CN111450021A - Sunscreen spray containing tryptophan and preparation method thereof - Google Patents
Sunscreen spray containing tryptophan and preparation method thereof Download PDFInfo
- Publication number
- CN111450021A CN111450021A CN202010334092.2A CN202010334092A CN111450021A CN 111450021 A CN111450021 A CN 111450021A CN 202010334092 A CN202010334092 A CN 202010334092A CN 111450021 A CN111450021 A CN 111450021A
- Authority
- CN
- China
- Prior art keywords
- parts
- tryptophan
- sunscreen
- cortex moutan
- sunscreen spray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title claims abstract description 46
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 46
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 33
- 239000007921 spray Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 44
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000002904 solvent Substances 0.000 claims abstract description 26
- 244000077995 Coix lacryma jobi Species 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229960000368 sulisobenzone Drugs 0.000 claims abstract description 17
- 239000003755 preservative agent Substances 0.000 claims abstract description 16
- 230000002335 preservative effect Effects 0.000 claims abstract description 16
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 14
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000008367 deionised water Substances 0.000 claims abstract description 14
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 14
- 229940041616 menthol Drugs 0.000 claims abstract description 14
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims abstract 2
- 229940035437 1,3-propanediol Drugs 0.000 claims abstract 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims abstract 2
- 239000000284 extract Substances 0.000 claims description 36
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 33
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 33
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 22
- 239000000243 solution Substances 0.000 claims description 17
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 15
- 239000002245 particle Substances 0.000 claims description 12
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 11
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 11
- 229930003268 Vitamin C Natural products 0.000 claims description 11
- 235000019154 vitamin C Nutrition 0.000 claims description 11
- 239000011718 vitamin C Substances 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000011259 mixed solution Substances 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 241000209205 Coix Species 0.000 claims 1
- 235000007354 Coix lacryma jobi Nutrition 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 6
- 230000003020 moisturizing effect Effects 0.000 abstract description 6
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 30
- 235000011187 glycerol Nutrition 0.000 description 12
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 9
- 239000000126 substance Substances 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 238000002834 transmittance Methods 0.000 description 3
- 229920000832 Cutin Polymers 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 230000000887 hydrating effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- -1 nipagin ester Chemical class 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010063493 Premature ageing Diseases 0.000 description 1
- 208000032038 Premature aging Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 231100000378 teratogenic Toxicity 0.000 description 1
- 230000003390 teratogenic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the field of cosmetics, and particularly relates to a sunscreen spray containing tryptophan, which comprises, by weight, 3-10 parts of tryptophan, 1-5 parts of benzophenone-4, 1-5 parts of a coix seed extracting solution, 1-5 parts of a cortex moutan extracting solution, 10-20 parts of glycerol, 20-25 parts of ethanol, 2-5 parts of 1, 3-propanediol, 3-10 parts of menthol, 1-5 parts of a solubilizer, 0-5 parts of a pH regulator, 0.3-0.5 part of a preservative and 20-55 parts of deionized water. The invention has the beneficial effects that: the sunscreen spray disclosed by the invention integrates sunscreen, moisturizing and skin care, and cosmetics such as a moisturizing agent and the like are not required to be applied before going out like the existing sunscreen agent.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a sunscreen spray containing tryptophan and a preparation method thereof.
Background
The sunlight damage to human skin mainly comes from ultraviolet A (UVA) and ultraviolet B (UVB), wherein UVA acts on the deep layer of the skin and is slow in action but can cause one-time blackening, and UVB acts on the surface layer of the skin to excite skin keratinocytes, relax blood vessels, increase blood flow and make the skin reddish to brown. UVA and UVB cause sunburn, peeling, tanning, etc. to the skin, which in turn causes premature aging of the skin, irreparable damage to the skin, and may also cause skin cancer if chronically affected by UVA and UVB.
