CN102366596B - Medicine for treating diabetes and preparation method thereof - Google Patents
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- CN102366596B CN102366596B CN 201110289637 CN201110289637A CN102366596B CN 102366596 B CN102366596 B CN 102366596B CN 201110289637 CN201110289637 CN 201110289637 CN 201110289637 A CN201110289637 A CN 201110289637A CN 102366596 B CN102366596 B CN 102366596B
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Abstract
The invention discloses a medicine for treating diabetes. The medicine is a Tibetan medicine, is also called Jiumei No. 3 diabetes tea and is composed of an active component or the active component and pharmaceutically acceptable accessories, wherein, the active component is prepared from turmeric, Berberis kansuensis, tribulus terrstris, banksia rose, rhododendron anthopogonoide, cortex lycii and brick tea according to a certain weight ratio. The medicine can be made into a medicinal tea type oral preparation, including bulk medicinal tea, bagged medicinal tea and decocted medicinal tea. The medicine provided in the invention has the functions of nourishing kidney and yin, generating body fluid, quenching thirst, tonifying qi and lowering down blood sugar, and is used for treating diabetes. In Tibetan medicine, the medicine is applicable to diabetes symptoms caused by disorder of Peigen, e.g., polydipsia, polyphagia, polyuria, macies, urine sugar and elevation of blood sugar levels. In traditional Chinese medicine, the medicine is applicable to diabetes caused by deficiency of both qi and yin.
Description
[technical field]
The present invention relates to a kind of medicine (for a long time U.S. No. 3 diabetic teas) for the treatment of diabetes and preparation method thereof, it is a kind of Tibetan medicine, belongs to the field of Chinese medicines.
[background technology]
Diabetes are a kind of common metabolism endocrinopathyes, and World Health Organization (WHO) classifies them one of as ten large difficult disease.Sickness rate is high, and the trend that rises is year by year arranged; According to statistics, India is present the first in the world diabetes big countries, has patient more than 4,000 ten thousand; China occupies second, and patient 3,000 ten thousand is arranged; There is patient more than 1,000 ten thousand in the 3rd, the U.S.; The WHO estimation, by 2005, the diabetes mellitus in China people will reach 5,000 ten thousand; Developed country more than 60 years old crowd nearly 10% be diabetics, China estimates more than 60 years old that in the crowd, diabetics reaches more than 8%; There is scholarly forecast China might become the first in the world diabetes big countries after India, this is not only because the Chinese population radix is maximum, also because Chinese Economy Development is quick, the compatriots overweight people that life is improved rapidly increases suddenly, and the obese people becomes diabetes Susceptible population; Type ii diabetes accounts for 90%～95% of diabetics total number of persons, and diabetes account for front 5 of the cause of death, and it is one of serious threat people ' s health disease.
The investigation discovery that diabetes mellitus in China association is up-to-date, the onset diabetes rate of China is up to 9.7%, and national diabetes patient is near one hundred million.China has surmounted India becomes diabetes the first big countries.
Diabetes rejuvenation trend is obvious, and onset diabetes increases the fastest in " cause type " personage of 30～45 years old.In the adult more than 20 years old, the diabetes prevalence of age markization is 9.7%, and the ratio of prediabetes is more up to 15.5%, and being equivalent to just has a hyperglycemia state person in every four adults.
China is since reform and opening-up, and people's lives are greatly improved, but following, the diabetes that are known as affluenza also become a kind of commonly encountered diseases, frequently-occurring disease gradually.Over nearly 30 years, the progress of the relevant diabetes control in the whole world is very rapid, China is quite a few to the combination of Chinese and Western medicine research of diabetes control, but significantly break through seldom, compare with external progress and have a long way to go, its reason is many-sided, but that one of them is science is not strong, therefore is difficult to have breakthrough.
Diabetes have become the fourth-largest cause of the death of the mankind, and the whole world has 3,800,000 people of surpassing to die from diabetes and complication thereof every year.The whole world has 2.46 hundred million diabeticss at present.China over nearly 20 years the onset diabetes rate increased more than 5 times, be one of global fastest-rising country.
Over nearly 30 years, the progress of the relevant diabetes control in the whole world is very rapid, China is quite a few to the combination of Chinese and Western medicine research of diabetes control, but significantly break through seldom, compare with external progress and have a long way to go, its reason is many-sided, but that one of them is science is not strong, therefore is difficult to have breakthrough.And the research of pure Tibetan medicine treatment diabetes yet there are no any report.
