CN1114421C - Chinese medicine for treating diabetes - Google Patents
Chinese medicine for treating diabetes Download PDFInfo
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- CN1114421C CN1114421C CN00107254A CN00107254A CN1114421C CN 1114421 C CN1114421 C CN 1114421C CN 00107254 A CN00107254 A CN 00107254A CN 00107254 A CN00107254 A CN 00107254A CN 1114421 C CN1114421 C CN 1114421C
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Abstract
The present invention relates to a Chinese medicine preparation for treating diabetes and a preparation method thereof. The Chinese medicine preparation is prepared from the components of fig root, water plantain, wallich garlic herb, dioscorea root, old tea, cutch and black soybean, and has significant efficacy, short treatment course, easy oral administration and no toxic and side effect; besides, the Chinese medicine preparation is the optimum Chinese medicine preparation for treating diabetes.
Description
The present invention relates to a kind of Chinese medicine preparation-Ke sugar spirit of diabetes and method of this Chinese medicine preparation of preparation for the treatment of.
Diabetes are a kind of endocrine metabolism diseases, and it is its common outstanding feature with hyperglycemia.Diabetes are absolute or relative deficiency because of insulin secretion, and the target tissue cell reduces insulin sensitivity, causes sugar, protein, fat and water, a series of metabolism disorders of electrolyte.Clinical with polydipsia, polyphagia, polyuria, become thin, excessive thirst, tired serve as main performance.The World Health Organization (WHO) is divided into insulin-dependent (I type) and non-insulin-depending type (II) type to diabetes, its cause of disease and pathogeny are not illustrated as yet fully, think relevant at present, the visible islet cells of pathology, big or middle, blood capillary, the neural change with inherited genetic factors, environmental factors and immunologic mechanism.As seen acute ketoacidosis, non-ketosis hyperosmolar coma; The chronic heart, brain, kidney, eye, nervous system lesion; And complications such as infection.
Diabetes pathological change complexity, complication are more, and its pathological changes is not only at lung, stomach, kidney, and involve the heart, brain, liver, spleen after the development and to the muscle arteries and veins of whole body, skeleton, skin, muscle etc.Mostly treatment to this disease at present is to adopt insulin injection and oral sulfonylurea and biguanides oral medicine, but the mild or moderate diabetes that these medicines only do not completely lose pancreatic function clinically are effective, very poor to juvenile form and severe diabetics curative effect, and relapse rate is higher, and takes certain effect of paying for a long time:
1. biguanide drug: curative effect is low, and to pay effect big, for a long time with producing the high lactose mass formed by blood stasis;
2. sulfaurea drugs: for a long time with infringement liver, kidney and hemocyte; With the sulphonamides cross allergy, the later stage produces secondary failure;
3. with producing antibody, biological activity reduces insulin for a long time, and dosage increases, and produces hyperinsulinemia, impels microangiopathies to take place and development.
China's traditional Chinese medical science successive dynasties doctor work has complete and argumentation system to diabetes.In theory of Chinese medical science, the category that diabetes spp motherland medical science " is quenched one's thirst ", quenching one's thirst is to become thin or turbid urine, urine is pleasantly sweet is the disease of feature with polydipsia, polyphagia, polyuria, health.Mostly the traditional Chinese medical science is to discuss on the dialectical basis of traditional three types of diabetes to diabetes controls, however its typing become increasingly complex, reached over one hundred kind, and curative effect not significantly, the phase course of treatment is long.The sickness rate of diabetes is more and more higher in the world, Europe its sickness rate be 2%, the U.S. be 5%, 1980 year in 300,000 census of the populations of China 14 provinces and cities, the onset diabetes rate is 6.09%.According to update, the sickness rate of China's Beijing area diabetes is 3.44% and is the gesture of rising gradually.Therefore press for a kind of evident in efficacy, the phase course of treatment short, be easy to take, do not have the medicine for treating diabetes that any poison is paid effect.
The inventor continues to prolong and holds secret prescription handed down in the family from generation to generation, clinical practice research in conjunction with two more than ten years, adopt the pure natural Chinese herbal medicine, be refined into a kind of Chinese medicine preparation for the treatment of diabetes through special technology, it is evident in efficacy, the phase course of treatment short, be easy to take, do not have any poison pays effect, is the best Chinese medicine preparation of treatment diabetes.
