CN111491927A - 通过降解双mek信号传导的癌症疗法 - Google Patents

通过降解双mek信号传导的癌症疗法 Download PDF

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Publication number
CN111491927A
CN111491927A CN201880074427.2A CN201880074427A CN111491927A CN 111491927 A CN111491927 A CN 111491927A CN 201880074427 A CN201880074427 A CN 201880074427A CN 111491927 A CN111491927 A CN 111491927A
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cancer
pac
active agent
kinase
inhibitor
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CN201880074427.2A
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Chinese (zh)
Inventor
保罗·J·赫根罗德
杰西·白
马修·布德罗
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University of Illinois System
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University of Illinois System
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201880074427.2A 2017-11-17 2018-11-16 通过降解双mek信号传导的癌症疗法 Pending CN111491927A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762587707P 2017-11-17 2017-11-17
US62/587,707 2017-11-17
PCT/US2018/061579 WO2019099873A1 (en) 2017-11-17 2018-11-16 Cancer therapy by degrading dual mek signaling

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CN111491927A true CN111491927A (zh) 2020-08-04

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CN201880074427.2A Pending CN111491927A (zh) 2017-11-17 2018-11-16 通过降解双mek信号传导的癌症疗法

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US (2) US11510919B2 (https=)
EP (1) EP3710433A4 (https=)
JP (1) JP7349155B2 (https=)
KR (1) KR20200090771A (https=)
CN (1) CN111491927A (https=)
AU (1) AU2018368453B2 (https=)
CA (1) CA3082575A1 (https=)
IL (1) IL274663B2 (https=)
MX (1) MX2020004991A (https=)
SG (1) SG11202004384YA (https=)
WO (1) WO2019099873A1 (https=)

Cited By (1)

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CN115677772A (zh) * 2021-07-30 2023-02-03 浙江大学智能创新药物研究院 一种用于egfr激酶抑制剂的化合物、组合物及其应用

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AU2018368453B2 (en) * 2017-11-17 2024-05-30 The Board Of Trustees Of The University Of Illinois Cancer therapy by degrading dual MEK signaling
CA3114385A1 (en) * 2018-10-05 2020-04-09 The Board Of Trustees Of The University Of Illinois Combination therapy for the treatment of uveal melanoma
EP3976062A4 (en) * 2019-05-30 2023-06-14 The Board Of Trustees Of The University Of Illinois PROCASPASE-3 ACTIVATION AND IMMUNOTHERAPY FOR THE TREATMENT OF CANCER

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