1, external research to the prevention and treatment in Chinese and western diabetes:
Few to the prevention and treatment in Chinese and western diabetes study abroad, only there are 4 pieces to the research of Radix Ginseng as the american diabetes association annual meeting that has in June, 2,003 10,000 multi-experts to participate in.
2, the current situation and existing problems analysis of domestic prevention and treatment in Chinese and western diabetes study:
Look back China's prevention and treatment in Chinese and western diabetes study in recent decades, although some good achievements are also arranged, often do not take the formal international conference interchange of getting on, thus unknown to the public in the world.And more be some low-level repetitive operation, thereby science is not strong.
According to statistics, China has 6,000 ten thousand above diabeticss at present, at present to diabetes particularly diabetic complication there is no so far effective method.
So high onset diabetes rate expedites the emergence of out the diabetic market that has a high potential.The diabetic field has also become the emphasis that each large medicine enterprise goes on an expedition.2008, global diabetes market total sales volume was up to 24,000,000,000 dollars, and in global diabetes medicament, the oral medicine market share is a little more than insulin preparation.
TCM treatment of diabetes has long history, particularly over nearly 30 years, along with the develop rapidly of modern science, adopts the method for the combination of Chinese and Western medicine, and the treatment of diabetes has been had irreplaceable advantage.
According to statistics, diabetics accounts for 80% by the mortality rate that cardiovascular and cerebrovascular disease causes, and makes its life expectancy reduce 1/3.Diabetics merges blood fat rising person more than 80%, and blood viscosity rising person reaches 90%.
Chinese medicine is slow to the therapeutical effect of diabetes, but belongs to the category that effects a permanent cure, and when blood glucose descends, body constitution is synchronously strengthened, and chronic complicating diseases is had preventive and therapeutic action preferably.
The traditional Chinese medical science thinks, the deficiency of YIN is the pathogenetic essence of glycosuria, insufficiency of the spleen be diabetes do not heal basic, blood stasis is the key that diabetic complications produces.Chinese medicine can be invigorated blood circulation the yin nourishing invigorating the spleen and benefiting QI and be combined dexterously, thereby diabetes fundamentally are effectively treated.Use Chinese medicine can make blood glucose, glucose in urine long-term stability in normal range.
The integral body of Chinese medicine is transferred and can be strengthened patient's body constitution in blood sugar lowering, corrects sugar, protein and fat metabolic disturbance, regulates number or the affinity of Insulin receptor INSR, to increase target cell to the sensitivity of insulin, the antagonism insulin resistant.
The integrally-regulated of Chinese medicine can prevent and treat the generation of diabetes multiple complications effectively.The diabetics majority exists that blood viscosity increases, hyperlipidemia and platelet aggregation rate increase these factors, has caused the basis of the concurrent cardiovascular and cerebrovascular disease of diabetics, peripheral angiopathy and important organ damage.Chinese medicine can reduce blood viscosity and blood fat etc. by benefiting QI for activating blood circulation, thereby prevent and treat complication in blood sugar lowering.
Tibetanmedicine calls diabetes " Jing Nisagu " disease, the general translations of Chinese " urine eliminating mass ".So-called " Jing Nisagu ", " capital Buddhist nun " means frequent micturition, and " Sa Gu " refers to consume the liquid of the muddiness of physical ability, that is to say that frequency of micturition, cloudy urine, consumption physical ability are the substitutive characteristics of primary disease." eight warps of medical science will originally be released " carries: " if ask this why because of, this be hindered by diet etc. and ' Baconic ' dissolve bladder.The thing that addles (waste matter), perspiration, oils and fats, precise and tiny elite in body also can jeopardize ' red bar ' in body and blood etc. under the diet of discomfort, thus, the thing that addles (waste matter) in body, perspiration etc. all can be sneaked into urine, cause urine muddy, and people's physical ability is subdued.Therefore and grand in body also can make the large material of human body ' seven ' bladder that runs off, turn to the urine eliminating external, thereby subdue physical ability." " ' Jing Nisagu ' its disease is seen: weak drowsiness, hyperhidrosis and companion's abnormal flavour are become thin, and hair and onyx are uninteresting simple and unadorned, and in mouthful, normal sense sweet taste and oropharynx are extremely dried, have a liking for cold drink, and the dysphoria with feverish sensation in the chest palms and soles urine is turbid, and urine mark place often has the insecticide such as Apis to assemble.”
