CN111494624A - 针对抗i型干扰素受体（ifnar）抗体的固定剂量方案 - Google Patents

针对抗i型干扰素受体（ifnar）抗体的固定剂量方案 Download PDF

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Publication number
CN111494624A
CN111494624A CN202010333445.7A CN202010333445A CN111494624A CN 111494624 A CN111494624 A CN 111494624A CN 202010333445 A CN202010333445 A CN 202010333445A CN 111494624 A CN111494624 A CN 111494624A
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leu
ser
ifn
ala
gly
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Chinese (zh)
Inventor
B·希格斯
Y·姚
B·王
L·罗斯科斯
L·常
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AstraZeneca AB
MedImmune LLC
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AstraZeneca AB
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Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN111494624A publication Critical patent/CN111494624A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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CN202010333445.7A 2012-06-13 2013-06-12 针对抗i型干扰素受体（ifnar）抗体的固定剂量方案 Pending CN111494624A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261659138P 2012-06-13 2012-06-13
US61/659,138 2012-06-13
CN201380043349.7A CN104603152A (zh) 2012-06-13 2013-06-12 针对抗i型干扰素受体(ifnar)抗体的固定剂量方案

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CN201380043349.7A Division CN104603152A (zh) 2012-06-13 2013-06-12 针对抗i型干扰素受体(ifnar)抗体的固定剂量方案

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CN111494624A true CN111494624A (zh) 2020-08-07

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CN202010333445.7A Pending CN111494624A (zh) 2012-06-13 2013-06-12 针对抗i型干扰素受体（ifnar）抗体的固定剂量方案
CN201810164604.8A Pending CN108310375A (zh) 2012-06-13 2013-06-12 针对抗i型干扰素受体（ifnar）抗体的固定剂量方案
CN201380043349.7A Pending CN104603152A (zh) 2012-06-13 2013-06-12 针对抗i型干扰素受体(ifnar)抗体的固定剂量方案

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CN201810164604.8A Pending CN108310375A (zh) 2012-06-13 2013-06-12 针对抗i型干扰素受体（ifnar）抗体的固定剂量方案
CN201380043349.7A Pending CN104603152A (zh) 2012-06-13 2013-06-12 针对抗i型干扰素受体(ifnar)抗体的固定剂量方案

