CN111449073A

CN111449073A - Insecticidal composition containing cyclic bromoantraniliprole

Info

Publication number: CN111449073A
Application number: CN201910057535.5A
Authority: CN
Inventors: 葛家成; 熊风; 李建国
Original assignee: Hailir Pesticides and Chemicals Group Co Ltd
Current assignee: Hailir Pesticides and Chemicals Group Co Ltd
Priority date: 2019-01-19
Filing date: 2019-01-19
Publication date: 2020-07-28

Abstract

The invention discloses a cyromaniliprole-containing insecticidal composition, wherein an effective active ingredient comprises a first active ingredient cyromaniliprole and a second active ingredient, namely one of lambda-cyhalothrin or lambda-cyhalothrin, the weight ratio of the first active ingredient to the second active ingredient is 1: 60-60: 1, and the sum of the contents is 1-80% of the total weight of the composition. The composition can be prepared into agriculturally allowable missible oil, suspending agent, wettable powder, water dispersible granules, emulsion in water, microemulsion, microcapsule, granules and aqueous agent. The insecticidal composition has reasonable components, has good effect on hemiptera, thysanoptera, lepidoptera and homoptera pests such as pod borer, corn borer, thrips, diamond back moth, plant hopper, aphid and the like, has the insecticidal effect which is not the simple superposition of the activities of all the components, and has obvious insecticidal effect, obvious synergistic effect, less dosage and good safety on crops compared with the prior single preparation.

Description

Insecticidal composition containing cyclic bromoantraniliprole

Technical Field

The invention relates to a desinsection composition containing cyromanilide and application thereof, the composition consists of first component cyromanilide, one of second active component lambda-cyhalothrin or beta-cypermethrin and pesticide auxiliary components, and belongs to the technical field of compound pesticides.

Background

The cyclic bromoantraniliprole (cyclobromoantrole) is an insecticide with a bisamide structure developed by Japan stone original industry company, has broad-spectrum insecticidal activity, can be used for numerous crops such as fruit trees, vegetables, potatoes, tea trees, soybeans, cotton and the like, and can be used for controlling lepidoptera, coleoptera, thysanoptera, diptera and homoptera pests.

Cyhalothrin is also called cyhalothrin and cyhalothrin. The insecticidal composition has the advantages of drug effect, inhibition of conduction of nerve axon parts of insects, effects of repelling, knocking down and poisoning insects, wide insecticidal spectrum, high activity, quick drug effect, rain wash resistance after spraying, easy generation of resistance to insects and mites after long-term use, and certain prevention effect on pests and harmful mites of piercing-sucking mouthparts. The high-efficiency, broad-spectrum and quick-acting pyrethroid insecticide and acaricide mainly has the effects of contact poisoning and stomach poisoning, and has no systemic action. The insecticidal composition has good effects on various pests such as lepidoptera, coleopteran, hemiptera and the like and other pests, leaf mites, rust mites, gall mites, tarsonchus and the like, can control the concurrent pests and mites, can control the cotton bollworm, cabbage caterpillar, aphid of a pipe-plant-constrictor, tea looper, tea caterpillar, tea orange gall mite, leaf gall mite, citrus leaf moth, orange aphid, citrus leaf mite, rust mite, peach fruit borer, oriental fruit moth and the like, and can also be used for controlling various soil and public health pests.

The beta-cypermethrin is a pyrethroid insecticide, has high biological activity, is a beta-cypermethrin high-efficiency isomer, and has the effects of contact poisoning and stomach poisoning. Broad spectrum, high killing speed and high insecticidal activity. Is suitable for preventing and controlling pests and sanitary pests on various plants such as cotton, vegetables, fruit trees, tea trees, forests and the like. The product is non-systemic pesticide with contact killing and stomach poisoning effects. The destruction of the functioning of the nervous system by interaction with the sodium channels of pests. It can be used for preventing and treating various pests such as fly, cockroach, mosquito, flea, louse, bedbug, and animal ectoparasite such as tick and mite in public health and animal husbandry.

