rhizoma.
Example 4
A traditional Chinese medicine composition for promoting fracture healing comprises the following raw materials: 12g of notopterygium root, 12g of radix angelicae pubescentis, 12g of safflower, 12g of angelica, 11g of myrrh, 12g of frankincense, 11g of peach kernel, 11g of ground beeltle, 10g of pseudo-ginseng, 12g of dragon's blood, 12g of earthworm, 10g of radix clematidis, 12g of leech, 12g of lycopodium clavatum, 14g of gentiana macrophylla, 11g of uncaria, 14g of Chinese starjasmine stem, 14g of erythrina bark, 11g of redeye fish, 12g of caulis sinomenii, 11g of dioscoreae nipponicae, 12g of beautiful millettia root, 12g of herba artemisiae, 12g of oldenlandia diffusa, 14g of gypsum, 13g of gastrodia elat.
Example 5
A traditional Chinese medicine composition for promoting fracture healing comprises the following raw materials: 10g of notopterygium root, 10g of radix angelicae pubescentis, 10g of safflower, 9g of angelica sinensis, 8g of myrrh, 10g of frankincense, 10g of peach kernel, 10g of ground beeltle, 9g of pseudo-ginseng, 11g of dragon's blood, 11g of earthworm, 9g of radix clematidis, 10g of leech, 11g of lycopodium clavatum, 12g of gentiana macrophylla, 9g of uncaria, 12g of Chinese starjasmine stem, 12g of erythrina bark, 10g of redeye fish, 10g of caulis sinomenii, 9g of yam rhizome, 10g of beautiful millettia root, 11g of equisetum, 10g of sweet wormwood, 10g of oldenlandia, 12g of gypsum, 10g of gastrodia elata, 12g of barbed skullcap and 12g of homalomena rhizoma.
Example 6
A traditional Chinese medicine composition for promoting fracture healing comprises the following raw materials: 10g of notopterygium root, 10g of radix angelicae pubescentis, 10g of safflower, 10g of angelica sinensis, 10g of myrrh, 10g of frankincense, 10g of peach kernel, 10g of ground beeltle, 10g of pseudo-ginseng, 10g of dragon's blood, 10g of earthworm, 10g of radix clematidis, 10g of leech, 10g of lycopodium clavatum, 10g of gentiana macrophylla, 10g of uncaria, 10g of Chinese starjasmine stem, 10g of erythrina bark, 10g of redeye fish, 10g of caulis sinomenii, 10g of dioscoreae nipponicae, 10g of beautiful millettia root, 10g of herba artemisiae, 10g of oldenlandia diffusa, 10g of gypsum, 10g of gastrodia.
Example 7
A traditional Chinese medicine composition for promoting fracture healing comprises the following raw materials: 15g of notopterygium root, 15g of radix angelicae pubescentis, 15g of safflower, 15g of angelica, 15g of myrrh, 15g of frankincense, 15g of peach kernel, 15g of ground beeltle, 15g of pseudo-ginseng, 15g of dragon's blood, 15g of earthworm, 15g of radix clematidis, 15g of leech, 15g of lycopodium clavatum, 15g of gentiana macrophylla, 15g of uncaria, 15g of Chinese starjasmine stem, 15g of erythrina bark, 15g of redeye fish, 15g of caulis sinomenii, 15g of dioscoreae nipponicae, 15g of beautiful millettia root, 15g of herba artemisiae, 15g of oldenlandia diffusa, 15g of gypsum, 15g of gastrodia elata, 15g of barbed skullcap herb and 15g of homalomena rhizome.