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US (1) US9493570B2 (enExample)
EP (1) EP2861621A4 (enExample)
JP (5) JP2015526391A (enExample)
KR (3) KR102185237B1 (enExample)
CN (3) CN111494624A (enExample)
AU (3) AU2013274389A1 (enExample)
CA (1) CA2876636C (enExample)
HK (1) HK1209758A1 (enExample)
WO (1) WO2013188494A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5160887B2 (ja) * 2004-06-21 2013-03-13 メダレックス インコーポレイテッド インターフェロンアルファレセプター１抗体及びその使用法
KR100680048B1 (ko) * 2006-01-23 2007-02-08 쌍용자동차 주식회사 자동차 도장용 크레인의 구조
US20180305761A1 (en) 2015-10-09 2018-10-25 Genefron Ltd. METHODS AND KITS FOR PREDICTION AND DIAGNOSIS OF HUMAN CYTOMEGALOVIRUS (hCMV) CONGENITAL TRANSMISSION
DK3478830T3 (da) 2016-07-01 2024-05-21 Resolve Therapeutics Llc Optimerede binucleasefusioner og metoder
CN106243226B (zh) * 2016-08-05 2019-02-12 北京智仁美博生物科技有限公司 抗人ifnar1的抗体及其用途
US20200031943A1 (en) 2017-03-21 2020-01-30 Austrianni Gmbh Type 1 interferon receptor antagonists for use in methods of treating tuberculosis and other infectious diseases
MX2020002070A (es) 2017-08-22 2020-03-24 Sanabio Llc Receptores solubles de interferon y usos de los mismos.
US11139051B2 (en) * 2018-10-02 2021-10-05 Origent Data Sciences, Inc. Systems and methods for designing clinical trials
EA202191133A1 (ru) * 2018-10-26 2021-07-12 Янссен Байотек, Инк. Сигнатуры интерферона типа i и способы их применения
CN113728006B (zh) * 2019-01-31 2022-10-14 广东旋玉健康生物科技有限公司 新型抗ifnar1抗体
CN111892653A (zh) * 2019-07-03 2020-11-06 长春恒晓生物科技有限责任公司 制备粘病毒抗性蛋白1抗体及建立检测mx1方法
MX2023012465A (es) * 2021-04-23 2024-04-04 Astrazeneca Ab Regimen de dosificacion de anti-ifnar1 para inyeccion subcutanea.
PT4192882T (pt) 2021-04-23 2025-05-02 Astrazeneca Ab Tratamento de nefrite lúpica com anticorpo anifrolumab de recetor inf anti-tipo i
WO2025022280A1 (en) 2023-07-21 2025-01-30 Astrazeneca Ab Treatment of neurodegenerative diseases
GB202402824D0 (en) * 2024-02-28 2024-04-10 Astrazeneca Ab Treatment of chronic kidney disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101594882A (zh) * 2006-12-06 2009-12-02 米迪缪尼有限公司 干扰素α诱导的药代动力学标记物
CN101952454A (zh) * 2008-02-08 2011-01-19 米迪缪尼有限公司 具有减弱的Fc配体亲和性的抗IFNAR1抗体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002250236A1 (en) * 2001-03-02 2002-09-19 Medimmune, Inc. Cd2 antagonists for treatment of autoimmune or inflammatory disease
US20040037809A1 (en) * 2002-06-28 2004-02-26 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of interferon beta
JP5160887B2 (ja) * 2004-06-21 2013-03-13 メダレックス インコーポレイテッド インターフェロンアルファレセプター１抗体及びその使用法
WO2006128210A1 (en) * 2005-06-03 2006-12-07 John Arthur Notaras A tiller
WO2006138275A2 (en) 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
CA2651866C (en) * 2006-05-11 2014-10-28 Universiteit Gent Sialoadhesin-related compositions and methods
RU2527068C2 (ru) * 2006-12-06 2014-08-27 Медиммун, Ллк Фармакодинамические маркеры, индуцированные интерфероном альфа
HUE025787T2 (en) * 2007-11-05 2016-05-30 Medimmune Llc Method for treating scleroderma
US20110287022A1 (en) * 2008-06-20 2011-11-24 Medlmmune, Llc Interferon alpha-induced pharmacodynamic markers
NZ591137A (en) 2008-08-15 2012-10-26 Merrimack Pharmaceuticals Inc Methods and systems for predicting response of cells to a therapeutic agent
PT2473636T (pt) 2009-09-03 2017-02-06 Medimmune Llc Diagnóstico de interferão de tipo-1

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101594882A (zh) * 2006-12-06 2009-12-02 米迪缪尼有限公司 干扰素α诱导的药代动力学标记物
CN101952454A (zh) * 2008-02-08 2011-01-19 米迪缪尼有限公司 具有减弱的Fc配体亲和性的抗IFNAR1抗体

Also Published As

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AU2013274389A1 (en) 2015-01-22
US9493570B2 (en) 2016-11-15
CA2876636A1 (en) 2013-12-19
JP2018065845A (ja) 2018-04-26
AU2018206851A1 (en) 2018-08-09
CA2876636C (en) 2022-09-13
AU2018206851B2 (en) 2020-07-30
AU2018206851C1 (en) 2021-11-25
KR102185237B9 (ko) 2021-08-06
EP2861621A1 (en) 2015-04-22
JP2015526391A (ja) 2015-09-10
JP2021167336A (ja) 2021-10-21
KR102185237B1 (ko) 2020-12-02
WO2013188494A1 (en) 2013-12-19
KR20200133395A (ko) 2020-11-27
CN104603152A (zh) 2015-05-06
HK1209758A1 (en) 2016-04-08
JP2019112429A (ja) 2019-07-11
JP6814238B2 (ja) 2021-01-13
US20150158949A1 (en) 2015-06-11
CN108310375A (zh) 2018-07-24
KR20210130270A (ko) 2021-10-29
JP7123225B2 (ja) 2022-08-22
JP2021042208A (ja) 2021-03-18
AU2020204613A1 (en) 2020-07-30
AU2020204613B2 (en) 2021-10-07
KR102320059B1 (ko) 2021-11-01
KR20150035825A (ko) 2015-04-07
EP2861621A4 (en) 2016-01-20

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