CN103919970B - A kind of Chinese medicine preparation treating infantile bronchitis and preparation method - Google Patents
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Abstract
The invention discloses a kind of Chinese medicine preparation treating infantile bronchitis and preparation method, belong to the field of Chinese medicines；The raw material of Chinese medicine preparation effective ingredient of the present invention consists of: Artemisia absinihium L, Resina Ferulae, Lignum Viticis Quinatae, Rhizoma Dioscoreae Nipponicae, Radix Angelicae Pubescentis, Membrana Follicularis ovi, Bufo siccus, dish, capsule, Herba Lysionoti carnosae, Sabia schumanniana Diels, Folium Rhododendri Micranthi, Folium Alismatis, Rhizoma Paridis, Semen Caesalpiniae and Herba Eupatorii Lindleyani；Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine is theoretical, there is effect of promoting blood circulation to remove obstruction in the collateral, nourishing YIN and clearing away lung-heat, resolving phlegm and relieving asthma, removing toxic substances dehumidifying, easy to use, good absorbing effect, without bad and toxic and side effects, according to clinical verification, infantile bronchitis, pneumonia etc. are had fabulous alleviation and therapeutic effect, is suitable to infantile bronchitis clinical treatment and nursing popularization and application.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating infantile bronchitis and preparation method
Background technology
Infantile bronchitis, name of disease is " bronchiolitis ".The cause of disease of bronchiolitis is mainly respiratory syncytial virus, can account for 80% or more；Other is followed successively by adenovirus, parainfluenza virus, rhinovirus, influenza virus etc.；Minority case can be caused by mycoplasma pneumoniae, and after infecting virus, tiny capillary bronchus is congested, edema, and mucous secretion increases, and adds that the mucomembranous epithelial cell of necrosis comes off and blocks tube chamber, causes obvious emphysema and pulmonary atelectasis.Inflammation can involve alveolar, alveolar wall and interstitial lung usually, therefore it is believed that it is a kind of specific type of pneumonia.
Infantile bronchitis is different from general tracheitis or bronchitis, and clinical symptoms is as pneumonia, but suppresses breathing heavily, and this disease mostly occurs the children's below 2.5 years old, and 80% within 1 years old, and majority is the children's of less than 6 months.Typical bronchiolitis often occurs after upper respiratory tract infection-3 days on the 2nd, dry persistent coughs and heating occur, body temperature with in, low-grade fevers is for being shown in, outbreak is breathed heavily and is suppressed as its feature, and the state of an illness is more serious to breathe heavily 3 days on the 2nd after suppressing generation, breathes heavily to breathe when suppressing outbreak and substantially speeds, reach 60 times more than-80 times per minute, and with prolonged expiration and exhaling property larynx breathe heavily toot；Children with serious disease substantially shows nose stir-frying and " three depressions sign " (namely occurring supraclavicular fossa, suprasternal fossa and epigastrium depression during air-breathing), green around the gills, mouth Zhou Faqing, or cyanosis occurs, and the normal dysphoria of infant moans ceaselessly；The heavier infant of the state of an illness can merge heart failure or respiratory failure, all can alleviate, death seldom occurs after major part case treatment.
Infantile bronchitis morbidity can suddenly can be delayed.Mostly first there is upper respiratory tract infection symptoms, it is possible to deep dry cough occurs frequently and relatively suddenly, gradually have bronchial secretion later.Infant will not be coughed up phlegm, and how to swallow through pharyngeal.Symptom the lighter is without obvious sickly complexion, and severe one is generated heat 38-39 DEG C, occasionally reaches 40 DEG C, and namely many 2-3 day moves back.Feel fatigue, impact sleep appetite, even vomit, suffer from diarrhoea, the symptom of digestive tract such as stomachache.Annual wool yield tells headache and breast 1 pain again.Cough general continuity 7-10 days, delay 2-3 week, or recurrent exerbation sometimes.As caused pneumonia without suitably treatment, leukocyte is normal or slightly lower, and rising person is likely to there is secondary bacterial infection.Healthy and strong children's's rare complications following, but at malnutrition, in the youngster such as immunologic hypofunction, congenital respiratory tract malformation, chronic nasopharyngitis, rickets, is not only susceptible to suffer from bronchitis, and easily Complicating Pneumonia In Patients, otitis media, laryngitis and nasal sinusitis.