Current sunscreen measures against ultraviolet rays mainly include physical sunscreen, which means the use of a substance capable of reflecting sunlight (TiO), and chemical sunscreen2ZnO) forms a protective film on the surface of skin to reflect ultraviolet rays out, thereby achieving the sun-screening effect, and chemical sun-screening means that chemical substances in the sun-screening product, such as phthalate, convert ultraviolet rays which damage the skin into harmless heat energy and the like to be released. The chemical sun-screening agent can enter skin tissues, has certain irritation to the skin, and can cause damage to the skin when being improperly used.
In some high-temperature areas throughout the year, the existing sunscreen spray only has a single sunscreen function, and can lose the function quickly along with the evaporation effect of high temperature, and the sunscreen spray needs to be coated with cosmetics such as a humectant before going out, and is inconvenient to use.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a sunscreen spray containing tryptophan, which has the characteristics of moisture retention, whitening, inflammation diminishing, repair, refreshing and consciousness restoring and is convenient to use on the basis of having a sunscreen effect.
The invention provides the following technical scheme:
a sunscreen spray containing tryptophan comprises, by weight, 3-10 parts of tryptophan, 1-5 parts of benzophenone-4, 1-5 parts of coix seed extract, 1-5 parts of cortex moutan extract, 10-20 parts of glycerol, 20-25 parts of ethanol, 2-5 parts of 1, 3-propylene glycol, 3-10 parts of menthol, 1-5 parts of solubilizer, 0-5 parts of pH regulator, 0.3-0.5 part of preservative and 20-55 parts of deionized water.
Preferably, the tryptophan is food grade tryptophan with a chiral structure which is all levorotatory.
Preferably, the preparation method of the coix seed extracting solution comprises the following steps: firstly, crushing the clean and dried coix seeds into small particles with the particle size smaller than 100 meshes, then mixing the small particles of the coix seeds with 1, 3-propylene glycol according to the mass ratio of 1:3, extracting for 1h at the temperature of 75-80 ℃, and filtering to obtain filtrate, namely the coix seed extracting solution.
Preferably, the preparation method of the cortex moutan extract comprises the following steps: firstly, crushing dried and clean cortex moutan into small particles with the particle size smaller than 100 meshes, then mixing the small particles of the cortex moutan with ethanol according to the mass ratio of 1:3, extracting for 1h at the temperature of 50-60 ℃, and filtering to obtain filtrate, namely cortex moutan extracting solution.
Preferably, the solubilizer is selected from any one or more aqueous solutions of sodium hydroxide, potassium hydroxide and triethanolamine.
Preferably, the pH regulator is selected from any one or two solutions of vitamin C and citric acid.
Preferably, the preservative is selected from any one or two of nipagin ester and phenoxyethanol.
The invention also provides a preparation method of the sunscreen spray, which comprises the following steps:
a. weighing tryptophan, deionized water, glycerol, ethanol, 1, 3-propylene glycol and menthol according to a certain proportion, uniformly mixing, slowly adding a solubilizer, and stirring until the tryptophan is completely dissolved;
b. sequentially adding the coix seed extract, the cortex moutan extract, benzophenone-4 and the preservative according to the proportion, and uniformly mixing;
c. adjusting pH to 6.0-8.0 with pH regulator according to the pH of the mixed solution
The invention has the beneficial effects that:
1. the sunscreen spray disclosed by the invention integrates sunscreen, moisturizing and skin care, and cosmetics such as a moisturizing agent and the like are not required to be applied before going out like the existing sunscreen agent.
