CN111467475A - Pharmaceutical composition for increasing laying rate of laying hens and preparation and application thereof - Google Patents

Pharmaceutical composition for increasing laying rate of laying hens and preparation and application thereof Download PDF

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CN111467475A
CN111467475A CN202010469175.2A CN202010469175A CN111467475A CN 111467475 A CN111467475 A CN 111467475A CN 202010469175 A CN202010469175 A CN 202010469175A CN 111467475 A CN111467475 A CN 111467475A
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parts
pharmaceutical composition
powder
semen
laying
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郭万恒
郭金皋
田勇
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Shijiazhuang Hengtaihe Animal Pharmacy Co ltd
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Shijiazhuang Hengtaihe Animal Pharmacy Co ltd
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
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Abstract

The invention discloses a pharmaceutical composition for improving the laying rate of laying hens, which comprises the following components in parts by weight: 30-90 parts of cortex lycii radicis, 30-60 parts of cortex mori radicis, 15-30 parts of semen euryales, 9-18 parts of polygala tenuifolia, 9-18 parts of semen plantaginis salted, 3-9 parts of semen lepidii, 15-30 parts of cyclodipeptide powder, 9-18 parts of fishbone powder, 0.05-0.5 part of calcium pantothenate and 0.5-5 parts of inositol. The invention exerts the synergistic effect among the medicines, nourishes essence and blood, activates and nourishes yin blood, has the effects of activating blood, warming kidney, strengthening spleen and stomach, invigorating qi and blood and making reproductive system younger for poultry, and can effectively improve the laying rate.

Description

Pharmaceutical composition for increasing laying rate of laying hens and preparation and application thereof
Technical Field
The invention relates to the technical field related to livestock breeding, in particular to a functionalized veterinary traditional Chinese medicine composition, a preparation process and an application method thereof.
Background
With the improvement of living standard, the health care consciousness of people is gradually enhanced, the people are sublimated when pursuing the living idea, return to nature and return to nature, and the requirements on food structure, nutritive value and food safety are higher and higher; people urgently need green livestock and poultry products which are free of pollution, residue, public nuisance, carcinogenesis, teratogenesis and mutation, natural and environment-friendly. How to reduce or not use chemical, synthetic, hormone and antibiotic medicines and ensure the breeding and production of pollution-free, green, environment-friendly and safe eggs becomes an important problem to be solved by urgent needs of livestock raising, veterinarians and breeding enterprises. In order to get rid of the harm of diseases and animal food residues to human beings, people use Chinese herbal medicines as additives to solve the trouble and worry of food safety.
Eggs are common food for residents in China and are important sources for protein intake of human bodies. The laying hens have the unique physiological characteristics of high body temperature, vigorous basal metabolism and rapid digestion, absorption and excretion of the feed. Laying hens are under the stress of cage culture, continuous ovulation and egg laying, so that a large amount of free radicals are generated in the bodies. Although a proper amount of free radicals have the functions of killing germs and regulating immunity, excessive free radicals can generate superoxide reaction on biological macromolecules, so that the change of cell structures and functions is caused, and the important reason for causing many diseases is that the excessive free radicals can generate superoxide reaction on the biological macromolecules. This further causes a problem of low laying rate, resulting in a vicious circle. For a long time, laying hen breeding relies on a farmer free-range mode. The free-ranging scale is small, the number is small, and the market demand cannot be met. The laying hen breeding is developed in a large-scale and intensive breeding mode. However, the traditional breeding technology cannot meet the requirement of large-scale breeding, and the disease prevention consciousness of farmers is weak, so that the types of epidemic diseases of the laying hens are increased, the disease condition is complicated, and the disease is difficult to prevent and treat. In order to reduce the occurrence of diseases and promote the growth and the laying rate, the addition of medicines such as chemistry, synthesis, hormone, antibiotics, trace elements and the like into the feed becomes an accessory means; in addition, the clinical use of drugs is inappropriate, and the large dose and the repeated use are very common, so that the drug resistance and the drug resistance of pathogenic microorganisms are continuously enhanced; the clinical manifestations of acute morbidity, quick infection, mixed infection, poor treatment effect and high mortality rate often cause serious cachexia that diagnosis is difficult to make and effective prevention and control measures are taken in time; meanwhile, the quality of eggs is difficult to guarantee.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition for improving the laying rate of laying hens and preparation and application thereof.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows.
