CN111529421A - Sunscreen agent containing tryptophan and tyrosine and preparation method thereof - Google Patents
Sunscreen agent containing tryptophan and tyrosine and preparation method thereof Download PDFInfo
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- CN111529421A CN111529421A CN202010329925.6A CN202010329925A CN111529421A CN 111529421 A CN111529421 A CN 111529421A CN 202010329925 A CN202010329925 A CN 202010329925A CN 111529421 A CN111529421 A CN 111529421A
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- China
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- parts
- tyrosine
- tryptophan
- sunscreen
- titanium dioxide
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- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 55
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title claims abstract description 45
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 title claims abstract description 45
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 title claims abstract description 45
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 47
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 30
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229910021485 fumed silica Inorganic materials 0.000 claims abstract description 19
- 230000000475 sunscreen effect Effects 0.000 claims abstract description 19
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims abstract description 18
- DLINORNFHVEIFE-UHFFFAOYSA-N hydrogen peroxide;zinc Chemical compound [Zn].OO DLINORNFHVEIFE-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000010776 emu oil Substances 0.000 claims abstract description 16
- 239000010497 wheat germ oil Substances 0.000 claims abstract description 16
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960000541 cetyl alcohol Drugs 0.000 claims abstract description 15
- 239000008367 deionised water Substances 0.000 claims abstract description 15
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 15
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 7
- 239000003755 preservative agent Substances 0.000 claims abstract description 7
- 230000002335 preservative effect Effects 0.000 claims abstract description 7
- 239000002562 thickening agent Substances 0.000 claims abstract description 7
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 22
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 13
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 12
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 12
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 12
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 12
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 12
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 12
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims description 12
- 125000004122 cyclic group Chemical group 0.000 claims description 12
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 12
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 12
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 12
- -1 nipagin ester Chemical class 0.000 claims description 12
- 229960005323 phenoxyethanol Drugs 0.000 claims description 12
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 12
- 229920000570 polyether Polymers 0.000 claims description 12
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 12
- 229920000053 polysorbate 80 Polymers 0.000 claims description 12
- 229920002545 silicone oil Polymers 0.000 claims description 12
- 239000000230 xanthan gum Substances 0.000 claims description 12
- 229920001285 xanthan gum Polymers 0.000 claims description 12
- 235000010493 xanthan gum Nutrition 0.000 claims description 12
- 229940082509 xanthan gum Drugs 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 11
- 239000012071 phase Substances 0.000 claims description 10
- 239000004408 titanium dioxide Substances 0.000 claims description 10
- 239000003921 oil Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 239000011787 zinc oxide Substances 0.000 claims description 7
- 239000002002 slurry Substances 0.000 claims description 6
- 235000013305 food Nutrition 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 239000004115 Sodium Silicate Substances 0.000 claims description 2
- 239000008346 aqueous phase Substances 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 13
- 239000002537 cosmetic Substances 0.000 abstract description 10
- 210000003491 skin Anatomy 0.000 description 28
- 235000011187 glycerol Nutrition 0.000 description 13
- 238000001514 detection method Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 7
- 230000037072 sun protection Effects 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 229910001385 heavy metal Inorganic materials 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000001153 anti-wrinkle effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010063493 Premature ageing Diseases 0.000 description 1
- 208000032038 Premature aging Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001965 increasing effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 239000011814 protection agent Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics, and particularly relates to a sunscreen agent containing tryptophan and tyrosine, which comprises, by weight, 3-7 parts of tryptophan, 3-7 parts of tyrosine, 2-4 parts of hydrophilic nano titanium dioxide, 2-4 parts of nano zinc dioxide, 3-5 parts of fumed silica, 2-4 parts of cetyl alcohol, 1-3 parts of isopropyl myristate, 1-3 parts of wheat germ oil, 0-2 parts of emu oil, 3-6 parts of glycerol, 3-5 parts of ethanol, 3-5 parts of a film forming agent, 1-2 parts of an emulsifier, 1-2 parts of a thickening agent, 0.2-0.5 part of a preservative and 55-65 parts of deionized water. The sunscreen agent provided by the invention integrates sunscreen and moisturizing skin care, and cosmetics such as a moisturizing agent and the like are not required to be applied before going out like the existing sunscreen agent.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a sunscreen agent containing tryptophan and tyrosine and a preparation method thereof.
