KR0184226B1 - Functional drinks containing melatonin - Google Patents

Abstract

The present invention relates to a functional beverage containing melatonin having antioxidant function and excellent stability.

The melatonin-containing beverage according to the present invention is characterized by comprising melatonin 0.1 to 10 mg, fermentation collagen 5 to 15 g, auxiliary ingredient, and remaining purified water.

The beverage according to the present invention can obtain an anti-aging effect by its excellent antioxidant ability by melatonin, and can recover some of the aged tissues by fermentation collagen. In addition, it can be obtained in a transparent liquid state as compared with a conventional beverage containing beta-carotene, and is maintained in a very stable state in which sedimentation does not occur even after long-term storage.

Description

Functional drinks containing melatonin

The present invention relates to a beverage containing melatonin, and more particularly to a functional beverage containing melatonin having antioxidant function and excellent stability.

Recently, as the income level has improved and the interest in health has increased, there has been an explosion in demand for health drinks having various functionalities instead of conventional beverages to solve the conventional thirst, and antioxidant Functional beverages containing substances are also being introduced. For example, Korean Patent Laid-Open Publication No. 95-16595 discloses an enteric-coated beverage having a bowel disease and a constipation-preventing function containing beta -carotene, oligosaccharide and dietary fiber as antioxidants.

Beta-carotene, however, is not only an essential nutrient of the human body as a precursor of vitamin A, but also a lipid peroxide, as described by Murakoshi et al. In Cancer Research, 52, 6583-6587 (1992) Beta carotene, represented by the formula C ₄₀ H ₅₆ , is known to have a protective effect against cancer by capturing free radicals, and it is known to inhibit harmful oxygen which damages the cell membrane, damages the genetic material, Since it is not contained, it is insoluble in water and its dissolution becomes a problem.

For example, data from the US Department of Agriculture and the National Cancer Institute suggest that according to the guidelines for good health and prevention of cancer, the recommended daily intake for adults is about 6 mg to achieve the antioxidant effect desired by beta carotene . Therefore, when a beverage containing beta-carotene is prepared on the basis that the average capacity of a functional beverage is 100-120 ml and one bottle is taken per day, the amount of beta-carotene contained is about 0.005-0.006%. However, since beta-carotene is insoluble in water, it is produced in an emulsified or dispersed form rather than dissolved in water. As the emulsifier, phosphatidylcholine is usually used.

Emulsification can be carried out directly at the time of manufacturing beverages, but because of the difficulty of emulsification, the emulsifying agent is used to emulsify the beta carotene in advance, and then it is added to other beverage compositions to prepare the final product. Therefore, a separate emulsification process is required. Also, when the emulsified particles are large, the turbidity of the product is increased, and even if a well-dispersed solution is obtained, there is a disadvantage that the stability is deteriorated and precipitates are formed when stored for a long period of time.

As another substance having a sulfation function, Sci., 107 (1995), and the like. However, since vitamin E is fat-soluble, there is a disadvantage that the amount of vitamin E to be used is limited. Therefore, a method of introducing a hydrophilic polyoxyethylene group or the like into vitamin E has been introduced at the international conference of IFSCC in order to improve the solubility, but in this case, it is difficult to apply it to beverage by dioxane which can be produced as a reaction by- there was.

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a beverage containing melatonin having a cosmetic effect such as an antioxidative function and an anti-aging function and having excellent solubility and stability.

The melatonin-containing beverage according to the present invention is characterized by comprising melatonin 0.1 to 10 mg, fermentation collagen 5 to 15 g, auxiliary ingredient, and remaining purified water. Based on the whole beverage, melatonin and fermented collagen are 10 ^-4 to 10 ^-2 wt% and 5 to 15 wt%, respectively.

The auxiliary components include vitamin C, vitamin B ₁ , vitamin B ₂ , vitamin B ₁₂ , niacin, pantothenic acid Ca, folic acid and saccharides.

Melatonin is not secreted when it is born, but as it grows, its secretion becomes stronger, and its secretion decreases around puberty, and only a small amount of melatonin is present in old age. In other words, it can be said that aging progresses with decrease of melatonin. Melatonin is synthesized from tryptophan, an essential amino acid in the pineal gland, a small tissue located in the center of the brain in vivo. Melatonin has strong antioxidant properties because it has a basic structure of tryptophan, and it has antioxidant properties twice as strong as vitamin E, which is known as a conventional antioxidant.

