CN111484421A - 一种抗菌用银离子化合物,无刺激性银离子抗菌剂及其制备方法、应用 - Google Patents
一种抗菌用银离子化合物,无刺激性银离子抗菌剂及其制备方法、应用 Download PDFInfo
- Publication number
- CN111484421A CN111484421A CN202010358860.8A CN202010358860A CN111484421A CN 111484421 A CN111484421 A CN 111484421A CN 202010358860 A CN202010358860 A CN 202010358860A CN 111484421 A CN111484421 A CN 111484421A
- Authority
- CN
- China
- Prior art keywords
- silver
- antibacterial
- silver ion
- amino acid
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 silver ion compound Chemical class 0.000 title claims abstract description 117
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 92
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 44
- 239000002085 irritant Substances 0.000 title claims description 17
- 231100000021 irritant Toxicity 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title abstract description 22
- 239000004332 silver Substances 0.000 claims abstract description 75
- 229910052709 silver Inorganic materials 0.000 claims abstract description 75
- 231100000344 non-irritating Toxicity 0.000 claims abstract description 31
- 239000003446 ligand Substances 0.000 claims abstract description 30
- 150000001413 amino acids Chemical class 0.000 claims abstract description 27
- 150000001768 cations Chemical class 0.000 claims abstract description 22
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims abstract description 17
- 150000001450 anions Chemical class 0.000 claims abstract description 13
- 229920001184 polypeptide Polymers 0.000 claims abstract description 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 11
- 229940049920 malate Drugs 0.000 claims abstract description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims abstract description 8
- 230000003115 biocidal effect Effects 0.000 claims abstract description 8
- 239000004480 active ingredient Substances 0.000 claims abstract description 7
- 239000001257 hydrogen Substances 0.000 claims abstract description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 7
- 229940095064 tartrate Drugs 0.000 claims abstract description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims description 39
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 24
- 239000000499 gel Substances 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 239000007864 aqueous solution Substances 0.000 claims description 14
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical class [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims description 14
- CQLFBEKRDQMJLZ-UHFFFAOYSA-M silver acetate Chemical compound [Ag+].CC([O-])=O CQLFBEKRDQMJLZ-UHFFFAOYSA-M 0.000 claims description 13
- 229940071536 silver acetate Drugs 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 108010016626 Dipeptides Proteins 0.000 claims description 10