Should sending treatment in time to hospital after children's's morbidity, if being caused by viral infection, morbidity early stage generally does not need to use antibiotic therapy；If the morbidity later stage can use antibiotic therapy when suspecting secondary bacterial infection, treatment is based on symptomatic treatment, can be summarized as " calm cough-relieving ", but owing to child physical endowment is weak, immunity is low, as pneumonia can be caused without suitably treatment, the symptoms such as leukocyte is on the low side, in order to child health is quickly grown up, recover trachea function, improve quality of life, the necessary safety of medicine for the treatment of infantile bronchitis, effectively, have no side effect, and Chinese materia medica is as the traditional medicine of China, there is effect strong, instant effect, the advantages such as lasting medicine, and there is no dependency, drug resistance and toxic and side effects, therefore a kind of Chinese medicine preparation treatment infantile bronchitis is selected, for infantile bronchitis, there is highly important clinical meaning.
Summary of the invention
The invention provides a kind of Chinese medicine preparation treating infantile bronchitis and preparation method；Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine is theoretical, there is effect of promoting blood circulation to remove obstruction in the collateral, nourishing YIN and clearing away lung-heat, resolving phlegm and relieving asthma, removing toxic substances dehumidifying, easy to use, good absorbing effect, without bad and toxic and side effects, according to clinical verification, infantile bronchitis, pneumonia etc. are had fabulous alleviation and therapeutic effect, is suitable to infantile bronchitis clinical treatment and nursing popularization and application.
For achieving the above object, technical scheme is implemented as follows:
A kind of Chinese medicine preparation treating infantile bronchitis, make described Chinese medicine preparation effective ingredient raw material composition and parts by weight be:
Artemisia absinihium L 62-92 part Resina Ferulae 59-89 part Lignum Viticis Quinatae 57-87 part Rhizoma Dioscoreae Nipponicae 55-85 part
Radix Angelicae Pubescentis 52-82 part Membrana Follicularis ovi 47-77 part Bufo siccus 44-74 part dish 42-72 part
Capsule 40-70 part Herba Lysionoti carnosae 37-67 part Sabia schumanniana Diels 35-65 part Folium Rhododendri Micranthi 33-63 part
Folium Alismatis 32-62 part Rhizoma Paridis 28-58 part Semen Caesalpiniae 27-57 part Herba Eupatorii Lindleyani 22-52 part.
Make described Chinese medicine preparation effective ingredient raw material composition and parts by weight be:
84 parts of Resina Ferulaes of Artemisia absinihium L, 79 portions of Rhizoma Dioscoreae Nipponicae of 81 parts of Lignum Viticis Quinatae 77 parts
74 parts of Membrana Follicularis ovis of Radix Angelicae Pubescentis, 67 portions of dishes of 69 parts of Bufo siccus 64 parts
63 parts of Herba Lysionoti carnosaes of capsule, 57 parts of Folium Rhododendri Micranthi of 59 parts of Sabia schumanniana Diels 55 parts
54 parts of Rhizoma Paridis of Folium Alismatis, 49 parts of Herba Eupatorii Lindleyanis of 50 parts of Semen Caesalpiniae 44 parts.
Make described Chinese medicine preparation effective ingredient raw material composition and parts by weight be:
77 parts of Resina Ferulaes of Artemisia absinihium L, 72 portions of Rhizoma Dioscoreae Nipponicae of 74 parts of Lignum Viticis Quinatae 70 parts
67 parts of Membrana Follicularis ovis of Radix Angelicae Pubescentis, 60 portions of dishes of 62 parts of Bufo siccus 57 parts
56 parts of Herba Lysionoti carnosaes of capsule, 50 parts of Folium Rhododendri Micranthi of 52 parts of Sabia schumanniana Diels 48 parts
47 parts of Rhizoma Paridis of Folium Alismatis, 42 parts of Herba Eupatorii Lindleyanis of 43 parts of Semen Caesalpiniae 37 parts.
Make described Chinese medicine preparation effective ingredient raw material composition and parts by weight be:
70 parts of Resina Ferulaes of Artemisia absinihium L, 65 portions of Rhizoma Dioscoreae Nipponicae of 66 parts of Lignum Viticis Quinatae 63 parts
60 parts of Membrana Follicularis ovis of Radix Angelicae Pubescentis, 52 portions of dishes of 55 parts of Bufo siccus 50 parts
46 parts of Herba Lysionoti carnosaes of capsule, 43 parts of Folium Rhododendri Micranthi of 45 parts of Sabia schumanniana Diels 41 parts
40 parts of Rhizoma Paridis of Folium Alismatis, 35 parts of Herba Eupatorii Lindleyanis of 35 parts of Semen Caesalpiniae 30 parts.
