CN111517971A - 一种抗真菌化合物、合成方法及其应用 - Google Patents

一种抗真菌化合物、合成方法及其应用 Download PDF

Info

Publication number
CN111517971A
CN111517971A CN202010405895.2A CN202010405895A CN111517971A CN 111517971 A CN111517971 A CN 111517971A CN 202010405895 A CN202010405895 A CN 202010405895A CN 111517971 A CN111517971 A CN 111517971A
Authority
CN
China
Prior art keywords
antifungal
amino acid
ester
antifungal compound
leucine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010405895.2A
Other languages
English (en)
Chinese (zh)
Inventor
裴泽军
孙欣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wuxi No 2 Peoples Hospital
Original Assignee
Wuxi No 2 Peoples Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wuxi No 2 Peoples Hospital filed Critical Wuxi No 2 Peoples Hospital
Priority to CN202010405895.2A priority Critical patent/CN111517971A/zh
Publication of CN111517971A publication Critical patent/CN111517971A/zh
Priority to PCT/CN2020/130777 priority patent/WO2021227436A1/fr
Priority to ZA2021/03638A priority patent/ZA202103638B/en
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202010405895.2A 2020-05-14 2020-05-14 一种抗真菌化合物、合成方法及其应用 Pending CN111517971A (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN202010405895.2A CN111517971A (zh) 2020-05-14 2020-05-14 一种抗真菌化合物、合成方法及其应用
PCT/CN2020/130777 WO2021227436A1 (fr) 2020-05-14 2020-11-23 Composé antifongique, son procédé de synthèse et son utilisation
ZA2021/03638A ZA202103638B (en) 2020-05-14 2021-05-27 Antifungal compound, and synthesis method and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010405895.2A CN111517971A (zh) 2020-05-14 2020-05-14 一种抗真菌化合物、合成方法及其应用

Publications (1)

Publication Number Publication Date
CN111517971A true CN111517971A (zh) 2020-08-11

Family

ID=71912350

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010405895.2A Pending CN111517971A (zh) 2020-05-14 2020-05-14 一种抗真菌化合物、合成方法及其应用

Country Status (3)

Country Link
CN (1) CN111517971A (fr)
WO (1) WO2021227436A1 (fr)
ZA (1) ZA202103638B (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019908A1 (fr) * 1995-11-29 1997-06-05 Nihon Nohyaku Co., Ltd. Derives de phenylalanine, substances optiquement actives, leurs sels ou composes de coordination, et leur utilisation en tant que fongicides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821403A (en) * 1972-01-20 1974-06-28 Rikagaku Kenkyusho Method of combatting bacteria or fungi on plants using amino acid higher alkyl esters
US8846638B2 (en) * 2012-05-17 2014-09-30 Enanta Pharmaceuticals, Inc. Macrocyclic nucleoside phosphoramidate derivatives
US8900625B2 (en) * 2012-12-15 2014-12-02 Nexmed Holdings, Inc. Antimicrobial compounds and methods of use
WO2015000076A1 (fr) * 2013-07-02 2015-01-08 Alectos Therapeutics Inc. Procédé photochimique de fluoration d'un composé organique présentant une liaison c-h sp3 non activée
JP6183851B2 (ja) * 2013-08-22 2017-08-23 国立研究開発法人農業・食品産業技術総合研究機構 土壌伝染性病害防除法及び土壌伝染性病害防除用微生物の検定方法
CN111087317B (zh) * 2019-11-11 2023-04-14 中国药科大学 不饱和阳离子脂质衍生物、制备方法以及在质粒递送系统中的应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019908A1 (fr) * 1995-11-29 1997-06-05 Nihon Nohyaku Co., Ltd. Derives de phenylalanine, substances optiquement actives, leurs sels ou composes de coordination, et leur utilisation en tant que fongicides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACT SERVICE: "RN：2364603-67-6等", 《CA网络版STN REGISTRY数据库》 *

Also Published As

Publication number Publication date
WO2021227436A1 (fr) 2021-11-18
ZA202103638B (en) 2022-02-23

Similar Documents

Publication Publication Date Title
CN115960088B (zh) 一种新型冠状病毒主蛋白酶的抑制剂及其制备方法和用途
CN114057702B (zh) 一种新型冠状病毒主蛋白酶的抑制剂及其制备方法和用途
EP1583526B1 (fr) 4-amidino- et 4-guanidinobenzylamines acylees utilisees pour inhiber la kallikreine plasmatique
KR101771093B1 (ko) 치환된 아졸, 항바이러스 활성 성분, 약학적 조성물, 이의 제조방법 및 이의 용도
KR101325620B1 (ko) 의약조성물 및 항진균제를 조합하여 사용하는 방법
KR20050083610A (ko) 데하이드로페닐아히스틴 및 그의 동족체, 및 이들의 합성방법
CA3053850A1 (fr) Agents antifongiques et utilisations asociees
EP3072892B1 (fr) Dérivé pyridine et son utilisation médicale
KR20140145126A (ko) Hcv ns5a의 저해제를 포함하는 고체형태, 이의 조성물 및 이에 의한 용도
CN102766198A (zh) 一种糖肽类抗真菌化合物及其制备方法与应用
RU2457216C1 (ru) Додекапептиды, обладающие кардиопротекторными свойствами
CN102295618B (zh) 一氧化氮供体型他米巴罗汀衍生物、其制备方法和用途
WO2011025875A1 (fr) Dérivés d’échinocandine
TW201247621A (en) Compounds from mycelium of Antrodia cinnamomea and use thereof
RU2415839C2 (ru) Новое производное ариламидина, его соль и содержащий их противогрибковый агент
JP2008507580A (ja) 反応性酸素種およびカルボニル種を阻害し得る組成物
CN111517971A (zh) 一种抗真菌化合物、合成方法及其应用
EP1483285B1 (fr) INHIBITEURS DU FACTEUR DE COAGULATION Xa, LEUR PRODUCTION ET LEUR UTILISATION
CN112457365B (zh) 一类靶向蛋白质水解通路的功能分子及其制备和应用
EP2376074B1 (fr) Procédé pour améliorer la bioactivation de substances pharmaceutiques
Sheha et al. Brain delivery of HIV protease inhibitors
CN113214238B (zh) 一类具有酰化哌嗪结构的吲哚恶二唑衍生物的制备和用途
KR20030022270A (ko) 아미노이소퀴놀린기를 함유하는 트롬빈 저해제
RU2586978C2 (ru) Производное даидзеина, его фармацевтически приемлемая соль и способ получения, а также содержащая его фармацевтическая композиция
CA3123368A1 (fr) Peptides ciblant les mitochondries

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20200811

RJ01 Rejection of invention patent application after publication