- 239000004599 antimicrobial Substances 0.000 claims description 10
- 229940001468 citrate Drugs 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 239000002537 cosmetic Substances 0.000 claims description 7
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 claims description 6
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 6
- BOYYFZLRUNZGFW-UHFFFAOYSA-M silver;dihydrogen phosphate Chemical compound [Ag+].OP(O)([O-])=O BOYYFZLRUNZGFW-UHFFFAOYSA-M 0.000 claims description 6
- 229920003169 water-soluble polymer Polymers 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 claims description 5
- 229920003023 plastic Polymers 0.000 claims description 5
- 239000004033 plastic Substances 0.000 claims description 5
- RUJQWQMCBPWFDO-UHFFFAOYSA-M silver;2-hydroxyacetate Chemical compound [Ag+].OCC([O-])=O RUJQWQMCBPWFDO-UHFFFAOYSA-M 0.000 claims description 5
- QUTYHQJYVDNJJA-UHFFFAOYSA-K trisilver;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Ag+].[Ag+].[Ag+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QUTYHQJYVDNJJA-UHFFFAOYSA-K 0.000 claims description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 229940071575 silver citrate Drugs 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- 244000215068 Acacia senegal Species 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 229920000084 Gum arabic Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- QRUPLCYFMWTKQD-UHFFFAOYSA-L [Ag+2].P(=O)(O)([O-])[O-] Chemical compound [Ag+2].P(=O)(O)([O-])[O-] QRUPLCYFMWTKQD-UHFFFAOYSA-L 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 239000005018 casein Substances 0.000 claims description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
- 235000021240 caseins Nutrition 0.000 claims description 2
- ZUVOYUDQAUHLLG-OLXYHTOASA-L disilver;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Ag+].[Ag+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O ZUVOYUDQAUHLLG-OLXYHTOASA-L 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 229940014259 gelatin Drugs 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 229940009188 silver Drugs 0.000 claims description 2
- LMEWRZSPCQHBOB-UHFFFAOYSA-M silver;2-hydroxypropanoate Chemical compound [Ag+].CC(O)C([O-])=O LMEWRZSPCQHBOB-UHFFFAOYSA-M 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 230000000845 anti-microbial effect Effects 0.000 claims 2
- 230000003385 bacteriostatic effect Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 16
- 241000282414 Homo sapiens Species 0.000 abstract description 7
- 230000015784 hyperosmotic salinity response Effects 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract description 3