The applicant finds that the compounding of the cyromaniliprole and the high-efficiency cyhalothrin or the high-efficiency cypermethrin with different action mechanisms has the following advantages and beneficial effects: 1. by using the compound scheme, the insecticidal composition has obvious synergistic effect on hemiptera, thysanoptera, lepidoptera and homoptera pests, and obviously improves the control effect; 2. the dosage and the times of medication are reduced, and the prevention and treatment cost is reduced; 3. overcomes the defect of easy generation of resistance after long-term single use, and prolongs the service life of the medicament.

Disclosure of Invention

The invention aims to provide an agricultural insecticidal composition which has reasonable components, obvious synergistic effect, good insecticidal effect, low medication cost and is safe to crops.

Another object of the present invention is to provide a dosage form of the insecticidal composition containing the cyclic bromoxynil.

The invention also aims to provide application of the composition in controlling hemiptera, thysanoptera, lepidoptera and homoptera pests.

In order to achieve the purpose, the technical scheme of the invention is as follows:

a composition containing cyclic bromoantraniliprole and application thereof are characterized in that a first active ingredient: cyclic bromodiamide, second active ingredient: one of lambda-cyhalothrin or beta-cypermethrin.

The weight ratio of the first active ingredient to the second active ingredient is 1: 60-60: 1, and the sum of the contents is 1-80% of the total weight of the composition, preferably 5-60%.

The insecticide composition containing the cyclic bromoantraniliprole can be prepared into preparations such as suspending agents, wettable powder, water dispersible granules, missible oil and aqueous emulsion according to a method known by technical personnel in the technical field.

The insecticidal composition containing the cyclic bromoantraniliprole consists of an active ingredient and an auxiliary ingredient which is allowed to be used by pesticides.

The auxiliary components of the pesticide preparation comprise a carrier and an auxiliary agent.

The carrier is one, two or three of water, solvent or filler, and the water is preferably deionized water.

Further, the solvent is selected from the group consisting of N, N-dimethylformamide, cyclohexanone, toluene, xylene, dimethyl sulfoxide, methanol, ethanol, trimethylcyclohexanone, N-octylpyrrolidone, ethanolamine, triethanolamine, and isopropylamine. One or more of N-methyl pyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, ethanolamine, isopropylamine, ethyl acetate or acetonitrile.

Further, the filler is selected from one or a mixture of more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch or light calcium carbonate.

The auxiliary agent at least comprises a surfactant, and other functional auxiliary agents such as an antifreezing agent, a thickening agent, a stabilizing agent, a disintegrating agent, a defoaming agent and the like can be added according to different use occasions and requirements.

Further, the surfactant is selected from one or four of an emulsifier, a dispersant, a wetting agent or a penetrant. The surfactant is a single agent or a compound preparation of a common nonionic surfactant or an anionic surfactant.

Further, the other functional auxiliary agents are selected from one or five of antifreeze, thickening agent, stabilizing agent, disintegrating agent or defoaming agent.

Further, the emulsifier is selected from one or more of agricultural milk No. 500 (calcium alkyl benzene sulfonate), OP series phosphate ester (nonylphenol polyoxyethylene ether phosphate ester), No. 600 phosphate ester (phenylphenol polyoxyethylene ether phosphate ester), styrene polyoxyethylene ether ammonium sulfate salt, magnesium salt of alkyl diphenyl ether disulfonate, triethanolamine salt, agricultural milk No. 400 (benzyldimethylphenol polyoxyethylene ether), agricultural milk No. 700 (alkylphenol formaldehyde resin polyoxyethylene ether), Ning milk No. 36 (phenethylphenol formaldehyde resin polyoxyethylene ether), agricultural milk No. 1600 (phenethylphenol polyoxyethylene polyoxypropylene ether), ethylene oxide-propylene oxide block copolymer, OP series (nonylphenol polyoxyethylene ether), BY series (castor oil polyoxyethylene ether), agricultural milk No. 33 (alkylaryl polyoxyethylene polyoxypropylene ether), span series (sorbitan monostearate), Tween series (sorbitan series polyoxyethylene ether) or AEO (fatty alcohol polyoxyethylene ether) A mixture of the components.