Background
The sunlight damage to human skin mainly comes from ultraviolet A (UVA) and ultraviolet B (UVB), wherein UVA acts on the deep layer of the skin and is slow in action but can cause one-time blackening, and UVB acts on the surface layer of the skin to excite skin keratinocytes, relax blood vessels, increase blood flow and make the skin reddish to brown. UVA and UVB cause sunburn, peeling, tanning, etc. to the skin, which in turn causes premature aging of the skin, irreparable damage to the skin, and may also cause skin cancer if chronically affected by UVA and UVB.
Current sunscreen measures against ultraviolet rays mainly include physical sunscreen, which means the use of a substance capable of reflecting sunlight (TiO), and chemical sunscreen2ZnO) forms a protective film on the surface of skin to reflect ultraviolet rays out, thereby achieving the sun-screening effect, and chemical sun-screening means that chemical substances in the sun-screening product, such as phthalate, convert ultraviolet rays which damage the skin into harmless heat energy and the like to be released. The chemical sun-screening agent can enter skin tissues, has certain irritation to the skin, and can cause damage to the skin when being improperly used.
In some perennial high-temperature areas, the existing sunscreen agent only has a single sunscreen function, and the sunscreen agent can lose the function quickly along with the evaporation effect of high temperature, and is very troublesome because cosmetics such as a humectant and the like need to be applied before going out; however, in the prior art, no technical scheme for solving the problem is found.
Disclosure of Invention
In order to solve the above problems, it is an object of the present invention to provide a sunscreen agent containing tryptophan and tyrosine, which has a sunscreen effect and also provides moisturizing, skin-beautifying, anti-inflammatory and restorative effects.
The invention provides the following technical scheme:
a sunscreen agent containing tryptophan and tyrosine comprises, by weight, 3-7 parts of tryptophan, 3-7 parts of tyrosine, 2-4 parts of nano titanium dioxide, 2-4 parts of nano zinc dioxide, 3-5 parts of fumed silica, 2-4 parts of cetyl alcohol, 1-3 parts of isopropyl myristate, 1-3 parts of wheat germ oil, 0-2 parts of emu oil, 3-6 parts of glycerol, 3-5 parts of ethanol, 3-5 parts of a film forming agent, 1-2 parts of an emulsifier, 1-2 parts of a thickening agent, 0.2-0.5 part of a preservative and 55-65 parts of deionized water.
Preferably, the tryptophan is food grade tryptophan with a chiral structure which is all levorotatory.
Preferably, the tyrosine is food-grade tyrosine with a chiral structure of all levorotation.
Preferably, the preparation method of the hydrophilic nano titanium dioxide comprises the following steps: titanium dioxide with the particle size of 20-30nm is selected and added with water to prepare titanium dioxide slurry, water-soluble sodium silicate with the mass of 5% of the titanium dioxide is added into the titanium dioxide slurry, the pH value of the titanium dioxide slurry is neutralized to 8-11 by using a sulfuric acid solution with the mass concentration of 10%, the reaction is carried out for 5 hours under the conditions of 85 ℃ and stirring, the mixture is filtered, washed to be neutral, dried at 105 ℃, and then ground into powder.
Preferably, the nano zinc oxide particle size is 15-30 nm.
Preferably, the specific surface area of the fumed silica is 600-800m3/g。
Preferably, the film forming agent is selected from one or two of cyclic dimethyl polysiloxane and polyether modified silicone oil; the emulsifier is selected from one or more of tween 60, tween 80, span 60 and span 80.
Preferably, the thickening agent is selected from any one or two of xanthan gum and hydroxyethyl cellulose; the preservative is selected from any one or two of nipagin ester and phenoxyethanol.