A pharmaceutical composition for improving the laying rate of laying hens comprises the following components in parts by weight: 30-90 parts of cortex lycii radicis, 30-60 parts of cortex mori radicis, 15-30 parts of semen euryales, 9-18 parts of polygala tenuifolia, 9-18 parts of semen plantaginis salted, 3-9 parts of semen lepidii, 15-30 parts of cyclodipeptide powder, 9-18 parts of fishbone powder, 0.05-0.5 part of calcium pantothenate and 0.5-5 parts of inositol.
As a preferable technical scheme of the invention, the pharmaceutical composition comprises the following components in parts by weight: 45-75 parts of cortex lycii radicis, 45-75 parts of cortex mori radicis, 18-28 parts of semen euryales, 12-16 parts of polygala tenuifolia, 12-16 parts of semen plantaginis salted, 4-8 parts of semen lepidii, 18-28 parts of cyclodipeptide powder, 12-16 parts of fishbone powder, 0.1-0.3 part of calcium pantothenate and 1-3 parts of inositol.
As a preferable technical scheme of the invention, the pharmaceutical composition comprises the following components in parts by weight: 60 parts of cortex lycii radicis, 45 parts of cortex mori radicis, 22 parts of semen euryales, 13.5 parts of polygala tenuifolia, 13.5 parts of salted plantain seed, 6 parts of semen lepidii, 22 parts of cyclodipeptide powder, 13.5 parts of fishbone powder, 0.2 part of calcium pantothenate and 2 parts of inositol.
As a preferable technical scheme of the invention, the pharmaceutical composition comprises the following components in parts by weight: 48 parts of cortex lycii radicis, 55 parts of cortex mori radicis, 25 parts of semen euryales, 12 parts of polygala tenuifolia, 14 parts of semen plantaginis preparata, 5 parts of semen lepidii, 24 parts of cyclodipeptide powder, 13 parts of fishbone powder, 0.2 part of calcium pantothenate and 1.5 parts of inositol.
As a preferable technical scheme of the invention, the pharmaceutical composition comprises the following components in parts by weight: 70 parts of cortex lycii radicis, 48 parts of cortex mori radicis, 28 parts of semen euryales, 15 parts of polygala tenuifolia, 13 parts of semen plantaginis preparata, 7 parts of semen lepidii, 20 parts of cyclic dipeptide powder, 16 parts of fishbone powder, 0.15 part of calcium pantothenate and 2 parts of inositol.
As a preferable technical scheme of the invention, the pharmaceutical composition comprises the following components in parts by weight: 45 parts of cortex lycii radicis, 45 parts of cortex mori radicis, 18 parts of semen euryales, 12 parts of polygala tenuifolia, 12 parts of semen plantaginis preparata, 4 parts of semen lepidii, 18 parts of cyclodipeptide powder, 12 parts of fishbone powder, 0.1 part of calcium pantothenate and 1 part of inositol.
As a preferable technical scheme of the invention, the pharmaceutical composition comprises the following components in parts by weight: 75 parts of cortex lycii radicis, 75 parts of cortex mori radicis, 28 parts of semen euryales, 16 parts of polygala tenuifolia, 16 parts of semen plantaginis preparata, 8 parts of semen lepidii, 28 parts of cyclodipeptide powder, 16 parts of fishbone powder, 0.3 part of calcium pantothenate and 3 parts of inositol.
A method for preparing a pharmaceutical composition for improving the laying rate of laying hens comprises the steps of weighing the components in parts by weight, directly mixing the components, crushing the mixture into fine powder, sieving the fine powder with a 200-mesh sieve, and preparing the powder.
Adopt the produced beneficial effect of above-mentioned technical scheme to lie in: the traditional Chinese veterinary medicine has the advantages of small toxic and side effects, no drug resistance, difficult residue and the like, is a pure natural medicine which is applied by human beings at first, and plays a great role in preventing and treating diseases of cultured animals, improving the immunity and the anti-stress capability of the cultured animals, promoting growth and development and the like in the veterinary medicine industry as a treasure in the world medical history of Chinese nationality. According to the dialectical view of traditional Chinese medicine, exogenous pathogenic factors are easy to attack in the egg laying process of poultry, and cold, dampness and heat pathogens (including bacteria and viruses) are mainly used, and feed malnutrition and the like can also be generalized in the exogenous range. Environmental emergency factors, which can affect the functional activities of viscera and qi and blood, thus affecting the spiritual mood of livestock and poultry, and affecting the regulation of Chong and ren functions, so called "pathogenic factors due to depression". The thoroughfare vessel and governor vessel are involved in the belt vessels due to the damage of the meridians and collaterals, and the egg laying of birds is reduced if the vessels are not functioning properly. Constitutional factors refer to the intrinsic factors of constitutional weakness, mainly the dysfunction of kidney, liver, heart and spleen, which results in deficiency of both qi and blood, insufficiency of thoroughfare and conception vessels, and insecurity of belt vessels. Imbalance of qi and blood, easy consumption of blood, often causes the body to be in the state of insufficient blood and deficient qi. The zang-fu organs are abnormal in function, mainly involving kidney, liver, heart and spleen. The invention exerts the synergistic effect among the medicines, nourishes essence and blood, activates and nourishes yin and blood, and has the effects of activating blood, warming kidney, strengthening spleen and stomach, invigorating qi and blood and making reproductive system younger for poultry; is nontoxic and harmless to the livestock; is suitable for free-range laying hens after 19 weeks old, and can effectively improve the laying rate.