Further, the dispersing agent is selected from one or a mixture of a plurality of polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene formaldehyde condensate sulfate, calcium alkylbenzene sulfonate, naphthalene sulfonic acid formaldehyde condensate sodium salt, alkylphenol polyoxyethylene, fatty amine polyoxyethylene, fatty acid polyoxyethylene or glycerol fatty acid ester polyoxyethylene.

Further, the wetting agent is selected from one or a mixture of more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, wetting penetrant F, Chinese honeylocust fruit powder, silkworm excrement and soapberry powder.

Further, the penetrating agent is selected from a mixture consisting of one or more of penetrating agent JFC (fatty alcohol-polyoxyethylene ether), penetrating agent T (diisooctyl maleate sulfonate), azone or organic silicon.

Further, the antifreezing agent is a mixture consisting of one or more of ethylene glycol, propylene glycol, glycerol or urea.

Further, the thickening agent is selected from one or more of xanthan gum, polyvinyl alcohol, bentonite, carboxymethyl cellulose or magnesium aluminum silicate.

Further, the stabilizing agent is selected from one or more of epoxidized soybean oil, epichlorohydrin, BHT, ethyl acetate and triphenyl phosphate.

Further, the disintegrating agent is selected from one or more of bentonite, urea, ammonium sulfate, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate.

Further, the defoaming agent is selected from one or a mixture of more of silicone oil, silicone compounds, C10-C20 saturated fatty acid compounds or C8-C10 fatty alcohol compounds.

The above substances are all commercially available.

The invention has reasonable combination, good insecticidal effect and low drug cost, and the activity and the insecticidal effect of the invention are not simple superposition of the activities of all components, but have obvious synergistic effect, good safety to crops and accordance with the safety requirement of pesticide preparations.

Detailed Description

The present invention will be further described with reference to the following examples.

Example 1: 36% Cyclobromantraniliprole high-efficiency cyhalothrin suspending agent (16: 20)

The formula is as follows: 16% of cyromaniliprole, 20% of high-efficiency cyhalothrin, TERSPERSE20204%, 1601#3% of agricultural milk, 1.8% of sodium naphthalenesulfonate, 1.5% of magnesium aluminum silicate, 0.8% of ethylene glycol, 0.1% of organosilicon, 0.1% of epichlorohydrin and the balance of deionized water to 100%.

The preparation method comprises the following steps: according to the formula proportion, the effective components of the cyromaniliprole, the efficient cyhalothrin, the surfactant and other functional additives are sequentially placed in a reaction kettle, water is added for uniform mixing, and the product is obtained through high-speed shearing, wet sanding and finally homogeneous filtration. The main equipment is a batching kettle, a colloid mill or a homogenizing mixer, and a sand mill.

Example 2: 15% Cyclobromantraniliprole-beta-cypermethrin suspension (5: 10)

The formula is as follows: 5% of cyromaniliprole, 10% of beta-cypermethrin, TERSPERSE20200.4%, 1601#2.5% of Nongru, 1% of sodium naphthalenesulfonate, 3.3% of magnesium aluminum silicate, 0.8% of ethylene glycol, 0.1% of organic silicon, 0.1% of epichlorohydrin and the balance of deionized water to 100%.

The preparation method comprises the following steps: as above.

Example 3 35% Cyclobromantraniliprole high-potency cyhalothrin wettable powder (15: 20)

The formula is as follows: 15% of cyromaniliprole, 20% of high-efficiency cyhalothrin, 0.6% of calcium lignosulphonate, 0.4% of alkyl naphthalene formaldehyde condensate sodium sulfonate, 0.4% of alkyl sodium sulfonate and clay added to 100%.

The preparation method comprises the following steps: according to the formula proportion of the embodiment, the active ingredients of the cyromaniliprole and the high-efficiency cyhalothrin are added into the carrier, the surfactant and other functional additives are added into the carrier, the mixture is mixed, and the wettable powder is prepared by mixing the components after airflow crushing. The main equipment is mixer and jet mill.

Example 4: 15% Cyclobromantraniliprole-beta-cypermethrin wettable powder (5: 10)

The formula is as follows: 5% of cyclic bromantraniliprole, 10% of beta-cypermethrin, 0.6% of calcium lignosulfonate, 0.3% of alkyl naphthalene formaldehyde condensate sodium sulfonate, 0.4% of alkyl sodium sulfonate and clay which are added to 100%.

