CN111511903B - 用于改善的免疫细胞疗法的nk抑制剂基因的靶向基因整合 - Google Patents
用于改善的免疫细胞疗法的nk抑制剂基因的靶向基因整合 Download PDFInfo
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- CN111511903B CN111511903B CN201880082153.1A CN201880082153A CN111511903B CN 111511903 B CN111511903 B CN 111511903B CN 201880082153 A CN201880082153 A CN 201880082153A CN 111511903 B CN111511903 B CN 111511903B
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2017/076798 WO2018073391A1 (en) | 2016-10-19 | 2017-10-19 | Targeted gene insertion for improved immune cells therapy |
| EPPCT/EP2017/076798 | 2017-10-19 | ||
| EP2018053343 | 2018-02-09 | ||
| EPPCT/EP2018/053343 | 2018-02-09 | ||
| PCT/EP2018/055957 WO2019076486A1 (en) | 2017-10-19 | 2018-03-09 | TARGETED GENE INTEGRATION OF NK INHIBITOR GENES FOR ENHANCED IMMUNE CELL THERAPY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111511903A CN111511903A (zh) | 2020-08-07 |
| CN111511903B true CN111511903B (zh) | 2024-10-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880082153.1A Active CN111511903B (zh) | 2017-10-19 | 2018-03-09 | 用于改善的免疫细胞疗法的nk抑制剂基因的靶向基因整合 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12209125B2 (enExample) |
| EP (2) | EP3684919A1 (enExample) |
| JP (2) | JP7621795B2 (enExample) |
| KR (2) | KR20250007705A (enExample) |
| CN (1) | CN111511903B (enExample) |
| AU (2) | AU2018353112B2 (enExample) |
| CA (1) | CA3084476A1 (enExample) |
| IL (1) | IL273828B2 (enExample) |
| MX (1) | MX2020004444A (enExample) |
| WO (2) | WO2019076486A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3592854A1 (en) * | 2017-04-13 | 2020-01-15 | Cellectis | New sequence specific reagents targeting ccr5 in primary hematopoietic cells |
| JP2020530993A (ja) * | 2017-08-02 | 2020-11-05 | オートラス リミテッド | キメラ抗原受容体または改変tcrを発現し、選択的に発現されるヌクレオチド配列を含む細胞 |
| WO2019076486A1 (en) | 2017-10-19 | 2019-04-25 | Cellectis | TARGETED GENE INTEGRATION OF NK INHIBITOR GENES FOR ENHANCED IMMUNE CELL THERAPY |
| US20200054675A1 (en) | 2018-06-01 | 2020-02-20 | Washington University | Suppression of cytokine release syndrome in chimeric antigen receptor cell therapy |
| US12378572B2 (en) | 2018-09-07 | 2025-08-05 | Crispr Therapeutics Ag | Universal donor cells |
| CN110055224B (zh) * | 2019-04-03 | 2023-06-30 | 深圳市体内生物医药科技有限公司 | 一种基因修饰的免疫细胞及其制备方法和应用 |
| WO2020222176A1 (en) | 2019-04-30 | 2020-11-05 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| JP7754722B2 (ja) * | 2019-05-01 | 2025-10-15 | ジュノー セラピューティクス インコーポレイテッド | 改変されたcd247遺伝子座からキメラ受容体を発現する細胞、関連ポリヌクレオチド、および方法 |
| MX2022000016A (es) * | 2019-06-27 | 2022-02-24 | Crispr Therapeutics Ag | Uso de linfocitos t con receptor de antigeno quimerico e inhibidores de linfocitos citoliticos naturales para el tratamiento del cancer. |
| WO2021044377A1 (en) | 2019-09-05 | 2021-03-11 | Crispr Therapeutics Ag | Universal donor cells |
| US11118196B2 (en) | 2019-09-05 | 2021-09-14 | Crispr Therapeutics Ag | Universal donor cells |
| US20230127263A1 (en) * | 2019-09-20 | 2023-04-27 | The University Of North Carolina At Chapel Hill | Modified t cells and methods of preparing the same |
| EP4090383A4 (en) | 2020-01-14 | 2024-01-24 | Synthekine, Inc. | IL2 ORTHOLOGIST AND APPLICATION METHOD |