2. The tryptophan of the invention has the following characteristics: the selected tryptophan is food grade, is an amino acid in a human body, can be metabolized by the human body, is harmless to users, has a chiral structure in molecules, has a strong absorption peak at 280nm, can convert ultraviolet rays into heat energy which is harmless to the skin and releases the heat energy, and the benzophenone-4 has the following characteristics: benzophenone-4 has water solubility, can well disperse in a re-water phase, is a broad-spectrum ultraviolet absorbent, has the advantages of high absorption efficiency, no toxicity, no teratogenic side effect, good light and heat stability and the like, and the coix seed extracting solution has the following characteristics: the coix seed extract can inhibit the generation of skin neutralizing pigment, has the effect of whitening skin, can remove aged cutin on the epidermal layer, improves rough skin phenomenon, avoids acne, and can moisten skin in dry environment, and the cortex moutan extract has the following characteristics: paeonol in cortex moutan extractive solution can inhibit the generation of intracellular oxygen free radical, whiten skin, reduce and discolor pigment deposited in skin, remove blood stasis and speckle, relieve inflammation, relieve swelling and pain, and relieve allergy. The added glycerin enables the product to have excellent moisturizing and hydrating effects; make the sun-proof spraying of this application have sun-proof, moisturize, skin care, skin makeup an organic whole, still have the effect of refreshing oneself and restoring consciousness concurrently to and convenient to use's characteristics, need not like current sun-proof cream, need go out to still need to paint cosmetics such as humectant to go.
Since tryptophan is slightly soluble in water, an alkaline solubilizer is required to increase the solubility; tryptophan and benzophenone-4 have strong ultraviolet absorption capacity and can play a role of a chemical sun-screening agent; the coix seed extract and the cortex moutan extract not only have strong absorption capacity on ultraviolet rays, but also have the effects of whitening skin, removing aged cutin and the like, and the 2 extracts are natural components, so that no report that the coix seed extract and the cortex moutan extract have obvious damage to human bodies is found in the existing report; the sunscreen lotion has synergistic effects of chemical sunscreen, physical sunscreen, whitening and skin care, and has better sunscreen effect.
Detailed Description
The present invention will be described in detail with reference to the following examples.
Example 1
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 4 parts of tryptophan, 1 part of benzophenone-4, 1 part of coix seed extract, 1 part of cortex moutan extract, 10 parts of glycerol, 20 parts of absolute ethyl alcohol, 3 parts of 1, 3-propylene glycol, 5 parts of menthol, 2 parts of a solubilizer, 1 part of a pH regulator, 0.5 part of a preservative and 51.5 parts of deionized water.
The solubilizer is one or more of sodium hydroxide solution, potassium hydroxide solution and triethanolamine of 1 mol/L, and the pH regulator is one or two of vitamin C and citric acid.
Example 2
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 5 parts of tryptophan, 2 parts of benzophenone-4, 2 parts of coix seed extract, 2 parts of cortex moutan extract, 10 parts of glycerol, 20 parts of absolute ethyl alcohol, 3 parts of 1, 3-propylene glycol, 5 parts of menthol, 2.5 parts of solubilizer, 1 part of pH regulator, 0.5 part of preservative and 47 parts of deionized water.
The solubilizer is one or more of sodium hydroxide solution, potassium hydroxide solution and triethanolamine of 1 mol/L, and the pH regulator is one or two of vitamin C and citric acid of 0.1 mol/L.
Example 3
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 6 parts of tryptophan, 3 parts of benzophenone-4, 3 parts of coix seed extract, 3 parts of cortex moutan extract, 10 parts of glycerol, 20 parts of absolute ethyl alcohol, 3 parts of 1, 3-propylene glycol, 5 parts of menthol, 3 parts of solubilizer, 2 parts of pH regulator, 0.5 part of preservative and 41.5 parts of deionized water.
The solubilizer is one or more of sodium hydroxide solution, potassium hydroxide solution and triethanolamine of 1 mol/L, and the pH regulator is one or two of vitamin C and citric acid of 0.1 mol/L.
Example 4
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 7 parts of tryptophan, 4 parts of benzophenone-4, 4 parts of coix seed extract, 4 parts of cortex moutan extract, 10 parts of glycerol, 20 parts of absolute ethyl alcohol, 3 parts of 1, 3-propylene glycol, 5 parts of menthol, 3.5 parts of a solubilizer, 2 parts of a pH regulator, 0.5 part of a preservative and 37 parts of deionized water.