The preparation method of a kind of Chinese medicine preparation treating infantile bronchitis, comprises the following steps that:
(1) take Artemisia absinihium L, Lignum Viticis Quinatae, Rhizoma Dioscoreae Nipponicae and dish decontamination, clean and put into container, add the distilled water of 7-9 times amount, after soaking 3-4 hour, boil 2-3 hour, extract；Again add 4-6 times amount distilled water, boil 1-2 hour, extract；It is eventually adding 2-3 times amount distilled water, heated and boiled 1-2 hour, extracts；Merge three extracting solution, filter, filtrate is condensed at 60 DEG C the thick paste of 1.15-1.25 times, drying under reduced pressure, standby；
(2) take Resina Ferulae, Membrana Follicularis ovi, capsule and Folium Alismatis and remove impurity, microwave drying, smash to pieces, be placed in mortar and grind into powder, cross 160 order fine powders, standby；
(3) taking Bufo siccus, taken out by the Venenum Bufonis on body, dry or dry or cut open the belly removing internal organs, and removes in the lump together with lower jaw and abdominal part, and is strutted by body cavity, dry, then put to baking oven roasting, stir at any time, with unburned, taking-up is smashed to pieces, is placed in mortar and grinds into powder, crosses 180 order fine powders, standby；
(4) taking Radix Angelicae Pubescentis, Herba Lysionoti carnosae, Sabia schumanniana Diels and Rhizoma Paridis to stir-fry with high heat after for several times, yellow wine is uniformly sprayed on surface, pulverizes, grind into powder after fried dry, crosses 200 order fine powders, standby；
(5) taking Folium Rhododendri Micranthi, Semen Caesalpiniae and Herba Eupatorii Lindleyani saline and mix thoroughly vexed, with the micro-stir-fry of little fire, taking-up is dried, and is placed in mortar and grinds into powder, crosses 150 order fine powders, standby；
(6) by the thick paste of step (1) gained, mix with the fine powder of step (5) gained with step (2), step (3), step (4), make Chinese medicinal granule, be the Chinese medicine preparation for treating infantile bronchitis of the present invention.
The property of medicine of Chinese medicine used by the present invention is as follows:
Artemisia absinihium L: bitter in the mouth, property is put down.Heat-clearing and toxic substances removing, pathogenic fire purging is stopped blooding.For chronic tracheitis, tonsillitis, icterohepatitis, eye crystalline film is scorching, traumatic hemorrhage.Modern medicine confirms, Artemisia absinihium L has eliminating the phlegm, relievings asthma and antibacterial effect, and tracheal cilia is transported Mucus Velocity certain facilitation, is conducive to alleviating the symptom of infantile bronchitis.
Resina Ferulae: bitter in the mouth, pungent, warm in nature；Return liver, spleen, stomach warp.Removing food stagnancy, dissipates painful abdominal mass, parasite killing.For meat stagnation, blood stasis lump in the abdomen, mass in abdomen, abdominal pain due to worm stagnation." Chinese Herbal Medicine in Xinjiang handbook " carries: " control neurasthenia, chronic bronchitis.”
Lignum Viticis Quinatae: lightly seasoned, property is put down.Relieving cough and relieving asthma, calmness is brought down a fever.For acute and chronic tracheitis, bronchitis, tachypnea of breathing with cough, fever of children is irritated.Modern medicine study confirm, Lignum Viticis Quinatae can lung qi dispersing evacuation of pus, relieving cough and relieving asthma, calmness is brought down a fever, make treatment infantile bronchitis important substance basis.
Rhizoma Dioscoreae Nipponicae: bitter in the mouth, property is put down；Return liver, lung meridian.Expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral
, cough-relieving.Before rheumatism numbness, numb limbs and tense tendons, chronic tracheitis, traumatic injury." Shaanxi Chinese herbal medicine " carries: " control cough, rheumatic arthritis, Kaschin-Beck disease arthralgia, dyspepsia, malaria, traumatic injury, carbuncle malignant boil.”