Example 8
The traditional Chinese medicine composition for promoting fracture healing of example 1 is prepared according to the following steps:
firstly, taking traditional Chinese medicine raw materials, removing moldy traditional Chinese medicine materials, cleaning the traditional Chinese medicine materials, drying, and keeping the traditional Chinese medicine materials for later use;
secondly, adding the dried traditional Chinese medicine raw materials into a grinder respectively, grinding for 10-30 minutes, sieving by using a 120-150-mesh filter screen, and grinding the filtered unqualified powder again after gathering; respectively putting the glass powder into different clean glass utensils, sealing the glass utensils to avoid air contact, prolonging the storage time and keeping the glass powder for later use;
mixing 8g of ground beetle and 6g of red-eye fish, adding an ethanol water solution with the weight 20 times of the total weight, mixing for 20-30 minutes under ultrasound, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to 5% of the total volume to obtain a concentrated extract for later use;
mixing 5g of notopterygium root, 7g of radix angelicae pubescentis, 8g of safflower, 4g of angelica, 5g of myrrh, 8g of frankincense, 5g of peach kernel, 7g of pseudo-ginseng, 9g of dragon blood, 6g of earthworm, 7g of radix clematidis, 8g of leech, 7g of lycopodium clavatum, 6g of gentiana macrophylla, 7g of uncaria, 8g of Chinese starjasmine stem, 7g of erythrina bark, 7g of caulis sinomenii, 6g of pangolin scales, 5g of beautiful millettia root, 7g of equisetum, 7g of sweet wormwood, 7g of oldenlandia diffusa, 7g of gypsum, 6g of gastrodia elata, 6g of barbed skullcap herb and 7g of obscured homalomena rhizome to obtain a mixture, adding water or ethanol with the weight being 10 times of the mixture, decocting for 1 hour, and filtering to obtain first filtrate and first filter residue; and (3) repeating the decoction step on the first filter residue, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate to obtain a mixed filtrate, distilling the mixed filtrate under reduced pressure to 5% of the total volume to obtain an extract, cooling to room temperature, adding the concentrated extract obtained in the third step, stirring and mixing uniformly to obtain a mixture, namely the traditional Chinese medicine composition for promoting fracture healing.
Example 9
The traditional Chinese medicine composition for promoting fracture healing of embodiment 2 is prepared by the following steps:
firstly, taking traditional Chinese medicine raw materials, removing moldy traditional Chinese medicine materials, cleaning the traditional Chinese medicine materials, drying, and keeping the traditional Chinese medicine materials for later use;
secondly, adding the dried traditional Chinese medicine raw materials into a grinder respectively, grinding for 10-30 minutes, sieving by using a 120-150-mesh filter screen, and grinding the filtered unqualified powder again after gathering; the glass is respectively put into different clean glass vessels and sealed, so that the air is prevented from being contacted, and the storage time is prolonged; standby;
thirdly, mixing 12g of ground beetle and 14g of red-eye fish, adding an ethanol water solution with the weight being 20-30 times of the total weight, mixing for 20-30 minutes under ultrasound, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to 10% of the total volume to obtain a concentrated extract for later use;
fourthly, mixing 15g of notopterygium root, 18g of radix angelicae pubescentis, 13g of safflower, 15g of angelica, 15g of myrrh, 20g of frankincense, 12g of peach kernel, 11g of pseudo-ginseng, 14g of dragon blood, 13g of earthworm, 11g of radix clematidis, 14g of leech, 15g of lycopodium clavatum, 16g of gentiana macrophylla, 12g of uncaria, 18g of Chinese starjasmine stem, 18g of erythrina bark, 14g of caulis sinomenii, 16g of caulis sinomenii, 15g of climbing fern rhizome, 18g of beautiful millettia root, 18g of equisetum, 13g of equisetum hiemale, 18g of sweet wormwood, 14g of oldenlandia diffusa, 16g of gypsum, 15g of gastrodia elata, 16g of barbed skullcap herb and 18g of obscured homalomena rhizome to obtain a mixture, adding the mixture into water or ethanol with the weight being 10-20 times of the weight of the mixture, decocting for 1.4 hours, and filtering to obtain first filtrate and first filter residue; and (3) repeating the decoction step on the first filter residue, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate to obtain a mixed filtrate, distilling the mixed filtrate under reduced pressure to 10% of the total volume to obtain an extract, cooling to room temperature, adding the concentrated extract obtained in the third step, stirring and mixing uniformly to obtain a mixture, namely the traditional Chinese medicine composition for promoting fracture healing.
