CN111529454A - Natto toothpaste and preparation method thereof - Google Patents
Natto toothpaste and preparation method thereof Download PDFInfo
- Publication number
- CN111529454A CN111529454A CN202010557538.8A CN202010557538A CN111529454A CN 111529454 A CN111529454 A CN 111529454A CN 202010557538 A CN202010557538 A CN 202010557538A CN 111529454 A CN111529454 A CN 111529454A
- Authority
- CN
- China
- Prior art keywords
- natto
- toothpaste
- phase mixture
- mixture
- minutes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000013557 nattō Nutrition 0.000 title claims abstract description 115
- 239000000606 toothpaste Substances 0.000 title claims abstract description 81
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 81
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000000843 powder Substances 0.000 claims abstract description 66
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 13
- 239000011159 matrix material Substances 0.000 claims abstract description 9
- 239000000203 mixture Substances 0.000 claims description 88
- 239000012071 phase Substances 0.000 claims description 39
- 238000003756 stirring Methods 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 239000003921 oil Substances 0.000 claims description 24
- 238000002156 mixing Methods 0.000 claims description 22
- 239000003906 humectant Substances 0.000 claims description 17
- 239000004088 foaming agent Substances 0.000 claims description 16
- 239000002562 thickening agent Substances 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 14
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 12
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 12
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 12
- 239000008346 aqueous phase Substances 0.000 claims description 12
- 229940091249 fluoride supplement Drugs 0.000 claims description 12
- 235000003599 food sweetener Nutrition 0.000 claims description 12
- 239000000600 sorbitol Substances 0.000 claims description 12
- 239000003765 sweetening agent Substances 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 11
- 239000000049 pigment Substances 0.000 claims description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 238000004945 emulsification Methods 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- 230000001804 emulsifying effect Effects 0.000 claims description 7
- 239000000377 silicon dioxide Substances 0.000 claims description 7
- 235000012239 silicon dioxide Nutrition 0.000 claims description 7
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 7
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 7
- 239000000230 xanthan gum Substances 0.000 claims description 7
- 229920001285 xanthan gum Polymers 0.000 claims description 7
- 235000010493 xanthan gum Nutrition 0.000 claims description 7
- 229940082509 xanthan gum Drugs 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 6
- 150000004676 glycans Chemical class 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- 229920005862 polyol Polymers 0.000 claims description 6
- 150000003077 polyols Chemical class 0.000 claims description 6
- 229920001282 polysaccharide Polymers 0.000 claims description 6
- 239000005017 polysaccharide Substances 0.000 claims description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 229910052782 aluminium Inorganic materials 0.000 claims description 5
- 229940043430 calcium compound Drugs 0.000 claims description 5
- 150000001674 calcium compounds Chemical class 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 244000068988 Glycine max Species 0.000 claims description 4
- 235000010469 Glycine max Nutrition 0.000 claims description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
- -1 aluminum compound Chemical class 0.000 claims description 4
- 239000007844 bleaching agent Substances 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 239000002210 silicon-based material Substances 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002907 Guar gum Polymers 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 3
- 239000002280 amphoteric surfactant Substances 0.000 claims description 3
- 125000000129 anionic group Chemical group 0.000 claims description 3
- 239000003945 anionic surfactant Substances 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 239000000679 carrageenan Substances 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 229940113118 carrageenan Drugs 0.000 claims description 3
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 3
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- 150000002191 fatty alcohols Chemical class 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
- 235000010417 guar gum Nutrition 0.000 claims description 3
- 229960002154 guar gum Drugs 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 229940083542 sodium Drugs 0.000 claims description 3
- 229940065859 sodium cocoyl glycinate Drugs 0.000 claims description 3
- 239000011775 sodium fluoride Substances 0.000 claims description 3
- 235000013024 sodium fluoride Nutrition 0.000 claims description 3
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- 239000003082 abrasive agent Substances 0.000 claims description 2
- 150000002222 fluorine compounds Chemical class 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 150000003377 silicon compounds Chemical class 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- 238000010025 steaming Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 208000002399 aphthous stomatitis Diseases 0.000 abstract description 8
- 208000007117 Oral Ulcer Diseases 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 7
- 210000000214 mouth Anatomy 0.000 abstract description 6
- 230000008439 repair process Effects 0.000 abstract description 3
- 230000001680 brushing effect Effects 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 25
- 150000003254 radicals Chemical class 0.000 description 20
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 19
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 19
- 229940042585 tocopherol acetate Drugs 0.000 description 19
- 239000007864 aqueous solution Substances 0.000 description 13
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 10
- 230000007760 free radical scavenging Effects 0.000 description 9
- 238000002835 absorbance Methods 0.000 description 8
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 7
- 239000004376 Sucralose Substances 0.000 description 5
- 235000019408 sucralose Nutrition 0.000 description 5
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 230000002000 scavenging effect Effects 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 239000000498 cooling water Substances 0.000 description 3
- 238000007872 degassing Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- OCZVHBZNPVABKX-UHFFFAOYSA-N 1,1-diphenyl-2-(2,4,6-trinitrophenyl)hydrazine;ethanol Chemical compound CCO.[O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1NN(C=1C=CC=CC=1)C1=CC=CC=C1 OCZVHBZNPVABKX-UHFFFAOYSA-N 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- 230000003405 preventing effect Effects 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008369 fruit flavor Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 229940086319 nattokinase Drugs 0.000 description 1
- 108010073682 nattokinase Proteins 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of articles for daily use, and particularly relates to natto toothpaste and a preparation method thereof. The natto toothpaste comprises natto powder and a toothpaste matrix, wherein the natto powder accounts for 0.5-8% of the total mass of the raw materials, and the toothpaste matrix accounts for 92-99.5% of the total mass of the raw materials. The natto toothpaste can effectively remove redundant free radicals in the oral cavity, takes effect immediately in the process of tooth brushing, and can quickly repair oral ulcer.