- 230000000638 stimulation Effects 0.000 abstract description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 30
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 20
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 12
- 229910001961 silver nitrate Inorganic materials 0.000 description 10
- 238000007865 diluting Methods 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 239000004471 Glycine Substances 0.000 description 7
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 7
- 239000004473 Threonine Substances 0.000 description 7
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 6
- 239000004247 glycine and its sodium salt Substances 0.000 description 6
- 230000003472 neutralizing effect Effects 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 229940029258 sodium glycinate Drugs 0.000 description 6
- WUWHFEHKUQVYLF-UHFFFAOYSA-M sodium;2-aminoacetate Chemical compound [Na+].NCC([O-])=O WUWHFEHKUQVYLF-UHFFFAOYSA-M 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 3
- 239000000645 desinfectant Substances 0.000 description 3
- 230000001815 facial effect Effects 0.000 description 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 2
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- PLKATZNSTYDYJW-UHFFFAOYSA-N azane silver Chemical compound N.[Ag] PLKATZNSTYDYJW-UHFFFAOYSA-N 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- 229910001414 potassium ion Inorganic materials 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- SAHTYPIPYPIKPB-QRPNPIFTSA-N (2s)-2-amino-3-phenylpropanoic acid;sodium Chemical group [Na].OC(=O)[C@@H](N)CC1=CC=CC=C1 SAHTYPIPYPIKPB-QRPNPIFTSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- LZDNBBYBDGBADK-KBPBESRZSA-N Val-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](N)C(C)C)C(O)=O)=CNC2=C1 LZDNBBYBDGBADK-KBPBESRZSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- VGGKJZKLPHEVPU-UHFFFAOYSA-K [Ag](Cl)(Cl)Cl.C(CC(O)(C(=O)O)CC(=O)O)(=O)O Chemical compound [Ag](Cl)(Cl)Cl.C(CC(O)(C(=O)O)CC(=O)O)(=O)O VGGKJZKLPHEVPU-UHFFFAOYSA-K 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Substances OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- YPJKMVATUPSWOH-UHFFFAOYSA-N nitrooxidanyl Chemical compound [O][N+]([O-])=O YPJKMVATUPSWOH-UHFFFAOYSA-N 0.000 description 1
- 239000012875 nonionic emulsifier Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 229960002901 sodium glycerophosphate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical group 0.000 description 1
- ZRVUAXXSASAVFG-QRPNPIFTSA-M sodium;(2s)-2-amino-3-phenylpropanoate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CC1=CC=CC=C1 ZRVUAXXSASAVFG-QRPNPIFTSA-M 0.000 description 1
