CN111529601A

CN111529601A - Traditional Chinese medicine composition for treating emphysema

Info

Publication number: CN111529601A
Application number: CN202010416534.8A
Authority: CN
Inventors: 仲崇允
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-18
Filing date: 2020-05-18
Publication date: 2020-08-14
Also published as: CN112972556A

Abstract

The invention discloses a traditional Chinese medicine composition for treating emphysema, belonging to an oral traditional Chinese medicine preparation. The traditional Chinese medicine composition for treating emphysema is generally used for 2 months as a treatment course, and can be recovered after 2-3 treatment courses, so that the treatment effect is remarkable. The clinical tracking of 50 people shows that the total effective rate is 100 percent, the obvious effect is 86 percent, and the cure rate is 56 percent.

Description

Traditional Chinese medicine composition for treating emphysema

Technical Field

The invention relates to the field of preparation of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for emphysema.

Background

Emphysema refers to the pathological condition of hypo-elasticity of the airway distal to the terminal bronchioles, hyper-distension, gas filling and enlargement of lung volume or the simultaneous destruction of airway wall. Clinical symptoms: dyspnea, shortness of breath, cough, expectoration, fullness in the chest, and fullness in the chest such as a plug. Cyanosis of the labial and nails, palpitation and edema can be seen after a long time of illness. Emphysema has several types according to its pathogenesis: senile emphysema, compensatory emphysema, interstitial emphysema, focal emphysema, paraseptal emphysema, and obstructive emphysema.

The traditional western medicine treatment mode is as follows:

bronchodilator drugs: these include anticholinergic drugs, beta 2 receptor agonists and theophylline drugs, which act on the smooth muscle of the tracheobronchial tube to cause it to relax, dilate spastic bronchi and relieve obstruction.

Glucocorticoids: the glucocorticoid has the main effects of relieving the inflammation of the bronchus and the bronchus, relieving congestion and edema of the mucous membrane of the bronchus, reducing secretion in the bronchus, and relieving smooth muscle spasm after relieving the inflammation of the bronchus wall, so the glucocorticoid has wide action mechanism and is an important medicament for treating the chronic obstructive pulmonary disease.

Phlegm-resolving medicines: the main action of expectorants is to dilute bronchial secretions, which can easily be expectorated.

Cough relieving medicines: some patients with severe cough may take antitussive medication to relieve cough symptoms.

The western medicine can only relieve or control the disease condition, but can not cure the disease. In addition, glucocorticoid has great side effects and is easy to cause femoral head necrosis.

Disclosure of Invention

The invention aims to improve the defects of the prior art and provide the traditional Chinese medicine composition for treating emphysema, which improves the cure rate of emphysema patients and has the characteristics of remarkable treatment effect, no toxic or side effect and the like.

The traditional Chinese medicine considers that: emphysema (pulmonary distention) refers to the recurrent attack, delayed and unhealed of various chronic lung diseases and the deficiency of the lung, spleen and kidney, which leads to the disadvantages of the lung duct, the obstruction of the air passage, the stagnation of lung qi and the fullness of the chest and falsework. The spleen is the source of phlegm generation, and the lung is the device for storing phlegm. The lung has a defense function of dispersing, purifying and descending, the deficiency of lung qi can easily invade exogenous pathogenic factors to damage lung qi, the deficiency of lung qi can affect water vapor distribution, phlegm can be generated, the deficiency of lung qi can affect the spleen to transport and transform food essence to nourish the whole body, and the deficiency of lung qi can generate phlegm and generate toxicity when food cannot be transported and transformed, so that the effects of tonifying qi, strengthening body resistance, clearing heat and detoxicating, tonifying lung and strengthening spleen, promoting blood circulation to remove blood stasis, eliminating phlegm and reducing swelling are needed.

Based on the theory, the invention provides a traditional Chinese medicine composition for treating emphysema, which comprises dried toad, cascara sagrada, negundo chastetree fruit, Japanese ardisia, adenophora tetraphylla, lespedeza cuneata, gnetum montanum and codonopsis pilosula.

Further, 3 parts of dried toad; 12 parts of cascara Sagrada and Vitex negundo; herba Ardisiae Japonicae, radix Adenophorae, herba Lespedezae Cuneatae, caulis Gneti, and radix Codonopsis 30 parts.