Description
Technical Field
The invention relates to the technical field of articles for daily use, and particularly relates to natto toothpaste and a preparation method thereof.
Background
The toothpaste is an essential product for cleaning the oral cavity, and along with the continuous improvement of the living standard of people, the health care consciousness is stronger, the function of the toothpaste is gradually changed from the initial simple cleaning to the cleaning and nursing health care direction, and the toothpaste is endowed with higher value. Recurrent oral ulcer is the most common and frequent oral disease, the incidence rate of general population is as high as 20%, and at least 2 hundred million people suffer from oral ulcer every year in China. Therefore, how to treat and protect oral diseases while keeping the cleaning ability of toothpaste, and then realize health care of oral cavity is a new demand of consumers. However, the toothpaste adopted by the prior art cannot well prevent and repair the dental ulcer.
In view of this, the invention is particularly proposed.
Disclosure of Invention
The invention aims to provide natto toothpaste and a preparation method thereof. The natto toothpaste can effectively remove redundant free radicals in the oral cavity, takes effect immediately in the process of tooth brushing, and can quickly repair oral ulcer.
The invention is realized by the following steps:
in a first aspect, the embodiment of the invention provides natto toothpaste, the raw materials comprise natto powder and a toothpaste matrix, the natto powder accounts for 0.5-8% of the total mass of the raw materials, and the toothpaste matrix accounts for 92% -99.5% of the total mass of the raw materials.
In an alternative embodiment, the natto powder comprises 1-3% by mass of the total mass of the raw materials.
In alternative embodiments, the toothpaste base comprises an abrasive, a thickener, a humectant, a foaming agent, and water;
preferably, the toothpaste base further comprises at least one of sweeteners, flavors, fluorides, whitening agents and pigments.
In an alternative embodiment, the natto toothpaste has the following composition in weight percent: 0.5-8% of natto powder, 30-50% of an abrasive, 0.5-1.5% of a thickening agent, 15-42% of a humectant, 0.1-0.3% of a sweetening agent, 0.5-5% of a foaming agent, 0.8-3% of an essence, 0-1% of a fluoride, 0-0.1% of a pigment and the balance of water.
In an alternative embodiment, the abrasive is selected from at least one of silicon-based compounds, calcium-based compounds, aluminum-based compounds, and polysaccharide-based substances;
preferably, the silicon-based compound comprises silicon dioxide;
preferably, the calcium compound includes at least one of calcium carbonate, calcium hydrogen phosphate dihydrate, and hydroxyapatite;
preferably, the polysaccharide substance comprises microcrystalline cellulose;
preferably, the aluminum-based compound includes aluminum hydroxide;
preferably, the thickener comprises a substance having adhesive properties;
preferably, the substance with adhesiveness is selected from at least one of sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer resin, xanthan gum, modified guar gum, carrageenan and colloidal magnesium aluminum silicate;
preferably, the humectant comprises a polyol and/or an alcohol-containing polymer;
preferably, the polyol comprises at least one of glycerol, sorbitol and propylene glycol;
preferably, the alcohol-containing polymer comprises polyethylene glycol;
preferably, the fluoride is selected from at least one of sodium monofluorophosphate, sodium fluoride, fluorosilicic acid and sodium fluorosilicate;
the foaming agent is selected from amphoteric surface active agents and/or anionic surface active agents;
preferably, the anionic surfactant comprises at least one of sodium lauryl sulfate, sodium cocoyl glycinate and sodium fatty alcohol ether sulfate;
preferably, the amphoteric surfactant comprises cocamidopropyl betaine.
