CN111542309A - 具有盐形式的活性物质的微针阵列 - Google Patents

具有盐形式的活性物质的微针阵列 Download PDF

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Publication number
CN111542309A
CN111542309A CN201880080460.6A CN201880080460A CN111542309A CN 111542309 A CN111542309 A CN 111542309A CN 201880080460 A CN201880080460 A CN 201880080460A CN 111542309 A CN111542309 A CN 111542309A
Authority
CN
China
Prior art keywords
microneedle array
salt form
intradermal administration
active substance
microneedles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880080460.6A
Other languages
English (en)
Chinese (zh)
Inventor
A·赫宁
T·希勒
G·沃尔
H·施皮尔吉斯
R·普拉克特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of CN111542309A publication Critical patent/CN111542309A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880080460.6A 2017-12-14 2018-12-14 具有盐形式的活性物质的微针阵列 Pending CN111542309A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102017130057 2017-12-14
DE102017130057.0 2017-12-14
PCT/EP2018/085083 WO2019115815A1 (de) 2017-12-14 2018-12-14 Mikronadelarray aufweisend einen wirkstoff in form von salzen

Publications (1)

Publication Number Publication Date
CN111542309A true CN111542309A (zh) 2020-08-14

Family

ID=65011948

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880080460.6A Pending CN111542309A (zh) 2017-12-14 2018-12-14 具有盐形式的活性物质的微针阵列

Country Status (7)

Country Link
US (1) US12397142B2 (https=)
EP (1) EP3723725B1 (https=)
JP (2) JP7837672B2 (https=)
CN (1) CN111542309A (https=)
CA (1) CA3085633A1 (https=)
ES (1) ES2908820T3 (https=)
WO (1) WO2019115815A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116850129A (zh) * 2023-05-24 2023-10-10 天津医科大学总医院 可精确控制盐酸丁丙诺啡释放的微针贴片
CN118750435A (zh) * 2024-06-12 2024-10-11 哈尔滨工业大学 一种舒芬太尼微针贴片及其制备方法和应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017112573A1 (de) * 2017-06-07 2018-12-13 Lts Lohmann Therapie-Systeme Ag Mikronadelsystem zur Applikation von Glukagon-ähnlichen-Peptid Analoga
DE102019129444A1 (de) 2019-10-31 2021-05-06 Lts Lohmann Therapie-Systeme Ag Lagtime-Verkürzung/Eisspray
CN113520986A (zh) * 2021-06-16 2021-10-22 暨南大学 一种任意曲面聚合物微针阵列及其制备方法
DE102021118997A1 (de) 2021-07-22 2023-01-26 Lts Lohmann Therapie-Systeme Ag. Mikronadelarray mit Antiseptika
DE102021130950A1 (de) * 2021-11-25 2023-05-25 Lts Lohmann Therapie-Systeme Ag. Applikationshilfe

Citations (19)

* Cited by examiner, † Cited by third party
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US20030187395A1 (en) * 2002-04-02 2003-10-02 Gabel Jonathan B. Intradermal delivery device
US20050226922A1 (en) * 2004-04-13 2005-10-13 Mahmoud Ameri Apparatus and method for transdermal delivery of fentanyl-based agents
US20080008745A1 (en) * 2006-06-21 2008-01-10 University Of Kentucky Research Foundation Transdermal delivery of naltrexone hydrochloride, naltrexol hydrochloride, and bis(hydroxy-methyl)propionyl-3-0 ester naltrexone using microneedles
US20080183144A1 (en) * 2007-01-22 2008-07-31 Trautman Joseph C Applicators for microneedles
US20090246265A1 (en) * 2008-03-26 2009-10-01 Alltranz Inc. Abuse deterrent transdermal formulations of opiate agonists and agonist-antagonists
JP2009254756A (ja) * 2008-04-14 2009-11-05 Kosumedei Seiyaku Kk マイクロニードルアレイ
CN101612141A (zh) * 2009-07-29 2009-12-30 考司美德制药株式会社 丁丙诺啡贴剂
US20100303892A1 (en) * 2007-08-29 2010-12-02 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing elongate hollow bodies
CN102406640A (zh) * 2010-09-26 2012-04-11 上海泰因生物技术有限公司 镇痛消炎类药物及镇痛消炎类药物微针透皮给药方法
JP2013032324A (ja) * 2011-08-03 2013-02-14 Bioserentack Co Ltd 局所麻酔薬を含有する即効性のマイクロニードル・アレイ・パッチ製剤
CN103429222A (zh) * 2011-03-07 2013-12-04 3M创新有限公司 微针装置和方法
CN103550191A (zh) * 2013-10-15 2014-02-05 温天文 一种布洛芬及其盐无痛微针透皮贴剂及其制备方法
WO2014193729A1 (en) * 2013-05-31 2014-12-04 3M Innovative Properties Company Microneedle injection apparatus comprising an inverted actuator
WO2014191979A1 (en) * 2013-05-31 2014-12-04 University Of The Witwatersrand, Johannesburg Polymeric hydrogel pharmaceutical compositions with on-demand release of a drug ain response to a electrical stimulus
CN104797287A (zh) * 2012-11-16 2015-07-22 3M创新有限公司 力控施用装置以及将微针装置施用到皮肤的方法
CN104902943A (zh) * 2013-01-08 2015-09-09 3M创新有限公司 用于向皮肤施用微针装置的施用装置
CN105073180A (zh) * 2013-03-22 2015-11-18 3M创新有限公司 包括计数器组件的微针施用装置
WO2017043517A1 (ja) * 2015-09-08 2017-03-16 富士フイルム株式会社 マイクロニードルアレイ
US20180099133A1 (en) * 2015-04-07 2018-04-12 Lts Lohmann Therapie-Systeme Ag Microneedle system for administering liquid formulations