Therefore, an object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of diabetes, it can be powder, electuary, pill, capsule, tablet and other peroral dosage form.
A present invention also purpose provides a kind of method for preparing the Chinese medicine preparation of treatment diabetes of the present invention.
The invention provides a kind of Chinese medicine preparation for the treatment of diabetes, it is by forming by following parts by weight of traditional Chinese medicines preparation of raw material:
Radix Fici 10-20 part; Rhizoma Alismatis 10-20 part; Herba Allii bulleyani 10-30 part; Rhizoma dioscoreae 15-40 part; Old tea 10-30 part; Catechu 10-20 part; Semen sojae atricolor 400-2000 part.
The preferred prescription of the present invention is:
Radix Fici 10-15 part; Rhizoma Alismatis 10-15 part; Herba Allii bulleyani 10-20 part; Rhizoma dioscoreae 15-30 part; Old tea 10-20 part; Catechu 10-15 part; Semen sojae atricolor 500-1500 part.
The preparation technology of Chinese medicine preparation of the present invention is as follows: earlier Radix Fici, Rhizoma Alismatis, Herba Allii bulleyani, Rhizoma dioscoreae, old tea, Catechu are put into water, the water yield is 20-50 a times of above-mentioned total dose, boils 1 and a half hours with slow fire, and medicinal residues are removed, and gets medicinal liquid.Semen sojae atricolor is fried to dried ripe, then Semen sojae atricolor is immersed in normal temperature fermentation in the medicinal liquid, about 1-10 of time days, dry then, pulverize, can be processed into powder, electuary, pill, capsule, tablet and other peroral dosage form as required.
Semen sojae atricolor, " Chinese medicine voluminous dictionary " nature and flavor are sweet, flat, have invigorate blood circulation, diuretic, the merit of dispeling the wind, detoxifying.Compendium of Material Medica is said: " controlling nephropathy, the diuretic therapeutic method to keep the adverse QI flowing downwards ", " Handbook of Prescriptions for Emergencies " " controlled and quenched one's thirst ", " Prescriptions for Universal Relief " " controlling suffers from a deficiency of the kidney quench one's thirst refractory person ".As seen originally build up one's health by taking tonic and suffer from a deficiency of the kidney and rush down stomach-fire.
Radix Fici, " Chinese medicine voluminous dictionary " nature and flavor are light, puckery, flat, say in " the SHENGCAO property of medicine is wanted fully " " it is sick to control fire ".
Herba Allii bulleyani, " Chinese medicine voluminous dictionary " nature and flavor are sweet, cold, say in " a thousand pieces of gold, dietetic therapy " in " should kidney, main defecation number, go dysphoria with smothery sensation ".
Rhizoma Alismatis, " Chinese medicine voluminous dictionary " nature and flavor are sweet, cold, " rushing down the kidney fire ".
Catechu, " Chinese medicine voluminous dictionary " nature and flavor hardship, puckery cold, Compendium of Material Medica " every last heat, is acted as expectorant clearly ", " the positive source of book on Chinese herbal medicine " " pathogenic fire reducing promotes the production of body fluid, and only quenches one's thirst ".
Old tea can be the tea more than 3 years, as TIEGUANYIN tea, green tea, black tea, scented tea etc.
The spirit of Chinese medicine preparation of the present invention-Ke sugar mainly remains the function of islet cells by activation, increase insulin secretion, and on the other hand, the intensifier target cell is to the sensitivity of insulin and onset.In addition, Chinese medicine preparation of the present invention-Ke sugar spirit treatment diabetes three types of diabetes is also controlled, treating both the principal and secondary aspects of a disease, and determined curative effect, and do not have any poison and pay effect.
Further specify the present invention by the following examples:
Embodiment 1
Radix Fici 15 grams; Rhizoma Alismatis 15 grams; Herba Allii bulleyani 15 grams; Rhizoma dioscoreae 15 grams; Old tea 15 grams; Catechu 15 grams; Semen sojae atricolor 800 grams.