In a second aspect, the present invention provides a method for preparing natto toothpaste according to the foregoing embodiment, wherein natto powder and a toothpaste base are mixed to form the natto toothpaste.
In an alternative embodiment, the step of preparing the natto toothpaste comprises: preparing natto powder;
preferably, the preparation method of natto powder comprises the following steps: fermenting and purifying soybeans;
preferably, the preparation method of natto powder comprises the following steps: soaking, steaming, fermenting, purifying and freeze-drying soybeans in sequence.
In an alternative embodiment, when the natto toothpaste comprises the following raw materials: when the abrasive agent, the thickening agent, the humectant and the foaming agent are used and the humectant contains sorbitol, the step of preparing the natto toothpaste comprises the following steps:
preparing an aqueous phase mixture from natto powder and sorbitol;
preparing an oil phase mixture by using components of a thickening agent and other humectants;
preparing a first mixture using a foaming agent and a friction agent;
then, mixing the oil phase mixture and the water phase mixture and then mixing the mixture with the first mixture;
preferably, the aqueous phase mixture also comprises sweetening agents, fluoride and whitening agents;
preferably, the oil phase mixture, the water phase mixture and the first mixture are mixed and emulsified for the first time, and then essence and pigment are added and emulsified for the second time.
In an alternative embodiment, the time for mixing the materials in forming the aqueous mixture is from 5 to 20 minutes;
preferably, the mixing time of the materials is 5-20 minutes when the oil phase mixture is formed;
preferably, the conditions under which the oil phase mixture and the aqueous phase mixture are mixed are: the vacuum degree is-0.06 to-0.04 MPa, the stirring time is 10 to 30 minutes, and the stirring speed is 600 and 900 revolutions per minute;
preferably, the conditions under which the oil phase mixture, the aqueous phase mixture and the first mixture are mixed are: the vacuum degree is-0.06-0.04 MPa;
preferably, the conditions of the first emulsification are: the vacuum degree is below-0.098 MPa, the emulsification time is 10-20 minutes, and the stirring speed is 600-900 revolutions per minute;
preferably, the vacuum degree when the essence is added is below-0.098 MPa;
preferably, the conditions of the second emulsification are: the vacuum degree is below-0.098 MPa, and the emulsifying time is 5-20 minutes.
In an alternative embodiment, the temperature during the preparation of the natto toothpaste does not exceed 30 ℃.
The invention has the following beneficial effects: the embodiment of the invention adopts the natto powder as the active ingredient, and the content of the natto powder is controlled, so that the natto powder can effectively remove free radicals in the oral cavity in a short time, and inhibit and prevent the generation of oral ulcer.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a graph showing the results of radical scavenging of aqueous solutions of natto powder of different concentrations after 30 minutes of light-shielding standing as provided in Experimental example 1;
FIG. 2 is a graph showing the results of scavenging free radicals of vitamin E acetate ethanol solutions of different concentrations after 30 minutes of light-shielding standing as provided in Experimental example 1;
FIG. 3 is a graph showing the results of scavenging free radicals of the natto powder aqueous solutions with different concentrations and the vitamin E acetate ethanol solutions with different concentrations during the dark storage for different times as provided in Experimental example 1;
fig. 4 is a graph of the detection results provided in experimental example 2.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The embodiment of the invention provides natto toothpaste, which comprises natto powder and a toothpaste matrix, wherein the natto powder accounts for 0.5-8% of the total mass of the raw materials, and the toothpaste matrix accounts for 92-99.5% of the total mass of the raw materials. Preferably, the mass of the natto powder accounts for 1-3% of the total mass of the raw materials. In the embodiment of the invention, natto powder is used as an active ingredient and the dosage of the natto powder is controlled, so that the free radicals in the oral cavity can be effectively eliminated in a short time, and the generation of the oral ulcer can be inhibited and prevented. If the active ingredients or the proportion is changed, the effect of the toothpaste on removing free radicals can be reduced, and the effect of the toothpaste on repairing canker sores is reduced.
Particularly, the natto powder contains a plurality of bioactive substances, such as nattokinase, natto isoflavone, superoxide dismutase and the like, and the substances have good effects of removing free radicals and further repairing and preventing oral ulcer.
Further, the toothpaste base comprises an abrasive, a thickening agent, a humectant, a foaming agent and water; the toothpaste base further comprises at least one of a sweetener, an essence, a fluoride, a whitening agent and a pigment. The use of the above toothpaste base enables the toothpaste to meet the most basic performance.
Further, the natto toothpaste comprises the following components in percentage by weight: 0.5-8% of natto powder, 30-50% of an abrasive, 0.5-1.5% of a thickening agent, 15-42% of a humectant, 0.1-0.3% of a sweetening agent, 0.5-5% of a foaming agent, 0.8-3% of an essence, 0-1% of a fluoride, 0-0.1% of a pigment and the balance of water. The natto toothpaste prepared by the materials and the proportion has good repairing and preventing effects on dental ulcer.
