JP7349155B2 - 二元的なｍｅｋシグナル伝達の低減によるがん治療 - Google Patents

二元的なｍｅｋシグナル伝達の低減によるがん治療 Download PDF

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JP7349155B2
JP7349155B2 JP2020526610A JP2020526610A JP7349155B2 JP 7349155 B2 JP7349155 B2 JP 7349155B2 JP 2020526610 A JP2020526610 A JP 2020526610A JP 2020526610 A JP2020526610 A JP 2020526610A JP 7349155 B2 JP7349155 B2 JP 7349155B2
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pac
cancer
active agent
cells
osimertinib
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ジェイ． ハーゲンローザー、ポール
ペー、ジェシー
ボードロー、マシュー
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ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Dermatology (AREA)
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  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020526610A 2017-11-17 2018-11-16 二元的なｍｅｋシグナル伝達の低減によるがん治療 Active JP7349155B2 (ja)

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US201762587707P 2017-11-17 2017-11-17
US62/587,707 2017-11-17
PCT/US2018/061579 WO2019099873A1 (en) 2017-11-17 2018-11-16 Cancer therapy by degrading dual mek signaling

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JP2021503457A JP2021503457A (ja) 2021-02-12
JP2021503457A5 JP2021503457A5 (https=) 2021-12-02
JP7349155B2 true JP7349155B2 (ja) 2023-09-22

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US (2) US11510919B2 (https=)
EP (1) EP3710433A4 (https=)
JP (1) JP7349155B2 (https=)
KR (1) KR20200090771A (https=)
CN (1) CN111491927A (https=)
AU (1) AU2018368453B2 (https=)
CA (1) CA3082575A1 (https=)
IL (1) IL274663B2 (https=)
MX (1) MX2020004991A (https=)
SG (1) SG11202004384YA (https=)
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SG11202004384YA (en) * 2017-11-17 2020-06-29 Univ Illinois Cancer therapy by degrading dual mek signaling
KR20210084442A (ko) * 2018-10-05 2021-07-07 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 포도막 흑색종 치료를 위한 병용 요법
KR20220016104A (ko) * 2019-05-30 2022-02-08 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 암 치료를 위한 프로카스파아제-3 활성화 및 면역요법
WO2023006088A1 (zh) * 2021-07-30 2023-02-02 浙江大学智能创新药物研究院 一种用于egfr激酶抑制剂的化合物、组合物及其应用

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