Example 10
The traditional Chinese medicine composition for promoting fracture healing of embodiment 3 is prepared according to the following steps:
firstly, taking traditional Chinese medicine raw materials, removing moldy traditional Chinese medicine materials, cleaning the traditional Chinese medicine materials, drying, and keeping the traditional Chinese medicine materials for later use;
secondly, adding the dried traditional Chinese medicine raw materials into a grinder respectively, grinding for 10-30 minutes, sieving by using a 120-150-mesh filter screen, and grinding the filtered unqualified powder again after gathering; the glass is respectively put into different clean glass vessels and sealed, so that the air is prevented from being contacted, and the storage time is prolonged; standby;
mixing 9g of ground beetle and 7g of pinkeyfish in parts by weight, adding an ethanol water solution which is 22 times of the total weight, mixing for 22 minutes under ultrasound, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to 8% of the total volume to obtain a concentrated extract for later use;
fourthly, mixing 9g of notopterygium root, 8g of radix angelicae pubescentis, 9g of safflower, 9g of angelica, 7g of myrrh, 8g of frankincense, 9g of peach kernel, 8g of pseudo-ginseng, 9g of dragon blood, 9g of earthworm, 8g of radix clematidis, 9g of leech, 10g of lycopodium clavatum, 8g of gentiana macrophylla, 8g of uncaria, 9g of Chinese starjasmine stem, 8g of erythrina bark, 9g of caulis sinomenii, 8g of pangolin scales, 8g of beautiful millettia root, 9g of equisetum, 8g of sweet wormwood, 8g of oldenlandia diffusa, 10g of gypsum, 8g of rhizoma gastrodiae, 8g of herba scutellariae barbatae and 8g of obscured homalomena rhizome to obtain a mixture, adding the mixture into water or ethanol with the weight being 12 times of the weight of the mixture, decocting for 1.2 hours, and filtering to obtain first filtrate and first filter residue; and (3) repeating the decoction step on the first filter residue, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate to obtain a mixed filtrate, distilling the mixed filtrate under reduced pressure to 6% of the total volume to obtain an extract, cooling to room temperature, adding the concentrated extract obtained in the third step, stirring and mixing uniformly to obtain a mixture, namely the traditional Chinese medicine composition for promoting fracture healing.
Example 11
The traditional Chinese medicine composition for promoting fracture healing of embodiment 4 is prepared according to the following steps:
firstly, taking traditional Chinese medicine raw materials, removing moldy traditional Chinese medicine materials, cleaning the traditional Chinese medicine materials, drying, and keeping the traditional Chinese medicine materials for later use;
secondly, adding the dried traditional Chinese medicine raw materials into a grinder respectively, grinding for 10-30 minutes, sieving by using a 120-150-mesh filter screen, and grinding the filtered unqualified powder again after gathering; the glass is respectively put into different clean glass vessels and sealed, so that the air is prevented from being contacted, and the storage time is prolonged; standby;
mixing 11g of ground beetle and 11g of pinkeyfish in parts by weight, adding an ethanol water solution with the weight 25 times that of the ground beetle and the pinkeyfish, mixing for 20-30 minutes under ultrasound, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to 6% of the total volume to obtain a concentrated extract for later use;
mixing 12g of notopterygium root, 12g of radix angelicae pubescentis, 12g of safflower, 12g of angelica, 11g of myrrh, 12g of frankincense, 11g of peach kernel, 10g of pseudo-ginseng, 12g of dragon blood, 12g of earthworm, 10g of radix clematidis, 12g of leech, 12g of lycopodium clavatum, 14g of gentiana macrophylla, 11g of uncaria, 14g of Chinese starjasmine stem, 14g of erythrina bark, 12g of caulis sinomenii, 11g of climbing fern rhizome, 12g of beautiful millettia root, 12g of common scouring rush herb, 12g of sweet wormwood, 12g of oldenlandia diffusa, 14g of gypsum, 13g of gastrodia elata, 14g of barbed skullcap herb and 13g of obscured homalomena rhizome to obtain a mixture, adding the mixture into water or ethanol with the weight 15 times of the weight of the mixture, decocting for 1.5 hours, and filtering to obtain first filtrate and first filter residue; and (3) repeating the decoction step on the first filter residue, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate to obtain a mixed filtrate, distilling the mixed filtrate under reduced pressure to 8% of the total volume to obtain an extract, cooling to room temperature, adding the concentrated extract obtained in the third step, stirring and mixing uniformly to obtain a mixture, namely the traditional Chinese medicine composition for promoting fracture healing.