Secondly, the friction agent is selected from at least one of silicon compounds, calcium compounds, aluminum compounds and polysaccharide substances; preferably, the silicon-based compound comprises silicon dioxide; preferably, the calcium compound includes at least one of calcium carbonate, calcium hydrogen phosphate dihydrate, and hydroxyapatite; preferably, the polysaccharide substance comprises microcrystalline cellulose; preferably, the aluminum-based compound includes aluminum hydroxide;
preferably, the thickener comprises a substance having adhesive properties; preferably, the substance with adhesiveness is selected from at least one of sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer resin, xanthan gum, modified guar gum, carrageenan and colloidal magnesium aluminum silicate;
preferably, the humectant comprises a polyol and/or an alcohol-containing polymer; preferably, the polyol comprises at least one of glycerol, sorbitol and propylene glycol; preferably, the alcohol-containing polymer comprises polyethylene glycol;
preferably, the fluoride is selected from at least one of sodium monofluorophosphate, sodium fluoride, fluorosilicic acid and sodium fluorosilicate;
the foaming agent is selected from amphoteric surface active agents and/or anionic surface active agents; preferably, the anionic surfactant comprises at least one of sodium lauryl sulfate, sodium cocoyl glycinate and sodium fatty alcohol ether sulfate; preferably, the amphoteric surfactant comprises cocamidopropyl betaine.
The essence is selected from one or more of herba Menthae flavor, herba Menthae Rotundifoliae flavor, wintergreen flavor, fruit flavor, tea refreshing flavor, and medicinal flavor, the whitening agent is selected from titanium dioxide, and the sweetener is selected from one or more of saccharin sodium, stevioside, stevia extract, sucralose, aspartame, xylitol, and acesulfame potassium.
It should be noted that the examples of the present invention only exemplify some of the optional materials and select materials having corresponding effects with respect to the abrasive, the thickener, the humectant, the foaming agent, the sweetener, the essence, the fluoride, the whitening agent, and the pigment.
The embodiment of the invention also provides a preparation method of the natto toothpaste, which comprises the steps of mixing the natto powder and a toothpaste matrix to form the natto toothpaste, and specifically preparing an aqueous phase mixture by using the natto powder and sorbitol; preparing an oil phase mixture by using the thickener and other components of the humectant (such as glycerin, polyethylene glycol and the like); preparing a first mixture using a foaming agent and a friction agent; then, mixing the oil phase mixture and the water phase mixture and then mixing the mixture with the first mixture; by adopting the method, the materials can be ensured to be fully and uniformly mixed, and the performance of the prepared natto toothpaste is further ensured.
Secondly, when natto toothpaste contains sweetener, fluoride, whitening agent, and water phase mixture is prepared, the above materials are also mixed with natto powder to prepare water phase mixture.
And when the natto toothpaste contains essence and pigment, mixing the oil phase mixture, the water phase mixture and the first mixture, emulsifying for the first time, adding the essence and the pigment, and emulsifying for the second time.
Further, when the water phase mixture is formed, the mixing time of the materials is 5-20 minutes; when the oil phase mixture is formed, the mixing time of all the materials is 5-20 minutes; the conditions under which the oil phase mixture and the aqueous phase mixture are mixed are: the vacuum degree is-0.06 to-0.04 MPa, the stirring time is 10 to 30 minutes, and the stirring speed is 600 and 900 revolutions per minute; the conditions under which the oil phase mixture, the aqueous phase mixture and the first mixture are mixed are: the vacuum degree is-0.06-0.04 MPa; the conditions for the first emulsification were: the vacuum degree is below-0.098 MPa, the emulsification time is 10-20 minutes, and the stirring speed is 600-; the vacuum degree when the essence is added is below-0.098 MPa; the conditions for the second emulsification were: the vacuum degree is below-0.098 MPa, and the emulsifying time is 5-20 minutes.
By adopting the conditions, the natto toothpaste can be further ensured to be uniformly mixed with various substances, so that the natto toothpaste has a good effect of removing free radicals, and the natto toothpaste has an excellent repairing effect on dental ulcer.