Wherein, the weight ratio of the rhamnus: sweet, slightly bitter and neutral. Has little toxicity. Relieve cough and dispel phlegm. Can be used for treating bronchitis and emphysema.

Japanese ardisia herb: mild in nature, pungent and slightly bitter in flavor. Resolve phlegm and stop cough, remove dampness by diuresis, activate blood. Can be used for treating cough, bloody sputum, and chronic bronchitis. The oral administration of herba Ardisiae Japonicae can reduce goblet cells, and relieve inflammatory cell infiltration, chronic tracheitis, emphysema and lung atrophy. The Japanese ardisia herb decoction has obvious functions of eliminating phlegm and relieving cough and has no tolerance. Herba Ardisiae Japonicae has effect in reducing oxygen consumption of trachea-lung tissue.

Radix adenophorae: sweet and cool. Entering the lung; the stomach meridian. Nourishing yin and clearing heat; moistening lung, eliminating phlegm and relieving cough; benefiting stomach and promoting fluid production. For chronic cough due to yin deficiency; dry and cough with little sputum; tracheitis, pertussis, cough due to lung heat, yellow and thick sputum. Radix Adenophorae has effects of relieving cough, eliminating phlegm, clearing lung-heat and relieving cough. The decoction of radix Adenophorae has expectorant effect lasting for more than 4 hr, and has obvious cardiotonic effect.

Caulis Gneti: bitter and slightly warm. Dispel wind, alleviate pain, activate blood, relieve swelling, resolve phlegm and stop cough. The most important pathogenesis of emphysema is airway remodeling and deformation, resulting in airway obstruction, which leads to labored breathing, thus affecting gas intake and causing asthma. The gnetum water-soluble alkaloid has direct expansion effect on tracheal smooth muscle; has effect in relieving spasm of bronchial smooth muscle. The caulis Gneti has effects of improving body defense ability and promoting pathological change repair. Before and after the usage of the gnetum gracilis for treating tracheitis, the sputum nucleus and the neutral cells in the sputum are reduced, the II and III grades of ciliated columnar epithelium are obviously reduced, the cell degeneration is lightened, and the virulence of the haemophilus influenzae is obviously weakened. In addition, the traditional Chinese medicine composition also has the effects of reducing blood pressure and expanding blood vessels, so that the contractility of the heart is strengthened, and the heart rate is not influenced, thereby being particularly suitable for patients with chronic tracheitis. The curative effect can be improved by properly prolonging the treatment course.

Closing the door at night: bitter, astringent and cool. Enter lung, liver and kidney meridians. Clearing away heat and toxic material, removing blood stasis, relieving swelling, invigorating kidney, arresting seminal emission, nourishing lung, invigorating spleen, eliminating phlegm, and relieving cough. The herba Lespedezae Cuneatae has certain phlegm eliminating or phlegm eliminating effects; has remarkable effects of relieving cough and reducing phlegm, and the action intensity is about equal to 2mg of codeine taken by each mouse; the obvious effect of the aminophylline on relaxing the tracheal smooth muscle is slower and longer in action time compared with the aminophylline. The herba Lespedezae Cuneatae has quick action on relieving cough, eliminating phlegm and relieving asthma, and most of the herbs have effect within 4 days after being taken.

Dried toad: sweet, pungent and cool. Has little toxicity. Relieve swelling, remove toxicity, alleviate pain, induce diuresis. It is contraindicated for pregnant women. The dried toad can restore the normal leucocyte of a patient and obviously improve the sign of the lung.

Codonopsis pilosula: sweet and neutral. It enters spleen and lung meridians. Tonify middle-jiao and Qi, invigorate spleen and benefit lung. Patients with emphysema are often destroyed by pulmonary microcirculation and resistance of pulmonary blood vessels is increased, and radix Codonopsis is used for treating weakness of spleen and lung, short breath, palpitation, dyspnea of deficiency type and cough, and can restore pulmonary microcirculation to normal, and the microcirculation is remarkably increased in number and the tube diameter is remarkably enlarged.

Vitex negundo L.var.negundo L: is bitter in taste; pungent taste; and (4) temperature. Entering the lung; the large intestine channel. Eliminating dampness and phlegm; relieving cough and asthma; regulating qi-flowing for relieving pain. Vitex negundo fruit is used for regulating qi and eliminating phlegm; relieving cough and asthma, has obvious expansion effect on tracheal smooth muscle and can generate strong and rapid asthma relieving effect. The total effective rate of relieving asthma is above 80%, and the medicine can reduce the tension of bronchial sheets, and has obvious effects of relieving cough and eliminating phlegm.