The preparation method comprises the following steps: as above.

Example 5: 35% cyromaniliprole-efficient cyhalothrin water dispersible granule (20: 15)

The formula is as follows: 20 percent of cyclic bromodiamide, 15 percent of high-efficiency cyhalothrin, GY-D063 percent, 2.5 percent of calcium lignosulfonate, 2.5 percent of sodium dibutylnaphthalene sulfonate, 2.5 percent of sodium dodecyl benzene sulfonate and 100 percent of kaolin.

The preparation method comprises the following steps: adding active ingredients of the cyromaniliprole and the efficient cyhalothrin into a carrier according to the formula proportion of an embodiment, adding a surfactant and other functional auxiliaries, mixing, performing jet milling, adding 10-25% of water, kneading, granulating, drying and screening to obtain a water dispersible granule product; or spraying water to the pulverized powder in a boiling granulator, granulating, drying, and sieving to obtain the final product. The main equipment comprises a mixer, a jet mill, a kneader, an extrusion granulator, a drying room or a fluidized bed for drying, or a boiling granulator and a sieving machine.

Example 6: 30% Cyclobromantraniliprole-beta-cypermethrin water dispersible granule (10: 20)

The formula is as follows: 10% of cyclic bromantraniliprole, 20% of beta-cypermethrin, 5% of GY-D065%, 3% of calcium lignosulfonate, 3.5% of sodium dibutylnaphthalene sulfonate, 2.5% of sodium dodecyl benzene sulfonate and 100% of kaolin.

The preparation method comprises the following steps: as above.

Example 7: 15% Cyclobromantraniliprole-efficient cyhalothrin emulsifiable concentrate (5: 10)

The formula is as follows: 5% of cyromaniliprole, 10% of lambda-cyhalothrin, 1.4% of agricultural emulsion 500#, 28% of dimethylformamide and the total amount of xylene is 100%.

The preparation method comprises the following steps: adding the active ingredients of the cyromaniliprole and the efficient cyhalothrin into the carrier according to the formula proportion of the embodiment, adding the surfactant and other functional auxiliaries, and stirring and mixing uniformly in a stirring and mixing kettle. The stirring and mixing kettle can be selected from an enamel reaction kettle, a stainless steel stirring kettle and the like.

Example 8: 24% Cyclobromantraniliprole-beta-cypermethrin emulsifiable concentrate (10: 14)

The formula is as follows: 10% of cyromaniliprole, 14% of beta-cypermethrin, 1.4% of agricultural emulsion 500#, 28% of dimethylformamide and the total amount of xylene is 100%.

The preparation method comprises the following steps: as above.

Example 9: 16% Cyclobromantraniliprole high-efficiency cyhalothrin emulsion in water (10: 6)

The formula is as follows: 10% of cyromanilide, 6% of efficient cyhalothrin, 3% of span-60 #, 2.5% of triphenyl ethylphenol polyoxyethylene ether phosphate, 4.5% of agricultural emulsion 700#, 0.5% of toluene, 9% of sodium benzoate and deionized water added to 100%.

The preparation method comprises the following steps: adding the active ingredients of the cyromazine and the high-efficiency cyhalothrin together with a solvent, an emulsifier and a cosolvent according to the proportion of the formula of the embodiment to dissolve the active ingredients into a uniform oil phase; mixing part of water, antifreeze agent, antimicrobial agent and other pesticide auxiliary agents together to form a uniform water phase; adding the oil phase into the water phase while stirring at a high speed in the reaction kettle, slowly adding water until a phase inversion point is reached, starting a shearing machine to shear at a high speed, adding the rest water, and shearing for about half an hour to form the aqueous emulsion.

Example 10: 30% aqueous emulsion of Cyclobromantraniliprole and beta-cypermethrin (10: 20)

The formula is as follows: 10% of cyclic bromodiamide, 20% of beta-cypermethrin, 3% of span-60 #, 3% of triphenylethylphenol polyoxyethylene ether phosphate, 4.5% of agricultural emulsion 700#, 15% of toluene, 10% of sodium benzoate and the balance of deionized water to 100%.

