CN111436610A - Bamboo leaf flavone red date effervescent tablet and preparation method thereof - Google Patents
Bamboo leaf flavone red date effervescent tablet and preparation method thereof Download PDFInfo
- Publication number
- CN111436610A CN111436610A CN202010399027.8A CN202010399027A CN111436610A CN 111436610 A CN111436610 A CN 111436610A CN 202010399027 A CN202010399027 A CN 202010399027A CN 111436610 A CN111436610 A CN 111436610A
- Authority
- CN
- China
- Prior art keywords
- bamboo leaf
- red date
- parts
- effervescent tablet
- leaf flavone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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Abstract
The invention discloses a bamboo leaf flavone and red date effervescent tablet and a preparation method thereof, and relates to the technical field of effervescent tablet processing. The bamboo leaf flavone and red date effervescent tablet is prepared from the following raw materials in parts by weight: 15-30 parts of bamboo leaf flavone, 10-20 parts of red dates, 1-8 parts of sweetening agent, 1-6 parts of adhesive, 0.5-4 parts of lubricant, 5-20 parts of acid agent and 5-20 parts of alkaline agent. The invention overcomes the defects of the prior art, and the bamboo leaf flavone and the red date active ingredients are respectively prepared into effervescent tablets, thereby achieving the advantages of convenient carrying and drinking. After the bamboo leaf flavone and red date effervescent tablet is taken, the effects of protecting heart and cerebral vessels, improving myocardial ischemia, improving cerebral ischemia, regulating blood fat and reducing blood viscosity are achieved, and the functions of preventing hypertension, enhancing immunity and the like are also achieved.
Description
Technical Field
The invention relates to the technical field of effervescent tablet processing, in particular to a bamboo leaf flavone red date effervescent tablet and a preparation method thereof.
Background
Cardiovascular and cerebrovascular diseases are the major diseases with the highest human mortality rate, and seriously threaten the health of human beings. According to statistics of the heart alliance in the world, 1 person in 3 people died of diseases worldwide dies of cardiovascular diseases, the number of the people died of the diseases worldwide due to heart diseases and stroke is up to 1750 ten thousand every year, and about 300 thousand people in China die of cardiovascular and cerebrovascular diseases every year, and accounts for about 40% of all the people died of the diseases. The food therapy is an important method for preventing cardiovascular and cerebrovascular diseases by nourishing and conditioning through food therapy and preventing diseases in the bud.
Lophatherum gracile is a perennial herb with fragrance, is a traditional medicinal and edible food, and contains a large amount of flavone, phenolic acid, anthraquinone compounds and the like. The bamboo leaf flavone is the main active component in the lophatherum gracile, and has the functions of preventing cardiovascular and cerebrovascular diseases, expanding capillaries, dredging microcirculation, regulating blood fat, reducing blood viscosity, preventing hypertension, improving sleep, enhancing immunity and the like. Bamboo leaf flavone is approved by the national committee of wei in 2014 as a new resource food, and the consumption of the bamboo leaf flavone is less than or equal to 2 g/day.
The red date has the reputation of 'natural vitamin pills', and has the effects of nourishing yin and tonifying yang. Red dates, warm in nature, sweet in taste, contain proteins, amino acids, sugars, organic acids, vitamins, trace elements, etc. Has the effects of invigorating spleen and replenishing qi, nourishing blood and tranquillizing, dilating blood vessel, enhancing myocardial contractility, and preventing cardiovascular diseases.
The effervescent tablet contains organic acid and bicarbonate or carbonate, and can release a large amount of carbon dioxide when meeting water to form effervescence. The effervescent tablet has the properties of both solid preparation and liquid preparation, and has wide application prospect in the health industry. Chinese patent (CN103719840A) reports that bamboo leaf flavone is obtained by taking bamboo leaves as raw materials through an alcohol extraction method, and then the bamboo leaf flavone is processed into bamboo leaf flavone chewable tablets. Chinese patent (CN109315576A) reports that the natto bamboo leaf flavone tablet candy prepared by taking bamboo leaf flavone, natto powder, red yeast rice powder, hydrolyzed collagen powder, hawthorn, kudzu root and the like as raw materials has the effects of protecting heart and cerebral vessels, regulating blood fat, reducing blood viscosity and effectively improving diseases such as coronary heart disease, hypertension, arteriosclerosis, stroke, varicose veins, gout and the like. At present, no report that bamboo leaf flavone and red date are used as raw materials to prepare effervescent tablets is available. The invention takes bamboo leaf flavone and red date as raw materials, processes the raw materials into nutrient effervescent tablets, can be dissolved rapidly by adding into hot water, is convenient to drink, and is fragrant, sweet and delicious. Has effects in invigorating spleen, invigorating qi, nourishing blood, tranquilizing mind, preventing cardiovascular diseases, lowering blood viscosity, preventing hypertension, and enhancing immunity.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the bamboo leaf flavone and red date effervescent tablet and the preparation method thereof.