Earlier Radix Fici, Rhizoma Alismatis, Herba Allii bulleyani, Rhizoma dioscoreae, old tea, Catechu are put into 2500 gram water, boiled 1 and a half hours, medicinal residues are removed, get medicinal liquid with slow fire.Semen sojae atricolor is fried to dried ripe, Semen sojae atricolor is immersed in the medicinal liquid ferments then, about 6-10 of time days, dry then, pulverize, be processed into powder.
Embodiment 2
Radix Fici 15 grams; Rhizoma Alismatis 15 grams; Herba Allii bulleyani 20 grams; Rhizoma dioscoreae 20 grams; Old tea 20 grams; Catechu 15 grams; Semen sojae atricolor 900 grams.
Earlier Radix Fici, Rhizoma Alismatis, Herba Allii bulleyani, Rhizoma dioscoreae, old tea, Catechu are put into 4000 gram water, boiled 1 and a half hours, medicinal residues are removed, get medicinal liquid with slow fire.Semen sojae atricolor is fried to dried ripe, Semen sojae atricolor is immersed in the medicinal liquid ferments then, about 5-8 of time days, dry then, pulverize, be processed into powder.
Chinese medicine preparation gram sugar spirit secondary every day of the present invention, each 10 grams, soaked taking, treating the course of treatment the shortest is 10 days, the longest is 1 month.Do not need oral any antidiabetic drug during the treatment.It is short that the present invention treats the Chinese medicine preparation gram sugar spirit phase course of treatment of diabetes, the defective of a plurality of courses of treatment is grown, will be passed through to the phase course of treatment that has overcome existing Chinese medicine preparation, and do not have any poison and pay effect, after the drug withdrawal, the state of an illness does not rebound, and its processing technology is simple, equipment requirements is not high, cost is low, and raw material is easy to get, and taking convenience.
Chinese medicine preparation of the present invention-Ke sugar spirit also can be used for treating kiney edema, chronic glomerulonephritis, uremia, acute nephritis.
Below be the clinical trial of Chinese medicine preparation of the present invention-Ke sugar spirit: toxicological study before () is clinical:
1. in order to guarantee the safety of clinical administration reliability, at first carry out acute toxicity testing, the experiment kunming mice, every day at upper and lower noon twice difference administration various dose (20g/kg, 50g/kg), observe continuously, 7 days as a result mice all act normally, abnormal responses such as short of breath, tic do not appear.None is only dead.When being equivalent to 1150 times of clinical consumptions of people, median lethal dose(LD 50) LD
50Do not detect, avirulence is described, clinical use is safe.
2. long term toxicity test: rat is carried out sub-acute toxicity test.Connect gastric infusion 1 month.(24g/kg, 15g/kg 6g/kg), promptly are equivalent to 120,75,30 times of the clinical consumption of people to be divided into matched group and large, medium and small three dosage groups at random.Matched group is given equal-volume water.Observe general state, behavior, fur color and luster, body weight, peripheral blood phase, hepatic and renal function, blood triglyceride, blood glucose, the dissection of respectively organizing rat, microscopy etc.The result shows, administration is respectively organized the general state, body weight, hepatic and renal function of rat etc. and matched group relatively, does not see notable difference, all in normal range.Experimental results show that it is safe and reliable using under clinical consumption.(2) clinical experiment
1. selection case: the object of observation of including in is 18-65 year, presses the diabetes diagnosis standard that WHO1980 formulates, the maturity-onset diabetes patient who makes a definite diagnosis, course of disease half a year-35 year.150 examples are organized in treatment, use the present invention to restrain the sugar spirit; Matched group 60 examples: blood sugar lowering, blood fat reducing treatment routinely, the insoral of use Jintan, Jiangsu Province county pharmaceutical factory.Treatment group and matched group sex, age distribution all do not have significant difference (P＞0.05).
2. diagnostic criteria:
1) the Western medicine diagnose standard adopts WHO tentative standard (venous plasma method) in 1980, all one of following conditions that meets, and then diagnosable is diabetes:
A., diabetic symptom is arranged, any time blood glucose 〉=11.1mmol/L or fasting glucose 〉=7.5mmol/L.