The solubilizer is one or more of sodium hydroxide solution, potassium hydroxide solution and triethanolamine of 1 mol/L, and the pH regulator is one or two of vitamin C and citric acid of 0.1 mol/L.
Example 5
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 8 parts of tryptophan, 5 parts of benzophenone-4, 5 parts of coix seed extract, 5 parts of cortex moutan extract, 10 parts of glycerol, 20 parts of absolute ethyl alcohol, 3 parts of 1, 3-propylene glycol, 5 parts of menthol, 4 parts of a solubilizer, 3 parts of a pH regulator, 0.5 part of a preservative and 31.5 parts of deionized water.
The solubilizer is one or more of sodium hydroxide solution, potassium hydroxide solution and triethanolamine of 1 mol/L, and the pH regulator is one or two of vitamin C and citric acid of 0.1 mol/L.
Example 6
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 8 parts of tryptophan, 5 parts of benzophenone-4, 5 parts of coix seed extract, 5 parts of cortex moutan extract, 12 parts of glycerol, 20 parts of absolute ethyl alcohol, 3 parts of 1, 3-propylene glycol, 5 parts of menthol, 4 parts of a solubilizer, 3 parts of a pH regulator, 0.5 part of a preservative and 29.5 parts of deionized water.
The solubilizer is one or more of sodium hydroxide solution, potassium hydroxide solution and triethanolamine of 1 mol/L, and the pH regulator is one or two of vitamin C and citric acid of 0.1 mol/L.
Example 7
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 8 parts of tryptophan, 5 parts of benzophenone-4, 5 parts of coix seed extract, 5 parts of cortex moutan extract, 14 parts of glycerol, 20 parts of absolute ethyl alcohol, 3 parts of 1, 3-propylene glycol, 5 parts of menthol, 4 parts of a solubilizer, 3 parts of a pH regulator, 0.5 part of a preservative and 27.5 parts of deionized water.
The solubilizer is one or more of sodium hydroxide solution, potassium hydroxide solution and triethanolamine of 1 mol/L, and the pH regulator is one or two of vitamin C and citric acid of 0.1 mol/L.
Example 8
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 8 parts of tryptophan, 5 parts of benzophenone-4, 5 parts of coix seed extract, 5 parts of cortex moutan extract, 16 parts of glycerol, 20 parts of absolute ethyl alcohol, 3 parts of 1, 3-propylene glycol, 5 parts of menthol, 4 parts of a solubilizer, 3 parts of a pH regulator, 0.5 part of a preservative and 25.5 parts of deionized water.
The solubilizer is one or more of sodium hydroxide solution, potassium hydroxide solution and triethanolamine of 1 mol/L, and the pH regulator is one or two of vitamin C and citric acid of 0.1 mol/L.
Example 9
A sunscreen agent containing tryptophan and tyrosine comprises, by weight, 8 parts of tryptophan, 5 parts of benzophenone-4, 5 parts of coix seed extract, 5 parts of cortex moutan extract, 18 parts of glycerol, 20 parts of absolute ethyl alcohol, 3 parts of 1, 3-propylene glycol, 5 parts of menthol, 4 parts of a solubilizer, 3 parts of a pH regulator, 0.5 part of a preservative and 23.5 parts of deionized water.
The solubilizer is one or more of sodium hydroxide solution, potassium hydroxide solution and triethanolamine of 1 mol/L, and the pH regulator is one or two of vitamin C and citric acid of 0.1 mol/L.
Firstly, performance detection:
the products of examples 1 to 9 were placed in quartz cuvettes of 1cm × 1 and 1cm × 5cm, respectively, and the ultraviolet light transmittance was calculated by simulating the sunlight with a mercury lamp and measuring the ultraviolet light of 280nm to 400nm with an ultraviolet spectrophotometer, and is shown in Table 1.