In the whole preparation process, the temperature is not more than 30 ℃, so that the active ingredients can be prevented from deteriorating, and the performance of the natto toothpaste is further ensured.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The formulation of natto toothpaste provided in this example is as follows:
| composition (I) | Weight percent of |
| Polyethylene glycol | 5％ |
| Sorbitol | 25.9％ |
| Xanthan gum | 0.5％ |
| Natto powder | 1％ |
| Sucralose | 0.14％ |
| Sodium monofluorophosphate | 0.76％ |
| Sodium carboxymethylcellulose | 0.5％ |
| Water (W) | 34.5％ |
| Silicon dioxide | 28％ |
| Titanium dioxide | 0.3％ |
| Sodium lauryl sulfate | 2.4％ |
| Essence | 1％ |
The embodiment provides a preparation method of natto toothpaste, which comprises the following steps:
mixing sucralose, titanium dioxide, sodium monofluorophosphate and natto powder which are weighed according to the formula with water, stirring for 10 minutes until the materials are completely dissolved and dispersed to form uniform white slurry, adding metered sorbitol, and continuously stirring for 5 minutes to form a water phase mixture.
Mixing xanthan gum, sodium carboxymethylcellulose and polyethylene glycol weighed according to the formula, and stirring for 5 minutes to form an oil phase mixture.
The silicon dioxide and the sodium lauryl sulfate which are weighed according to the formula are mixed and stirred for 10 minutes to form a first mixture.
The oil phase mixture and the water phase mixture were mixed at a stirring speed of 900 rpm for 10 minutes to obtain a second mixture.
Adding the first mixture into the second mixture under the condition that the vacuum degree is-0.05 MPa, homogenizing and stirring, and continuously vacuumizing and maintaining negative pressure in the process of adding the first mixture; after the first mixture is fed, continuously keeping the vacuum degree below-0.094 MPa, stirring for 30 minutes, and controlling the paste preparation temperature to be 20-30 ℃. If the temperature is higher than 30 ℃, the cooling water is started.
Then reducing the vacuum degree to-0.04 MPa, adding essence, vacuumizing and degassing until the reading reaches more than-0.094 MPa, and stirring for 8 minutes under vacuum.
Example 2 to example 6
The embodiment provides a preparation method of natto toothpaste, which comprises the following steps:
mixing sucralose, titanium dioxide, sodium monofluorophosphate and natto powder which are weighed according to the formula with water, stirring for 5 minutes until the materials are completely dissolved and dispersed to form uniform white slurry, adding metered sorbitol, and continuously stirring for 10 minutes to form a water phase mixture.
Mixing xanthan gum, sodium carboxymethylcellulose and polyethylene glycol weighed according to the formula, and stirring for 20 minutes to form an oil phase mixture.
The silicon dioxide and the sodium lauryl sulfate which are weighed according to the formula are mixed and stirred for 10 minutes to form a first mixture.
Mixing the oil phase mixture and the water phase mixture at a stirring speed of 800 r/min under a vacuum degree of-0.04 MPa, and stirring for 30 min to obtain a second mixture.
Starting stirring at the stirring speed of 600 rpm under the vacuum degree of-0.04 MPa, adding the first mixture into the second mixture, homogenizing and stirring, and continuously vacuumizing to keep negative pressure in the process of adding the first mixture; after the first mixture is introduced, continuously keeping the vacuum degree below-0.098 MPa, stirring and emulsifying for 20 minutes, and controlling the paste preparation temperature to be 20-30 ℃. If the temperature is higher than 30 ℃, the cooling water is started.
Then reducing the vacuum degree to-0.04 MPa, adding essence, vacuumizing and degassing until the reading reaches more than-0.098 MPa, and stirring for 5 minutes under vacuum.
The embodiment provides a preparation method of natto toothpaste, which comprises the following steps:
mixing sucralose, titanium dioxide, sodium monofluorophosphate and natto powder which are weighed according to the formula with water, stirring for 20 minutes until the materials are completely dissolved and dispersed to form uniform white slurry, adding metered sorbitol, and continuously stirring for 10 minutes to form a water phase mixture.
Mixing xanthan gum, sodium carboxymethylcellulose and polyethylene glycol weighed according to the formula, and stirring for 10 minutes to form an oil phase mixture.
The silicon dioxide and the sodium lauryl sulfate which are weighed according to the formula are mixed and stirred for 10 minutes to form a first mixture.
Mixing the oil phase mixture and the water phase mixture at a speed of 900 r/min under a vacuum degree of-0.06 MPa, and stirring for 10 min to obtain a second mixture.
Starting stirring at the stirring speed of 900 rpm under the vacuum degree of-0.04 MPa, adding the first mixture into the second mixture, homogenizing and stirring, and continuously vacuumizing to keep negative pressure in the process of adding the first mixture; after the first mixture is introduced, continuously keeping the vacuum degree below-0.098 MPa, stirring and emulsifying for 10 minutes, and controlling the paste preparation temperature to be 20-30 ℃. If the temperature is higher than 30 ℃, the cooling water is started.
Then reducing the vacuum degree to-0.04 MPa, adding essence, vacuumizing and degassing until the reading reaches more than-0.098 MPa, and stirring for 20 minutes under vacuum.