Tibetan medicine's theory is thought: the trouble diabetes are relevant to " three categories of etiologic factors " imbalance of self body.Under normal circumstances, human body " dragon " (being equivalent to wind, gas), " red bar " (refer to gallbladder, fire, the root that causes all heat symptom-complex diseases), " Baconic " (refer to water, soil, the root that causes all sympotoms caused by cold factors diseases) " three categories of etiologic factors " be in poised state, could keep the normal operation of body function.the pathogenic factor of diabetes is because serious unbalance appears in human body " three categories of etiologic factors ", usually comparatively significant performance is that " red bar " and " dragon " contained partially, " Baconic " is on the weak side, caused seven large cereal nutrients of human body (precise and tiny, blood, muscle, fat, skeleton, marrow, seminal fluid) can not normally decompose, excretion and conveying, dirty thing in blood is assembled too much, the vitals function that causes the human bodies such as heart kidney is impaired, show as clinically xerostomia easily hungry, urine urgency-frequency, weak dreaminess, the symptom such as become thin, simultaneously with heating, visual deterioration, the symptoms such as skin pruritus.
The Tibetan medicine reaches and falls " red bar " and " dragon " by conditioning, balance " three categories of etiologic factors ", and righting " Baconic " is purpose, make seven large cereal nutrients in body be decomposed normally and drain, reduce harmful composition in blood, make pancreas obtain nutrition, islet function progressively recovers; Regulate simultaneously dietary, the custom of making the life better, finally reach nutrition pancreas, reduce blood glucose, improve complication, improve the purpose of patient's live and work quality.
The medicine of diabetes comprises orally-taken blood sugar reducing medicine and insulin at present.The orally-taken blood sugar reducing medicine comprises: (1) sulfonylurea drugs; (2) biguanides; (3) meals glucose regulator; (4) alpha-glucosidase inhibitor; (5) aldose reductase inhibitor; (6) Study of Thiazolidinedione derivatives as Insulin Sensitizer; (7) other drug.
According to the difference of hypoglycemic mechanism, the orally-taken blood sugar reducing medicine can be divided into Drugs Promoting Insulin Secretion (sulphanylureas, meals glucose regulator), euglycemic agent (biguanides, Study of Thiazolidinedione derivatives as Insulin Sensitizer) and other drug (alpha-glucosidase inhibitor, non-insulin glucose-lowering hormonal agents for diabetes).
Sulfonylurea drugs is divided into the three generations, and the first generation comprises tolbutamide, chlorpropamide, tolazamide and acetohexamide; The second filial generation comprises glibenclamide, glipizide, glibornuride, gliclazide and gliquidone; The third generation just has glimepiride.
Biguanides comprises metformin and phenformin, and the latter abroad stops using at present, domestic also seldom use.
Meals glucose regulator has repaglinide and Nateglinide.
Alpha-glucosidase inhibitor has acarbose and voglibose.
Study of Thiazolidinedione derivatives as Insulin Sensitizer has rosiglitazone, troglitazone and pioglitazone.
The non-insulin glucose-lowering hormonal agents for diabetes has Pramlintide and Exenatide.
The untoward reaction of Remedies for diabetes:
1, insulin:
The untoward reaction of insulin has: (1) anaphylaxis, and use the patient of insulin urticaria and vasodilation can occur in the injection site; (2) hypoglycemic reaction; (3) insulin resistant; (4) injection site is lipoatrophy or hypertrophy; (5) refraction of eye imbalance.
2, sulfonylurea drugs:
The untoward reaction of sulfonylurea drugs: accidental hypoglycemia, diarrhoea can be arranged, feel sick, vomit, have a headache, have a stomachache or discomfort, erythra is more rare, and rare and serious have jaundice, liver function injury, granulocytopenia (showing as pharyngalgia, heating, infection), a thrombocytopenia (showing as hemorrhage, purpura) etc.
3, biguanides:
The untoward reaction of biguanides is modal is: gastrointestinal reaction, show as inappetence, nausea,vomiting,diarrhea, stomachache, mouthful in metallic taste etc.Sometimes the patient have weak, tired, lose weight, dizziness and erythra etc.
4, meals glucose regulator:
The untoward reaction of meals glucose regulator has: hypoglycemia, visual abnormality, gastrointestinal reaction, allergic rash, pruritus and urticaria etc.Only a few patient the liver transaminase occurs and increases, and its degree is light and be one to cross property, seldom causes drug withdrawal.
