JP3287658B2 - Oral composition containing tea powder - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition containing tea powder. In more detail, by blending tea powder directly as it is, it does not impair the effectiveness of tea's original antioxidant effect, etc., has sufficient tea flavor, and incorporates natural herbal ingredients Oral compositions.

[0002]

2. Description of the Related Art Oral compositions, especially dentifrices, are daily necessities indispensable for modern life and are used by many consumers.
For this reason, the safety of these oral compositions is very important, and many inventions have been made on improving the safety of oral compositions. For example, there is a technique of using an amino acid-based surfactant which is a highly safe foaming agent, and a technique of blending a stimulant-reducing agent. However, these oral compositions also use various synthetic surfactants, synthetic binders and the like, and despite various safety considerations, lip due to irritation to the oral mucosa There are various cases where a flame or the like becomes a problem. Therefore, development of a more safe oral composition such as dentifrices that does not contain these stimulants is desired.

[0003] Examples of oral compositions containing tea extracts include, for example, JP-A-64-9922, JP-A-1-190624, JP-A-3-218320, and JP-A-4-178320. No. 6,086,098 is known.
However, such a tea extract is very easily oxidized and is oxidized within a short period of time when it is added to a usual composition, so that it loses its effect on enhancing periodontal tissue function and preventing gingival aging. There was a problem. Japanese Patent Publication No. 62-60367 discloses an oral composition in which black tea leaves are ground to form a paste, but when green tea leaves are used, astringency or bitterness is obtained. Is strongly unfavorable.

[0004]

Means for Solving the Problems The present inventor has conducted various studies in order to solve the above-mentioned problems, and as a result, discovered that a synthetic substance blended in an ordinary oral composition causes irritation. It was studied to make an oral composition without blending these synthetic substances at all. As a result, an oral composition consisting only of natural ingredients mixed with tea powder was obtained, and the present invention was completed. That is, the gist of the present invention relates to an oral composition characterized by blending tea powder, a foaming agent composed of a plant component, and a sweetener composed of a plant component.

[0005] The present invention is an oral composition comprising only natural ingredients, which comprises, as natural ingredients, tea powder, a vegetable foaming ingredient and a sweetening ingredient. Therefore, the oral composition of the present invention is a highly safe oral composition not found in the conventional oral composition, and at the same time, by blending tea powder, the flavor and taste originally possessed by tea are obtained. It is a composition for oral cavity that makes good use of, and has good stability of catechins and flavones contained in tea and stable antioxidant activity.

[0006] The tea powder used in the present invention is a powder of ordinary tea leaves (young leaves or adult leaves). The type of tea in the present invention is not particularly limited, and for example, Japanese varieties, Chinese varieties and the like are used. Mixing a tea extract with an ordinary oral composition is a known technique as described above. The catechins and flavones, which are the active ingredients contained in these extracts, are effective as deodorizing ingredients against bad breath and the like, and are also very useful substances having an active oxygen scavenging action (hereinafter referred to as SOD activity). However, it is affected by the action of oxidation or the like over time, and its effect is reduced. For this reason, if the oral composition has been on the market for about one year, most of the composition loses its deodorizing ability and SOD activity.

However, instead of the extract as in the present invention,
When tea leaves are powdered as they are, these catechins and flavones are stably maintained in the cells and their efficacy is maintained. That is, these components, which are deodorant components and SOD active components, are stably compounded in the oral composition for a long period of time. In addition, these flavones are also very useful as a fragrance, and thus the stably blended flavones impart a refreshing flavor to the oral composition as a fragrance, and the taste of the oral composition is extremely enhanced. It also has the effect of increasing.

[0008] The tea powder can be easily powdered with a hammer mill (manufactured by Fuji Paudal Co., Ltd.) without any particular limitation. The amount of the tea powder is usually 15 to 70% by weight, preferably 2 to 70% by weight.
5 to 60% by weight. If the amount is less than 15% by weight, a sufficient effect of compounding cannot be expected, and it is not preferable to add more than 70% by weight in relation to other components. In the present invention, one kind of tea powder may be used, or two or more kinds of powders may be mixed and used.

[0009] As the foaming agent used in the present invention, plants containing saponins, such as mukuro, pomegranate, fennel,
Powders or extracts of plants such as onji, senega, horse chestnut and the like can be used. These plants are a kind of crude drug, and have been used for body washing in the old days, and their safety is very high. An object of the present invention is to provide a highly safe oral composition, and a highly safe oral composition is prepared by blending a saponin which is a natural foaming component as a foaming agent. be able to. The amount of these foaming agents varies depending on the foaming power, but is usually 0.5 to 30% by weight, preferably 2 to 20% by weight. If the amount is less than 0.5% by weight, the effect as a foaming agent cannot be sufficiently exerted. If the amount is more than 30% by weight, the foaming property is too high and is not suitable as an oral composition.