The melatonin used in the present invention may be a natural acid or a compound. When a natural acid is used, a product extracted from a substance having a high content of melatonin can be used, and an extract of a substance having a large content of melatonin can be used. However, the oat which is known to contain a lot of melatonin is 1.8 x 10 ^-6 mg / kg, which is less than the daily requirement. Therefore, extracted and concentrated or synthesized products should be added. Melatonin, which is synthesized in the body, may also be used, but it is not preferable because proteins likely to cause viruses or antibody reactions may be contaminated.

The content of melatonin (product of American Allergy Co., USA, Life Extension Co., USA) according to the present invention is 0.1 to 10 mg, preferably 0.5 to 6 mg, of the total beverage composition. If it is less than 0.1 mg, the desired antioxidant function can not be obtained. If it is more than 10 mg, it is not preferable because it causes drowsiness or the possibility of inhibiting ovulation formation in a very small number of women. That is, when the daily intake of melatonin is 75 mg or more, when melatonin acts simultaneously with progesterone, ovulation of the female can be inhibited. Therefore, in view of the fact that the present invention is a functional beverage, it is preferable that it is not more than 10 mg, assuming that one or two bottles are to be eaten per day. Melatonin, unlike beta carotene, has excellent solubility in water, so there is no limit to how it can be introduced into beverages. Melatonin may be introduced into beverages by, for example, dissolving melatonin in ethanol and then adding it to a base containing fermentation collagen and auxiliary components, etc. to dissolve melatonin; Dissolving melatonin in a fermented collagen extract and dissolving it in a base containing other auxiliary components; And a method of mixing and dissolving melatonin, fermentation collagen and auxiliary components at the same time.

Of the components constituting the present invention, fermentation collagen is important. Collagen is a fibrous protein found in multicellular animals. Its structural properties play an important role in reinforcing the elasticity and tensile strength of dermis, muscles and teeth, and binding between cells and cells. However, this also ages as the age increases and the amount decreases. Collagen, on the other hand, can be used as a dietary supplement that not only restores elasticity of the skin but also improves muscle strength. In fact, gomtang and suldong have large amounts of collagen. In addition, collagen can restore the disequilibrium of connective tissues due to aging. However, when the amount of collagen is large, the absorption rate into the body is slowed because it is not completely dissolved. In other words, collagen has a molecular weight of about 300,000, so it can be partially absorbed into the body by partially hydrolyzing it by a proteolytic element such as papain or peptidase. Therefore, the use of the partially hydrolyzed collagen not only enhances the aesthetic effect by the liberated amino acid but also can be absorbed into the body more quickly because of hydrolysis and low molecular weight.

The fermentation collagen according to the present invention (manufactured by Nippon Goyo Kagaku Co., Ltd.) is completely degraded by enzymes and is completely dissolved in water and has a fast absorption rate into the body. The content of fermented collagen is 5 to 15 g, preferably 8 to 12 g, in the total beverage composition. When the amount is less than 5 g, the desired aging prevention effect and the aging recovery effect are insufficient, and when it is 15 g or more, the viscosity is increased, which is not suitable as a beverage and the manufacturing cost is increased. Fermentation collagen may not be added considering the manufacturing cost.

Among the auxiliary ingredients, niacin is nicotinic acid, which is a kind of vitamin B complex, and is effective for skin discoloration and dry skin. Pantothenic acid Ca is a component of coenzyme A and plays an important role in metabolism of lipid and saccharide. Folic acid is a kind of vitamin B complex and has hematopoiesis. Saccharides are sugary, honey, fructose or oligosaccharides, but oligosaccharides are most preferable.

Vitamin C content of each of the secondary components of the total beverage composition is 350 ~ 600mg, vitamin B ₁ is 0.6 ~ 0.9mg, vitamin B ₂ is 0.65 ~ 1.0mg Vitamin B ₁₂ is 2 to 4, niacin is 5.0 ~ 7.5mg , 3.5 to 4.0 mg of pantothenic acid Ca, 0.3 to 0.7 mg of folic acid, and 6 to 16 g of saccharides, but its composition and content can be changed according to the taste of the consumer.