Experimental example 1
Comparative example: vitamin E acetate, for reasons: vitamin E is an extremely strong antioxidant, is very easy to oxidize and cannot exist stably, and is usually applied in the form of vitamin E acetate, so that the vitamin E acetate is selected as a contrast and has certain representativeness.
The experimental process comprises the following steps: dissolving natto powder in water to obtain natto water solution with concentration of 0.25mg/ml, 0.50mg/ml and 1.00 mg/ml. Vitamin E acetate was dissolved in ethanol to form ethanol solutions of vitamin E acetate at concentrations of 0.25mg/ml, 0.50mg/ml, and 1.00 mg/ml.
(1) And respectively adding the natto powder aqueous solution with different concentrations and the vitamin E acetate ethanol solution with different concentrations into the ethanol solution with the same volume of DPPH, standing for 30 minutes in a dark place, and scanning by setting a range of 440-600nm by using an ultraviolet spectrophotometer. Wherein, the volume of the added natto powder aqueous solution is the same as that of the vitamin E acetate ethanol solution.
(2) Adding the natto powder aqueous solution with different concentrations and the vitamin E acetate ethanol solution with different concentrations in the same volume into the ethanol solution with the same volume of DPPH, keeping the natto powder aqueous solution and the vitamin E acetate ethanol solution in the same volume for different times in a dark place, and scanning the natto powder aqueous solution and the vitamin E acetate ethanol solution in the range of 440 nm and 600nm by using an ultraviolet spectrophotometer.
Selecting absorbance data at 517nm, and recording the absorbance of the DPPH ethanol solution as A0Adding natto dry powder water solution or vitamin E acetate ethanol solution, and recording the absorbance as AiThe radical clearance a is calculated according to the following formula:
the detection results are shown in fig. 1-fig. 3 and table 1, wherein fig. 1 is a graph showing the free radical scavenging results of the natto powder aqueous solutions with different concentrations after standing for 30 minutes in a dark place; FIG. 2 is a graph showing the results of scavenging free radicals of vitamin E acetate ethanol solutions with different concentrations after standing for 30 minutes in a dark place; FIG. 3 is a graph showing the results of scavenging free radicals of natto powder aqueous solutions with different concentrations and vitamin E acetate ethanol solutions with different concentrations after being stored in dark for different times.
TABLE 1 comparison of the rate of free radical scavenging by natto powder and vitamin E acetate
As can be seen from FIG. 1, the absorbance at 517nm is continuously decreased with the increase of the concentration of natto powder, which indicates that DPPH free radicals are eliminated by natto powder, and the free radical clearance rate reaches 78.3% at the concentration of 1.00 mg/ml; in comparison, in fig. 2, the change of the absorbance at 517nm is not large with the increase of the concentration of the vitamin E acetate, and the free radical clearance rate is below 20%. The comparison shows that the free radical scavenging effect of the natto powder is more than three times that of the vitamin E acetate, and the natto powder has extremely strong free radical scavenging capacity.
From fig. 3, the free radical clearance rate of the natto powder aqueous solution is a stable straight line within ten minutes after the natto powder aqueous solution is added into DPPH, and the free radical clearance rate within 1 minute reaches 76.9%, which indicates that the natto powder can play a role in clearing free radicals within 1 minute, the clearance rate of vitamin E acetate free radicals continuously and slowly increases, and the natto powder aqueous solution tends to be stable until 6 minutes.
The results show that the natto powder has strong free radical scavenging capacity, has quick action time, can take effect in a short time, and meets the use requirement of toothpaste environment.
Experimental example 2: the toothpaste added with 3%, 8% and 12% of natto powder is adopted, the selected materials in the toothpaste, such as the abrasive, the thickening agent, the foaming agent, the sweetening agent, the fluoride, and the like, are the same, the content is the same, the balance of the corresponding example is water, a free radical scavenging test is carried out, and the anti-free radical capability of the natto toothpaste is evaluated.
The experimental process comprises the following steps: adding natto powder into toothpaste to prepare natto toothpaste, wherein the natto powder content is 3%, 8% and 12% respectively. Dissolving the toothpaste containing different amounts of natto powder in water solution, centrifuging, adding the obtained clear liquid into ethanol solution with the same volume of DPPH, standing for 30 minutes in a dark place, and scanning by setting the range of 440-600nm by using an ultraviolet spectrophotometer.