The preparation method comprises the following steps: as above.

In the above preparation examples, cyhalothrin and beta-cypermethrin can be substituted for each other, and the preparation method and the formula are not described again.

Indoor case of activity

Example 11: combined toxicity determination of cyromaniliprole and lambda-cyhalothrin or lambda-cypermethrin mixing on corn borer

The test basis is as follows: department of agriculture NY/T1154.6-2006 "indoor bioassay Standard for pesticides section 6: immersion insect method, NY/T1154.7-2006 "standard for indoor bioassay of pesticides section 7: combined action assay of compounding.

The test method comprises the following steps: an immersion method is adopted to measure indoor toxicity, and the technical grade of the cyclic bromantraniliprole, the technical grade of the high-efficiency cyhalothrin and the technical grade of the high-efficiency cypermethrin are prepared into 5 liquid medicines with series concentration for later use.

Selecting indoor cultured corn borer nymphs with consistent age, placing the nymphs in a refrigerator at 4 ℃ for 10 minutes, taking out the nymphs when the nymphs are inactive, soaking the nymphs in a medicinal liquid for 10 seconds, taking out the nymphs, absorbing the redundant medicinal liquid by using absorbent paper, marking the nymphs respectively, then placing the nymphs in a climatic chamber at 26 ℃ and with relative humidity of 70%, and feeding the nymphs with fresh and clean corn leaves. Treating nymph 30 heads at each concentration, repeating for 4 times, taking water containing corresponding amount of Tween 80 as a control, checking the result 48 hours after the application, wherein the control death rate is higher than 20%, and the standard of the death of the test insects is that the test insects are lightly touched by a small writing brush, and the non-responders are regarded as dead after 5s, otherwise, the test insects are regarded as live.

Based on the results of the investigation, the mortality of each treatment was calculated. And (4) solving a toxicity regression equation, lethal medium concentration, correlation coefficient and the like, and solving a co-toxicity coefficient (CTC value) by using a Sun cloud Pepper method.

The joint effect of the insecticidal composition containing the cyclic bromodiamide on the corn borers is evaluated by adopting a co-toxicity coefficient method, the logarithm of the concentration of the pesticide and the control efficiency rate value sphere regression equation of the pesticide on the corn borers are calculated to obtain the L C50 value of the pesticide, then the co-toxicity coefficient is obtained, the joint effect of the pesticide on the corn borers is evaluated by the co-toxicity coefficient, the co-toxicity coefficient is more than 120 and is represented as a synergistic effect, the co-toxicity coefficient is less than 80 and is represented as an antagonistic effect, and the co-toxicity coefficient is between 80 and 120 and is represented as an additive effect.

TABLE 1 toxicity test results of the mixture of cyromaniliprole and lambda-cyhalothrin against corn borer

Table 2 toxicity test results of the mixture of the cyromaniliprole and the beta-cypermethrin to the corn borer

As shown in the tables 1 and 2, the synergistic effect of the cyromaniliprole and the lambda-cyhalothrin is between 1:50 and 40: 1.

Example 12: combined toxicity determination of cyromaniliprole and lambda-cyhalothrin or lambda-cypermethrin mixed pairing peach fruit borer

The test basis is as follows: department of agriculture NY/T1154.6-2006 "indoor bioassay Standard for pesticides section 6: insecticidal Activity test InsectCrystal method, NY/T1154.7-2006 "indoor bioassay of pesticides test guidelines section 7: combined action assay of compounding.

Selecting peach fruit borers with consistent age and indoor culture, soaking the test insects in the liquid medicine for 10s, absorbing the redundant liquid medicine by using filter paper, and transferring the test insects to normal conditions for feeding. And (4) repeating the treatment every time, soaking 20 heads every time, taking water containing corresponding amount of Tween 80 as a control, checking the result 48 hours after the drug is applied, wherein the control mortality rate is higher than 20 percent, and the test insect death standard is that the test insect is lightly touched by a small writing brush, and a non-responder is considered to be dead after 5 seconds, otherwise, the test insect is considered to be live.