Example 12
The traditional Chinese medicine composition for promoting fracture healing of example 5 can be prepared by the following steps:
firstly, taking traditional Chinese medicine raw materials, removing moldy traditional Chinese medicine materials, cleaning the traditional Chinese medicine materials, drying, and keeping the traditional Chinese medicine materials for later use;
secondly, adding the dried traditional Chinese medicine raw materials into a grinder respectively, grinding for 30 minutes, sieving by a 150-mesh filter screen, and grinding the filtered unqualified powder again after gathering; the glass is respectively put into different clean glass vessels and sealed, so that the air is prevented from being contacted, and the storage time is prolonged;
thirdly, mixing the ground beetle and the red-eye fish in parts by weight, adding an ethanol water solution which is 20 times of the total weight, mixing for 20 minutes under ultrasound, filtering to obtain a filtrate, and concentrating under reduced pressure to obtain a concentrated extract for later use; wherein the mass percent of the ethanol water solution is 70 percent;
adding the rest components into water or ethanol with the weight being 10 times of that of the rest components in parts by weight, decocting for 1 hour, concentrating under reduced pressure to obtain extract, cooling to room temperature, adding the concentrated extract obtained in the step III, and uniformly mixing to obtain a mixture, namely the traditional Chinese medicine composition for promoting fracture healing.
Example 13
The Chinese medicinal composition for promoting fracture healing of the embodiment 6 can be prepared by the following steps:
firstly, taking traditional Chinese medicine raw materials, removing moldy traditional Chinese medicine materials, cleaning the traditional Chinese medicine materials, drying, and keeping the traditional Chinese medicine materials for later use;
secondly, adding the dried traditional Chinese medicine raw materials into a grinder respectively, grinding for 10 minutes, sieving by a 120-mesh filter screen, and grinding again after gathering the filtered unqualified powder; the glass is respectively put into different clean glass vessels and sealed, so that the air is prevented from being contacted, and the storage time is prolonged;
mixing 10g of ground beetle and 10g of pinkeyfish in parts by weight, adding an ethanol water solution with the weight being 20-30 times of the total weight, mixing for 20-30 minutes under ultrasound, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to 5% of the total volume to obtain a concentrated extract for later use; the mass percentage of the ethanol water solution is 70 percent.
Mixing 10g of notopterygium root, 10g of radix angelicae pubescentis, 10g of safflower, 10g of angelica, 10g of myrrh, 10g of frankincense, 10g of peach kernel, 10g of pseudo-ginseng, 10g of dragon's blood, 10g of earthworm, 10g of radix clematidis, 10g of leech, 10g of lycopodium clavatum, 10g of gentiana macrophylla, 10g of uncaria, 10g of Chinese starjasmine stem, 10g of erythrina bark, 10g of caulis sinomenii, 10g of pangolin scales, 10g of beautiful millettia root, 10g of equisetum, 10g of sweet wormwood, 10g of oldenlandia diffusa, 10g of gypsum, 10g of rhizoma gastrodiae, 10g of herba scutellariae barbatae and 10g of obscured homalomena rhizome to obtain a mixture, adding the mixture into water or ethanol with the weight being 10-20 times of the weight of the mixture, decocting for 1.5 hours, and filtering to obtain first filtrate and first filter residue; and (3) repeating the decoction step on the first filter residue, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate to obtain a mixed filtrate, distilling the mixed filtrate under reduced pressure to 8% of the total volume to obtain an extract, cooling to room temperature, adding the concentrated extract obtained in the third step, stirring and mixing uniformly to obtain a mixture, namely the traditional Chinese medicine composition for promoting fracture healing.