The invention also provides a preparation method of the sun-screening agent, which is characterized by comprising the following steps:
a. preparing an aqueous phase: uniformly mixing deionized water, glycerol and ethanol according to a proportion, then sequentially adding an emulsifier and a preservative, and uniformly stirring;
b. preparing an oil phase: mixing cetyl alcohol, isopropyl myristate, wheat germ oil, emu oil and film-forming agent in proportion, and stirring;
c. adding the oil phase into the water phase at the rotating speed of 200-00r/min, after the two are completely mixed, sequentially adding tryptophan, tyrosine, nano titanium dioxide, nano zinc dioxide and fumed silica, stirring until the two are completely and uniformly mixed, finally adding the thickening agent, and stirring to form a uniform and stable state.
The invention has the beneficial effects that:
1. the sunscreen agent provided by the invention integrates sunscreen and moisturizing skin care, and cosmetics such as a moisturizing agent and the like are not required to be applied before going out like the existing sunscreen agent.
2. The tryptophan of the invention has the following characteristics: the selected tryptophan is food grade, is an amino acid in a human body, can be metabolized by the human body, is harmless to users, has a levorotatory chiral structure in molecules, has a strong absorption peak at 280nm, can convert ultraviolet rays into heat energy which is harmless to the skin and releases the heat energy, and the tyrosine has the following characteristics: the selected tyrosine is food grade, is an amino acid in a human body, can be metabolized by the human body, is harmless to users, has a left-handed chiral structure in a molecule, has a certain absorption peak at 280nm, and can convert ultraviolet rays into heat energy which is harmless to the skin and release the heat energy; the hydrophilic nano titanium dioxide has high transparency, no stimulation to skin of a human body, good compatibility with a cosmetic system and strong antibacterial action, not only absorbs ultraviolet rays, but also can reflect or scatter the ultraviolet rays, has better chemical stability and light stability, is nontoxic and tasteless, and also has strong antibacterial action; the nano zinc dioxide has the size of 15 nm-30 nm, the surface is not treated, and the nano zinc dioxide has hydrophilicityThe cosmetic has high transparency, can absorb ultraviolet rays in cosmetics, can reflect or scatter the ultraviolet rays, and has extremely strong antibacterial, bacteriostatic and mildewproof properties; specific surface area of fumed silica of 600m-800m3The emulsion has high surface activity, can obviously thicken and increase the stability and thixotropy of the product, and is very smooth in application without astringent feeling.
The selected tryptophan and the tyrosine are both in a levorotatory chiral structure, have strong ultraviolet absorption capacity and can play a role of a chemical sun-screening agent; the titanium oxide and the zinc oxide can absorb most of UVA and UVB, and the nano-scale titanium oxide and the nano-scale zinc oxide can reflect and scatter ultraviolet rays, so that the paint has a physical sun-screening effect, and the dosage is not limited by the country; the added fumed silica can form a protective layer on the surfaces of the nano-scale zinc oxide and nano-scale zinc oxide particles, so that the uneven surfaces of the particles are filled, the attraction among the particles is weakened, the possibility of agglomeration is reduced, the system is more uniform and stable, and the additionally obtained thixotropic property can help the product to be uniformly spread on the surface of the skin, the skin feel and hand feel during smearing are improved, and the product performance is comprehensively improved. The added glycerin enables the product to have excellent moisturizing and hydrating effects; the added wheat germ oil has the functions of moistening skin and conditioning skin, can prevent the skin from aging in advance, maintain the health of connective tissues and activate the circulation of the skin, and also has certain effects on whelk, acne, psoriasis, eczema and the like; the added emu oil has strong anti-inflammatory function and excellent skin permeability.
Detailed Description
The present invention will be described in detail with reference to the following examples.