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10353629A1 (de) 2003-11-17 2005-06-16 Lts Lohmann Therapie-Systeme Ag Vorrichtung zur transdermalen Verabreichung von Wirkstoffen
US20090182306A1 (en) * 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
DK2613784T3 (da) 2010-09-07 2018-01-29 Emplicure Ab Indretning til transdermal indgivelse af lægemiddel
US9017289B2 (en) * 2010-11-03 2015-04-28 Covidien Lp Transdermal fluid delivery device
JP6370802B2 (ja) * 2012-12-28 2018-08-08 テイコク ファーマ ユーエスエー インコーポレーテッド 持続性ブプレノルフィン経皮送達組成物およびそれの使用方法
GB201503961D0 (en) 2015-03-09 2015-04-22 Emplicure Ab A transdermal drug administration device

Patent Citations (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187395A1 (en) * 2002-04-02 2003-10-02 Gabel Jonathan B. Intradermal delivery device
US20050226922A1 (en) * 2004-04-13 2005-10-13 Mahmoud Ameri Apparatus and method for transdermal delivery of fentanyl-based agents
US20080008745A1 (en) * 2006-06-21 2008-01-10 University Of Kentucky Research Foundation Transdermal delivery of naltrexone hydrochloride, naltrexol hydrochloride, and bis(hydroxy-methyl)propionyl-3-0 ester naltrexone using microneedles
US20080183144A1 (en) * 2007-01-22 2008-07-31 Trautman Joseph C Applicators for microneedles
US20100303892A1 (en) * 2007-08-29 2010-12-02 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing elongate hollow bodies
US20090246265A1 (en) * 2008-03-26 2009-10-01 Alltranz Inc. Abuse deterrent transdermal formulations of opiate agonists and agonist-antagonists
JP2009254756A (ja) * 2008-04-14 2009-11-05 Kosumedei Seiyaku Kk マイクロニードルアレイ
CN101612141A (zh) * 2009-07-29 2009-12-30 考司美德制药株式会社 丁丙诺啡贴剂
CN102406640A (zh) * 2010-09-26 2012-04-11 上海泰因生物技术有限公司 镇痛消炎类药物及镇痛消炎类药物微针透皮给药方法
CN103429222A (zh) * 2011-03-07 2013-12-04 3M创新有限公司 微针装置和方法
JP2013032324A (ja) * 2011-08-03 2013-02-14 Bioserentack Co Ltd 局所麻酔薬を含有する即効性のマイクロニードル・アレイ・パッチ製剤
CN104797287A (zh) * 2012-11-16 2015-07-22 3M创新有限公司 力控施用装置以及将微针装置施用到皮肤的方法
CN104902943A (zh) * 2013-01-08 2015-09-09 3M创新有限公司 用于向皮肤施用微针装置的施用装置
CN105073180A (zh) * 2013-03-22 2015-11-18 3M创新有限公司 包括计数器组件的微针施用装置
WO2014193729A1 (en) * 2013-05-31 2014-12-04 3M Innovative Properties Company Microneedle injection apparatus comprising an inverted actuator
WO2014191979A1 (en) * 2013-05-31 2014-12-04 University Of The Witwatersrand, Johannesburg Polymeric hydrogel pharmaceutical compositions with on-demand release of a drug ain response to a electrical stimulus
CN105283216A (zh) * 2013-05-31 2016-01-27 3M创新有限公司 包括倒置致动器的微针注入设备
CN105451714A (zh) * 2013-05-31 2016-03-30 约翰内斯堡威特沃特斯兰德大学 响应电刺激按需释放药物的聚合物水凝胶药物组合物
CN103550191A (zh) * 2013-10-15 2014-02-05 温天文 一种布洛芬及其盐无痛微针透皮贴剂及其制备方法
US20180099133A1 (en) * 2015-04-07 2018-04-12 Lts Lohmann Therapie-Systeme Ag Microneedle system for administering liquid formulations
WO2017043517A1 (ja) * 2015-09-08 2017-03-16 富士フイルム株式会社 マイクロニードルアレイ

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116850129A (zh) * 2023-05-24 2023-10-10 天津医科大学总医院 可精确控制盐酸丁丙诺啡释放的微针贴片
CN118750435A (zh) * 2024-06-12 2024-10-11 哈尔滨工业大学 一种舒芬太尼微针贴片及其制备方法和应用

Also Published As

Publication number Publication date
US20200297985A1 (en) 2020-09-24
ES2908820T3 (es) 2022-05-04
EP3723725B1 (de) 2022-02-02
EP3723725A1 (de) 2020-10-21
JP2021506790A (ja) 2021-02-22
US12397142B2 (en) 2025-08-26
JP7837672B2 (ja) 2026-03-31
BR112020010729A2 (pt) 2020-11-10
CA3085633A1 (en) 2019-06-20
WO2019115815A1 (de) 2019-06-20
JP2024039052A (ja) 2024-03-21

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