Example 14
The Chinese medicinal composition for promoting fracture healing of example 7 can be prepared by the following steps:
firstly, taking traditional Chinese medicine raw materials, removing moldy traditional Chinese medicine materials, cleaning the traditional Chinese medicine materials, drying, and keeping the traditional Chinese medicine materials for later use;
secondly, adding the dried traditional Chinese medicine raw materials into a grinder respectively, grinding for 10 minutes, sieving by a 120-mesh filter screen, and grinding again after gathering the filtered unqualified powder; the glass is respectively put into different clean glass vessels and sealed, so that the air is prevented from being contacted, and the storage time is prolonged;
mixing 15g of ground beetle and 15g of pinkeyfish in parts by weight, adding an ethanol water solution with the weight being 20-30 times of the total weight, mixing for 20-30 minutes under ultrasound, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to 5% of the total volume to obtain a concentrated extract for later use; the mass percentage of the ethanol water solution is 90 percent.
Fourthly, mixing 15g of notopterygium root, 15g of radix angelicae pubescentis, 15g of safflower, 15g of angelica, 15g of myrrh, 15g of frankincense, 15g of peach kernel, 15g of pseudo-ginseng, 15g of dragon's blood, 15g of earthworm, 15g of radix clematidis, 15g of leech, 15g of lycopodium clavatum, 15g of gentiana macrophylla, 15g of uncaria, 15g of Chinese starjasmine stem, 15g of erythrina bark, 15g of caulis sinomenii, 15g of climbing fern rhizome, 15g of pangolin scales, 15g of horsetail, 15g of sweet wormwood, 15g of oldenlandia diffusa, 15g of gypsum, 15g of rhizoma gastrodiae, 15g of herba scutellariae barbatae and 15g of homalomena rhizoma to obtain a mixture, adding the mixture into water or ethanol with the weight being 10-20 times of the weight of the mixture, decocting for 1.5 hours, and filtering to obtain first filtrate and first filter residue; and (3) repeating the decoction step on the first filter residue, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate to obtain a mixed filtrate, distilling the mixed filtrate under reduced pressure to 6% of the total volume to obtain an extract, cooling to room temperature, adding the concentrated extract obtained in the third step, stirring and mixing uniformly to obtain a mixture, namely the traditional Chinese medicine composition for promoting fracture healing.
The mixture obtained in the fourth step of examples 8 to 14 may be subjected to the following post-treatment steps as required: drying the obtained mixture, pulverizing into fine powder, sealing, and packaging to retain medicinal effects of the Chinese medicinal composition, and is convenient for transportation and storage.
When in use, the auxiliary agent with the weight 0.5-1.5 times of that of the raw material is added and stirred into a paste; the auxiliary agent is rice wine, cassava wine or tea oil; preferably, the addition amount of the auxiliary agent is 1.0 time of the weight of the mixture.
Decocting at 40-50 ℃ for 0.5-1 hour in the stirring process, and cooling for use. The amount of the auxiliary agent is preferably "stick-on-stick" or "tear-off-stick".
The clinical test for promoting fracture healing comprises the following steps:
the inventor carries out clinical observation and treatment on 65 patients with fracture in 2015 to date, and the age is 18-60 years old.
The treatment method comprises the following steps:
the traditional Chinese medicine composition of the embodiment 5-7 is prepared into a plaster which is pasted on a fracture part once, one plaster is pasted once, one time is 6-8 hours once, 7 days are 1 course of treatment, and the application is carried out for 1-5 courses of treatment. The treatment time is calculated according to the severity of the illness state of the patient, 1 course of treatment is pasted to the mild patient, and 5 courses of treatment are pasted to the severe patient.
Treatment criteria were:
and (3) healing: based on the X-ray image, the fracture line is fuzzy, continuous callus passes through the fracture line, the swelling and pain are eliminated, and the patient can move freely;
the method has the following advantages: the callus is obviously formed, the fracture broken end is wrapped and scratched, the swelling and pain are eliminated, and the patient can move locally;
and (4) invalidation: no callus or little callus, and obvious swelling and pain.
Clinical results:
58 cases (89.23%) of clinical recovery, 6 cases (9.23%) of effective cases, 1 case (1.54%) of ineffective cases and 98.46% of total effective rate.
In the using process, the swelling and pain of general patients are relieved within 3-5 days after the application of the traditional Chinese medicine, and the traditional Chinese medicine composition for promoting fracture healing has the effects of promoting blood circulation to remove blood stasis, clearing heat to cool blood, and relieving swelling and pain, and has good social benefits.
