CN111448217A - 双特异性抗原结合构建体 - Google Patents

双特异性抗原结合构建体 Download PDF

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Publication number
CN111448217A
CN111448217A CN201880078802.0A CN201880078802A CN111448217A CN 111448217 A CN111448217 A CN 111448217A CN 201880078802 A CN201880078802 A CN 201880078802A CN 111448217 A CN111448217 A CN 111448217A
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leu
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CN201880078802.0A
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English (en)
Chinese (zh)
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C·布朗什托
S·范德旺宁
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ArgenX BVBA
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ArgenX BVBA
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Application filed by ArgenX BVBA filed Critical ArgenX BVBA
Publication of CN111448217A publication Critical patent/CN111448217A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN201880078802.0A 2017-12-22 2018-12-21 双特异性抗原结合构建体 Pending CN111448217A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762609523P 2017-12-22 2017-12-22
US62/609,523 2017-12-22
PCT/EP2018/086755 WO2019122409A1 (en) 2017-12-22 2018-12-21 Bispecific antigen binding construct

Publications (1)

Publication Number Publication Date
CN111448217A true CN111448217A (zh) 2020-07-24

Family

ID=64959348

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880078802.0A Pending CN111448217A (zh) 2017-12-22 2018-12-21 双特异性抗原结合构建体

Country Status (9)

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US (2) US12071486B2 (enExample)
EP (2) EP3728328B1 (enExample)
JP (2) JP7657591B2 (enExample)
CN (1) CN111448217A (enExample)
AU (1) AU2018387829B2 (enExample)
CA (1) CA3079793A1 (enExample)
DK (1) DK3728328T5 (enExample)
IL (1) IL274676A (enExample)
WO (1) WO2019122409A1 (enExample)

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EP4090687A4 (en) * 2020-01-19 2024-02-21 Nanjing GenScript Biotech Co., Ltd. Multispecific anti-claudin-18.2 constructs and uses thereof
GB202203269D0 (en) 2022-03-09 2022-04-20 Argenx Iip Bv TGF-Beta antibodies
US12195546B2 (en) 2022-12-19 2025-01-14 Sanofi CD28/OX40 bispecific antibodies
EP4652195A2 (en) * 2023-01-20 2025-11-26 Invetx, Inc. Bispecific binding agents for use in companion animals

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GB2504139B (en) 2012-07-20 2014-12-31 Argen X Bv Antibodies to highly conserved targets produced by the immunisation of Camelidae species
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Publication number Publication date
AU2018387829B2 (en) 2024-12-19
EP4495142A2 (en) 2025-01-22
EP3728328B1 (en) 2024-10-23
US12071486B2 (en) 2024-08-27
US20190218310A1 (en) 2019-07-18
EP4495142A3 (en) 2025-05-07
AU2018387829A1 (en) 2020-05-07
WO2019122409A1 (en) 2019-06-27
DK3728328T5 (da) 2025-02-17
JP7657591B2 (ja) 2025-04-07
US20240368311A1 (en) 2024-11-07
DK3728328T3 (da) 2025-01-02
CA3079793A1 (en) 2019-06-27
JP2021506310A (ja) 2021-02-22
JP2023139025A (ja) 2023-10-03
IL274676A (en) 2020-06-30
EP3728328A1 (en) 2020-10-28

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