Example 1
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 3 parts of tryptophan, 7 parts of tyrosine, 3 parts of hydrophilic nano titanium dioxide, 2 parts of nano zinc dioxide, 3 parts of fumed silica, 3 parts of cetyl alcohol, 2 parts of isopropyl myristate, 1 part of wheat germ oil, 0.5 part of emu oil, 2 parts of cyclic dimethylpolysiloxane, 1 part of polyether modified silicone oil, 3 parts of glycerol, 5 parts of ethanol, 0.5 part of Tween 60, 0.5 part of Tween 80, 0.5 part of span 60, 0.5 part of span 80, 0.5 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.2 part of nipagin ester, 0.3 part of phenoxyethanol and 62.2 parts of deionized water.
Example 2
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 4 parts of tryptophan, 6 parts of tyrosine, 3 parts of hydrophilic nano titanium dioxide, 2 parts of nano zinc dioxide, 3 parts of fumed silica, 3 parts of cetyl alcohol, 2 parts of isopropyl myristate, 1 part of wheat germ oil, 0.5 part of emu oil, 2 parts of cyclic dimethylpolysiloxane, 1 part of polyether modified silicone oil, 3 parts of glycerol, 5 parts of ethanol, 0.5 part of Tween 60, 0.5 part of Tween 80, 0.5 part of span 60, 0.5 part of span 80, 0.5 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.2 part of nipagin ester, 0.3 part of phenoxyethanol and 62.2 parts of deionized water.
Example 3
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 5 parts of tryptophan, 5 parts of tyrosine, 3 parts of hydrophilic nano titanium dioxide, 2 parts of nano zinc dioxide, 3 parts of fumed silica, 3 parts of cetyl alcohol, 2 parts of isopropyl myristate, 1 part of wheat germ oil, 0.5 part of emu oil, 2 parts of cyclic dimethylpolysiloxane, 1 part of polyether modified silicone oil, 3 parts of glycerol, 5 parts of ethanol, 0.5 part of Tween 60, 0.5 part of Tween 80, 0.5 part of span 60, 0.5 part of span 80, 0.5 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.2 part of nipagin ester, 0.3 part of phenoxyethanol and 62.2 parts of deionized water.
Example 4
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 6 parts of tryptophan, 4 parts of tyrosine, 3 parts of hydrophilic nano titanium dioxide, 2 parts of nano zinc dioxide, 3 parts of fumed silica, 3 parts of cetyl alcohol, 2 parts of isopropyl myristate, 1 part of wheat germ oil, 0.5 part of emu oil, 2 parts of cyclic dimethylpolysiloxane, 1 part of polyether modified silicone oil, 3 parts of glycerol, 5 parts of ethanol, 0.5 part of Tween 60, 0.5 part of Tween 80, 0.5 part of span 60, 0.5 part of span 80, 0.5 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.2 part of nipagin ester, 0.3 part of phenoxyethanol and 62.2 parts of deionized water.
Example 5
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 7 parts of tryptophan, 3 parts of tyrosine, 3 parts of hydrophilic nano titanium dioxide, 2 parts of nano zinc dioxide, 3 parts of fumed silica, 3 parts of cetyl alcohol, 2 parts of isopropyl myristate, 1 part of wheat germ oil, 0.5 part of emu oil, 2 parts of cyclic dimethylpolysiloxane, 1 part of polyether modified silicone oil, 3 parts of glycerol, 5 parts of ethanol, 0.5 part of Tween 60, 0.5 part of Tween 80, 0.5 part of span 60, 0.5 part of span 80, 0.5 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.2 part of nipagin ester, 0.3 part of phenoxyethanol and 61.2 parts of deionized water.
Example 6
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 5 parts of tryptophan, 5 parts of tyrosine, 3 parts of hydrophilic nano titanium dioxide, 2 parts of nano zinc dioxide, 3 parts of fumed silica, 3 parts of cetyl alcohol, 2 parts of isopropyl myristate, 1.5 parts of wheat germ oil, 1 part of emu oil, 2 parts of cyclic dimethylpolysiloxane, 1 part of polyether modified silicone oil, 3 parts of glycerol, 5 parts of ethanol, 0.5 part of Tween 60, 0.5 part of Tween 80, 0.5 part of span 60, 0.5 part of span 80, 0.5 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.2 part of nipagin ester, 0.3 part of phenoxyethanol and 60.2 parts of deionized water.