Detailed Description
The following examples illustrate the invention in detail. The raw materials and various devices used in the invention are conventional commercially available products, and can be directly obtained by market purchase.
In the following description of embodiments, for purposes of explanation and not limitation, specific details are set forth, such as particular system structures, techniques, etc. in order to provide a thorough understanding of the embodiments of the present application. It will be apparent, however, to one skilled in the art that the present application may be practiced in other embodiments that depart from these specific details. In other instances, detailed descriptions of well-known systems, devices, circuits, and methods are omitted so as not to obscure the description of the present application with unnecessary detail.
It will be understood that the terms "comprises" and/or "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It should also be understood that the term "and/or" as used in this specification and the appended claims refers to and includes any and all possible combinations of one or more of the associated listed items.
As used in this specification and the appended claims, the term "if" may be interpreted contextually as "when", "upon" or "in response to" determining "or" in response to detecting ". Similarly, the phrase "if it is determined" or "if a [ described condition or event ] is detected" may be interpreted contextually to mean "upon determining" or "in response to determining" or "upon detecting [ described condition or event ]" or "in response to detecting [ described condition or event ]".
Furthermore, in the description of the present application and the appended claims, the terms "first," "second," "third," and the like are used for distinguishing between descriptions and not necessarily for describing or implying relative importance.
Reference throughout this specification to "one embodiment" or "some embodiments," or the like, means that a particular feature, structure, or characteristic described in connection with the embodiment is included in one or more embodiments of the present application. Thus, appearances of the phrases "in one embodiment," "in some embodiments," "in other embodiments," or the like, in various places throughout this specification are not necessarily all referring to the same embodiment, but rather "one or more but not all embodiments" unless specifically stated otherwise. The terms "comprising," "including," "having," and variations thereof mean "including, but not limited to," unless expressly specified otherwise.
Example 1
A pharmaceutical composition for improving the laying rate of laying hens comprises the following components in parts by weight: 60 parts of cortex lycii radicis, 45 parts of cortex mori radicis, 22 parts of semen euryales, 13.5 parts of polygala tenuifolia, 13.5 parts of salted plantain seed, 6 parts of semen lepidii, 22 parts of cyclodipeptide powder, 13.5 parts of fishbone powder, 0.2 part of calcium pantothenate and 2 parts of inositol.
The preparation method comprises weighing the above materials in parts by weight, directly mixing the above materials, pulverizing into fine powder, sieving with 200 mesh sieve, and making into powder.
Example 2
The present embodiment is different from embodiment 1 in that: the pharmaceutical composition comprises the following components in parts by weight: 48 parts of cortex lycii radicis, 55 parts of cortex mori radicis, 25 parts of semen euryales, 12 parts of polygala tenuifolia, 14 parts of semen plantaginis preparata, 5 parts of semen lepidii, 24 parts of cyclodipeptide powder, 13 parts of fishbone powder, 0.2 part of calcium pantothenate and 1.5 parts of inositol.
The preparation method comprises weighing the above materials in parts by weight, directly mixing the above materials, pulverizing into fine powder, sieving with 200 mesh sieve, and making into powder.
Example 3
The present embodiment is different from embodiment 1 in that: the pharmaceutical composition comprises the following components in parts by weight: 70 parts of cortex lycii radicis, 48 parts of cortex mori radicis, 28 parts of semen euryales, 15 parts of polygala tenuifolia, 13 parts of semen plantaginis preparata, 7 parts of semen lepidii, 20 parts of cyclic dipeptide powder, 16 parts of fishbone powder, 0.15 part of calcium pantothenate and 2 parts of inositol.