Radix Angelicae Pubescentis: acrid in the mouth, hardship, slightly warm in nature；GUIXIN, liver, kidney, bladder warp.Expelling wind and removing dampness, numbness relieving and pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few the moon volt wind headache." property of medicine opinion ": " in controlling, all rheumatism is cold, and to dyspnea gas, musculus cutaneus hardship is itched, brothers' spasm and pain, strain, main air poison toothache." modern medicine study confirms, Radix Angelicae Pubescentis has certain antitussive, antiasthmatic effect, especially treatment chronic bronchitis etc. is had significant curative effect.
Membrana Follicularis ovi: sweet in the mouth, light, warm in nature；Return spleen, stomach, lung meridian.Tonifying the lung and stopping cough, nourishing YIN and clearing away lung-heat.For chronic tracheitis, pharyngalgia aphonia, scrofula tuberculosis, ulcer being unable to heal." decoction pieces is newly joined " carries: " clearing away lung-heat, opens sound silent, controls void and coughs, raw dregs.”
Bufo siccus: sweet in the mouth, pungent, cool in nature, slightly poisonous；Return lung, spleen, Liver Channel.Subduing swelling and detoxicating, pain relieving diuresis.For chronic tracheitis, carbuncle furuncle furuncle, laryngopharynx swelling and pain, edema, dysuria.Modern medicine study confirms, Bufo siccus has broken crux, row water wets, the effect of removing toxic substances analgesic therapy, especially treats the important substance basis of children chronic bronchitis.
Dish: sweet in the mouth, light, cool in nature.Expelling wind and clearing away heat, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, antitussive diuresis.For cough due to lung-heat, chronic tracheitis, acute rheumatic arthritis, dysuria；Dermatitis rhus, venom, furuncle carbuncle are controlled in external." conventional Chinese herbal medicine handbook " load: " clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Cure cold heating, laryngopharynx swelling and pain, aphonia；Cough due to lung-heat, hemoptysis；Acute rheumatic arthritis.”
Capsule: sweet in the mouth, acid, warm in nature.Expelling wind and removing dampness, promoting blood circulation to remove blood stasis.For rheumatalgia, oedema due to nephritis, beriberi edema, dysentery jaundice, chronic tracheitis." Changsha medicine solution " carries: " promoting the circulation of blood is stimulated the menstrual flow, and repercussiveization is coagulated.Treat edema, by arthralgia chiefly caused by damp pathogen, lower disease block, removing blood stasis with potent drugs blood, wash urticaria wind scabies, apply foot swelling and pain in knee." modern medicine study confirmation, treatment pneumonia and chronic tracheitis are had remarkable result by capsule, can release bronchial muscular spasm, and antiasthmatic effect is better, and has certain cough-suppressing phlegm-dispelling functions.
Herba Lysionoti carnosae: acrid in the mouth, hardship, property is put down.Dispelling wind stopping cough, spleen invigorating removing food stagnancy.For cough-relieving of catching a cold, chronic tracheitis, leptospirosis, over-strained hemoptysis, infantile malnutrition." Guizhou medical herbs " carries: " wind dispelling, cough-relieving, granulation promoting, hemostasis, qi-restoratives, softening the hard mass.”
Sabia schumanniana Diels: acrid in the mouth, puckery, warm in nature；Return lung meridian.Eliminating phlegm and stopping cough, expelling wind and activating blood circulation.For chronic tracheitis, arthritis, traumatic injury." Jiangxi medical herbs " carries: " expelling wind and activating blood circulation.”
Folium Rhododendri Micranthi: acrid in the mouth, acid, warm in nature, very toxic；GUIXIN, lung, large intestine channel.Dispelling wind and removing obstruction in the collateral, menstruction regulating and pain relieving, preventing phlegm from forming and stopping coughing.For chronic tracheitis, rheumatic arthralgia, lumbago, dysmenorrhea, puerperal arthralgia." plateau Chinese herbal treatment handbook " carries: " control bronchitis, dysentery, analgesia；External application is fractured.”
Folium Alismatis: salty in the mouth, property is put down.Kidney tonifying cough-relieving, stimulating milk secretion of promoting blood circulation.For controlling chronic tracheitis, under galactostasis, relieving cough and asthma." Japan hanako materia medica " carries: " strong water is dirty, stimulating milk secretion, promoting blood circulation.”