5, Study of Thiazolidinedione derivatives as Insulin Sensitizer:
The untoward reaction of Study of Thiazolidinedione derivatives as Insulin Sensitizer comprises: (1) anemia; (2) cardiovascular system reaction; (3) neural psychiatric system reaction; (4) hypoglycemic reaction; (5) gastrointestinal reaction etc.
6, non-insulin glucose-lowering hormonal agents for diabetes:
The non-insulin glucose-lowering hormonal agents for diabetes also has some untoward reaction, wherein feels sick the most common, and after the severe hypoglycemia event easily betides and uses in 3h, anorexia, vomiting, weak and dizzy etc. also can appear in the patient.
Treatment diabetes Chinese patent medicine commonly used mainly contains following several at present:
(1) diabetes pill; (2) JIANGTANGSHU; (3) YUQUAN WAN; (4) blood sugar lowering first sheet; (5) Ganluxiaoke capsules; (6) LIUWEI DIHUANG WAN, MAIWEIDIHUANGWAN; (7) SHIHUYEGUANG WAN; (8) Radix Rehmanniae Pilulae for Improving Eyesight; (9) SHENQI JIANGTANG sheet; (10) Kelening capsule; (11) the clever sheet of quenching one's thirst; (12) JINQI JIANGTANG PIAN; (13) TANGMAIKANG KELI; (14) ten eight flavor Fructus Chebulae diuresis balls.But the curative effect of these Chinese medicine preparation still can not be satisfactory however.
Therefore, still there is tight demand in people's Chinese medicine (Tibetan medicine) preparation that curative effect is better treated diabetes.Up to now, also do not find the report of any relevant pharmaceutical composition of the present invention.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, has finally found the Tibetan medicine oral drugs (for a long time U.S. No. 3 diabetic teas) that the treatment of better curative effect diabetes are arranged, thereby has completed the present invention.
[summary of the invention]
The object of the invention just is to provide a kind of medicine of more effectively treating diabetes.
Another object of the present invention has been to provide the preparation method of this medicine.
Medicine of the present invention is a kind of Tibetan medicine, formed or be comprised of active component and pharmaceutically acceptable adjuvant by active component, wherein said active component is to be made by following bulk drugs: Rhizoma Curcumae Longae, Radix Berberidis Amurensis, Fructus Tribuli, the Radix Aucklandiae, Rhododendron, Cortex Lycii.
It has selected Rhizoma Curcumae Longae, Radix Berberidis Amurensis, Fructus Tribuli, the Radix Aucklandiae, Rhododendron, Cortex Lycii to make up as crude drug, and wherein (1) Rhizoma Curcumae Longae is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae Curcuma longa L..Nature and flavor are hot, bitter, and temperature has the removing blood stasis circulation of qi promoting, the effect of inducing menstruation to relieve menalgia; Be used for the treatment of the breast side of body and twinge, amenorrhea ， WEIJIA, rheumatism shoulder arm pain, the diseases such as tumbling and swelling; Have the pharmacological actions such as function of gallbladder promoting, blood pressure lowering, antibiotic, blood fat reducing, antitumor, resisting pathogenic microbes, antioxidation.(2) Radix Berberidis Amurensis is the dry skin of Berberidaceae plant kansu barberry bark Berbeis kansuensis Schneid., and nature and flavor are cool, bitter, place heat is clearly arranged, relieving heat toxin, the function of holding back yellow fluid; Be used for epidemic disease, old calentura, grasserie; Berberine has hypoglycemic activity.(3) Fructus Tribuli is the dry mature fruit of zygophyllaceae plant Tribulus terrestns L., and nature and flavor are hot, bitter, tepor, return Liver Channel; The suppressing the hyperactive liver resolving depression is arranged, and promoting blood circulation by removing wind makes eye bright, antipruritic function; Be used for having a headache dizzy, sternal rib pain, breast closes acute mastitis, conjunctival congestion cataracta, rubella pruritus; Have and resist myocardial ischemia, blood fat is transferred in blood pressure lowering, promotes the effect of glandular hormone sample, the anti-ageing pharmacological action of waiting for a long time; The clinical coronary heart disease that is used for the treatment of, cerebrovascular disorders, angioneurotic headache, infantile autumn diarrhea etc.(4) Radix Aucklandiae is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne..The nature and flavor acrid, bitter, warm is returned spleen, stomach, large intestine, three warmers, gallbladder meridian, and promoting the circulation of QI to relieve pain are arranged, the function of strengthening the spleen to promote digestion; Be used for breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia etc.(5) Rhododendron is dried floral and the leaf of ericad Rhododendron Rhododendron anthopogonoides Maxim..Nature and flavor are sweet, puckery, flat, and clearing heat for detumescence is arranged, the function of the kidney invigorating; Be used for tracheitis, emphysema, edema, physical weakness and water and soil are uncomfortable, dyspepsia, gastroptosis, flatulence, the skin ulcer pestilence is controlled in external.(6) Cortex Lycii is the dry root bark of matrimony vine of solanaceae plant Lycium chinense Mil1. or lycium barbarum Lycium barbarum L..Nature and flavor are sweet, cold, return lung, liver, kidney channel, have removing heat from blood to remove steaming, the function of lung heat clearing pathogenic fire reducing; Be used for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, the cough due to lung-heat, spitting of blood, epistaxis, interior-heat are quenched one's thirst etc.; Root bark contains cinnamic acid and volume aldehydes matter, betanin; Have blood pressure lowering, blood sugar lowering, the pharmacological action such as analgesic.Make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat diabetes.