Example 7
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 5 parts of tryptophan, 5 parts of tyrosine, 3 parts of hydrophilic nano titanium dioxide, 2 parts of nano zinc dioxide, 3 parts of fumed silica, 3 parts of cetyl alcohol, 2 parts of isopropyl myristate, 2 parts of wheat germ oil, 1.5 parts of emu oil, 2 parts of cyclic dimethylpolysiloxane, 1 part of polyether modified silicone oil, 3 parts of glycerol, 5 parts of ethanol, 0.5 part of Tween 60, 0.5 part of Tween 80, 0.5 part of span 60, 0.5 part of span 80, 0.5 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.2 part of nipagin ester, 0.3 part of phenoxyethanol and 59.2 parts of deionized water.
Example 8
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 5 parts of tryptophan, 5 parts of tyrosine, 3 parts of hydrophilic nano titanium dioxide, 2 parts of nano zinc dioxide, 3 parts of fumed silica, 3 parts of cetyl alcohol, 2 parts of isopropyl myristate, 3 parts of wheat germ oil, 2 parts of emu oil, cyclic dimethyl polysiloxane, 1 part of polyether modified silicone oil, 3 parts of glycerol, 5 parts of ethanol, 0.5 part of Tween 60, 0.5 part of Tween 80, 0.5 part of span 60, 0.5 part of span 80, 0.5 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.2 part of nipagin ester, 0.3 part of phenoxyethanol and 61.2 parts of deionized water.
Example 9
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 5 parts of tryptophan, 5 parts of tyrosine, 3 parts of hydrophilic nano titanium dioxide, 2 parts of nano zinc dioxide, 4 parts of fumed silica, 3 parts of cetyl alcohol, 2 parts of isopropyl myristate, 1 part of wheat germ oil, 0.5 part of emu oil, 2 parts of cyclic dimethylpolysiloxane, 1 part of polyether modified silicone oil, 3 parts of glycerol, 5 parts of ethanol, 0.5 part of Tween 60, 0.5 part of Tween 80, 0.5 part of span 60, 0.5 part of span 80, 0.5 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.2 part of nipagin ester, 0.3 part of phenoxyethanol and 60.2 parts of deionized water.
Example 10
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 5 parts of tryptophan, 5 parts of tyrosine, 3 parts of hydrophilic nano titanium dioxide, 2 parts of nano zinc dioxide, 5 parts of fumed silica, 3 parts of cetyl alcohol, 2 parts of isopropyl myristate, 1 part of wheat germ oil, 0.5 part of emu oil, 2 parts of cyclic dimethylpolysiloxane, 1 part of polyether modified silicone oil, 3 parts of glycerol, 5 parts of ethanol, 0.5 part of Tween 60, 0.5 part of Tween 80, 0.5 part of span 60, 0.5 part of span 80, 0.5 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.2 part of nipagin ester, 0.3 part of phenoxyethanol and 63.7 parts of deionized water.
Firstly, performance detection:
the performances of the sunscreens prepared in examples 1-10 were tested according to QB/T1857-2013 skin moisturizing cream and technical specifications for cosmetic safety (2015), wherein the main techniques are as follows: 1. appearance: the paste is fine, smooth and uniform; 2. fragrance: no peculiar smell exists; 3. heat resistance: moisturizing at 40 +/-1 ℃ for 24 hours, wherein the oil permeability after the room temperature is recovered is not more than 3%; 4. cold resistance: keeping the temperature at (-8 +/-2) DEG C for 24h, and no obvious shape difference exists between the room temperature and the room temperature before the test; 5. heavy metal content: less than or equal to 10mg/kg of lead, less than or equal to 2mg/kg of arsenic, less than or equal to 1mg/kg of mercury and less than or equal to 5mg/kg of cadmium; 6. bacterial colony: staphylococcus aureus/g: no detection is carried out, the total number of colonies/(CFU/g) is less than or equal to 1000, and the heat-resistant coliform group bacteria/g: undetectable, pseudomonas aeruginosa: the total number of mould and yeast/(CFU/g) is less than or equal to 100, the performance detection of the appearance and the like of the sun-screening agent is shown in table 1, and the heavy metal content and the colony count are shown in table 2.