Rhizoma Paridis: acrid in the mouth, cold in nature, poisonous；Return liver, the heart, lung meridian.Heat-clearing and toxic substances removing, antiasthmatic-antitussive, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.For carbuncle furuncle, scrofula sore throat, chronic tracheitis, infantile convulsion is twitched, snake bite and insect sting." former volume sought by book on Chinese herbal medicine " carries: " strengthening the spleen juice, rises the clearing heat in QI system of stomach, up in lung, and with the benefit strong lean kidney of blood gas, consumptive disease is coughed internal injury.Invigorate blood circulation, hemostasis, detumescence, removing toxic substances.”
Semen Caesalpiniae: acrid in the mouth, hardship, warm in nature, poisonous；Return lung, large intestine channel.Removing toxic substances dehumidifying, relieving cough and resolving phlegm, parasite killing.For dysentery, chronic tracheitis, infantile malnutrition, malnutrition due to parasitic infestation." conventional glossary of Herbs and Drugs among the people " carries: " dispersing wind and cold controls cough.Eliminating cold-damp, controls lumbago, toothache, hemorrhoid.”
Herba Eupatorii Lindleyani: bitter in the mouth, property is put down；Enter liver, gallbladder meridian.Heat-clearing and toxic substances removing, eliminating phlegm relieving asthma, blood pressure lowering.For chronic tracheitis, bronchitis, hypertension.Modern medicine study confirm, Herba Eupatorii Lindleyani to treatment chronic bronchitis there is significant curative effect, it is possible to don't lung cough-relieving, resolving phlegm and relieving asthma.
The present invention compared with prior art, has the advantages that
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine is theoretical, there is effect of promoting blood circulation to remove obstruction in the collateral, nourishing YIN and clearing away lung-heat, resolving phlegm and relieving asthma, removing toxic substances dehumidifying, easy to use, good absorbing effect, without bad and toxic and side effects, according to clinical verification, infantile bronchitis, pneumonia etc. are had fabulous alleviation and therapeutic effect, is suitable to infantile bronchitis clinical treatment and nursing popularization and application.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Artemisia absinihium L 90g Resina Ferulae 87g Lignum Viticis Quinatae 84g Rhizoma Dioscoreae Nipponicae 82g
Radix Angelicae Pubescentis 80g Membrana Follicularis ovi 75g Bufo siccus 72g dish 70g
Capsule 68g Herba Lysionoti carnosae 65g Sabia schumanniana Diels 63g Folium Rhododendri Micranthi 61g
Folium Alismatis 60g Rhizoma Paridis 56g Semen Caesalpiniae 55g Herba Eupatorii Lindleyani 50g.
The processing step of Chinese medicine preparation preparation method of the present invention is:
(1) take Artemisia absinihium L, Lignum Viticis Quinatae, Rhizoma Dioscoreae Nipponicae and dish decontamination, clean and put into container, add the distilled water of 7-9 times amount, after soaking 3-4 hour, boil 2-3 hour, extract；Again add 4-6 times amount distilled water, boil 1-2 hour, extract；It is eventually adding 2-3 times amount distilled water, heated and boiled 1-2 hour, extracts；Merge three extracting solution, filter, filtrate is condensed at 60 DEG C the thick paste of 1.15-1.25 times, drying under reduced pressure, standby；
(2) take Resina Ferulae, Membrana Follicularis ovi, capsule and Folium Alismatis and remove impurity, microwave drying, smash to pieces, be placed in mortar and grind into powder, cross 160 order fine powders, standby；
(3) taking Bufo siccus, taken out by the Venenum Bufonis on body, dry or dry or cut open the belly removing internal organs, and removes in the lump together with lower jaw and abdominal part, and is strutted by body cavity, dry, then put to baking oven roasting, stir at any time, with unburned, taking-up is smashed to pieces, is placed in mortar and grinds into powder, crosses 180 order fine powders, standby；
(4) taking Radix Angelicae Pubescentis, Herba Lysionoti carnosae, Sabia schumanniana Diels and Rhizoma Paridis to stir-fry with high heat after for several times, yellow wine is uniformly sprayed on surface, pulverizes, grind into powder after fried dry, crosses 200 order fine powders, standby；
(5) taking Folium Rhododendri Micranthi, Semen Caesalpiniae and Herba Eupatorii Lindleyani saline and mix thoroughly vexed, with the micro-stir-fry of little fire, taking-up is dried, and is placed in mortar and grinds into powder, crosses 150 order fine powders, standby；
(6) by the thick paste of step (1) gained, mix with the fine powder of step (5) gained with step (2), step (3), step (4), make Chinese medicinal granule, be the Chinese medicine preparation for treating infantile bronchitis of the present invention.