The content of the auxiliary component is 0.35 to 0.6 wt%, vitamin B ₁ is 6 x 10 ^-4 to 9 x 10 ^-4 wt%, and vitamin B ₂ is 6.5 x 10 ^-4 to 10 wt% ^-3 % by weight, vitamin B ₁₂ is 2 × 10 ^-6 to 4 × 10 ^-6 % by weight, niacin is 5 × 10 ^-3 to 7.5 × 10 ^-3 % by weight, pantothenic acid Ca is 3.55 × 10 ^-3 to 4.0 × 10 ^-3 wt%, folate 3 × 10 ^-4 to 7 × 10 ^-4 wt%, and saccharide 6 wt% to 16 wt%.

The amount of purified water is adjusted by adjusting the amount so that the total content of the beverage is 100 ml.

Hereinafter, the present invention will be described in more detail with reference to the following examples and comparative examples, but the present invention is not limited to these examples.

[Example]

The syrup was prepared by mixing melatonin, vitamin C, vitamin B ₁ , vitamin B ₂ , vitamin B _12, niacin, pantothenic acid Ca, folic acid and oligosaccharide at room temperature with purified water according to the procedure described in Table 1, At < RTI ID = 0.0 > 90 C < / RTI > for 35 to 60 seconds and then cooled to prepare a beverage.

[Example 2]

A beverage was prepared in the same manner as in Example 1 except that 5 g of fermentation collagen (manufactured by Kyoei Kogyo Co., Ltd.) was further added in addition to the components of Example 1 above.

[Example 3]

A beverage was prepared in the same manner as in Example 2 except that 10 g of fermentation collagen was added.

[Example 4]

A beverage was prepared in the same manner as in Example 2 except that 10 mg of melatonin was added.

[Example 5]

A beverage was prepared in the same manner as in Example 2 except that 0.5 mg of melatonin was added.

[Comparative Example 1]

A beverage was prepared in the same manner as in Example 2, except that 50 mg of melatonin was added.

[Comparative Example 2]

According to the contents shown in Table 2, fermented collagen, vitamin C, vitamin E, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin B ₁₂ , niacin, pantothenic acid Ca, folic acid and oligosaccharide were mixed well with purified water at room temperature to prepare syrup The prepared syrup was sterilized at a temperature of 90 DEG C for 60 seconds and then cooled. The beverage was then prepared by adding the emulsified beta carotene to the cooled syrup.

Stability test

The beverages prepared from each of the above Examples and Comparative Examples were subjected to a stability test. Transparency of the prepared beverage was observed with naked eyes. The presence or absence of precipitates was observed after the beverage was left at room temperature for 2 months. The results are shown in Table 3.

As shown in Table 3, even in Comparative Example 1 containing 50 mg of melatonin, there is no problem in the stability of the drink, but since the ovulation formation of the female can be suppressed as described above, the invention is not discussed here. In addition, Comparative Example 2 is a beverage containing beta-carotene and its properties are inappropriate as beverages.

As described above, the beverage according to the present invention can obtain an anti-aging effect by its excellent antioxidant ability by melatonin, and can recover some of the aged tissue by fermentation collagen. In addition, it can be obtained in a transparent liquid state as compared with a conventional beverage containing beta-carotene, and is maintained in a very stable state in which sedimentation does not occur even after long-term storage.

Claims (1)

Based on the total beverage melatonin 10 ^-4 to 10 ^-2% by weight, fermenting the collagen 5-15% by weight of vitamin C, 0.35 - 0.6 wt%, vitamin ^{_{B 1, 6 × 10 -4 ~}} 9 × 10 -4 % by weight , Vitamin B ₂ , 6.5 × 10 ^-4 to 10 ^-3 wt%, vitamin B ₁₂ , 2 × 10 ^-6 to 4 × 10 ^-6 wt%, niacin 5 × 10 ^-3 to 7.5 × 10 ^-3 wt% Wherein the content of pantothenic acid Ca is 3.55 x 10 ^-3 to 4.0 x 10 ^-3 wt%, folate 3 x 10 ^-4 to 7 x 10 ^-4 wt%, saccharide 6 to 16 wt%, and the remainder purified water. One functional drink.