| CA3185455A1 (en) * | 2020-06-11 | 2021-12-16 | Novartis Ag | Zbtb32 inhibitors and uses thereof |
| US20230340067A1 (en) * | 2020-06-26 | 2023-10-26 | St. Jude Children's Research Hospital, Inc. | Methods of generating an activation inducible expression system in immune cells |
| EP3943097A1 (en) * | 2020-07-24 | 2022-01-26 | AB2 Bio SA | Car-t cell therapy |
| WO2022020860A2 (en) * | 2020-07-24 | 2022-01-27 | Board Of Regents, The University Of Texas System | Engineered t cells and tumor-infiltrating lymphocytes to increase tumor killing |
| WO2022112596A1 (en) | 2020-11-30 | 2022-06-02 | Cellectis Sa | Use of aminoquinoline compounds for higher gene integration |
| CN114874983A (zh) * | 2020-12-29 | 2022-08-09 | 博雅辑因(北京)生物科技有限公司 | 鉴定t细胞调节基因的方法 |
| WO2022144856A1 (en) | 2020-12-31 | 2022-07-07 | Crispr Therapeutics Ag | Universal donor cells |
| IL308012A (en) * | 2021-04-30 | 2023-12-01 | Cellectis Sa | Anti-MUC1 for novel chimeric antigen receptors and genetically engineered immune cells for solid tumor immunotherapy |
| AU2022301099A1 (en) * | 2021-07-01 | 2024-02-15 | Ningbo T-Maximum Biopharmaceuticals Co., Ltd. | Antigen-binding polypeptide targeting b7h3 and application thereof |
| CN117940465A (zh) * | 2021-08-12 | 2024-04-26 | 苏州克睿基因生物科技有限公司 | 经修饰的细胞、其制备方法及应用 |
| US20250249100A1 (en) * | 2022-04-25 | 2025-08-07 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for preventing t cell exhaustion |
| CN115820697B (zh) * | 2022-09-23 | 2024-07-30 | 中国海洋大学 | 一种免疫细胞及其制备方法和应用 |
| WO2024216346A1 (en) * | 2023-04-20 | 2024-10-24 | Peter Maccallum Cancer Institute | Compositions and methods for immunotherapy - ii |
| WO2024258835A1 (en) * | 2023-06-16 | 2024-12-19 | The Trustees Of Columbia University In The City Of New York | Removal of endogenous tcr chains for enhanced tcr-based immunotherapies |
| WO2025015130A1 (en) * | 2023-07-12 | 2025-01-16 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Compositions and methods for the inhibition of natural killer cells |
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| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
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| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| WO1994024277A1 (en) | 1993-04-13 | 1994-10-27 | Sloan-Kettering Institute For Cancer Research | Protection of human bone marrow from high dose antifolate therapy using mutated human dihydrofolate reductase dna |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
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| US6642043B1 (en) | 1996-03-12 | 2003-11-04 | Sloan-Kettering Institute For Cancer Research | Double mutants of dihydrofolate reductase and methods of using same |
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| JP4753119B2 (ja) | 2003-03-14 | 2011-08-24 | セレクティス ソシエテ アノニム | 大量処理の生体外エレクトロポレーション法 |
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| US20140134195A1 (en) * | 2011-04-20 | 2014-05-15 | University Of Washington Through Its Center For Commercialization | Beta-2 microglobulin-deficient cells |
| CN111676196A (zh) | 2012-05-25 | 2020-09-18 | 塞勒克提斯公司 | 工程化异体和免疫抑制耐受性t细胞的方法 |
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