JP7837672B2 - 塩形態の有効成分を含むマイクロニードルアレイ - Google Patents

塩形態の有効成分を含むマイクロニードルアレイ

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Publication number
JP7837672B2
JP7837672B2 JP2020532587A JP2020532587A JP7837672B2 JP 7837672 B2 JP7837672 B2 JP 7837672B2 JP 2020532587 A JP2020532587 A JP 2020532587A JP 2020532587 A JP2020532587 A JP 2020532587A JP 7837672 B2 JP7837672 B2 JP 7837672B2
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JP
Japan
Prior art keywords
microneedle array
microneedles
salt form
intradermal delivery
applicator system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2020532587A
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English (en)
Japanese (ja)
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JP2021506790A (ja
JP2021506790A5 (https=
Inventor
アンドレアス・ヘニング
トーマス・ヒル
ガーブリエル・ヴァウアー
ハイコ・シュピルギース
ロルフ・プラハト
Original Assignee
エルテーエス ローマン テラピー－ジステーメ アーゲー
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Publication of JP2021506790A publication Critical patent/JP2021506790A/ja
Publication of JP2021506790A5 publication Critical patent/JP2021506790A5/ja
Priority to JP2024000392A priority Critical patent/JP2024039052A/ja
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Publication of JP7837672B2 publication Critical patent/JP7837672B2/ja
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020532587A 2017-12-14 2018-12-14 塩形態の有効成分を含むマイクロニードルアレイ Active JP7837672B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024000392A JP2024039052A (ja) 2017-12-14 2024-01-05 塩形態の有効成分を含むマイクロニードルアレイ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102017130057 2017-12-14
DE102017130057.0 2017-12-14
PCT/EP2018/085083 WO2019115815A1 (de) 2017-12-14 2018-12-14 Mikronadelarray aufweisend einen wirkstoff in form von salzen

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024000392A Division JP2024039052A (ja) 2017-12-14 2024-01-05 塩形態の有効成分を含むマイクロニードルアレイ

Publications (3)

Publication Number Publication Date
JP2021506790A JP2021506790A (ja) 2021-02-22
JP2021506790A5 JP2021506790A5 (https=) 2022-01-06
JP7837672B2 true JP7837672B2 (ja) 2026-03-31

Family

ID=65011948

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020532587A Active JP7837672B2 (ja) 2017-12-14 2018-12-14 塩形態の有効成分を含むマイクロニードルアレイ
JP2024000392A Withdrawn JP2024039052A (ja) 2017-12-14 2024-01-05 塩形態の有効成分を含むマイクロニードルアレイ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024000392A Withdrawn JP2024039052A (ja) 2017-12-14 2024-01-05 塩形態の有効成分を含むマイクロニードルアレイ

Country Status (7)

Country Link
US (1) US12397142B2 (https=)
EP (1) EP3723725B1 (https=)
JP (2) JP7837672B2 (https=)
CN (1) CN111542309A (https=)
CA (1) CA3085633A1 (https=)
ES (1) ES2908820T3 (https=)
WO (1) WO2019115815A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017112573A1 (de) * 2017-06-07 2018-12-13 Lts Lohmann Therapie-Systeme Ag Mikronadelsystem zur Applikation von Glukagon-ähnlichen-Peptid Analoga
DE102019129444A1 (de) 2019-10-31 2021-05-06 Lts Lohmann Therapie-Systeme Ag Lagtime-Verkürzung/Eisspray
CN113520986A (zh) * 2021-06-16 2021-10-22 暨南大学 一种任意曲面聚合物微针阵列及其制备方法
DE102021118997A1 (de) 2021-07-22 2023-01-26 Lts Lohmann Therapie-Systeme Ag. Mikronadelarray mit Antiseptika
DE102021130950A1 (de) * 2021-11-25 2023-05-25 Lts Lohmann Therapie-Systeme Ag. Applikationshilfe
CN116850129A (zh) * 2023-05-24 2023-10-10 天津医科大学总医院 可精确控制盐酸丁丙诺啡释放的微针贴片
CN118750435A (zh) * 2024-06-12 2024-10-11 哈尔滨工业大学 一种舒芬太尼微针贴片及其制备方法和应用

Citations (7)