The preparation method comprises weighing the above materials in parts by weight, directly mixing the above materials, pulverizing into fine powder, sieving with 200 mesh sieve, and making into powder.
Example 4
The present embodiment is different from embodiment 1 in that: the pharmaceutical composition comprises the following components in parts by weight: 45 parts of cortex lycii radicis, 45 parts of cortex mori radicis, 18 parts of semen euryales, 12 parts of polygala tenuifolia, 12 parts of semen plantaginis preparata, 4 parts of semen lepidii, 18 parts of cyclodipeptide powder, 12 parts of fishbone powder, 0.1 part of calcium pantothenate and 1 part of inositol.
The preparation method comprises weighing the above materials in parts by weight, directly mixing the above materials, pulverizing into fine powder, sieving with 200 mesh sieve, and making into powder.
Example 5
The present embodiment is different from embodiment 1 in that: the pharmaceutical composition comprises the following components in parts by weight: 75 parts of cortex lycii radicis, 75 parts of cortex mori radicis, 28 parts of semen euryales, 16 parts of polygala tenuifolia, 16 parts of semen plantaginis preparata, 8 parts of semen lepidii, 28 parts of cyclodipeptide powder, 16 parts of fishbone powder, 0.3 part of calcium pantothenate and 3 parts of inositol.
The preparation method comprises weighing the above materials in parts by weight, directly mixing the above materials, pulverizing into fine powder, sieving with 200 mesh sieve, and making into powder.
Example 6 safety test
The powder of the pharmaceutical composition of examples 1-5 of the invention is mixed with the feed according to the proportion of 1:100 and evenly stirred, and then the layer chicken is fed with the evenly stirred feed and continuously fed for 14 days, and the layer chicken is normal in ingestion and growth and has no abnormal occurrence. Feeding the mice with the uniformly mixed feed, continuously feeding and observing for 14 days, wherein death and abnormal toxic reaction are not found in the test period, and after the test is finished, dissecting the test mice, and observing the liver, the kidney, the spleen, the stomach, the heart, the lung and the intestines, wherein abnormal changes are not found. According to the acute toxicity standard, the product belongs to the nontoxic grade.
Example 7 cultivation test
A control test is carried out in a Gao city culture area, the powder of the pharmaceutical composition of the embodiment 1-5 of the invention and feed are mixed and stirred uniformly according to the proportion of 1:100, 6000 laying hens at the age of 50 weeks in the same henhouse are divided into six groups of 1000 laying hens, wherein one group is fed with common feed (without the pharmaceutical composition of the invention) as a control group, and the rest five groups are respectively fed with the feed added with the pharmaceutical composition of the invention of the embodiment 1-5; the rest daily management is the same, the daily management is carried out according to the conventional operation, the egg laying of each group of laying hens is respectively recorded and divided into 5 time periods, each time period is one week, and the egg laying condition of the laying hens is recorded as follows:
table 1 egg production rate record table;
age of egg-laying day (week) Group 1 (example 1) Group 2 (example 2) Group 3 (example 3) Group 4 (example 4) Group 5 (example 5) Group 6 (control group)
51 85% 83% 81% 79% 82% 71%
52 87% 85% 84% 80% 85% 77%
53 92% 89% 85% 89% 88% 77.5%
54 94% 92% 89% 91% 90% 79%
55 94% 93% 93% 94% 93.5% 82.1%
Table 2 egg laying weight table (units: grams);
age of egg-laying day (week) Group 1 (example 1) Group 2 (example 2) Group 3 (example 3) Group 4 (example 4) Group 5 (example 5) Group 6 (control group)
51 60.1 60.0 58.7 55.1 59.2 52.1
52 62.6 62.2 59.6 61.5 60.1 55.3
53 65.3 65.0 64.2 62.7 63.0 58.2
54 67.1 66.5 66.1 64.3 65.4 59.7
55 70.4 68.2 69.9 68.6 69.0 62.4
Table 3 table of soft-preserved and preserved-sand egg laying rates;
age of egg-laying day (week) Group 1 (example 1) Group 2 (example 2) Group 3 (example 3) Group 4 (example 4) Group 5 (example 5) Group 6 (control group)
51 3.2% 3.1% 3.4% 3.6% 3.3% 5.1%
52 3.2% 3.0% 3.4% 3.4% 3.22% 5.0%
53 3.1% 3.0% 3.2% 3.15% 3.2% 4.5%
54 2.9% 2.95% 3.1% 3.1% 3.05% 4.0%
55 2.5% 2.8% 3.1% 2.9% 2.7% 4.0%
The test results show that after the laying hens are fed with the feed, the laying rate is improved by 8-15%, the egg weight is averagely increased by 3-8g, and the soft preserved eggs and the preserved sand eggs are obviously reduced.