In the present invention, the above-mentioned plant is used alone,
Alternatively, two or more kinds may be used, and the powder and the extract may be used alone or in combination. Preparation of plant powders and extracts containing saponins can be easily prepared by known methods, and the preparation method is not particularly limited. For example, the powder is pulverized by a hammer mill or the like, and the extract is obtained by extracting the plant with water, ethanol, methanol, or the like to obtain an extract. For example, 100 g of mud roe is powdered, extracted three times with 1 liter of 50% ethanol at room temperature, and the extracts are combined and concentrated to dryness to obtain 15 g of an extract.

In the present invention, a natural sweet plant component is also used as a sweetener. Synthetic sweeteners used in ordinary oral compositions have concerns about safety, but natural plant components have high safety, so oral compositions that strongly demand safety as in the present invention Is perfect for As the sweetener composed of such a plant component, it is preferable to use a powder or an extract of licorice, lakanca, stevia, sweet tea and the like.
The amount of the sweetener also varies depending on the intensity of the sweetness, but is usually 0.1 to 30% by weight, preferably 0.5 to 20% by weight. If it is less than 0.1% by weight, a sufficient compounding effect cannot be expected, and if it exceeds 20% by weight, bitterness and aftertaste are undesirably produced.

In the present invention, one or more powders or extracts of the aforementioned sweet plants can be used alone or in combination. Preparation of the sweet plant powder and extract can be easily prepared by a known method, and the preparation method is not particularly limited. For example, the same method as in the preparation of the foaming agent is used.

The composition of the oral composition of the present invention is not particularly limited as long as it is applied to the oral cavity such as toothpaste and toothpaste. Of these dosage forms, the preferred dosage form is dentifrice, especially powdered dentifrice is the most suitable dosage form. The oral composition of the present invention can contain various additives depending on such various uses and dosage forms. For example, when the present invention is applied to a dentifrice composition, water-insoluble inorganic salts are used as an abrasive. The inorganic salts used here are insoluble in water and have no problem in safety. As such inorganic salts, calcium carbonate, calcium phosphate, sodium silicate, and the like used in ordinary oral compositions such as dentifrices can be used. The amount of these compounds is usually 5 to 5.
It is 50% by weight, preferably 5 to 30% by weight.

When the composition of the present invention is used as a toothpaste, it is very useful to further add glycerin to improve the sweetness and the preservability of the toothpaste. In this case, high-purity (80 to 100%) glycerin liquid is preferably mixed without water. The preferred amount of glycerin is usually 1
0 to 70% by weight.

The other additives used in the present invention are natural components which vary depending on various uses but are all considered in consideration of safety. Examples of natural flavors include light loads, nutmeg, rosemary, sage, basil and the like. used.

In the oral composition of the present invention, various medicinal agents can be appropriately compounded in addition to the above-mentioned components. For example,
Examples include natural antibacterial agents such as hinokitiol, glycyrrhetinate, powder of loofah root, natural anti-inflammatory agents such as bryonolic acid, azulene and glycyrrhizin, astringents such as salt, and blood flow improvers such as vitamin E.

In order to prepare the composition for oral cavity of the present invention, necessary amounts of the above-mentioned various crude drugs and other raw materials are combined, crushed and mixed, and the desired powder is obtained by a conventional method using the obtained mixed powder. A composition. In the step of obtaining the mixed powder, it is preferable to use a mechanical device capable of operating at a temperature as low as possible. For example, screw (5-23 rpm)
And a pulverizer such as a sample mill manufactured by Fuji Paudal Co., Ltd. having a hammer (60000/1200 rpm),
By mounting and pulverizing a stainless steel screen having an opening diameter of 0.5 mm, a homogeneous powder can be obtained without dispersing each component.

These milled mixtures can then be made into the desired preparations by customary methods.
If it is a powder toothpaste, it may be used as it is or another component may be added. In the case of toothpaste, glycerin may be added and mixed again as described above. It goes without saying that also in these additives and the production method, it is necessary to pay attention to safety and to avoid the heating step as much as possible.

[0019]

The present invention will be described in more detail with reference to the following examples and test examples, but the present invention is not limited to these examples.

Example 1 A toothpaste composition having the following composition was prepared by a conventional method. In addition, the tea powder was prepared using a sample mill made by Fuji Paudal, and the same powder was used in the following examples. Component name Amount (% by weight) Tea powder 63.0 Calcium carbonate 30.0 Lacanca powder 2.0 Mukuroji powder 5.0 Total 100.0

Examples 2 and 3 A toothpaste composition having the following composition was prepared by a conventional method.

Example 4 A toothpaste composition having the following composition was prepared by a conventional method. Component name Amount (% by weight) Tea powder 50 Calcium carbonate 40 Licorice ethanol extract 5 Muclodiethanol extract 5 Total 100

Example 5 A toothpaste composition having the following composition was prepared by a conventional method. Ingredient name Compounding amount (% by weight) Tea powder 70 Calcium phosphate 21 Stevia water extract 3 Pomelo grass water extract 6 Total 100

Daily stability test (1): To compare the stability of SOD activity between tea powder and tea extract, tea powder, the composition of Example 1 containing tea powder, and tea A two-week stability test after 4 weeks at 4 ° C. was performed using the ethanol extract of the above. The sample solution was prepared by adding 1 ml of 50% by volume ethanol to 0.1 g of each of the tea powder and the composition of Example 1, stirring, incubating at 25 ° C. for 1 hour, extracting, and obtaining. The extract was centrifuged to prepare a clear sample solution. As for the ethanol extract of tea, a sample solution was prepared by adding 10 ml of 50% by volume ethanol to 1 g of the extract obtained with 50% ethanol.

