CN111533798A - 用于癌症免疫治疗的肽及其肽组合物 - Google Patents

用于癌症免疫治疗的肽及其肽组合物 Download PDF

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Publication number
CN111533798A
CN111533798A CN202010263602.1A CN202010263602A CN111533798A CN 111533798 A CN111533798 A CN 111533798A CN 202010263602 A CN202010263602 A CN 202010263602A CN 111533798 A CN111533798 A CN 111533798A
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peptide
cells
cancer
peptides
cell
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Chinese (zh)
Inventor
M·迪·马尔科
S·海顿
D·科瓦勒斯基
M·夫勒
A·内尔德
H·拉姆森
S·斯蒂凡诺维奇
N·特劳特魏因
J·S·沃茨
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Immatics Biotechnologies GmbH
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Immatics Biotechnologies GmbH
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N2501/998—Proteins not provided for elsewhere

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
  • Hematology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
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  • Developmental Biology & Embryology (AREA)
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CN202010263602.1A 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物 Pending CN111533798A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762483702P 2017-04-10 2017-04-10
DE102017107697.2 2017-04-10
DE102017107697 2017-04-10
US62/483,702 2017-04-10
CN201880023922.0A CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

Related Parent Applications (1)

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CN201880023922.0A Division CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

Publications (1)

Publication Number Publication Date
CN111533798A true CN111533798A (zh) 2020-08-14

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Family Applications (12)

Application Number Title Priority Date Filing Date
CN202010263602.1A Pending CN111533798A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263513.7A Pending CN111499714A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263511.8A Pending CN111533796A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN201880023922.0A Pending CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263512.2A Pending CN111528539A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263601.7A Pending CN111548406A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263571.XA Pending CN111499715A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263514.1A Pending CN111647062A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263572.4A Pending CN111548404A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263515.6A Pending CN111533797A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263573.9A Pending CN111548405A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263575.8A Pending CN111499716A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

Family Applications After (11)

Application Number Title Priority Date Filing Date
CN202010263513.7A Pending CN111499714A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263511.8A Pending CN111533796A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN201880023922.0A Pending CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263512.2A Pending CN111528539A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263601.7A Pending CN111548406A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263571.XA Pending CN111499715A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263514.1A Pending CN111647062A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263572.4A Pending CN111548404A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263515.6A Pending CN111533797A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263573.9A Pending CN111548405A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263575.8A Pending CN111499716A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

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US (3) US20220332760A1 (https=)
EP (2) EP3609530A1 (https=)
JP (3) JP2020516681A (https=)
KR (2) KR20190137829A (https=)
CN (12) CN111533798A (https=)
AU (2) AU2018251839B2 (https=)
BR (1) BR112019020959A2 (https=)
CA (1) CA3059644A1 (https=)
CL (1) CL2019002880A1 (https=)
CO (1) CO2019012077A2 (https=)
CR (3) CR20210159A (https=)
IL (1) IL269741A (https=)
MA (2) MA51170A (https=)
MX (1) MX2019012225A (https=)
PE (1) PE20191711A1 (https=)
PH (1) PH12019502308A1 (https=)
SG (2) SG11201909153UA (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019020959A2 (pt) * 2017-04-10 2020-05-05 Immatics Biotechnologies Gmbh peptídeos e combinações dos mesmos para uso na imunoterapia contra câncer
MX2019015879A (es) * 2017-07-07 2020-02-07 Immatics Biotechnologies Gmbh Nuevos peptidos y nuevas combinacones de peptidos para el uso en la inmunoterapia contra el cancer de pulmon, incluyendo el nsclc, el sclc y otros canceres.
JP2023530235A (ja) * 2020-06-03 2023-07-14 フェス・セラピューティクス，インコーポレーテッド 個別化された処置方法のための製剤
CN111978375B (zh) * 2020-08-28 2022-10-04 深圳市乐土生物医药有限公司 具有细胞毒性t细胞诱导能力的蛋白质或多肽
CN112010960A (zh) * 2020-09-10 2020-12-01 热休(厦门)细胞生物科技有限公司 一种肿瘤抗原复合物体外致敏dc、t细胞获得肿瘤特异性杀伤细胞ctl及其制备方法
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