CN113350432A - A Chinese medicinal composition for treating allergic rhinitis and asthma syndrome - Google Patents
A Chinese medicinal composition for treating allergic rhinitis and asthma syndrome Download PDFInfo
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- CN113350432A CN113350432A CN202110715493.7A CN202110715493A CN113350432A CN 113350432 A CN113350432 A CN 113350432A CN 202110715493 A CN202110715493 A CN 202110715493A CN 113350432 A CN113350432 A CN 113350432A
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Abstract
The invention discloses a traditional Chinese medicine for treating allergic rhinitis and asthma syndrome, which is prepared from the following raw material medicines in parts by weight: 2-4 parts of asteriscus Pseudosciaenae and clove; 4.5 to 9 parts by weight of elecampane inula root, grassleaf sweelflag rhizome, lightyellow sophora root, pseudo-ginseng and Chinese thorowax root; 6-12 parts by weight of cortex mori, fructus viticis negundo, radix polygoni multiflori preparata and cynomorium songaricum; 9-18 parts of paniculate Bolbostemma rhizome, Chinese gall, and common andrographis herb; 15-30 parts of carpet bugle.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine for treating allergic rhinitis and asthma syndrome.
Background
The nasal-bronchial reflex exists between the nose and the bronchus, and when the nasal mucosa of a person is stimulated, the respiratory rhythm can be influenced, and the smooth muscle of an airway is tensed, and the secretion of glands is increased. The upper respiratory tract allergic inflammation of allergic rhinitis can gradually spread to the lower respiratory tract, and allergic pharyngitis, allergic bronchitis and asthma can occur in sequence, so that the phenomenon of full respiratory tract allergy is formed. The lower respiratory allergic inflammation of asthma is in fact an extension of the inflammation of the upper respiratory tract of allergic rhinitis. Patients with allergic rhinitis and asthma syndrome have a large amount of eosinophilic infiltration of the nasal and bronchial mucosa, lymphocytosis, goblet cell hyperplasia, abundant epithelial and subcutaneous microcirculation, and a large amount of plasma exudation.
Patients with severe allergic rhinitis and asthma syndrome can be forced to take a sitting position or breathe with an end, dry cough or cough with a large amount of white foam phlegm, even cyanosis, etc. At present, the disease cannot be cured radically, a Chinese and western combined mode is adopted for treatment, the traditional Chinese medicine is taken as the basis, the western medicine is used for assisting in treatment to relieve pain, the symptoms of most asthma patients can be well controlled, and recurrence is reduced.
Disclosure of Invention
The invention aims to improve the defects of the prior art and provide the traditional Chinese medicine composition for treating allergic rhinitis and asthma syndrome, which can effectively improve or even eliminate the clinical symptoms of patients and has the characteristics of obvious treatment effect, short treatment period, no toxic or side effect and the like.
The invention provides a traditional Chinese medicine for treating allergic rhinitis and asthma syndrome, which is prepared from the following raw material medicines in parts by weight: 2-4 parts of asteriscus Pseudosciaenae and clove; 4.5 to 9 parts by weight of elecampane inula root, grassleaf sweelflag rhizome, lightyellow sophora root, pseudo-ginseng and Chinese thorowax root; 6-12 parts by weight of cortex mori, fructus viticis negundo, radix polygoni multiflori preparata and cynomorium songaricum; 9-18 parts of paniculate Bolbostemma rhizome, Chinese gall, and common andrographis herb; 15-30 parts of carpet bugle.
In a preferred embodiment, the traditional Chinese medicine composition for treating allergic rhinitis and asthma syndrome consists of the following raw material medicines in parts by weight: 4 parts of asteriscus Pseudosciaenae and 4 parts of clove; 9 parts of elecampane inula root, grassleaf sweelflag rhizome, lightyellow sophora root, pseudo-ginseng and Chinese thorowax root; 12 parts by weight of cortex mori radicis, fructus viticis negundo, radix polygoni multiflori preparata and cynomorium songaricum; 18 parts of bolbostemma paniculatum, pagoda tree fern and common andrographis herb; 30 parts of ajuga reptans.
Wherein, the white mulberry root-bark: sweet and cold in nature. It enters lung meridian. Purge lung, relieve dyspnea, induce diuresis to alleviate edema. Introducing the medicine into lung.
Grassleaf sweelflag rhizome: pungent, bitter and warm. It enters heart and stomach meridians. Inducing resuscitation and eliminating phlegm. Rhizoma Acori Graminei has antiasthmatic effect, and can resist bronchoconstriction caused by histamine, and improve lung ventilation function of patients with bronchial asthma.