Usage and dosage: oral, each 2 bags (often wrapping 15g), every day 3 times, warm water delivery service in 1 hour after meal, 10 days is a course for the treatment of, and usual 3-4 the course for the treatment of is effective, and pertinacious disease needs 5-6 the course for the treatment of.
Embodiment 2
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Artemisia absinihium L 84g Resina Ferulae 81g Lignum Viticis Quinatae 79g Rhizoma Dioscoreae Nipponicae 77g
Radix Angelicae Pubescentis 74g Membrana Follicularis ovi 69g Bufo siccus 67g dish 64g
Capsule 63g Herba Lysionoti carnosae 59g Sabia schumanniana Diels 57g Folium Rhododendri Micranthi 55g
Folium Alismatis 54g Rhizoma Paridis 50g Semen Caesalpiniae 49g Herba Eupatorii Lindleyani 44g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage and embodiment 1 are identical.
Embodiment 3
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Artemisia absinihium L 77g Resina Ferulae 74g Lignum Viticis Quinatae 72g Rhizoma Dioscoreae Nipponicae 70g
Radix Angelicae Pubescentis 67g Membrana Follicularis ovi 62g Bufo siccus 60g dish 57g
Capsule 56g Herba Lysionoti carnosae 52g Sabia schumanniana Diels 50g Folium Rhododendri Micranthi 48g
Folium Alismatis 47g Rhizoma Paridis 43g Semen Caesalpiniae 42g Herba Eupatorii Lindleyani 37g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage and embodiment 1 are identical.
Embodiment 4
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Artemisia absinihium L 70g Resina Ferulae 66g Lignum Viticis Quinatae 65g Rhizoma Dioscoreae Nipponicae 63g
Radix Angelicae Pubescentis 60g Membrana Follicularis ovi 55g Bufo siccus 52g dish 50g
Capsule 46g Herba Lysionoti carnosae 45g Sabia schumanniana Diels 43g Folium Rhododendri Micranthi 41g
Folium Alismatis 40g Rhizoma Paridis 35g Semen Caesalpiniae 35g Herba Eupatorii Lindleyani 30g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage and embodiment 1 are identical.
Clinical data:
1, case selection:
Selecting the infantile bronchitis patient 360 example clinical observation that my institute or outer court make a definite diagnosis, patient is randomly divided into two groups, treatment group 180 example, wherein male 90 example, women 90 example, age 0.5-2.5 year, 1 years old mean age, the course of disease 3 months-20 months, 11 months mean aves.Matched group 180 example, wherein male 92 example, women 88 example, age 0.5-2.5 month, 11.5 months mean aves, the course of disease 3 months-18 months, average 10 months.The course of disease of two groups of cases, degrees of symptoms are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group patient takes medicine of the present invention, oral, and each 2 bags (often wrapping 15g), every day 3 times, in 1 hour after meal, warm water brews, and within 10 days, is a course for the treatment of, and usual 3-4 the course for the treatment of is effective, and pertinacious disease needs 5-6 the course for the treatment of.
Matched group takes bactrim, a 0.05kg, 2 times on the one, oral meal.
3, efficacy determination:
(1) curing: the transference cures such as dry cough, vomiting, diarrhoea, hypoimmunity, appetite strengthens, dynamic.
(2) effective: above-mentioned symptom is alleviated to some extent, appetite strengthens, dynamic.
(3) invalid: disease is unchanged.
4, result:
Take in the treatment group of medicine of the present invention, cure 140 examples, effective 30 examples, invalid 10 examples, cure rate 77.8%, total effective rate 94.4%.
Matched group is cured 75 examples, effective 80 examples, invalid 25 examples, cure rate 41.7%, total effective rate 86.1%.
Result above shows, treatment group cure rate and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, yellow ××, female, 2.5 months, baby, Shanghai people.The frequent dry cough of patient, often vomiting, diarrhoea, and with heating paresthesia, body temperature reaches 40 DEG C once in a while.To our hospital afterwards, diagnose as infantile bronchitis.After taking 3 courses for the treatment of of Chinese medicine preparation of the present invention, the transference cure such as Nausea and vomiting, pulmonary function recovers, and laboratory indexes is all normal.Follow up a case by regular visits to and do not recur so far.