Selecting absorbance data at 517nm, and recording the absorbance of the DPPH ethanol solution as A0The absorbance of the DPPH solution after the toothpaste clear solution was added was recorded as AiThe radical clearance a is calculated according to the following formula:
TABLE 2 toothpaste free radical scavenging data (517nm) for different natto powder contents
| Content of natto powder | 3％ | 8％ | 12％ |
| Free radical scavenging rate | 61.06％ | 61.23％ | 60.1％ |
From table 2 and fig. 4, the curve of the removal rate of DPPH free radicals by toothpaste clear solutions containing natto powder of different concentrations, wherein 3% toothpaste aqueous solution has better removal effect, reaching 61.06%; the natto concentration is increased to 8 percent, and the effect is slightly improved to 61.23 percent; the concentration is further increased to 12 percent, which is not beneficial to improving the free radical scavenging effect, so the addition amount of the natto powder is selected to be 3 to 8 percent.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The natto toothpaste is characterized in that raw materials comprise natto powder and a toothpaste matrix, wherein the natto powder accounts for 0.5-8% of the total mass of the raw materials, and the toothpaste matrix accounts for 92-99.5% of the total mass of the raw materials.
2. The natto toothpaste according to claim 1, wherein the natto powder is 1 to 3% by mass of the total mass of the raw materials.
3. The natto toothpaste according to claim 1, wherein the toothpaste base comprises an abrasive, a thickener, a humectant, a foaming agent, and water;
preferably, the toothpaste base further comprises at least one of sweeteners, flavors, fluorides, whitening agents and pigments.
4. The natto toothpaste according to any one of claims 1 to 3, wherein the natto toothpaste comprises the following components in weight percent: 0.5-8% of natto powder, 30-50% of an abrasive, 0.5-1.5% of a thickening agent, 15-42% of a humectant, 0.1-0.3% of a sweetening agent, 0.5-5% of a foaming agent, 0.8-3% of an essence, 0-1% of a fluoride, 0-0.1% of a pigment and the balance of water.
5. The natto toothpaste according to claim 4, wherein the abrasive is at least one selected from the group consisting of a silicon compound, a calcium compound, an aluminum compound and a polysaccharide;
preferably, the silicon-based compound comprises silicon dioxide;
preferably, the calcium compound includes at least one of calcium carbonate, calcium hydrogen phosphate dihydrate, and hydroxyapatite;
preferably, the polysaccharide substance comprises microcrystalline cellulose;
preferably, the aluminum-based compound includes aluminum hydroxide;
preferably, the thickener comprises a substance having adhesive properties;
preferably, the substance with adhesiveness is selected from at least one of sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer resin, xanthan gum, modified guar gum, carrageenan and colloidal magnesium aluminum silicate;
preferably, the humectant comprises a polyol and/or an alcohol-containing polymer;
preferably, the polyol comprises at least one of glycerol, sorbitol and propylene glycol;
preferably, the alcohol-containing polymer comprises polyethylene glycol;
preferably, the fluoride is selected from at least one of sodium monofluorophosphate, sodium fluoride, fluorosilicic acid and sodium fluorosilicate;
the foaming agent is selected from amphoteric surface active agents and/or anionic surface active agents;
preferably, the anionic surfactant comprises at least one of sodium lauryl sulfate, sodium cocoyl glycinate and sodium fatty alcohol ether sulfate;
preferably, the amphoteric surfactant comprises cocamidopropyl betaine.
6. The method for preparing natto toothpaste according to claim 1, wherein natto powder and a toothpaste base are mixed to form the natto toothpaste.
7. The method of claim 6, wherein the step of preparing the natto toothpaste comprises: preparing natto powder;
preferably, the preparation method of natto powder comprises the following steps: fermenting and purifying soybeans;
preferably, the preparation method of natto powder comprises the following steps: soaking, steaming, fermenting, purifying and freeze-drying soybeans in sequence.
8. The preparation method according to claim 6, wherein when the natto toothpaste comprises the following raw materials: when the abrasive agent, the thickening agent, the humectant and the foaming agent are used and the humectant contains sorbitol, the step of preparing the natto toothpaste comprises the following steps:
preparing an aqueous phase mixture from natto powder and sorbitol;
preparing an oil phase mixture by using components of a thickening agent and other humectants;
preparing a first mixture using a foaming agent and a friction agent;
then, mixing the oil phase mixture and the water phase mixture and then mixing the mixture with the first mixture;
preferably, the aqueous phase mixture also comprises sweetening agents, fluoride and whitening agents;
preferably, the oil phase mixture, the water phase mixture and the first mixture are mixed and emulsified for the first time, and then essence and pigment are added and emulsified for the second time.