Ajuga reptans: bitter and cold in flavor. Clear heat and remove toxicity, cool blood and pacify liver. Can be used for treating upper respiratory infection, tonsillitis, pharyngitis, bronchitis, pneumonia, lung abscess, etc., and herba Ajugae can directly inhibit cough center, and has significant cough relieving effect. The ajuganol extract can directly stimulate airway mucosa secretory cells to increase secretion, has a certain dissolving effect on acid mucopolysaccharide fibers in phlegm, and can reduce permeability of trachea during inflammation, thereby playing the roles of diminishing inflammation and eliminating phlegm; the carpet bugle can directly expand bronchial smooth muscle and has strong anti-infection function, can resist the contraction of bronchial smooth muscle caused by histamine, has inhibition function on the release of histamine and anaphylactic slow reaction substance of lung tissue, and has remarkable effect of relieving asthma.
Clove: 2, pungent taste; and (4) temperature. Invigorating spleen; the stomach; descending adverse flow of qi in the kidney meridian; warming kidney and supporting yang.
Clove has stronger effect of relaxing airway smooth muscle, remarkably resists histamine and can prevent asthma patients from whetting.
Flavescent sophora root: bitter and cold. It enters heart, liver, stomach, large intestine and bladder meridians. Clear heat and dry dampness, kill parasites and induce diuresis. Matrine has the effect of relieving asthma by exciting central beta receptor, relieving bronchospasm and inhibiting the release of antibody and slow-reacting substance. Radix Sophorae Flavescentis can reduce release of allergic medium, has obvious inhibiting effect on serum IgE antibody formation, has asthma relieving effect similar to aminophylline for patients with asthma caused by histamine, and has obvious talkback effect on total matrine and flavone.
Vitex negundo L.var.negundo L: is bitter in taste; pungent taste; and (4) temperature. Entering the lung; the large intestine channel. Regulating qi and eliminating phlegm; relieving cough and asthma; resolve dampness and alleviate pain. The vitex negundo has obvious expansion effect on tracheal smooth muscle and can quickly and obviously relieve asthma. The vitex negundo can reduce the bronchial tension and has obvious effect of resisting the increase of lung overflow caused by histamine; can remarkably prolong the latent period of asthma. The vitex negundo has obvious effects of relieving cough and eliminating phlegm.
Preparing fleece-flower root: bitter, sweet, astringent and warm. It enters liver, heart and kidney meridians. Tonify liver and kidney, replenish essence and blood, blacken beard and hair, and strengthen tendons and bones. Radix Polygoni Multiflori can increase adrenal weight. Polygonum multiflorum has the function similar to that of adrenal cortex.
Pseudo-ginseng: sweet, slightly bitter and warm in taste. It enters liver and stomach meridians. Disperse blood stasis, stop bleeding, resolve swelling and alleviate pain.
Notoginseng radix has direct antiinflammatory effect, and depends on pituitary-adrenal system. Panax notoginsenosides PNS significantly reduced the content of ascorbic acid in adrenal gland, which reflects the enhancement of adrenal cortex function. The total arasaponin has effect in increasing blood plasma corticosterone content, and indirectly enhancing adrenal cortex function.
And (3) locking the positive: sweet and warm. It enters spleen, kidney and large intestine meridians. Tonify kidney yang, replenish essence and blood, moisten intestines to relieve constipation. The cynomorium songaricum aqueous extract can improve the cortisol level of a patient with hypothalamus-pituitary-adrenal cortex axis inhibition, and has the function of promoting adrenal cortex secretion and the adrenal cortex hormone-like effect to a certain extent. The cynomorium songaricum alcohol extract can recover the phagocytic function of macrophages.
Andrographis paniculata: bitter and cold. It enters heart, lung, large intestine and bladder meridians. Clear heat and remove toxicity, cool blood and relieve swelling. The andrographis paniculata can obviously reduce the content of vitamin C in adrenal gland, excite the anterior pituitary function, promote the synthesis and release of ACTH, and further enhance the function of adrenal cortex. Herba Andrographitis can obviously reduce exudation of capillary vessel wall and hemorrhagic necrotic exudation.
Bupleurum root: bitter and slightly cold. It enters liver and gallbladder meridians. Harmonize exterior and interior, soothe liver and raise yang. The bupleurum can cause thymus gland atrophy and adrenal weight to be obviously increased, the bupleurum can excite the anterior lobe of the pituitary to secrete adrenocorticotropic hormone, stimulate the adrenal gland to cause synthesis and secretion of corticosterone, and greatly increase plasma corticosterone. The anti-inflammatory effect of bupleurum is related to stimulation of adrenal gland and promotion of adrenal cortex system.
Herba Gei Piloselloidis: 2, pungent taste; bitter; and (5) slightly warming. Clearing away heat and toxic material, dispelling pathogenic wind and promoting diuresis, promoting blood circulation, dredging collaterals and relieving swelling. Researches find that the Chinese herbal medicine of the Japanese Galium has good curative effect on allergic rhinitis and nasosinusitis.