The above-mentioned embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not substantially depart from the spirit and scope of the embodiments of the present invention, and are intended to be included within the scope of the present invention.

Claims (8)

1. A pharmaceutical composition for increasing laying rate of laying hens is characterized in that: the pharmaceutical composition comprises the following components in parts by weight: 30-90 parts of cortex lycii radicis, 30-60 parts of cortex mori radicis, 15-30 parts of semen euryales, 9-18 parts of polygala tenuifolia, 9-18 parts of semen plantaginis salted, 3-9 parts of semen lepidii, 15-30 parts of cyclodipeptide powder, 9-18 parts of fishbone powder, 0.05-0.5 part of calcium pantothenate and 0.5-5 parts of inositol.
2. The pharmaceutical composition for increasing laying rate of laying hens according to claim 1, wherein: the pharmaceutical composition comprises the following components in parts by weight: 45-75 parts of cortex lycii radicis, 45-75 parts of cortex mori radicis, 18-28 parts of semen euryales, 12-16 parts of polygala tenuifolia, 12-16 parts of semen plantaginis salted, 4-8 parts of semen lepidii, 18-28 parts of cyclodipeptide powder, 12-16 parts of fishbone powder, 0.1-0.3 part of calcium pantothenate and 1-3 parts of inositol.
3. The pharmaceutical composition for increasing laying rate of laying hens according to claim 1, wherein: the pharmaceutical composition comprises the following components in parts by weight: 60 parts of cortex lycii radicis, 45 parts of cortex mori radicis, 22 parts of semen euryales, 13.5 parts of polygala tenuifolia, 13.5 parts of salted plantain seed, 6 parts of semen lepidii, 22 parts of cyclodipeptide powder, 13.5 parts of fishbone powder, 0.2 part of calcium pantothenate and 2 parts of inositol.
4. The pharmaceutical composition for increasing laying rate of laying hens according to claim 1, wherein: the pharmaceutical composition comprises the following components in parts by weight: 48 parts of cortex lycii radicis, 55 parts of cortex mori radicis, 25 parts of semen euryales, 12 parts of polygala tenuifolia, 14 parts of semen plantaginis preparata, 5 parts of semen lepidii, 24 parts of cyclodipeptide powder, 13 parts of fishbone powder, 0.2 part of calcium pantothenate and 1.5 parts of inositol.
5. The pharmaceutical composition for increasing laying rate of laying hens according to claim 1, wherein: the pharmaceutical composition comprises the following components in parts by weight: 70 parts of cortex lycii radicis, 48 parts of cortex mori radicis, 28 parts of semen euryales, 15 parts of polygala tenuifolia, 13 parts of semen plantaginis preparata, 7 parts of semen lepidii, 20 parts of cyclic dipeptide powder, 16 parts of fishbone powder, 0.15 part of calcium pantothenate and 2 parts of inositol.
6. The pharmaceutical composition for increasing laying rate of laying hens according to claim 1, wherein: the pharmaceutical composition comprises the following components in parts by weight: 45 parts of cortex lycii radicis, 45 parts of cortex mori radicis, 18 parts of semen euryales, 12 parts of polygala tenuifolia, 12 parts of semen plantaginis preparata, 4 parts of semen lepidii, 18 parts of cyclodipeptide powder, 12 parts of fishbone powder, 0.1 part of calcium pantothenate and 1 part of inositol.
7. The pharmaceutical composition for increasing laying rate of laying hens according to claim 1, wherein: the pharmaceutical composition comprises the following components in parts by weight: 75 parts of cortex lycii radicis, 75 parts of cortex mori radicis, 28 parts of semen euryales, 16 parts of polygala tenuifolia, 16 parts of semen plantaginis preparata, 8 parts of semen lepidii, 28 parts of cyclodipeptide powder, 16 parts of fishbone powder, 0.3 part of calcium pantothenate and 3 parts of inositol.
8. A method for preparing a pharmaceutical composition for improving the laying rate of laying hens is characterized by comprising the following steps: weighing the material components according to the weight part ratio, directly mixing the medicine components, crushing the medicine components into fine powder, sieving the fine powder by a 200-mesh sieve, and preparing the powder.
CN202010469175.2A 2020-05-28 2020-05-28 Pharmaceutical composition for increasing laying rate of laying hens and preparation and application thereof Pending CN111467475A (en)

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