TABLE 1 sunscreen appearance test results
As can be seen from Table 1, the sunscreens of examples 1-10 are fine, uniform, odorless, and have good heat and cold resistance.
TABLE 2 detection results of heavy metals and colony content of sunscreen
As can be seen from the data in Table 2, the sunscreens of examples 1-10 have heavy metal contents meeting the requirements of technical specifications for cosmetic safety (2015), good antibacterial properties and long shelf life.
Secondly, sun protection durability detection:
the same mass of the sunscreen agents of examples 1 to 10 was uniformly applied to the back of the hand, the sunscreen effect of the sunscreen agent was measured using an SPF measuring instrument and recorded as 0-SPF, the back of the hand was put into clear water for 5 seconds each time, the sunscreen factor of the back of the hand after 3 times of putting into clear water was recorded as 1-SPF, the operation of putting the back of the hand into clear water was repeated every 30 minutes for 3 times for 5 seconds each time, the sunscreen factor of the back of the hand after 1 hour was measured and recorded as 2-SPF, the sunscreen factor of the back of the hand after 2 hours was measured and recorded as 3-SPF, and the measurement results were recorded in table 3.
Table 3 sunscreen SPF test results
| Item | 0-SPF | 1-SPF | 2-SPF | 3-SPF |
| Example 1 | 28.2 | 27.9 | 26.1 | 24.4 |
| Example 2 | 27.8 | 27.2 | 25.8 | 24.2 |
| Example 3 | 27.2 | 26.6 | 24.9 | 23.3 |
| Example 4 | 26.7 | 26.0 | 24.7 | 22.8 |
| Example 5 | 26.3 | 25.7 | 24.1 | 22.9 |
| Example 6 | 27.4 | 26.8 | 25.3 | 23.6 |
| Example 7 | 27.1 | 26.4 | 24.9 | 23.3 |
| Example 8 | 27.6 | 26.8 | 25.5 | 24.3 |
| Example 9 | 28.3 | 27.1 | 24.5 | 23.3 |
| Example 10 | 28.9 | 28.1 | 26.3 | 24.7 |
As can be seen from the data in Table 3, in examples 1 to 10, the initial sun protection index is high, and after slight stirring in clear water, the sun protection index is not reduced obviously, after 1 hour, the sun protection index can still reach more than 24, and after 2 hours, the sun protection index is more than 22, which shows that the sun protection agents prepared in examples 1 to 10 of the present invention have good waterproof effect and sun protection durability.
Third, anti-wrinkle and moisturizing effect detection of sun-screening agent
1. And (3) detecting the moisturizing effect: groups 1-10 of observers used the sunscreen agents of examples 1-10 above. Randomly selecting 100 women of 30-40 years old as observers, randomly dividing the observers into 10 groups, using 10 persons in each group, using 3g of the liquid medicine every morning, uniformly smearing the liquid medicine on the face, continuously using the liquid medicine for 1 month, detecting the skin moisture content of each observer before and after use by using a skin moisture tester (Corneometer, C + K, Germany), and averaging the detection results of 10 persons in each group, wherein the detection results are shown in Table 4;
2. and (3) anti-wrinkle effect detection: the same observer was applied with 3g of the test part in the morning and evening, respectively, at a distance of 10 cm from the base of the palm on the inner side of the arm, 3g of the test part was applied every day, and the change in texture of the test part before and after use was measured using a Skin image analysis system (Skin visiometers sv600), and the change in elasticity value of the test part was measured using a Skin elasticity meter (Cutometer dual mpa 580).