Elecampane inula root: pungent, bitter and warm in flavor. It enters liver and spleen meridians. Strengthen spleen and stomach, regulate qi and relieve depression, alleviate pain and prevent abortion. Researches find that the civil engineering essential oil has good function of dissolving mucus, can discharge excessive mucus out of the body, and has good curative effect on cold, allergic rhinitis, nasosinusitis, nasopharynx mucositis, chronic bronchitis, cough and the like. The effect is best when the civil essential oil is used.
Fish brain stones: sweet in taste; salty; is cold in nature. It enters bladder meridian. Promoting urination and treating stranguria; clearing away heat and toxic material. Researches find that the asteriscus Pseudosciaenae has good curative effect on allergic rhinitis.
Paniculate Bolbostemma rhizome: is bitter in taste; is cool in nature. Entering the lung; spleen meridian. Clearing away heat and toxic materials; disperse stagnation and relieve swelling, resolve phlegm. Researches find that the rhizoma bolbostemmae has good curative effect on allergic rhinitis.
The invention is prepared from Chinese traditional herbal medicines, and the traditional Chinese medicine for effectively treating allergic rhinitis and asthma syndrome is combined by orderly matching certain natural extracts with determined components and clear efficacies according to a plurality of principles of traditional Chinese medicine treatment based on syndrome differentiation and modern medicine.
The traditional Chinese medicine composition has the advantages of easily available raw materials, simple process, low cost and high efficiency, and is beneficial to pharmaceutical enterprises for medicine production and quality control; the product has low price and is easy to be accepted by patients.
The invention can be used throughout the whole process of treating allergic rhinitis and asthma syndrome, and clinical experiment results show that the prescription is used for treatment, one dose is taken every day, 100 ml of water is decocted, the decoction is divided into two parts, and one part is taken in the morning and at night, the curative effect is obviously improved in one to three months, the treatment effect is obvious, both the symptoms and root causes are treated, the effect is quick, the effect after healing is good, the cost is low, the safety and reliability are realized, no obvious toxic or side reaction exists, the patient can take the medicine for a long time, no adverse reaction exists in the patient after the medicine is taken for many years, and the blood examination is normally followed.
The invention also provides an oral preparation prepared from the traditional Chinese medicine composition for treating allergic rhinitis and asthma syndrome, wherein the oral preparation comprises oral liquid, tablets, capsules, pills and the like, preferably the dosage forms are tablets and capsules, and one dose is taken every day in the morning and at night.
The traditional Chinese medicine composition can be prepared into various dosage forms. For example, the decocted liquid medicine is sterilized and disinfected and then packaged to prepare oral liquid; or concentrating the decoction, oven drying, adding pharmaceutically acceptable adjuvants, and making into tablet, capsule, pill, etc.
The medically acceptable auxiliary materials comprise starch, dextrin, sodium carboxymethylcellulose, polyethylene glycol, calcium hydrophosphate, sodium alginate, potassium sorbate and the like.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention in any way, and it will be apparent to those skilled in the art that the above description of the present invention can be applied to various modifications, equivalent variations or modifications without departing from the spirit and scope of the present invention.
Claims (4)
1. The traditional Chinese medicine for treating allergic rhinitis and asthma syndrome is characterized by comprising the following raw material medicines in parts by weight: 2-4 parts of asteriscus Pseudosciaenae and clove; 4.5 to 9 parts by weight of elecampane inula root, grassleaf sweelflag rhizome, lightyellow sophora root, pseudo-ginseng and Chinese thorowax root; 6-12 parts by weight of cortex mori, fructus viticis negundo, radix polygoni multiflori preparata and cynomorium songaricum; 9-18 parts of paniculate Bolbostemma rhizome, Chinese gall, and common andrographis herb; 15-30 parts of carpet bugle.
2. The traditional Chinese medicine for treating allergic rhinitis and asthma syndrome according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 4 parts of asteriscus Pseudosciaenae and 4 parts of clove; 9 parts of elecampane inula root, grassleaf sweelflag rhizome, lightyellow sophora root, pseudo-ginseng and Chinese thorowax root; 12 parts by weight of cortex mori radicis, fructus viticis negundo, radix polygoni multiflori preparata and cynomorium songaricum; 18 parts of bolbostemma paniculatum, pagoda tree fern and common andrographis herb; 30 parts of ajuga reptans.
3. An oral preparation for treating allergic rhinitis and asthma syndrome, which is prepared from the Chinese medicinal composition of any one of claims 1 or 2.
4. The oral preparation for treating allergic rhinitis and asthma syndrome according to claim 3, which comprises oral liquid, tablet, capsule, pill, preferably oral liquid and tablet.
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