The joint action of the insecticidal composition containing the cyclic bromoantraniliprole provided by the invention on the peach fruit borers is evaluated by adopting a co-toxicity coefficient method, the regression equation of the logarithm of the concentration of the medicament and the control efficiency rate value of the medicament on the peach fruit borers is adopted, and L C of the medicament is obtained by calculation₅₀And (4) obtaining the co-toxicity coefficient. The combined action of the medicament on the peach fruit borers is evaluated by the co-toxicity coefficient, the co-toxicity coefficient is more than 120 and is expressed as the synergy, the co-toxicity coefficient is less than 80 and is expressed as the antagonism, and the co-toxicity coefficient is between 80 and 120 and is expressed as the addition action.

TABLE 3 toxicity test results of Palo Bromide and lambda-cyhalothrin mixed with Palo peach fruit moth

TABLE 4 toxicity assay results of Palo Bromide and beta-cypermethrin mixed to Palo Sus Tao Xin Chong

Tables 3 and 4 show that the combined action of the cyromaniliprole and the lambda-cyhalothrin or the lambda-cypermethrin on the peach fruit borer is synergistic in the period of 1:40-20: 1.

Test of field drug effect

Example 13: the field pesticide effect of the mixture of the cyromaniliprole and the high-efficiency cyhalothrin or the high-efficiency cypermethrin on the corn borer is achieved.

Test agents: 15 percent of cyromaniliprole-efficient cyhalothrin suspending agent, 15 percent of cyromaniliprole-efficient cypermethrin suspending agent, 25 percent of cyromaniliprole suspending agent, 25 percent of efficient cyhalothrin suspending agent and 4.5 percent of efficient cypermethrin emulsifiable concentrate.

The purpose of the test is as follows: the test control effect of the pesticide on the corn borers and peach fruit borers verifies the control effect of the mixed pesticide on the corn borers and peach fruit borers and the safety of the mixed pesticide on the corn borers and the peach fruit borers.

And (3) test crops: corn and peach tree

The control object is: corn borer and peach fruit borer

And (3) test treatment: each treatment is repeated for 4 times, each cell is 30 square meters, and the total number of the cells is 24, and the cells are randomly arranged in a distinguishing way.

The test method comprises the following steps: and (4) carrying out insect population base number investigation before pesticide application, investigating the number of residual live insects 5 days and 10 days after pesticide application, and calculating the death rate and the control effect of the larvae.

CK₀The number of live insects in unit of head before drug application in the blank control area;

CK₁the number of live insects in unit of head after the drug is applied to the blank control area;

PT₀the number of live insects before the pesticide is applied in the pesticide treatment area is the unit of head;

PT₁the number of live insects after the pesticide is applied in the pesticide treatment area is the unit of head.

TABLE 5 test results of the field efficacy of corn borer control

TABLE 6 test results for prevention and treatment of peach fruit borer

The field efficacy test result shows that the control effect of the compound preparation is more than 85% in 5 days and 10 days after the compound preparation is applied, and the control effect of the single preparation is less than 80%, which indicates that the control effect of the compound preparation is obviously higher than that of the single preparation after the compound of the cyromaniliprole and the high-efficiency cyhalothrin or the high-efficiency cypermethrin.

Claims

1. The insecticidal composition containing the cyromaniliprole is characterized in that an effective active ingredient is composed of a first active ingredient cyromaniliprole and a second active ingredient, namely one of lambda-cyhalothrin or lambda-cyhalothrin, and the weight ratio of the first active ingredient to the second active ingredient is 1: 60-60: 1.

2. The insecticidal composition according to claim 1, wherein the weight ratio of the first active ingredient to the second active ingredient is 1:30 to 30: 1.

3. An insecticidal composition according to claim 1, wherein the sum of the contents of the first and second active ingredients is from 1% to 80%, preferably from 5% to 60% of the total weight of the composition.

4. The insecticidal composition as claimed in claim 1, wherein the composition can be prepared into various types of formulations allowed in pesticides, preferably suspending agents, wettable powder, water dispersible granules, emulsifiable concentrates and aqueous emulsion.

5. The insecticidal composition according to claim 1, wherein said composition is useful for controlling pests from the hemiptera, thysanoptera, lepidoptera, and homoptera crops.