- REULQIKBNNDNDX-UHFFFAOYSA-M sodium;2,3-dihydroxypropyl hydrogen phosphate Chemical compound [Na+].OCC(O)COP(O)([O-])=O REULQIKBNNDNDX-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0091—Complexes with metal-heteroatom-bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L101/00—Compositions of unspecified macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明属于抗菌技术领域,具体涉及一种抗菌用银离子化合物,还涉及一种无刺激性银离子抗菌剂及其制备方法、应用。本发明的抗菌用银离子化合物中阳离子为银离子和氨基酸配体形成的配位阳离子,所述氨基酸配体选自氨基酸和/或多肽,阴离子选自乙酸根、磷酸氢根、磷酸二氢根、甘油磷酸氢根、甘油磷酸根、乳酸根、乙醇酸根、酒石酸根、柠檬酸根、苹果酸根中的一种或多种。本发明的抗菌用银离子化合物具有良好的稳定性和配伍性,长期放置不会产生分解变色,没有不良气味,耐盐性良好,并且无刺激。以本发明的抗菌用银离子化合物为活性成分制成的抗菌液、抗菌凝胶等抗菌剂具有较好的抗菌性,并且无刺激性,可与人体直接接触。
Description
技术领域
本发明属于抗菌技术领域,具体涉及一种抗菌用银离子化合物,还涉及一种无刺激性银离子抗菌剂及其制备方法、应用。
背景技术
消毒抗菌制品能够有效杀死自然界中有害细菌、真菌和病毒等微生物,有效保障了人类的健康,因此消毒抗菌制品已成为人民生活中不可缺少的一部分。消毒抗菌制品按照自然属性可以分为天然抗菌剂、有机抗菌剂和无机抗菌剂。银离子具有极强的杀菌性能,并且对人毫无伤害,因此银系杀菌剂是一种常用的无机杀菌剂。银系抗菌剂中银有纳米银单质和银离子两种存在形式,其中纳米银单质同样是通过转化为银离子来发挥抗菌作用的,因此当银以银离子形式存在时抗菌效果较好。
目前,银离子的来源基本都是硝酸银的水溶液,有些简单的银离子抗菌剂是直接以硝酸银溶液为原液制成。以硝酸银为原料制成的银离子抗菌剂,存在以下问题:硝酸银不稳定,在久置后会发生分解反应从而使得银离子的抗菌效果降低;硝酸根对皮肤具有刺激性,对伤口愈合也不利,不利于在护肤化妆品中的应用。另外,含有银离子的抗菌剂应用在凝胶、敷料以及织物中形成抗菌产品时,在紫外线照射下银离子易被还原形成黑色银沉淀,不仅影响外观更影响抗菌效果。
为提高银离子的稳定性,常采用氨水与硝酸银形成银氨络合离子,但是银氨络合离子的氨味重并且耐盐性差;目前市场上出现了无硝酸根的电解银抗菌剂,但是其中银离子浓度较低,抗菌效果较差。
发明内容
本发明的目的在于提供一种抗菌用银离子化合物,该抗菌用银离子化合物具有较好的稳定性并且无刺激。
本发明的目的还在于提供一种无刺激性银离子抗菌剂,该抗菌剂无刺激并且具有较好的抗菌效果。
本发明的目的还在于提供一种上述无刺激性银离子抗菌剂的制备方法。
本发明的目的还在于提供一种上述无刺激性银离子抗菌剂在护肤化妆品中的应用。
为实现上述目的,本发明采用的技术方案为:
一种抗菌用银离子化合物,其阳离子为银离子和氨基酸配体形成的配位阳离子,所述氨基酸配体选自氨基酸和/或多肽,阴离子选自乙酸根、磷酸氢根、磷酸二氢根、甘油磷酸氢根、甘油磷酸根、乳酸根、乙醇酸根、酒石酸根、柠檬酸根、苹果酸根中的一种或多种。
本发明抗菌用银离子化合物的结构式为[(Ag)mAn]X,其中A为氨基酸配体,X为阴离子,m是X的负电荷数;n是银离子的配体数,不同的氨基酸n不同。氨基酸配体中,所用氨基酸为常用的氨基酸小分子如甘氨酸中的一种或多种,所用多肽为氨基酸个数为2~5的多肽中的一种或多种。氨基酸配体与银离子进行配位时,多是其中的氮原子和/或氧原子与银离子进行配位。当氮原子和氧原子同时与银离子形成配位时,形成多原子配位的螯合银离子,配体数根据具体配位分子而定。
本发明的抗菌用银离子化合物中,所用甘油磷酸氢根的化学式为(HPO3OCH2CH2OHCH2OH)-,所用甘油磷酸根的化学式为(PO3OCH2CH2OHCH2OH)2-。
本发明的抗菌用银离子化合物中,银离子与氨基酸配体配位形成的配位阳离子能够发挥银离子的抗菌性,并且具有较好的稳定性,不易分解变色。本发明的抗菌用银离子化合物中的阴离子均无毒、无刺激,甚至有的对人体有益,从而使得本发明的抗菌用银离子化合物在使用时对人体无刺激性。因此本发明的抗菌用银离子化合物具有良好的稳定性和配伍性,长期放置不会产生分解变色,没有不良气味和刺激性,耐盐性良好。
在采用本发明的抗菌用银离子化合物时,其具体的存在形式可以根据实际需要而定,如可以是溶液,或可将其负载于一些固体载体,或可分散于其他材料如塑料中。
本发明的无刺激性银离子抗菌剂采用的技术方案为:
一种无刺激性银离子抗菌剂,其活性成分为抗菌用银离子化合物,抗菌用银离子化合物中的阳离子为银离子和氨基酸配体形成的配位阳离子,所述氨基酸配体选自氨基酸和/或多肽,阴离子选自乙酸根、磷酸氢根、磷酸二氢根、甘油磷酸氢根、甘油磷酸根、乳酸根、乙醇酸根、酒石酸根、柠檬酸根、苹果酸根中的一种或多种。
优选的,所用多肽为所述多肽为二肽、三肽、四肽、五肽中的一种或多种。
本发明的无刺激性银离子抗菌剂以上述抗菌用银离子化合物为活性成分,在具有较好的抗菌效果同时对皮肤无刺激。
为适应不同的使用需求,本发明的无刺激性银离子抗菌剂能够制成多种制剂。
优选的,本发明的无刺激性银离子抗菌剂为抗菌液,抗菌液为抗菌用银离子化合物的水溶液。优选的,抗菌液中银离子的质量浓度为0.001~0.65%。进一步优选的,所述抗菌液中银离子的质量浓度为0.06~0.65%。
当银离子质量浓度为0.03~0.65%时,银离子质量浓度较高,抗菌液可作为浓缩液经过稀释后使用。当银离子质量浓度为0.001~0.002%时,抗菌液可直接用于人体抗菌。本发明中的银离子的质量浓度是指体系中银离子的总量。
另外,在抗菌液中还可以添加起一些现有的抗菌液常用的添加剂如乙醇、过氧化氢、过氧乙酸等物质。
优选的,本发明的无刺激性银离子抗菌剂为抗菌凝胶,抗菌凝胶包括凝胶载体和负载在凝胶载体上的活性成分,其中凝胶载体主要由水溶性高分子形成,活性成分即为本发明的抗菌用银离子化合物。
优选的,所述抗菌凝胶中银离子的浓度为10~20ppm。