B., diabetic symptom is arranged, and blood glucose does not reach above-mentioned standard, carry out 75g oral glucose tolerance test (OGTT), 2 hours blood glucose 〉=11.1mmol/L.
C. if the non-diabetic symptom, except that above-mentioned standard, add a standard in addition, promptly OGTT1 hour blood glucose 〉=11.1mmol/L or another time OGTT2 hour blood glucose 〉=11.1mmol/L, or another time empty stomach 〉=7.8mmol.
2) tcm diagnosis standard: allly have that thirsty polydipsia, rapid digestion of food are easily hungry, a frequent micturition and sweet, body sees that gradually patient such as become thin just can make a definite diagnosis.
3. therapeutic scheme:
Observe 210 examples altogether, be divided into 2 groups at random, 150 examples are organized in treatment, use the present invention to restrain the sugar spirit, and every day twice, each 10 grams serve on for 3 weeks.Matched group 60 examples, the insoral of use Jintan, Jiangsu Province county pharmaceutical factory, every day twice, each 4.Conventional before the test experimenter is done detailed health check-up, surveys fasting glucose, glucose in urine (treat preceding 4 weeks, surveyed fasting glucose every 10 days, glucose in urine 1 time, continuous 3 times, with 3 averages as treating preceding control value).Weekly with examining 1 time, inquire the situation of taking medicine after the test, 1 empty stomach and 2 hours after the meal blood glucose are surveyed in the record state of an illness and side effect.Viewing duration is not taken other class medicines.
4. efficacy assessment standard:
A. produce effects: treatment back symptom disappears substantially, fasting glucose＜7.2mmol/L, 2 hours after the meal blood glucose＜8.3mmol/L, twenty-four-hour urine sugar quantitatively＜10.0g; Or blood glucose, twenty-four-hour urine sugar quantitatively descends more than 30% before the treatment.
B. effective: treatment back symptom is obviously improved, fasting glucose＜8.3mmol/L, 2 hours after the meal blood glucose＜10.0mmol/L, twenty-four-hour urine sugar quantitatively＜25mg; Or blood glucose, twenty-four-hour urine sugar quantitatively descends more than 10% before the treatment; Or use and can reduce insulin dosage behind this medicine and keep fasting glucose＜7.2mmol/L, 2 hours after the meal blood glucose＜8.3mmol/L, twenty-four-hour urine sugar quantitatively＜10.0g.
C. invalid: treatment back symptom does not have obvious improvement, and blood glucose, glucose in urine descend and do not reach above-mentioned standard.
5. therapeutic outcome: before and after the physico-chemical examination treatment relatively:
| The treatment group | Matched group | |||||
| Case load | Before the treatment | After the treatment | Case load | Before the treatment | After the treatment | |
| Fasting glucose | 150 | 10.96±2.1 6 | 6.78±2.36 | 60 | 11.00±2.46 | 7.68±2.16 |
| 2 hours after the meal blood glucose | 148 | 13.52±2，6 1 | 8.22±2.16 | 56 | 13.3?1±2.43 | 10.50±3.28 |
Treatment group and matched group curative effect compare:
Case load produce effects enabledisable total effective rate
Treatment organizes 150 96 39 15 90%
Matched group 60 21 19 20 67%
6. side effect: 150 examples are organized in this treatment, and matched group 60 examples are not all found obvious adverse reaction and toxic and side effects at viewing duration.
7. conclusion:
(1) Chinese medicine preparation gram sugar of the present invention is clever has the obvious treatment effect to diabetes, and patient's fasting glucose and 2 hours after the meal blood glucose all obviously descend after the medication, shows that the present invention restrains sugar spirit energy control of diabetes patient's blood glucose.
(2) 150 examples are organized in this treatment, and total effective rate is 90%; Matched group 60 examples, total effective rate are 67%, two group of relatively no significant difference (P＞0.05).
(3) this product is safe and reliable, no obvious adverse reaction and toxic and side effects.