Typical cases are as follows:
case 1: wangzhi, a man, a 24-year old, stumbled by stones when riding an electric vehicle, and causes fracture of the left foot, multiple soft tissue scratches and difficult pain, the Chinese medicinal composition of the embodiment 12 is adopted to prepare the plaster which is stuck to the fracture of the left foot once, one plaster is stuck for 6-8 hours once a day, one treatment course is 7 days, after one treatment course, the soft tissues of all parts of the body are healed, and the pain feeling of the fracture is obviously relieved. After 2 treatment courses of continuous use, the X-ray image fracture line is fuzzy, continuous callus passes through the fracture line, swelling and pain are eliminated, patients can move freely normally, the disease is cured, and the disease is rechecked after 6 months without relapse.
Case 2: after a certain grandchild, 48 years old, and going downstairs with high-heeled shoes carelessly stepping on wrong stairs to fall, so that lower limb bleeding and pain are caused, the right thigh is swollen, the left leg is fractured, and the left leg is reset and fixed by a hand method, the traditional Chinese medicine composition provided by the embodiment 13 of the invention is pasted on the femoral shaft on the left side, one paste is carried out once a day, one time is carried out for 6-8 hours, 7 days is a treatment course, the pain feeling is obviously relieved after one treatment course, the state of illness is fully cured after 3 treatment courses of continuous use, and the disease is rechecked and does not relapse after 6 months.
Case 3: in a 20-year-old plum, when a user falls down to hurt the right wrist and get a pressure-sore and cannot normally move, the traditional Chinese medicine composition disclosed by the invention in the embodiment 14 is prepared into an ointment and is pasted on the right wrist one time, 6-8 hours are carried out for one time, and 7 days are a treatment course. After one course of treatment, the local swelling is obviously relieved, the pain is obviously relieved, the fracture is completely healed and the disease is cured after the X-ray film rechecking is carried out for 1 course of treatment.
Case 4: in Song Dynasty, male age 35, the ankle joint is red, swollen, distending and painful when being kicked, walking is difficult, and local burning sensation is obvious, the traditional Chinese medicine composition of the embodiment 13 is pasted on the ankle joint, the pain sensation is relieved the next day, burning is subsided, the ankle joint is healed after being pasted for 3 days, and the walking can be carried out freely.
The above description is exemplary of the present invention and is not intended to limit the present invention, and any modification, equivalent replacement, or improvement made without departing from the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (5)

1. A traditional Chinese medicine composition for promoting fracture healing is characterized in that: the composite material is prepared from the following raw materials in parts by weight: 9-12 parts of notopterygium root, 8-12 parts of radix angelicae pubescentis, 9-12 parts of safflower, 9-12 parts of angelica sinensis, 7-11 parts of myrrh, 8-12 parts of frankincense, 9-11 parts of peach kernel, 9-11 parts of ground beetle, 8-10 parts of pseudo-ginseng, 9-12 parts of dragon's blood, 9-12 parts of earthworm, 8-10 parts of radix clematidis, 9-12 parts of leech, 10-12 parts of lycopodium clavatum, 8-14 parts of gentiana macrophylla, 8-11 parts of uncaria, 9-14 parts of Chinese starjasmine stem, 8-14 parts of erythrina bark, 7-11 parts of redeye fish, 9-12 parts of caulis sinomenii, 8-11 parts of climbing fern, 8-11 parts of beautiful millettia root, 8-12 parts of common scouring rush herb, 9-12 parts of sweet wormwood herb, 8-12 parts of spreading hedyotis herb, 10-14 parts of gypsum, 8-13 parts of gastrodia elata, 8-14 parts of barbat skullcap herb and 8-13 parts of homalomena rhizome.