The method of measuring the SOD activity is as follows. A superoxide radical is generated in a sample solution by xanthine oxidase, and an azo dye, nitroblue tetrazolium (NBT), is added to the solution to measure the absorbance. The amount of trapped radicals (SOD activity) was measured. Specifically, 3.6 ml of a 0.05 M Na ₂ CO ₃ buffer (pH 10.2), 3 m
M xanthine aqueous solution 0.15 ml, 3 mM EDTA
0.15 ml of an aqueous solution, 0.15 ml of a 0.15% by weight bovine serum albumin aqueous solution, and a 0.75 mM NBT aqueous solution of 0.1%.
15 ml and 0.15 ml of the sample solution,
After standing at 10 ° C. for 10 minutes, 0.15 ml of xanthine oxidase (manufactured by Sigma) was added.
Incubated for 0 minutes. After incubation, 6 mM
Adding a CuCl ₂ solution 0.15 ml, stop the enzymatic reaction, the absorbance was measured at 560 nm. Separately, as a blank test, the same operation was performed using distilled water instead of the sample solution. For the control, the same operation was performed using 50% by volume of ethanol instead of the sample solution. The results are shown in Table 1. The tea powder of the present invention, or the composition of Example 1 containing the tea powder, has a higher residual SOD activity than the ethanol extract of tea, and has an excellent antioxidant effect. I was

[0026]

[Table 1]

Daily stability test (2): A composition was prepared by adding the composition of Example 3 and an ethanol extract of tea instead of the tea powder of the present composition. Activity was measured. The method for preparing the sample solution and the method for measuring the SOD activity are the same as those in the daily stability test (1). Assuming that the SOD activity when the composition of Example 3 containing the tea powder and the sample solution of the ethanol extract of tea were prepared was 100%, the residual activity of SOD was examined over time. The results are shown in FIG. 1, and it was found that the composition of Example 3 in which the tea powder was blended had more stable SOD activity for a long time than the composition in which the ethanol extract of tea was blended. .

Oral mucosal exfoliation test: An oral mucosal exfoliation test was performed using the compositions obtained in Examples 1 to 3 and a commercially available toothpaste (T). In the test method, three golden hamsters (male, body weight 100 to 116 g) in each group were anesthetized under general anesthesia and the oral composition was administered to the cheek pouch. The administration was carried out by injecting 0.25 mg of each composition and commercially available toothpaste (T) into the cheek pouch using a sonde. After being left for 30 minutes after administration, the cheek pouch was washed with 25 ml of distilled water and left for 24 hours. Thereafter, the cheek pouch tissue was excised, and immediately a tissue specimen was prepared according to a conventional method, and observed with an optical microscope. If the histologically exfoliated mucosa was observed, it was regarded as positive +, and if it was not observed, it was negative-. Table 2 shows the results.

[0029]

[Table 2]

As is evident from Table 2, the oral composition of the present invention did not cause side effects such as mucous membrane detachment and was highly safe and preferred as an oral composition.

[0031]

EFFECT OF THE INVENTION The oral composition of the present invention exhibits a stable antioxidant effect, thereby enhancing the periodontal tissue function, exerting an excellent effect on preventing gingival aging, and natural ingredients such as crude drugs. It is a highly safe oral composition composed only of

[Brief description of the drawings]

FIG. 1 is a diagram showing the results of a daily stability test (2) in which the antioxidant effects of tea powder and tea extract were compared.

──────────────────────────────────────────────────続 き Continuation of the front page (72) Inventor Eiichi Naeshiro 6-15 Minamikusu no Sato-cho, Daito-shi, Osaka (72) Inventor Hajime Watanabe 1-14-5, Yamato, Takatsuki-shi, Osaka (56) References JP-A Sho57 JP-197207 (JP, A) JP-A-4-273814 (JP, A) JP-A-4-178320 (JP, A) JP-A-64-99922 (JP, A) JP-A-58-190445 (JP, A) JP-A-3-220117 (JP, A) JP-A-60-75424 (JP, A) JP-A-64-42411 (JP, A) JP-A-57-106607 (JP, A) 82307 (JP, A) Hira 4-84335 (JP, U) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (4)

(57) [Claims] 1. An oral composition comprising a tea powder, a foaming agent comprising a plant component, and a sweetener comprising a plant component. 2. The foaming agent according to claim 1, which is a powder and / or extract of a plant selected from the group consisting of sorghum, pomegranate, fennel, onji, senega, and horse chestnut.
The oral composition according to any one of the preceding claims. 3. The oral composition according to claim 1, wherein the sweetening agent is a plant powder and / or an extract selected from the group consisting of licorice, laccanium, stevia, and sweet tea. 4. The composition according to claim 1, further comprising glycerin.
4. The composition for oral cavity according to 2 or 3.