The consumption of medicine of the present invention (for a long time U.S. No. 3 diabetic teas) component is also groped to sum up to draw through the inventor in a large number, and each amounts of components is for all to have good therapeutic effect in the following weight parts scope:
1～2 part, Rhizoma Curcumae Longae, 1～2 part of Radix Berberidis Amurensis, 1～2 part of Fructus Tribuli, 0.5～1.5 part of the Radix Aucklandiae, 2～3 parts of Rhododendrons, 1～2 part of Cortex Lycii, 0.25～0.75 part of brick tea.
Be preferably: 1.5 parts, Rhizoma Curcumae Longae, 1.5 parts of Radix Berberidis Amurensis, 1.5 parts of Fructus Tribulis, 1 part of the Radix Aucklandiae, 2.5 parts of Rhododendrons, 1.5 parts of Cortex Lycii, 0.5 part of brick tea.
The preparation of medicine activity component of the present invention can be the crude drug convection drying of above-mentioned consumption to be pulverized make; Also the crude drug of above-mentioned consumption can be adopted the conventional method of Chinese medicine preparation such as decoction and alcohol sedimentation technique or ethanol extract from water precipitation (referring to " pharmaceutics of Chinese drugs " 73-74 page of Cao Chunlin chief editor, Science and Technology of Shanghai publishing house publishes in November, 1986) to make.
The active component of medicine of the present invention can add conventional adjuvant required when preparing dosage form, as binding agent etc. with the method for Chinese medicinal of routine (referring to Cao Chunlin chief editor's " pharmaceutics of Chinese drugs ", Science and Technology of Shanghai publishing house publishes in November, 1986) be prepared into medicinal tea, comprise block medicinal tea, packed medicinal tea and decoct medicinal tea.
Medicine of the present invention has nourishing kidney yin, promoting the production of body fluid to quench thirst, the function of QI invigorating blood sugar lowering.Be used for the treatment of diabetes.Polydipsia, polyphagia, the polyuria that the Tibetan medicine is used for being caused by " Baconic " imbalance, become thin, the diabetess such as glucose in urine and blood sugar increasing.The traditional Chinese medical science is used for the diabetes due to deficiency of both QI and YIN.
The usage and dosage of medicine of the present invention (for a long time U.S. No. 3 diabetic teas) is: boiled water brews to be drunk.A 2g, 1～4 time on the one.
[specific embodiment]
Come by the following examples further to set forth the preparation method of medicine of the present invention.
The block medicinal tea preparation of [embodiment 1] medicine of the present invention:
Take Rhizoma Curcumae Longae 300g, Radix Berberidis Amurensis 300g, Fructus Tribuli 300g, Radix Aucklandiae 200g, Rhododendron 500g, Cortex Lycii 300g, jointly be ground into coarse powder after mixing, add brick tea 100g, mixing is pressed into bulk, namely gets block medicinal tea, is called U.S. No. 3 diabetic teas of a specified duration.