Table 4 moisturizing and wrinkle resistance test results
As can be seen from the data in Table 4, the sunscreen agents prepared according to the methods of examples 1 to 10 have good moisturizing and moisturizing effects, increased skin elasticity and decreased texture after being applied for one month, which indicates that the sunscreen agents prepared according to the methods of examples 1 to 10 have good effects of improving the elasticity and texture of human skin, and can resist wrinkle, moisturize and moisturize.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. A sunscreen agent containing tryptophan and tyrosine is characterized by comprising, by weight, 3-7 parts of tryptophan, 3-7 parts of tyrosine, 2-4 parts of hydrophilic nano titanium dioxide, 2-4 parts of nano zinc dioxide, 3-5 parts of fumed silica, 2-4 parts of cetyl alcohol, 1-3 parts of isopropyl myristate, 1-3 parts of wheat germ oil, 0-2 parts of emu oil, 3-6 parts of glycerol, 3-5 parts of ethanol, 3-5 parts of a film forming agent, 1-2 parts of an emulsifier, 1-2 parts of a thickening agent, 0.2-0.5 part of a preservative and 55-65 parts of deionized water.
2. The sunscreen containing tryptophan and tyrosine according to claim 1, wherein the tryptophan is food grade tryptophan with a chiral structure which is all levorotatory.
3. The composition of claim 1 wherein said tyrosine is a food grade tyrosine having a chiral structure that is all levorotatory.
4. The sunscreen agent containing tryptophan and tyrosine according to claim 1, wherein the hydrophilic nano titanium dioxide is prepared by the following method: titanium dioxide with the particle size of 20-30nm is selected and added with water to prepare titanium dioxide slurry, water-soluble sodium silicate with the mass of 5% of the titanium dioxide is added into the titanium dioxide slurry, the pH value of the titanium dioxide slurry is neutralized to 8-11 by using a sulfuric acid solution with the mass concentration of 10%, the reaction is carried out for 5 hours under the conditions of 85 ℃ and stirring, the mixture is filtered, washed to be neutral, dried at 105 ℃, and then ground into powder.
5. The sunscreen agent containing tryptophan and tyrosine according to claim 1, wherein the nano zinc oxide particle size is 15-30 nm.
6. The sunscreen agent containing tryptophan and tyrosine as claimed in claim 1, wherein the fumed silica has a specific surface area of 600-800m3/g。
7. The sunscreen agent containing tryptophan and tyrosine according to claim 1, wherein the film forming agent is selected from one or two of cyclic dimethyl polysiloxane and polyether modified silicone oil; the emulsifier is selected from one or more of tween 60, tween 80, span 60 and span 80.
8. The sunscreen containing tryptophan and tyrosine according to claim 1, wherein the thickener is selected from any one or two of xanthan gum and hydroxyethyl cellulose; the preservative is selected from any one or two of nipagin ester and phenoxyethanol.
9. A process for the preparation of a sunscreen according to claim 1 comprising the steps of:
a. preparing an aqueous phase: uniformly mixing deionized water, glycerol and ethanol according to a proportion, then sequentially adding an emulsifier and a preservative, and uniformly stirring;
b. preparing an oil phase: mixing cetyl alcohol, isopropyl myristate, wheat germ oil, emu oil and film-forming agent in proportion, and stirring;
c. adding the oil phase into the water phase at the rotation speed of 200-300r/min, after the oil phase and the water phase are completely mixed, sequentially adding tryptophan, tyrosine, nano titanium dioxide, nano zinc dioxide and fumed silica, stirring until the oil phase and the water phase are completely and uniformly mixed, and finally adding a thickening agent and stirring into a uniform and stable state.
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| CN112057355A (en) * | 2020-09-29 | 2020-12-11 | 河南英能新材料科技有限公司 | Sunscreen skin care product additive and application thereof |
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| CN107213037A (en) * | 2017-06-09 | 2017-09-29 | 安徽启威生物科技有限公司 | A kind of fat of Oromaius norvaehollandeae Anti-bacterium hand cream |
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