Below further specify effect of the present invention with example:
Example 1. grandsons, the man, 56 years old, it was surplus to suffer from diabetes 5 years, and on May 12nd, 1992 was admitted to hospital for the second time, obeyed diabetes pill the day before yesterday of being admitted to hospital, fasting glucose 13.6mmol/L. xerostomia, polydipsia, constipation, abdominal distention, weak.Be admitted to hospital the back successively with treatments such as diamicron, insulin, fenofibrate 4 months, check fasting glucose 11.5mmol/L, cholesterol 7.1mmol/L.Take the present invention from February 3rd, 1993 and restrain the sugar spirit, every day 2 times, each 10 grams are taken the present invention and are restrained the sugar spirit after 7 days, and symptoms such as thirst and liking drink, dysphoria with feverish sensation in the chest palms and soles, cardiopalmus, insomnia are obviously improved.After 3 weeks, symptom disappears substantially, and fasting glucose is reduced to 6.45mmol/L, 2 hours after the meal blood glucose 7.11mmol/L, and efficacy evaluation is a produce effects.
Claims (4)
1. Chinese medicine preparation for the treatment of diabetes, it is by forming by following parts by weight of traditional Chinese medicines preparation of raw material: Radix Fici 10-20 part, Rhizoma Alismatis 10-20 part, Herba Allii bulleyani 10-30 part, Rhizoma dioscoreae 15-40 part, old tea 10-30 part, Catechu 10-20 part, Semen sojae atricolor 400-2000 part.
2. according to the Chinese medicine preparation of the treatment diabetes of claim 1, it is by forming by following parts by weight of traditional Chinese medicines preparation of raw material:
Radix Fici 10-15 part, Rhizoma Alismatis 10-15 part, Herba Allii bulleyani 10-20 part, Rhizoma dioscoreae 15-30 part, old tea 10-20 part, Catechu 10-15 part, Semen sojae atricolor 500-1500 part.
3. according to the Chinese medicine preparation of the treatment diabetes of claim 1, it can be powder, electuary, pill, capsule or Tabules.
4. according to the preparation method of the Chinese medicine preparation of the treatment diabetes of claim 1, earlier Radix Fici, Rhizoma Alismatis, Herba Allii bulleyani, Rhizoma dioscoreae, old tea, Catechu are put into water, the water yield is 20-50 a times of above-mentioned total dose, boils 1 and a half hours with slow fire, and medicinal residues are removed, get medicinal liquid, Semen sojae atricolor is fried to dried ripe, then Semen sojae atricolor is immersed in normal temperature fermentation in the medicinal liquid, the time is 1-10 days, dry then, pulverize, make finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00107254A CN1114421C (en) | 2000-04-29 | 2000-04-29 | Chinese medicine for treating diabetes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00107254A CN1114421C (en) | 2000-04-29 | 2000-04-29 | Chinese medicine for treating diabetes |
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| Publication Number | Publication Date |
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| CN1273830A CN1273830A (en) | 2000-11-22 |
| CN1114421C true CN1114421C (en) | 2003-07-16 |
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| CN00107254A Expired - Fee Related CN1114421C (en) | 2000-04-29 | 2000-04-29 | Chinese medicine for treating diabetes |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110565A (en) * | 1994-04-21 | 1995-10-25 | 梁清吉 | Anti-thristy melbine capsule and its production method |
| CN1243006A (en) * | 1999-07-07 | 2000-02-02 | 陈大明 | Chinese medicine preparation for treating diabetes |
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2000
- 2000-04-29 CN CN00107254A patent/CN1114421C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110565A (en) * | 1994-04-21 | 1995-10-25 | 梁清吉 | Anti-thristy melbine capsule and its production method |
| CN1243006A (en) * | 1999-07-07 | 2000-02-02 | 陈大明 | Chinese medicine preparation for treating diabetes |
Non-Patent Citations (3)
| Title |
|---|
| 中医杂志1985,26(6) 1985-06-30 安邦煜等甘露消渴胶囊治疗非胰岛素依赖型糖尿病102例临床观察 * |
| 湖南中医学院学报，1996,16(2) 1996-02-28 左文标等降糖益肾丸治疗糖尿病性肾病临床观察 * |
| 湖南中医学院学报，1996,16(2) 1996-02-28 左文标等降糖益肾丸治疗糖尿病性肾病临床观察;中医杂志1985,26(6) 1985-06-30 安邦煜等甘露消渴胶囊治疗非胰岛素依赖型糖尿病102例临床观察 * |
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