所用水溶性高分子为制备凝胶材料常用的高分子材料,优选的,所述水溶性高分子为卡波姆、明胶、海藻酸钠、干酪素、瓜尔胶、甲壳胺、阿拉伯树胶、黄原胶、甲基纤维素、羧甲基纤维素、羟乙基纤维素、羟丙基甲基纤维素中的一种或多种。
抗菌凝胶中还可以添加有其他凝胶类材料常用的添加
本发明的无刺激性银离子抗菌剂的制备方法采用的技术方案为:
一种上述无刺激性银离子抗菌剂的制备方法,包括以下步骤:难溶性银盐、配体盐于水中进行配位反应;所述难溶性盐为乙酸银、磷酸氢银、磷酸二氢银、甘油磷酸氢银、甘油磷酸银、乳酸银、乙醇酸银、酒石酸银、柠檬酸银、苹果酸银中的一种或多种;所述配体盐为氨基酸盐和/或多肽盐。
本发明的无刺激性银离子抗菌剂的制备方法简单,有利于大规模生产。
其中难溶性银盐可以为市售产品,也可以为自行合成。优选的,难溶性银盐由能使银离子沉淀的水溶性盐与硝酸银反应形成;所述水溶性盐中阳离子为钠离子、钾离子、铵离子中的一种,阴离子为乙酸根、磷酸氢根、磷酸二氢根、甘油磷酸氢根、甘油磷酸根、乳酸根、乙醇酸根、酒石酸根、柠檬酸根、苹果酸根中的一种。如能使银离子沉淀的水溶性盐为甘油磷酸氢钠,其化学式为NaHPO3OCH2CH2OHCH2OH。硝酸银为常见的市售试剂,以硝酸银为原料提供银离子,成本较低;水溶性盐使硝酸银中的银离子沉淀形成难溶性银盐,从而除去了刺激性的硝酸根。
反应时间可根据各原料的实际用量进行调整。优选的,所述反应时间为1~3h。
上述难溶性银盐是指在水中溶解度很小的银盐。水溶性盐与硝酸银在水中反应形成难溶性银盐。难溶性银盐的合成以及与氨基酸配位反应涉及的反应为:
MmX+mAgNO3→(Ag)mX↓+mMNO3
(Ag)mX+nA→[(Ag)mAn]X
其中,MmX为水溶性盐,其中M为钠离子、钾离子、铵离子中的一种;X为乙酸根、磷酸氢根、磷酸二氢根、甘油磷酸氢根、甘油磷酸根、乳酸根、乙醇酸根、酒石酸根、柠檬酸根、苹果酸根。m是X的负电荷,(Ag)mX即为难溶性银盐,A表示氨基酸配体,n是银离子的配体数,不同的氨基酸配体n不同。
所述难溶性银盐中的银离子、配体盐的摩尔比为(2.5~3.5):(6.5~7.5)。优选的,所述难溶性银盐中的银离子与氨基酸的摩尔比为3:7。
难溶性银盐、氨基酸盐于水中反应后得到的无刺激性银离子抗菌剂为抗菌液。向反应后的体系中加入水溶性高分子混合均匀,然后调节pH值即可得到抗菌凝胶。
本发明的无刺激性银离子抗菌剂的应用的技术方案为:
一种上述无刺激性银离子抗菌剂在抑菌制剂、护肤化妆品以及抗菌塑料中的应用。
本发明的无刺激性银离子抗菌剂对人体皮肤无刺激,可与人体密切接触。因此本发明的无刺激性抗菌剂如抗菌液可以加入到现有的抑菌制剂中提升抗菌效果;还可以加入到到洗面奶、洁肤乳液等护肤化妆品的基础料中,从而使得护肤化妆品具有抗菌性。
当本发明的无刺激性银离子抗菌剂应用与护肤化妆品如精华液、乳液、霜膏时,可将其与非离子乳化剂复配使用。
具体实施方式
下面结合具体实施例对本发明进一步说明。
一、抗菌用银离子化合物的实施例
实施例1
本实施例的抗菌用银离子化合物为醋酸甘氨酸合银,阳离子为银离子和甘氨酸配体形成的配位阳离子,阴离子为乙酸根。本实施例的抗菌用银离子化合物的制备方法为:将0.03mol的醋酸银与过量的甘氨酸钠水溶液(甘氨酸钠水溶液由0.07mol的甘氨酸和质量浓度为20%的氢氧化钠水溶液中和形成)混合反应2h后,然后蒸发浓缩,即得。
实施例2
本实施例的抗菌用银离子化合物为甘油磷酸苏氨酸合银,阳离子为银离子和苏氨酸配体形成的配位阳离子,阴离子为甘油磷酸根。其制备方法参照实施例1中的制备过程,区别仅在于将甘氨酸钠替换为苏氨酸钠,将醋酸银替换为甘油磷酸银。
实施例3
本实施例的抗菌用银离子化合物为磷酸二氢苯丙氨酸合银,阳离子为银离子和苯丙氨酸配体形成的配位阳离子,阴离子为磷酸二氢根。其制备方法参照实施例1中的制备过程,区别仅在于将甘氨酸钠替换为苯丙氨酸钠,将醋酸银替换为磷酸二氢银。
实施例4
本实施例的抗菌用银离子化合物为柠檬酸组氨酸合银,阳离子为银离子和组氨酸形成的配位阳离子,阴离子为柠檬酸根。其制备方法参照实施例1中的制备过程,区别仅在于将甘氨酸钠替换为组氨酸钠,将0.03mol醋酸银替换0.01mol的为柠檬酸银(为柠檬酸三银)。
实施例5
本实施例的抗菌用银离子化合物为乙醇酸二肽合银,阳离子为银离子和二肽(缬氨酰色氨酸,CAS号24587-37-9)配体形成的配位阳离子,阴离子为乙醇酸根。其制备方法参照实施例1中的制备过程,区别仅在于将甘氨酸钠替换为二肽钠盐,将醋酸银替换为乙醇酸银。
二、无刺激性银离子抗菌剂的实施例
实施例6
本实施例的无刺激性银离子抗菌剂为抗菌液,其中银离子的质量浓度为0.3231%(3231ppm)。具体由以下方法制得:将0.03mol的乙酸银加入到含甘氨酸钠的溶液中(由0.07mol的甘氨酸酸与质量浓度为20%的氢氧化钠水溶液中和形成),然后稀释至1000g,即得。
实施例7
本实施例的无刺激性银离子抗菌剂为抗菌液,其中银离子的质量浓度为0.6472%(6472ppm)。具体由以下方法制得:将0.03mol的甘油磷酸银加入到含苏氨酸钠的溶液(由0.14mol的苏氨酸与质量浓度为20%的氢氧化钠水溶液中和形成)中,然后稀释,即得。
实施例8
本实施例的无刺激性银离子抗菌剂为抗菌液,其中银离子的质量浓度为0.3238%(3238ppm)。具体由以下方法制得:将0.03mol的磷酸二氢银加入到含苯丙氨酸钠的溶液(由0.07mol的苯丙氨酸与质量浓度为20%的氢氧化钠水溶液中和形成)中,然后稀释至1000g,即得。
实施例9
本实施例的无刺激性银离子抗菌剂为抗菌液,其中银离子的质量浓度为0.0647%(647ppm)。具体由以下方法制得:将0.01mol的柠檬三银加入到组氨酸钠的溶液(由0.07mol的苏氨酸与质量浓度为20%的氢氧化钠水溶液中和形成)中,然后稀释至5000g,即得。
实施例10
本实施例的无刺激性银离子抗菌剂为抗菌液,其中银离子的质量浓度为0.6474%(6474ppm)。具体由以下方法制得:将0.03mol的磷酸二氢银加入到含二肽钠的溶液(由0.07mol的二肽与质量浓度为20%的氢氧化钠水溶液中和形成)中,然后稀释至500g,即得。
三、无刺激性银离子抗菌剂的制备方法的实施例
实施例11
本实施例为实施例6的抗菌液的制备方法,包括以下步骤:
将5.3g甘氨酸(0.07mol)溶于400mL水中,在搅拌下滴加质量浓度为20%的氢氧化钠水溶液进行中和,在搅拌下将醋酸银粉末5g(0.03mol)徐徐加入到上述溶液中,反应2h结束,再稀释到1000g,形成银离子质量浓度为0.3231%(3231ppm)的醋酸甘氨酸合银溶液。