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JP2007532645A (ja) 2004-04-13 2007-11-15 アルザ コーポレイション フェンタニルに基づく薬剤の経皮送達システム用の器具および方法
JP2010516337A (ja) 2007-01-22 2010-05-20 コリウム インターナショナル， インコーポレイテッド マイクロニードルアレイ用アプリケータ
CN102406640A (zh) 2010-09-26 2012-04-11 上海泰因生物技术有限公司 镇痛消炎类药物及镇痛消炎类药物微针透皮给药方法
JP2013536875A (ja) 2010-09-07 2013-09-26 オレクソ・アクチエボラゲット 経皮薬物投与デバイス
WO2016142705A1 (en) 2015-03-09 2016-09-15 Emplicure Ab A transdermal drug administration device
WO2016162449A1 (de) 2015-04-07 2016-10-13 Lts Lohmann Therapie-Systeme Ag Mikronadelsystem zur applikation von flüssigen formulierungen
JP2017051312A (ja) 2015-09-08 2017-03-16 富士フイルム株式会社 マイクロニードルアレイ

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US6780171B2 (en) * 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
DE10353629A1 (de) 2003-11-17 2005-06-16 Lts Lohmann Therapie-Systeme Ag Vorrichtung zur transdermalen Verabreichung von Wirkstoffen
US20080008745A1 (en) * 2006-06-21 2008-01-10 University Of Kentucky Research Foundation Transdermal delivery of naltrexone hydrochloride, naltrexol hydrochloride, and bis(hydroxy-methyl)propionyl-3-0 ester naltrexone using microneedles
US20090182306A1 (en) * 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
DE102007041557B4 (de) 2007-08-29 2011-03-31 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System enthaltend längliche Hohlkörper
EP2254561A2 (en) * 2008-03-26 2010-12-01 AllTranz Inc. Abuse deterrent transdermal formulations of opiate agonists and agonist-antagonists
JP2009254756A (ja) * 2008-04-14 2009-11-05 Kosumedei Seiyaku Kk マイクロニードルアレイ
CN101612141B (zh) 2009-07-29 2012-10-03 考司美德制药株式会社 丁丙诺啡贴剂
US9017289B2 (en) * 2010-11-03 2015-04-28 Covidien Lp Transdermal fluid delivery device
ES2542012T3 (es) * 2011-03-07 2015-07-29 3M Innovative Properties Company Dispositivos de microagujas y métodos
JP2013032324A (ja) 2011-08-03 2013-02-14 Bioserentack Co Ltd 局所麻酔薬を含有する即効性のマイクロニードル・アレイ・パッチ製剤
EP2919849B1 (en) * 2012-11-16 2021-01-06 Kindeva Drug Delivery L.P. Force-controlled applicator for applying a microneedle device to skin
JP6370802B2 (ja) * 2012-12-28 2018-08-08 テイコク ファーマ ユーエスエー インコーポレーテッド 持続性ブプレノルフィン経皮送達組成物およびそれの使用方法
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JP2010516337A (ja) 2007-01-22 2010-05-20 コリウム インターナショナル， インコーポレイテッド マイクロニードルアレイ用アプリケータ
JP2013536875A (ja) 2010-09-07 2013-09-26 オレクソ・アクチエボラゲット 経皮薬物投与デバイス
CN102406640A (zh) 2010-09-26 2012-04-11 上海泰因生物技术有限公司 镇痛消炎类药物及镇痛消炎类药物微针透皮给药方法
WO2016142705A1 (en) 2015-03-09 2016-09-15 Emplicure Ab A transdermal drug administration device
WO2016162449A1 (de) 2015-04-07 2016-10-13 Lts Lohmann Therapie-Systeme Ag Mikronadelsystem zur applikation von flüssigen formulierungen
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Also Published As

Publication number Publication date
US20200297985A1 (en) 2020-09-24
ES2908820T3 (es) 2022-05-04
EP3723725B1 (de) 2022-02-02
EP3723725A1 (de) 2020-10-21
JP2021506790A (ja) 2021-02-22
US12397142B2 (en) 2025-08-26
BR112020010729A2 (pt) 2020-11-10
CN111542309A (zh) 2020-08-14
CA3085633A1 (en) 2019-06-20
WO2019115815A1 (de) 2019-06-20
JP2024039052A (ja) 2024-03-21

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