TABLE 1
| Item | UVA transmittance/%) | UVB transmittance/%) |
| Example 1 | 14.3 | 4.2 |
| Example 2 | 13.6 | 4.0 |
| Example 3 | 13.1 | 3.7 |
| Example 4 | 12.7 | 3.3 |
| Example 5 | 12.3 | 3.0 |
| Example 6 | 12.1 | 2.9 |
| Example 7 | 12.2 | 3.0 |
| Example 8 | 12.1 | 3.0 |
| Example 9 | 12.0 | 2.9 |
In order to verify the skin feeling and the atomization effect of each group of sunscreen spray, 90 volunteers with oily or mixed skin are selected, the volunteers are aged 18-40 years and divided into 9 groups, 10 people in each group are respectively tried, the sunscreen spray described in the embodiments 1-9 is respectively sprayed once in the morning, at noon and at night, after the sunscreen spray is continuously used for one month, the skin feeling and the atomization effect are sequentially graded from good to poor into 10 grades, 9 grades, 8 grades, 7 grades, 6 grades, 5 grades, 4 grades, 3 grades, 2 grades, 1 grade and 0 grade, the average value is counted and tested, a skin tester (Corneometer, C + K, Germany) is used for testing the moisture content of the skin of the volunteers, and the test results are shown in Table 2.
TABLE 2
As can be seen from the data in Table 2, the sunscreen sprays prepared according to the methods of examples 1 to 9 have good moisturizing and hydrating effects after being applied for one month, which indicates that the sunscreen agents prepared according to the methods of examples 1 to 9 have good improving effects on the elasticity and texture of human skin, and can resist wrinkles, moisturize and moisturize water.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. A sunscreen spray containing tryptophan is characterized by comprising, by weight, 3-10 parts of tryptophan, 1-5 parts of benzophenone-4, 1-5 parts of coix seed extract, 1-5 parts of cortex moutan extract, 10-20 parts of glycerol, 20-25 parts of ethanol, 2-5 parts of 1, 3-propanediol, 3-10 parts of menthol, 1-5 parts of solubilizer, 0-5 parts of pH regulator, 0.3-0.5 part of preservative and 20-55 parts of deionized water.
2. The sunscreen spray containing tryptophan as claimed in claim 1, wherein the tryptophan is food grade tryptophan with all-levorotatory chiral structure.
3. The tryptophan-containing sunscreen spray as claimed in claim 1, wherein the extract of Job's tears is prepared by: firstly, crushing the clean and dried coix seeds into small particles with the particle size smaller than 100 meshes, then mixing the small particles of the coix seeds with 1, 3-propylene glycol according to the mass ratio of 1:3, extracting for 1h at the temperature of 75-80 ℃, and filtering to obtain filtrate, namely the coix seed extracting solution.
4. The sunscreen spray containing tryptophan according to claim 1, wherein the cortex moutan extract is prepared by the following steps: firstly, crushing dried and clean cortex moutan into small particles with the particle size smaller than 100 meshes, then mixing the small particles of the cortex moutan with ethanol according to the mass ratio of 1:3, extracting for 1h at the temperature of 50-60 ℃, and filtering to obtain filtrate, namely cortex moutan extracting solution.
5. The sunscreen spray containing tryptophan as claimed in claim 1, wherein the solubilizer is selected from one or more aqueous solutions of sodium hydroxide, potassium hydroxide and triethanolamine.
6. The tryptophan-containing sunscreen spray according to claim 1, wherein the pH regulator is selected from any one or two of vitamin C and citric acid.
7. The tryptophan-containing sunscreen spray according to claim 1, wherein the preservative is selected from any one or two of parabens and phenoxyethanol.