实施例12
本实施例为实施例7的抗菌液的制备方法,其过程基本与实施例11相同,区别仅在于:将甘氨酸替换为苏氨酸(0.14mol),将醋酸银替换为8.37g甘油磷酸银粉末,得银离子质量浓度为0.6472%(6472ppm)的甘油磷酸苏氨酸合银溶液。
实施例13
本实施例为实施例8的抗菌液的制备方法,其过程基本与实施例11相同,区别仅在于:将甘氨酸替换为12.61g苯丙氨酸,将醋酸银替换为6.15g磷酸二氢银,得银离子质量浓度为0.3238%(3238ppm)的磷酸二氢苯并氨酸合银溶液。
实施例14
本实施例为实施例9的抗菌液的制备方法,包括以下步骤:将10.86g组氨酸(0.07mol)溶于400mL水中,在搅拌下滴加质量浓度为20%的氢氧化钠水溶液进行中和;之后在搅拌下将柠檬酸三银粉末5.127g(银离子为0.03mol)徐徐加入到上述溶液中,反应2h结束,再稀释到5000g,形成得银离子质量浓度为0.0647%(647ppm)的柠檬酸组氨酸酸合银溶液。
实施例15
本实施例为实施例10的抗菌液的制备方法,包括以下步骤:将21.24g二肽(0.07mol)溶于400mL水中,在搅拌下滴加质量浓度为20%的氢氧化钠水溶液进行中和;之后在搅拌下将乙醇酸银粉末5.49g徐徐加入到上述溶液中,反应2h结束,再稀释到500g,得银离子质量浓度为0.6474%(6474ppm)的乙醇酸二肽合银溶液。
四、本发明的无刺激性抗菌剂的应用在以下实施例中体现:
实施例16
将实施例12中得到的醋酸甘氨酸合银溶液稀释至银离子浓度为40ppm,然后取500mL在搅拌下加入到500g质量浓度为8%的卡波姆水溶液中,然后用质量浓度为10%的氢氧化钠溶液调节pH至5~6,即得抗菌凝胶。
实施例17
将实施例6~10的抗菌液分别进行稀释,将其中银离子的质量浓度稀释到10ppm,即可作为日常个人消毒剂使用。
实施例18
将实施例6~10的抗菌液分别进行稀释,先将其中银离子的质量浓度稀释到200ppm,然后取500g与浓度为30%的双氧水33.33g混合均匀并加水稀释至1000g,得混合溶液(其中银离子浓度为100ppm,双氧水的浓度为1000ppm)。该混合液可作为公共场所的消毒剂。
实施例19
取实施例10中的抗菌液1.52g,在搅拌条件下加入到1公斤的洗面奶中,即得抗菌洗面奶。
实施例20
取实施例6~10中的任意一种抗菌液与纳米碳酸钙混合,使其中银离子质量浓度为0.04%,干燥成粉体并取20重量份与塑料80重量份熔融混合,形成的塑料制品含银离子80ppm。
五、试验例部分
实施例1
将实施例6~10的抗菌液分别稀释至银离子质量浓度为100ppm,然后置于37℃恒温恒湿箱储存90d后,经火焰收分光光度法检测主要有效成分银含量。与保存前比较,有效成分下降率仅为3.5%。
试验例2
将6~10实施例的抗菌液稀释至银离子的质量浓度为10ppm,按照《消毒剂技术规范》2.1.8.2进行抗菌测试,结果表明本发明制成的无刺激性抗菌剂对大肠杆菌和金黄色葡萄球菌的抗菌率均大于99%。
Claims (9)
1.一种抗菌用银离子化合物,其特征在于,所述抗菌用银离子化合物的阳离子为银离子和氨基酸配体形成的配位阳离子,所述氨基酸配体选自氨基酸和/或多肽,阴离子选自乙酸根、磷酸氢根、磷酸二氢根、甘油磷酸氢根、甘油磷酸根、乳酸根、乙醇酸根、酒石酸根、柠檬酸根、苹果酸根中的一种或多种。
2.一种无刺激性银离子抗菌剂,其特征在于,其活性成分为抗菌用银离子化合物,所述抗菌用银离子化合物的阳离子为银离子和氨基酸配体形成的配位阳离子,所述氨基酸配体选自氨基酸和/或多肽,阴离子选自乙酸根、磷酸氢根、磷酸二氢根、甘油磷酸氢根、甘油磷酸根、乳酸根、乙醇酸根、酒石酸根、柠檬酸根、苹果酸根中的一种或多种。
3.根据权利要求2所述的无刺激性银离子抗菌剂,其特征在于,所述多肽为二肽、三肽、四肽、五肽中的一种或多种。
4.根据权利要求2或3所述的无刺激性银离子抗菌剂,其特征在于,所述无刺激性银离子抗菌剂为抗菌液,抗菌液为抗菌用银离子化合物的水溶液,所述抗菌液中银离子的质量浓度为0.001~0.65%。
5.根据权利要求2或3所述的无刺激性银离子抗菌剂,其特征在于,所述无刺激性银离子抗菌剂为抗菌凝胶,所述抗菌凝胶包括凝胶载体和负载在凝胶载体上的所述活性成分,所述凝胶载体主要由水溶性高分子形成。
6.根据权利要求5所述的无刺激性银离子抗菌剂,其特征在于,所述水溶性高分子为卡波姆、明胶、海藻酸钠、干酪素、瓜尔胶、甲壳胺、阿拉伯树胶、黄原胶、甲基纤维素、羧甲基纤维素、羟乙基纤维素、羟丙基甲基纤维素中的一种或多种。
7.一种如权利要求2~6任一项所述的无刺激性银离子抗菌剂的制备方法,其特征在于,包括以下步骤:难溶性银盐、配体盐于水中进行配位反应;所述难溶性盐为乙酸银、磷酸氢银、磷酸二氢银、甘油磷酸氢银、甘油磷酸银、乳酸银、乙醇酸银、酒石酸银、柠檬酸银、苹果酸银中的一种或多种;所述配体盐为氨基酸盐和/或多肽盐。
8.根据权利要求7所述的无刺激性银离子抗菌剂的制备方法,所述难溶性银盐中的银离子、配体盐的摩尔比为(2.5~3.5):(6.5~7.5)。
9.一种如权利要求2~6任一项所述的无刺激性银离子抗菌剂在抑菌制剂、护肤化妆品以及抗菌塑料中的应用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010358860.8A CN111484421A (zh) | 2020-04-29 | 2020-04-29 | 一种抗菌用银离子化合物,无刺激性银离子抗菌剂及其制备方法、应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010358860.8A CN111484421A (zh) | 2020-04-29 | 2020-04-29 | 一种抗菌用银离子化合物,无刺激性银离子抗菌剂及其制备方法、应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN111484421A true CN111484421A (zh) | 2020-08-04 |
Family