9. The method according to claim 8, wherein the aqueous phase mixture is formed by mixing the materials for 5 to 20 minutes;
preferably, the mixing time of the materials is 5-20 minutes when the oil phase mixture is formed;
preferably, the conditions under which the oil phase mixture and the aqueous phase mixture are mixed are: the vacuum degree is-0.06 to-0.04 MPa, the stirring time is 10 to 30 minutes, and the stirring speed is 600 and 900 revolutions per minute;
preferably, the conditions under which the oil phase mixture, the aqueous phase mixture and the first mixture are mixed are: the vacuum degree is-0.06-0.04 MPa;
preferably, the conditions of the first emulsification are: the vacuum degree is below-0.098 MPa, the emulsification time is 10-20 minutes, and the stirring speed is 600-900 revolutions per minute;
preferably, the vacuum degree when the essence is added is below-0.098 MPa;
preferably, the conditions of the second emulsification are: the vacuum degree is below-0.098 MPa, and the emulsifying time is 5-20 minutes.
10. The method according to claim 8, wherein the natto toothpaste is prepared at a temperature of not more than 30 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010557538.8A CN111529454A (en) | 2020-06-18 | 2020-06-18 | Natto toothpaste and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010557538.8A CN111529454A (en) | 2020-06-18 | 2020-06-18 | Natto toothpaste and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111529454A true CN111529454A (en) | 2020-08-14 |
Family
ID=71976504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010557538.8A Pending CN111529454A (en) | 2020-06-18 | 2020-06-18 | Natto toothpaste and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111529454A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112933086A (en) * | 2021-03-16 | 2021-06-11 | 江苏雪豹日化有限公司 | Bactericide-containing composition capable of removing halitosis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011126819A (en) * | 2009-12-18 | 2011-06-30 | Lion Corp | Composition for oral cavity |
| JP2014040403A (en) * | 2012-08-23 | 2014-03-06 | Masaki Hamada | Natto toothpaste and natto mouthrinse |
| CN108670889A (en) * | 2018-07-25 | 2018-10-19 | 佛山市仁汇医药科技有限公司 | A kind of toothpaste and preparation method thereof of anti-treating dental ulcer |
-
2020
- 2020-06-18 CN CN202010557538.8A patent/CN111529454A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011126819A (en) * | 2009-12-18 | 2011-06-30 | Lion Corp | Composition for oral cavity |
| JP2014040403A (en) * | 2012-08-23 | 2014-03-06 | Masaki Hamada | Natto toothpaste and natto mouthrinse |
| CN108670889A (en) * | 2018-07-25 | 2018-10-19 | 佛山市仁汇医药科技有限公司 | A kind of toothpaste and preparation method thereof of anti-treating dental ulcer |
Non-Patent Citations (2)
| Title |
|---|
| 《中医堂》编委会: "《食物药效全典》", 30 April 2015, 黑龙江科学技术出版社 * |
| MAKOTO ASHIUCHIA,ET AL.: "Rapid purification and plasticization of d-glutamate-containing poly-gamma-glutamate from Japanese fermented soybean food natto", 《JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112933086A (en) * | 2021-03-16 | 2021-06-11 | 江苏雪豹日化有限公司 | Bactericide-containing composition capable of removing halitosis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2855732C (en) | Aqueous oral care compositions | |
| RU2414210C1 (en) | Medication for removal of tobacco resins and based on it composition | |
| TW201446276A (en) | Oral care composition and processes for preparing same | |
| US20060193791A1 (en) | Antiplaque oral care compositions | |
| AU2002256299B2 (en) | Stable herbal dentifrice | |
| CN111529454A (en) | Natto toothpaste and preparation method thereof | |
| WO1999043293A1 (en) | Stable herbal dentifrice | |
| JP2009096748A (en) | Liquid composition for oral cavity | |
| JP2003252745A (en) | MATRIX METALLOPROTEINASE (MMPs) INHIBITOR | |
| JP3878612B2 (en) | Composition for suppressing active oxygen, and external preparation for skin and cosmetic containing the composition | |
| CN113908109A (en) | Propolis anti-allergy toothpaste and preparation method thereof | |
| FR2565485A1 (en) | STABLE TOOTHPASTE CONTAINING DEXTRANASE | |
| US20040115138A1 (en) | Stable herbal dentifrice | |
| KR102296156B1 (en) | A hydrogel toothpaste composition with improved functionality | |
| JPH10251155A (en) | Protease inhibitor | |
| TW202106320A (en) | Use of ilex latifolia thunb extract | |
| JP2012106941A (en) | Aqueous composition and optical stabilization method of vitamin b6 in the aqueous composition | |
| JP3287658B2 (en) | Oral composition containing tea powder | |
| JP2001089345A (en) | Anti-dental caries agent | |
| JP2019214515A (en) | Gelatinous composition | |
| RU2789083C2 (en) | Method for obtaining a dextranase preparation and its use | |
| JP5720352B2 (en) | Liquid oral composition | |
| JP7424770B2 (en) | Gingival tissue destruction inhibitor | |
| KR0184226B1 (en) | Functional drinks containing melatonin | |
| KR20170125751A (en) | Oral composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200814 |
|
| RJ01 | Rejection of invention patent application after publication |