2. The traditional Chinese medicine composition for promoting fracture healing according to claim 1, which is characterized in that: the composite material is prepared from the following raw materials in parts by weight: 10 parts of notopterygium root, 10 parts of radix angelicae pubescentis, 10 parts of safflower, 9 parts of angelica, 8 parts of myrrh, 10 parts of frankincense, 10 parts of peach kernel, 10 parts of ground beeltle, 9 parts of pseudo-ginseng, 11 parts of dragon's blood, 11 parts of earthworm, 9 parts of radix clematidis, 10 parts of leech, 11 parts of lycopodium clavatum, 12 parts of gentiana macrophylla, 9 parts of uncaria, 12 parts of Chinese starjasmine stem, 12 parts of erythrina bark, 10 parts of redeye fish, 10 parts of caulis sinomenii, 9 parts of climbing fern, 10 parts of beautiful millettia root, 11 parts of equisetum, 10 parts of sweet wormwood, 10 parts of spreading hedyotis herb, 12 parts of gypsum, 10 parts of gastrodia elata, 12 parts of barbed skullcap herb and 12 parts of homalomena rhizome.
3. The preparation method of the traditional Chinese medicine composition for promoting fracture healing of claim 1, which is characterized by comprising the following steps: the method comprises the following steps:
firstly, taking traditional Chinese medicine raw materials, removing moldy traditional Chinese medicine materials, cleaning the traditional Chinese medicine materials, drying, and keeping the traditional Chinese medicine materials for later use;
secondly, adding the dried traditional Chinese medicine raw materials into a grinder respectively, grinding for 10-30 minutes, sieving by using a 120-150-mesh filter screen, and grinding the filtered unqualified powder again after gathering; the glass is respectively put into different clean glass vessels and sealed, so that the air is prevented from being contacted, and the storage time is prolonged; standby;
mixing 9-11 parts of ground beetle and 7-11 parts of pinkeye fish in parts by weight, adding an ethanol water solution with the weight being 20-30 times of the total weight, mixing for 20-30 minutes under ultrasound, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to 5-10% of the total volume to obtain a concentrated extract for later use;
mixing 9-12 parts of notopterygium root, 8-12 parts of radix angelicae pubescentis, 9-12 parts of safflower, 9-12 parts of angelica, 7-11 parts of myrrh, 8-12 parts of frankincense, 9-11 parts of peach kernel, 8-10 parts of pseudo-ginseng, 9-12 parts of dragon's blood, 9-12 parts of earthworm, 8-10 parts of radix clematidis, 9-12 parts of leech, 10-12 parts of lycopodium clavatum, 8-14 parts of gentiana macrophylla, 8-11 parts of uncaria, 9-14 parts of Chinese starjasmine stem, 8-14 parts of erythrina bark, 9-12 parts of caulis sinomenii, 8-12 parts of caulis sino, 8-11 parts of climbing fern rhizome, 8-12 parts of beautiful millettia root, 9-12 parts of equisetum, 9-12 parts of artemisia apiacea, 8-12 parts of oldenlandia diffusa, 10-14 parts of gypsum, 8-13 parts of gastrodia elata, 8-14 parts of herba, adding water or ethanol with the weight 10-20 times that of the mixture, decocting for 1-2 hours, and filtering to obtain a first filtrate and a first filter residue; and (3) repeating the decocting step on the first filter residue, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate to obtain a mixed filtrate, distilling the mixed filtrate under reduced pressure until the volume of the mixed filtrate is 5-10% of the total volume of the mixed filtrate to obtain an extract, cooling to room temperature, adding the concentrated extract obtained in the third step, stirring and mixing uniformly to obtain a mixture, drying the obtained mixture, crushing into fine powder, sealing and packaging to obtain the traditional Chinese medicine composition for promoting fracture healing.
4. The preparation method of the traditional Chinese medicine composition for promoting fracture healing according to claim 3, which is characterized by comprising the following steps: the mass percentage of the ethanol water solution is 70-95%.
5. The use of the Chinese medicinal composition for promoting fracture healing of claim 1 in the preparation of a medicament for promoting fracture healing.
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1899378A (en) * 2006-07-04 2007-01-24 郭吉山 External application Chinese medicine for bone wound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1899378A (en) * 2006-07-04 2007-01-24 郭吉山 External application Chinese medicine for bone wound

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
小切口复位自锁髓内钉固定配合中药熏洗治疗肱骨干骨折;李明治;《中国现代药物应用》;20120930;第6卷(第17期);第29-30页 *
李明治.小切口复位自锁髓内钉固定配合中药熏洗治疗肱骨干骨折.《中国现代药物应用》.2012,第6卷(第17期),第29-30页. *

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