ID=71791885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010358860.8A Pending CN111484421A (zh) | 2020-04-29 | 2020-04-29 | 一种抗菌用银离子化合物,无刺激性银离子抗菌剂及其制备方法、应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111484421A (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112174987A (zh) * | 2020-10-12 | 2021-01-05 | 洛阳冠银生物科技有限公司 | 一种可溶性含银离子可聚合单体及其制备方法、含银聚合物、抗菌涂料 |
CN112868665A (zh) * | 2021-01-13 | 2021-06-01 | 东莞市八谷生物技术有限公司 | 一种含超分子银的消毒剂及其制备方法 |
CN114532359A (zh) * | 2021-04-22 | 2022-05-27 | 北京洁尔爽高科技有限公司 | 一种稳定组合物及其应用和含该组合物的产品 |
Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11155934A (ja) * | 1997-11-27 | 1999-06-15 | Fujikura Rubber Ltd | 抗菌性ゴム部品 |
JP2000016905A (ja) * | 1998-07-01 | 2000-01-18 | Tokuriki Kagaku Kenkyusho:Kk | 抗菌抗かび剤および抗菌抗かび材料 |
US6242009B1 (en) * | 1999-04-20 | 2001-06-05 | Kareem I. Batarseh | Microbicidal formulations and methods to control microorganisms |
CN101003490A (zh) * | 2007-02-06 | 2007-07-25 | 中国医学科学院医药生物技术研究所 | 硝酸氨基酸螯合银及其制备方法和用途 |
CN101016249A (zh) * | 2007-02-28 | 2007-08-15 | 北京科技大学 | β-肾上腺素激动剂莱克多巴胺的合成方法 |
CN101036623A (zh) * | 2006-03-17 | 2007-09-19 | 株式会社优丽可 | 利用光能的单剂型染发料 |
JP2011195582A (ja) * | 2010-02-25 | 2011-10-06 | Nippon Soda Co Ltd | 抗菌、殺菌若しくは抗ウイルス性組成物 |
CN102718330A (zh) * | 2012-05-31 | 2012-10-10 | 重庆安碧捷生物科技有限公司 | 环保型有机银复合循环水处理剂及其应用 |
CN103563983A (zh) * | 2012-07-24 | 2014-02-12 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种纳米银过氧化物复合杀菌液及其制备方法 |
CN104944537A (zh) * | 2015-06-17 | 2015-09-30 | 何素梅 | 一种水产养殖杀菌剂 |
JP2016204309A (ja) * | 2015-04-23 | 2016-12-08 | 株式会社ネオス | 液状抗菌剤組成物及びその製造方法並びに抗菌処理方法 |
CN106517107A (zh) * | 2016-08-08 | 2017-03-22 | 苏州影睿光学科技有限公司 | 一种水相近红外纳米颗粒的制备方法 |
CN106745185A (zh) * | 2016-12-23 | 2017-05-31 | 中南大学 | 一种形貌可控的硫化银的制备方法 |
CN110150316A (zh) * | 2019-06-02 | 2019-08-23 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种纳米银/次氯化物复合杀菌液的制备方法 |
-
2020
- 2020-04-29 CN CN202010358860.8A patent/CN111484421A/zh active Pending
Patent Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11155934A (ja) * | 1997-11-27 | 1999-06-15 | Fujikura Rubber Ltd | 抗菌性ゴム部品 |
JP2000016905A (ja) * | 1998-07-01 | 2000-01-18 | Tokuriki Kagaku Kenkyusho:Kk | 抗菌抗かび剤および抗菌抗かび材料 |
US6242009B1 (en) * | 1999-04-20 | 2001-06-05 | Kareem I. Batarseh | Microbicidal formulations and methods to control microorganisms |
CN101036623A (zh) * | 2006-03-17 | 2007-09-19 | 株式会社优丽可 | 利用光能的单剂型染发料 |
CN101003490A (zh) * | 2007-02-06 | 2007-07-25 | 中国医学科学院医药生物技术研究所 | 硝酸氨基酸螯合银及其制备方法和用途 |
CN101016249A (zh) * | 2007-02-28 | 2007-08-15 | 北京科技大学 | β-肾上腺素激动剂莱克多巴胺的合成方法 |
JP2011195582A (ja) * | 2010-02-25 | 2011-10-06 | Nippon Soda Co Ltd | 抗菌、殺菌若しくは抗ウイルス性組成物 |
CN102718330A (zh) * | 2012-05-31 | 2012-10-10 | 重庆安碧捷生物科技有限公司 | 环保型有机银复合循环水处理剂及其应用 |