2, Cai's ××, man, 4 months, baby, Shantou, Guangdong people.Patient's green around the gills, mouth Zhou Faqing, and frequent dysphoria, moan ceaselessly, heart failure when being in a bad way, cough are more than, and after taking 4 courses for the treatment of of Chinese medicine preparation of the present invention, above symptom is substantially alleviated, and after continuing to take 2 courses for the treatment of, have rosy cheeks, breathing smooth and easy, appetite strengthens, and follows up a case by regular visits to and does not recur so far.
3, Yuan's ××, female, 7 months, baby, Kunming, Yunnan people.Patient has obvious acute attack to breathe heavily to suppress and dyspneic symptom, and body temperature is not high, and my institute checks later, it has been found that it is inconspicuous that patient breathes heavily pulmonary rale when suppressing outbreak, can hear and be diagnosed with infantile bronchitis by fine rales after alleviation.After taking 1 course for the treatment of of Chinese medicine preparation of the present invention, symptom takes a turn for the better, after continuing to take 3 courses for the treatment of, and transference cure, to breathe smooth and easy, activity is freely.
4, grandson's ××, man, 11 months, baby, people from Jing Zhou, Hubei.The frequent persistent cough of patient, does not heal for many months, sooner or later increases the weight of, and is obvious with night especially.Amount of expectoration more or less, is fast with expectoration, especially in the winter time easily acute attack, and aggravation, period took multi-medicament, and effect is all without positive effect, rear to our hospital, is diagnosed as infantile bronchitis.After taking 4 courses for the treatment of of Chinese medicine preparation of the present invention, symptom is wholly absent, and appetite increases, and body constitution strengthens, livelihood restoration is normal.
5, Jiang's ××, female, 13 months, baby, people from Yingkou, Liaoning.Originally patient has cold symptoms, many coughs, frequent sneeze, and cough increases the weight of after a few days, ictal dyspnea occurs, breathe heavily suppress, the symptom such as pale complexion, lip cyanosis, once taking various hormone, cough suppressing medicine etc., effect is all inconspicuous, comes my institute and is diagnosed as infantile bronchitis.After taking 3 courses for the treatment of of Chinese medicine preparation of the present invention, symptom takes a turn for the better, and after continuing to take 2 courses for the treatment of, transference cure, activity freely, is breathed smooth and easy, it does not have recurrence.
6, hole ××, man, 15 months, baby, people from Nanchang.Patient's body constitution is thin and weak, does not often have appetite, and dry cough is breathed heavily more, and breathes substantially quickening when breathing, and uses several drugs to treat, and effect is unsatisfactory, protracted course of disease, recurrent exerbation.To our hospital beginning takes Chinese medicine preparation of the present invention afterwards, and after taking 3 courses for the treatment of, symptom substantially alleviates, and after then taking 3 courses for the treatment of, physical recovery is normal, and immunity strengthens.
Claims (5)
1. the Chinese medicine preparation treating infantile bronchitis, it is characterised in that: make described Chinese medicine preparation effective ingredient raw material composition and parts by weight be:
Artemisia absinihium L 62-92 part Resina Ferulae 59-89 part Lignum Viticis Quinatae 57-87 part Rhizoma Dioscoreae Nipponicae 55-85 part
Radix Angelicae Pubescentis 52-82 part Membrana Follicularis ovi 47-77 part Bufo siccus 44-74 part dish 42-72 part
Capsule 40-70 part Herba Lysionoti carnosae 37-67 part Sabia schumanniana Diels 35-65 part Folium Rhododendri Micranthi 33-63 part
Folium Alismatis 32-62 part Rhizoma Paridis 28-58 part Semen Caesalpiniae 27-57 part Herba Eupatorii Lindleyani 22-52 part.
2. the Chinese medicine preparation treating infantile bronchitis, it is characterised in that: make described Chinese medicine preparation effective ingredient raw material composition and parts by weight be:
84 parts of Resina Ferulaes of Artemisia absinihium L, 79 portions of Rhizoma Dioscoreae Nipponicae of 81 parts of Lignum Viticis Quinatae 77 parts
74 parts of Membrana Follicularis ovis of Radix Angelicae Pubescentis, 67 portions of dishes of 69 parts of Bufo siccus 64 parts
63 parts of Herba Lysionoti carnosaes of capsule, 57 parts of Folium Rhododendri Micranthi of 59 parts of Sabia schumanniana Diels 55 parts
54 parts of Rhizoma Paridis of Folium Alismatis, 49 parts of Herba Eupatorii Lindleyanis of 50 parts of Semen Caesalpiniae 44 parts.