8. A method of preparing a sunscreen spray as claimed in claim 1 comprising the steps of:
a. weighing tryptophan, deionized water, glycerol, ethanol, 1, 3-propylene glycol and menthol according to a certain proportion, uniformly mixing, slowly adding a solubilizer, and stirring until the tryptophan is completely dissolved;
b. sequentially adding the coix seed extract, the cortex moutan extract, benzophenone-4 and the preservative according to the proportion, and uniformly mixing;
c. adjusting pH value to 6.0-8.0 with pH regulator according to the pH value of the mixed solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010334092.2A CN111450021A (en) | 2020-04-24 | 2020-04-24 | Sunscreen spray containing tryptophan and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010334092.2A CN111450021A (en) | 2020-04-24 | 2020-04-24 | Sunscreen spray containing tryptophan and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111450021A true CN111450021A (en) | 2020-07-28 |
Family
ID=71670497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010334092.2A Pending CN111450021A (en) | 2020-04-24 | 2020-04-24 | Sunscreen spray containing tryptophan and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111450021A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113041167A (en) * | 2021-03-23 | 2021-06-29 | 上海创元化妆品有限公司 | Novel use method of sun-proof system |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109248127A (en) * | 2018-10-26 | 2019-01-22 | 蔡少青 | A kind of anti-inflammatory anti-itch sun water |
-
2020
- 2020-04-24 CN CN202010334092.2A patent/CN111450021A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109248127A (en) * | 2018-10-26 | 2019-01-22 | 蔡少青 | A kind of anti-inflammatory anti-itch sun water |
Non-Patent Citations (1)
| Title |
|---|
| 国家药典委员会 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113041167A (en) * | 2021-03-23 | 2021-06-29 | 上海创元化妆品有限公司 | Novel use method of sun-proof system |
| CN113041167B (en) * | 2021-03-23 | 2023-12-12 | 上海创元化妆品有限公司 | Use method of sun protection system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107213063B (en) | Fair and bright facial mask and preparation method thereof | |
| CN112494406A (en) | Whitening and freckle-removing cosmetic and preparation method thereof | |
| CN113181085A (en) | Composition matrix for improving skin problems after makeup and application of composition matrix in cosmetics | |
| KR101887378B1 (en) | Cosmetic composition with antioxidant effect | |
| CN110339076B (en) | Sun-screening composition with broad-spectrum light protection effect and preparation method and application thereof | |
| CN101588788A (en) | Cosmetic composition for protecting skin against UV light and wrinkle improvement containing the extract of Magnolia sieboldii flower extracts | |
| CN112545955B (en) | Anti-aging repair composition and preparation method and application thereof | |
| CN108852869B (en) | Skin care composition for resisting blue light pollution and application thereof | |
| CN113616583A (en) | Anti-allergy and relieving composition and preparation method thereof | |
| CN109044905A (en) | A kind of anti-oxidant remediation composition of moisturizing, facial mask and preparation method thereof | |
| KR101981696B1 (en) | Mist Composition comprising natural complex extracts | |
| US5916542A (en) | Natural-base antisolar and antierythema mixture | |
| KR20180015865A (en) | Baby cosmetic composition for skin moisturizing | |
| CN110960468B (en) | Preparation method of anti-aging and anti-blue-light cosmetic containing plant extract | |
| WO2017019265A1 (en) | Topical skin care composition for day use | |
| CN110101591B (en) | Long-acting moisturizing composition and preparation method and application thereof | |
| CN110585034A (en) | Anti-allergy soothing moisturizing toner and preparation method thereof | |
| CN111450021A (en) | Sunscreen spray containing tryptophan and preparation method thereof | |
| KR102233140B1 (en) | Cosmetic composition for skin improvement containing low molecular weight hyaluronic acid | |
| CN111297733A (en) | Paeonol-containing high-moisture-retention sun-screening agent and preparation method thereof | |
| WO2014094380A1 (en) | Bee venom composition with sun-proof effect | |
| CN113384510B (en) | Fermented composition with anti-photoaging, relieving and cooling effects and preparation method and application thereof | |
| CN108836904A (en) | A kind of skin care compositions of wrinkle reduction and the preparation method and application thereof | |
| KR20110118497A (en) | Cosmetic composition for moisturizing and elasiticity of skin containing the laminaria japonica extract, undaria pinnatifida extract and plantago asiatica seed extract | |
| CN115006303A (en) | Anti-allergy moisturizing skin-activating essence lotion and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200728 |
|
| RJ01 | Rejection of invention patent application after publication |