CN103563983A (zh) * | 2012-07-24 | 2014-02-12 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种纳米银过氧化物复合杀菌液及其制备方法 |
JP2016204309A (ja) * | 2015-04-23 | 2016-12-08 | 株式会社ネオス | 液状抗菌剤組成物及びその製造方法並びに抗菌処理方法 |
CN104944537A (zh) * | 2015-06-17 | 2015-09-30 | 何素梅 | 一种水产养殖杀菌剂 |
CN106517107A (zh) * | 2016-08-08 | 2017-03-22 | 苏州影睿光学科技有限公司 | 一种水相近红外纳米颗粒的制备方法 |
CN106745185A (zh) * | 2016-12-23 | 2017-05-31 | 中南大学 | 一种形貌可控的硫化银的制备方法 |
CN110150316A (zh) * | 2019-06-02 | 2019-08-23 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种纳米银/次氯化物复合杀菌液的制备方法 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112174987A (zh) * | 2020-10-12 | 2021-01-05 | 洛阳冠银生物科技有限公司 | 一种可溶性含银离子可聚合单体及其制备方法、含银聚合物、抗菌涂料 |
CN112174987B (zh) * | 2020-10-12 | 2023-05-30 | 洛阳冠银生物科技有限公司 | 一种可溶性含银离子可聚合单体及其制备方法、含银聚合物、抗菌涂料 |
CN112868665A (zh) * | 2021-01-13 | 2021-06-01 | 东莞市八谷生物技术有限公司 | 一种含超分子银的消毒剂及其制备方法 |
CN112868665B (zh) * | 2021-01-13 | 2022-03-15 | 东莞市八谷生物技术有限公司 | 一种含超分子银的消毒剂及其制备方法 |
CN114532359A (zh) * | 2021-04-22 | 2022-05-27 | 北京洁尔爽高科技有限公司 | 一种稳定组合物及其应用和含该组合物的产品 |
CN114532359B (zh) * | 2021-04-22 | 2024-01-30 | 北京洁尔爽高科技有限公司 | 一种稳定组合物及其应用和含该组合物的产品 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN111484421A (zh) | 一种抗菌用银离子化合物,无刺激性银离子抗菌剂及其制备方法、应用 | |
US3930000A (en) | Silver-zinc allantoinate compositions and method of killing bacteria and fungi therewith | |
US5407656A (en) | Method and compositions for the production of chlorine dioxide | |
JP3055796B2 (ja) | 殺菌消毒剤組成物 | |
US3830908A (en) | Anti-microbial compositions utilizing allantoin compounds and complexes | |
CA2733509C (en) | Antimicrobial silver solutions | |
US3856805A (en) | Silver zinc allantoin complex | |
US5616347A (en) | Chlorine dioxide skin medicating compositions for preventing irritation | |
JP2004510794A (ja) | 新規抗菌剤およびそのような抗菌剤を含有する抗菌脱臭性溶液 | |
US3830825A (en) | Zinc sulf-hydroxy allantoinate | |
CN102670648B (zh) | 液态碘消毒制剂、制备方法及使用的容器 | |
CN111820240A (zh) | 一种基于纳米金属丝的抗菌消毒添加剂及其制备方法 | |
CN102688257A (zh) | 一种液态分子碘消毒制剂、制备方法及使用的容器 | |
JPS6328403B2 (zh) | ||
CA2426988A1 (en) | Multicomponent compositions containing chitosan and methods of preparing same | |
US6303111B1 (en) | Nontoxic biocompatible deodorizing compositions | |
CN108623706A (zh) | 微波和络合协同氧化制备壳寡糖-铜络合物的方法 | |
EP0275207B1 (en) | Pharmaceutical and veterinary compositions | |
JPH08109106A (ja) | 植物成長促進剤 | |
CN110463721A (zh) | 一种基于过氧化氢的消毒灭菌剂及其制备方法 | |
CN109893539B (zh) | 一种复合抗菌气雾剂及其制备方法 | |
CN115671135A (zh) | 一种次碘酸离子、碘三阴离子溶液的制备方法及其应用 | |
US2906761A (en) | Argentiferous germicidal medium and process for making same | |
DE894896C (de) | Silberhaltige keimtoetende Mittel | |
JP3239079B2 (ja) | 切り花延命剤及び切り花延命法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200804 |
|
RJ01 | Rejection of invention patent application after publication |