Codonopsis pilosula is used for tonifying spleen and benefiting lung; leonurus japonicus can tonify kidney, astringe essence, tonify lung and invigorate spleen, while Leonurus japonicus can tonify spleen, lung and kidney. Herba Ardisiae Japonicae, radix Adenophorae, herba Lespedezae Cuneatae, caulis Gneti, and radix Codonopsis have effect in improving immunity.

Through clinical verification, the rhamnus davurica, the Japanese ardisia herb and the adenophora stricta have good treatment effects on lung qi weakness, chronic tracheitis and emphysema; leptoradix Lespedezae Cuneatae, caulis Gneti, and Bufo siccus have good therapeutic effects on chronic tracheitis, cough, asthma, and edema.

The invention is prepared from Chinese traditional herbal medicines, and the traditional Chinese medicine for effectively treating emphysema is formed by orderly matching certain natural extracts with determined components and clear effects according to a plurality of principles of traditional Chinese medicine treatment based on syndrome differentiation and modern medicine.

The formula can tonify qi, reduce phlegm, relieve cough and asthma, tonify kidney, tonify lung, invigorate spleen, promote blood circulation, remove blood stasis, eliminate phlegm, reduce swelling, improve the body resistance, avoid lung infection, relieve edema, expand air passage, discharge secretion, get through blocked trachea, relieve air passage resistance, thereby rapidly controlling the emphysema condition and rapidly helping patients to recover.

The traditional Chinese medicine composition adopts natural traditional Chinese medicine raw materials, is simple in medicine use, reasonable in formula and less in side effect, can enable the traditional Chinese medicine components to be mutually cooperated and complement each other, can play a role in mutual promotion, and fully plays a role in treating emphysema.

The traditional Chinese medicine composition provided by the invention has a remarkable curative effect on emphysema. The treatment cost of the invention is relatively low and is far lower than that of western medicine.

The traditional Chinese medicine formula disclosed by the invention is used for fundamentally solving the problem, 50 patients are treated by adopting the traditional Chinese medicine clinical application disclosed by the invention, one dose is taken every day, the decoction is 100 ml, the decoction is divided into two parts, one part is taken in the morning and at night, 2 months are taken as a treatment course, the patients can be recovered after 2-3 treatment courses, and the treatment effect is obvious. The clinical tracking of 50 people shows that the total effective rate is 100 percent, the obvious effect is 86 percent, and the cure rate is 56 percent.

The oral preparation comprises oral liquid, tablets, capsules, pills and the like, and the preferable dosage forms are the oral liquid and the capsules, and one dose is taken every day in the morning and at night.

The traditional Chinese medicine composition can be prepared into various dosage forms. For example, the decocted liquid medicine is sterilized and disinfected and then packaged to prepare oral liquid; or concentrating the decoction, oven drying, adding pharmaceutically acceptable adjuvants, and making into tablet, capsule, pill, etc.

The medically acceptable auxiliary materials comprise starch, dextrin, sodium carboxymethylcellulose, polyethylene glycol, calcium hydrophosphate, sodium alginate, potassium sorbate and the like.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention in any way, and it will be apparent to those skilled in the art that the above description of the present invention can be applied to various modifications, equivalent variations or modifications without departing from the spirit and scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating emphysema is characterized by comprising dried toad, cascara sagrada, negundo chastetree fruit, Japanese ardisia, adenophora tetraphylla, Leptochloa cuneata, gnetum montanum and radix codonopsitis.

2. The traditional Chinese medicine composition for emphysema according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 3 parts of dried toad; 12 parts of cascara Sagrada and Vitex negundo; herba Ardisiae Japonicae, radix Adenophorae, herba Lespedezae Cuneatae, caulis Gneti, and radix Codonopsis 30 parts.

3. An oral preparation for treating emphysema, which is prepared from the Chinese medicinal composition of any one of claims 1 to 3.

4. The oral preparation for treating breast cancer according to claim 2, which is characterized by comprising oral liquid, tablets, capsules and pills, preferably capsules and tablets.