3. the Chinese medicine preparation treating infantile bronchitis, it is characterised in that: make described Chinese medicine preparation effective ingredient raw material composition and parts by weight be:
77 parts of Resina Ferulaes of Artemisia absinihium L, 72 portions of Rhizoma Dioscoreae Nipponicae of 74 parts of Lignum Viticis Quinatae 70 parts
67 parts of Membrana Follicularis ovis of Radix Angelicae Pubescentis, 60 portions of dishes of 62 parts of Bufo siccus 57 parts
56 parts of Herba Lysionoti carnosaes of capsule, 50 parts of Folium Rhododendri Micranthi of 52 parts of Sabia schumanniana Diels 48 parts
47 parts of Rhizoma Paridis of Folium Alismatis, 42 parts of Herba Eupatorii Lindleyanis of 43 parts of Semen Caesalpiniae 37 parts.
4. the Chinese medicine preparation treating infantile bronchitis, it is characterised in that: make described Chinese medicine preparation effective ingredient raw material composition and parts by weight be:
70 parts of Resina Ferulaes of Artemisia absinihium L, 65 portions of Rhizoma Dioscoreae Nipponicae of 66 parts of Lignum Viticis Quinatae 63 parts
60 parts of Membrana Follicularis ovis of Radix Angelicae Pubescentis, 52 portions of dishes of 55 parts of Bufo siccus 50 parts
46 parts of Herba Lysionoti carnosaes of capsule, 43 parts of Folium Rhododendri Micranthi of 45 parts of Sabia schumanniana Diels 41 parts
40 parts of Rhizoma Paridis of Folium Alismatis, 35 parts of Herba Eupatorii Lindleyanis of 35 parts of Semen Caesalpiniae 30 parts.
5. the preparation method of the Chinese medicine preparation of the treatment infantile bronchitis as described in any one of claim 1-4, it is characterised in that: comprise the following steps that:
(1) take Artemisia absinihium L, Lignum Viticis Quinatae, Rhizoma Dioscoreae Nipponicae and dish decontamination, clean and put into container, add the distilled water of 7-9 times amount, after soaking 3-4 hour, boil 2-3 hour, extract；Again add 4-6 times amount distilled water, boil 1-2 hour, extract；It is eventually adding 2-3 times amount distilled water, heated and boiled 1-2 hour, extracts；Merge three extracting solution, filter, filtrate is condensed at 60 DEG C the thick paste of 1.15-1.25 times, drying under reduced pressure, standby；
(2) take Resina Ferulae, Membrana Follicularis ovi, capsule and Folium Alismatis and remove impurity, microwave drying, smash to pieces, be placed in mortar and grind into powder, cross 160 order fine powders, standby；
(3) taking Bufo siccus, taken out by the Venenum Bufonis on body, dry or dry or cut open the belly removing internal organs, and removes in the lump together with lower jaw and abdominal part, and is strutted by body cavity, dry, then put to baking oven roasting, stir at any time, with unburned, taking-up is smashed to pieces, is placed in mortar and grinds into powder, crosses 180 order fine powders, standby；
(4) taking Radix Angelicae Pubescentis, Herba Lysionoti carnosae, Sabia schumanniana Diels and Rhizoma Paridis to stir-fry with high heat after for several times, yellow wine is uniformly sprayed on surface, pulverizes, grind into powder after fried dry, crosses 200 order fine powders, standby；
(5) taking Folium Rhododendri Micranthi, Semen Caesalpiniae and Herba Eupatorii Lindleyani saline and mix thoroughly vexed, with the micro-stir-fry of little fire, taking-up is dried, and is placed in mortar and grinds into powder, crosses 150 order fine powders, standby；
(6) by the thick paste of step (1) gained, mix with the fine powder of step (5) gained with step (2), step (3), step (4), make Chinese medicinal granule, be the described Chinese medicine preparation for treating infantile bronchitis.
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Effective date of registration: 20171214 Address after: Three factory town of Haimen city of Nantong province Jiangsu 226100 China Road No. 899 in 1. Patentee after: Nantong Zhongxing multielement composite steel tube Co., Ltd. Address before: Derek street in Jimo City, Shandong province 266200 Qingdao City No. 4 people's Hospital of Jimo City Patentee before: Yu Yongfeng |
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Granted publication date: 20160706 Termination date: 20180427 |
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