The packed medicinal tea preparation of [embodiment 2] medicine of the present invention:
Take Rhizoma Curcumae Longae 350g, Radix Berberidis Amurensis 250g, Fructus Tribuli 360g, Radix Aucklandiae 160g, Rhododendron 550g, Cortex Lycii 260g, jointly be ground into coarse powder after mixing, add brick tea 70g, mixing is packed into and is drunk tea bag, namely gets packed medicinal tea.
The decoction medicinal tea preparation of [embodiment 3] medicine of the present invention:
Take Rhizoma Curcumae Longae 280g, Radix Berberidis Amurensis 340g, Fructus Tribuli 230g, Radix Aucklandiae 180g, Rhododendron 600g, Cortex Lycii 280g, jointly be ground into coarse powder after mixing, add brick tea 90g, mixing in the bag of packing into, namely gets the decoction medicinal tea.
Below further set forth the beneficial effect of medicine of the present invention (for a long time U.S. No. 3 diabetic teas) by test example, these test examples have comprised pharmacodynamics test and the clinical observation on the therapeutic effect test of medicine of the present invention (for a long time U.S. No. 3 diabetic teas).
[test example 1] medicine of the present invention (for a long time U.S. No. 3 diabetic teas) brings out the pharmacodynamics test of the impact of hyperglycemic rat blood glucose value and glycolated hemoglobin to normal animal blood glucose, spontaneous hyperglycemia and serum insulin on impact, the streptozotocin of mouse blood sugar:
Test material:
The NIH mice, weight 18～22g; The NOD mice, weight 25～35g; The SD rat, weight 180～220g, female, male half and half, provided by animal housing of Part of Qinghai Plateau biological study institute.
Anthology invention medicine (for a long time U.S. No. 3 diabetic teas); Glibenclamide tablet (Glibenclamide Tablets), the 2.5mg/ sheet, lot number: 20090712, metal and stone pharmacy head factory in Shantou is produced; Acarbose sheet: Beijing Bayer medicine health Co., Ltd (lot number: 20090607); Mount Tai I-insulin radioimmunoassay, RIA medicine box, Isotope Research institute of China Atomic Energy Science Research Institute.Streptozotocin: Sigma company produces, glycolated hemoglobin test kit (microtrabeculae method): kind city, Ningbo City biochemical reagents factory.
1, the impact of medicine of the present invention (for a long time U.S. No. 3 diabetic teas) on normal animal blood glucose:
Experimental technique: the NIH mice, 50, female, hero half and half after 6h, is measured blood glucose on an empty stomach, is divided at random 5 groups according to blood glucose value and Animal Sex equilibrium, and gavage gives following medicine respectively: Normal group (distilled water); Glyburide group (25mg/kg); Medicine of the present invention (for a long time U.S. No. 3 diabetic teas) is pressed the basic, normal, high dosage group of crude drug (2,4,8mg/kg).Successive administration 7d, the administration volume is pressed 20ml/kg, empty stomach 6h before administration in the 7th day, after administration, the 1h animal is got blood, measures the animal blood glucose value with blood glucose meter.Experimental result sees Table 1.
The impact of table 1 medicine of the present invention (for a long time U.S. No. 3 diabetic teas) on normal mouse blood sugar value
Annotate: compare with Normal group
*P＜0.01.
Experimental result: the basic, normal, high dosage group of medicine of the present invention (for a long time U.S. No. 3 diabetic teas) has no significant effect normal mouse blood sugar.
2, medicine of the present invention (for a long time U.S. No. 3 diabetic teas) is on the impact of spontaneous hyperglycemia and the serum insulin impact on mouse blood sugar:
Experimental technique: the NOD mice, on an empty stomach after 6h, measure blood glucose, select blood glucose value higher than 50 of the animals of 11.1mmol/L, be divided at random 5 groups, gavage gives following medicine respectively: matched group (distilled water); Glyburide group (25mg/kg); Medicine of the present invention (for a long time U.S. No. 3 diabetic teas) is pressed the basic, normal, high dosage group of crude drug (2,4,8mg/kg).Successive administration 14d measures the animal blood glucose value with blood glucose meter, uses the serum measured by radioimmunoassay insulin, the results are shown in Table 2,3.
The impact of table 2 medicine of the present invention (for a long time U.S. No. 3 diabetic teas) on spontaneous hyperglycemia mouse blood sugar
Annotate: compare with model control group
*P＜0.05,
*P＜0.01.
The impact of table 3 medicine of the present invention (for a long time U.S. No. 3 diabetic teas) on spontaneous hyperglycemia mice serum insulin
Annotate: compare with model control group
*P＜0.05,
*P＜0.01.
Experimental result: the basic, normal, high dosage group of the oral medicine of the present invention of NOD mice (for a long time U.S. No. 3 diabetic teas), can reduce blood glucose and rising serum insulin.
3, medicine of the present invention (for a long time U.S. No. 3 diabetic teas) brings out the impact of hyperglycemic rat blood glucose value and glycolated hemoglobin on streptozotocin:
Impact on rat blood sugar and glycolated hemoglobin:
Experimental technique: after SD rat, fasting be can't help water 24h, low dose of intravenous injection streptozotocin 25mg/kg, 1 time/week, add simultaneously the high heat forage feed and bring out type ii diabetes, 1 week was measured blood glucose after the 2nd injection, 50 of the rats of selection fasting glucose 〉=7.8mmol/L are tested.Be divided at random 5 groups, 10 every group, give respectively following medicine: hyperglycemia model group (distilled water); Acarbose group (25mg/kg); Medicine of the present invention (for a long time U.S. No. 3 diabetic teas) is pressed the basic, normal, high dosage group of crude drug (2,4,8mg/kg).Separately establish 10 of normal control rats (gavage equal-volume distilled water).Give Experimental agents by above dosage gavage, continuous 14d, empty stomach 12h before the 14d administration, 1h measures blood glucose and glycolated hemoglobin after the last administration.Experimental result sees Table 4,5.
Table 4 medicine of the present invention (for a long time U.S. No. 3 diabetic teas) brings out the impact of hyperglycemic rat blood glucose on streptozotocin
Annotate: compare with Normal group
△ △P＜0.01;
Compare with model group
*P＜0.05,
*P＜0.01.
Table 5 medicine of the present invention (for a long time U.S. No. 3 diabetic teas) brings out the impact of hyperglycemic rat glycolated hemoglobin on streptozotocin
Annotate: compare with Normal group
△ △P＜0.01;
Compare with model group
*P＜0.05,
*P＜0.01.
Impact on blood glucose after Oral Administration in Rats sucrose:
Experimental technique: the same, give trial drug by above dosage gavage, continuous 14d, before administration in the 14th day, empty stomach 6h, contain sucrose 0.125g/ml in medicine in the time of by above dosed administration, and the administration volume is pressed 20ml/kg.With blood glucose meter measure to after sucrose 0.5,1, the 2h blood glucose value.Experimental result sees Table 6.
The impact of table 6 medicine of the present invention (for a long time U.S. No. 3 diabetic teas) on blood glucose after Oral Administration in Rats sucrose
Annotate: compare with Normal group
△P＜0.05
△ △P＜0.01;
Compare with model group
*P＜0.05
*P＜0.01.
Experimental result: medicine of the present invention (for a long time U.S. No. 3 diabetic teas) after oral administration, has the effect that reduces blood glucose and glycolated hemoglobin to the hyperglycemic rat that the mould index of chain urea rises.And blood sugar increasing time and reduction blood glucose peak concentration after deferrable Oral Administration in Rats sucrose.
Experimental result shows, medicine of the present invention (for a long time U.S. No. 3 diabetic teas) has no significant effect normal mouse blood sugar, but the blood sugar increasing time after deferrable Oral Administration in Rats sucrose, can reduce spontaneous hyperglycemia and rising serum insulin, can reduce blood glucose and glycolated hemoglobin that streptozotocin brings out hyperglycemic rat, so medicine of the present invention (for a long time U.S. No. 3 diabetic teas) there is positive impetus at Tibetan medicine to the treatment field of diabetes.
[test example 2] medicine of the present invention (for a long time U.S. No. 3 diabetic teas) treatment diabetes clinical observation on the therapeutic effect:
Physical data:
My institute uses medicine of the present invention (for a long time U.S. No. 3 diabetic teas) treatment Diabetes Clinic and inpatient 124 examples, and all data are divided into treatment group and matched group at random, treatment group 68 examples, male 44 examples wherein, female's 24 examples.40～50 years old age, 16 examples, 50～60 years old 38 example,＞61 years old person's 14 example.Companion's coronary heart disease 8 examples, cerebrovascular disease 6 examples, Peripheral neuropathy 5 examples.Matched group 56 examples, male 32 examples, female's 24 examples.40～50 years old age, 14 examples, 50～60 years old 32 example,＞60 years old 10 example.Wherein accompany coronary disease patient 6 examples, cerebrovascular disease 6 examples, Peripheral neuropathy person 4 examples.The average 12.8mmol/L for the treatment of group fasting glucose, glucose in urine (+++), matched group fasting glucose meansigma methods is 13.2mmol/L.Two groups of patients all have the three-many-one-little symptom, meet the diagnostic criteria of traditional Chinese medical science diabetes.Western medicine diagnose meets the diabetes diagnosis standard of WHO formulation in 1999, and confirms as type 2 diabetes mellitus.
Therapeutic Method:
Treatment group: adopt medicine of the present invention (for a long time U.S. No. 3 diabetic teas), boiled water brews to be drunk.A 2g, 1～4 time on the one.30 days is a course for the treatment of.
Matched group: oral diabetes pill, LIUWEI DIHUANG WAN, to keep on a diet, the course for the treatment of is the same.Observe treatment two groups of clinical symptoms of fore-and-aft observing and sign, fasting glucose, blood fat, hemorheology index.
The clinical efficacy evaluation criteria:
Produce effects: transference cure, below fasting glucose 6.0mmol/L, the 6.8mmol/L that on average descends, glucose in urine ();
Effectively: transference cure, fasting glucose 8.0mmol/L, glucose in urine (++);
Invalid: symptom makes moderate progress, fasting glucose＞8mmol/L, glucose in urine (++).
Table 7 liang group patient clinical curative effect relatively
Table 8 a liang group fasting glucose changes situation (mmol/L)
Blood fat change situation before and after table 9 liang group treatment (M ± SD)
Annotate: with front relatively P＜0.05 for the treatment of.
Before and after the treatment of table 10 liang group, hemorheology sexually revises situation (M ± SD)
Annotate: with front relatively P＜0.05 for the treatment of.
Clinical observation result: use medicine of the present invention (for a long time U.S. No. 3 diabetic teas) treatment diabetes type II patient 68 examples, produce effects 42 examples, effective 16 examples, total effective rate 85.30%, matched group are observed 56 examples equally, produce effects 28 examples, effective 17 examples, total effective rate be 80.36%, two group obvious to diabetics blood sugar lowering curative effect, but no significant difference (P＜0.05).
Claims (7)
1. medicine for the treatment of diabetes, it is characterized in that it is comprised of active component or is comprised of active component and pharmaceutically acceptable adjuvant, wherein said active component is to be made by the crude drug of following weight portion: 1～2 part, Rhizoma Curcumae Longae, 1～2 part of Radix Berberidis Amurensis, 1～2 part of Fructus Tribuli, 0.5～1.5 part of the Radix Aucklandiae, 2～3 parts of Rhododendrons, 1～2 part of Cortex Lycii, 0.25～0.75 part of brick tea.
2. medicine according to claim 1, wherein said active component is to be made by the crude drug of following weight portion: 1.5 parts, Rhizoma Curcumae Longae, 1.5 parts of Radix Berberidis Amurensis, 1.5 parts of Fructus Tribulis, 1 part of the Radix Aucklandiae, 2.5 parts of Rhododendrons, 1.5 parts of Cortex Lycii, 0.5 part of brick tea.
3. medicine according to claim 1 and 2, it is peroral dosage form.
4. medicine according to claim 3, it is medicinal tea.
5. the preparation method of the described medicine of claim 1, it comprises the following steps: to take the raw material of following weight portion: 1～2 part, Rhizoma Curcumae Longae, 1～2 part of Radix Berberidis Amurensis, 1～2 part of Fructus Tribuli, 0.5～1.5 part of the Radix Aucklandiae, 2～3 parts of Rhododendrons, 1～2 part of Cortex Lycii, mix, jointly be ground into coarse powder; Add 0.25～0.75 part of brick tea, mixing is made active component.
6. according to preparation method claimed in claim 5, wherein take the raw material of following weight portion: 1.5 parts, Rhizoma Curcumae Longae, 1.5 parts of Radix Berberidis Amurensis, 1.5 parts of Fructus Tribulis, 1 part of the Radix Aucklandiae, 2.5 parts of Rhododendrons, 1.5 parts of Cortex Lycii, brick tea 0.5.
7. according to claim 5 or 6 described preparation methoies, it also comprises the following steps: active component and pharmaceutically acceptable adjuvant are made medicinal tea, comprises block medicinal tea, packed medicinal tea and decocts medicinal tea.
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