In order to achieve the above purpose, the technical scheme of the invention is realized by the following technical scheme: the bamboo leaf flavone and red date effervescent tablet is characterized by comprising the following raw materials in percentage by mass: 15-30 parts of bamboo leaf flavone, 10-20 parts of red dates, 1-8 parts of sweetening agent, 1-6 parts of adhesive, 0.5-4 parts of lubricant, 5-20 parts of acid agent and 5-20 parts of alkaline agent.
The preparation method of the bamboo leaf flavone red date effervescent tablet comprises the following steps:
step 1, preparing bamboo leaf flavonoid powder, namely cleaning fresh lophatherum gracile, crushing, adding water, decocting and concentrating; freeze drying the concentrated juice, pulverizing, and sieving to obtain bamboo leaf flavone powder;
step 2, red date powder is prepared by selecting, cleaning, removing cores, pulping, decocting red dates to paste, freeze-drying at low temperature, crushing and sieving to obtain red date powder for later use;
step 3, preparing bamboo leaf flavone granules: uniformly stirring and mixing the bamboo leaf flavone powder, the sweetening agent, the adhesive, the stabilizer and the acid agent in a stirrer, adding 70-95% ethanol, mixing for 20-40 minutes, performing wet granulation, and drying at 50 ℃ for 3-5 hours to obtain bamboo leaf flavone granules;
step 4, preparation of red date granules: uniformly stirring and mixing red date powder, a sweetening agent, an adhesive, a stabilizer and an alkaline agent in a stirrer, adding 70-95% ethanol, mixing for 20-40 minutes, performing wet granulation, and evaporating ethanol in the subsequent drying process to obtain red date granules;
and 5, uniformly mixing the bamboo leaf flavone granules, the red date granules and the lubricant, and tabletting to obtain the bamboo leaf flavone and red date effervescent tablets.
Further, the sweetener: one or more of stevioside, glycyrrhizin, maltitol, xylitol, sucralose and sorbitol; preferably, the sweetener is one or two of stevioside and liquiritigenin.
The adhesive is as follows: one or more than one of xanthan gum, maltodextrin, cyclodextrin, microcrystalline cellulose, carrageenan and sodium carboxymethylcellulose; preferably, the adhesive is formed by compounding one or two of xanthan gum and maltodextrin.
The lubricant is as follows: one or more of magnesium stearate, silicon dioxide, stearic acid, talcum powder, polyethylene glycol 6000, sodium dodecyl sulfate and magnesium dodecyl sulfate; preferably, the lubricant is formed by compounding one or two of magnesium stearate and sodium lauryl sulfate.
The acid agent is one or more of citric acid, malic acid, tartaric acid, lactic acid and fumaric acid; preferably, the acid agent is one or two of citric acid and apple.
The alkaline agent is formed by compounding one or more of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and calcium carbonate; preferably, the alkaline agent is formed by compounding one or two of sodium carbonate and sodium bicarbonate.
The specific implementation mode is as follows:
example 1: bamboo leaf flavone red date effervescent tablet
The raw materials comprise, by mass, 30 parts of bamboo leaf flavone, 10 parts of red date, 8 parts of sweetening agents (stevioside 2 parts, liquiritigenin 2 parts and maltitol 4 parts), 6 parts of binding agents (xanthan gum 2 parts, maltodextrin 2 parts and cyclodextrin 2 parts), 4 parts of lubricating agents (magnesium stearate 2 parts, polyethylene glycol 60001 parts and sodium dodecyl sulfate 1 parts), 20 parts of acid agents (citric acid 10 parts, malic acid 5 parts and tartaric acid 5 parts), and 20 parts of alkaline agents (sodium carbonate 10 parts, sodium bicarbonate 5 parts and calcium carbonate 5 parts).
The sweetener is formed by compounding stevioside, liquiritigenin and maltitol.
The adhesive is formed by compounding xanthan gum, maltodextrin and cyclodextrin.
The lubricant is formed by compounding magnesium stearate, polyethylene glycol 6000 and sodium dodecyl sulfate.
The acid agent is formed by compounding three types of citric acid, malic acid and tartaric acid.
The alkaline agent is formed by compounding three components of sodium carbonate, sodium bicarbonate and calcium carbonate.
The preparation method of the bamboo leaf flavone red date effervescent tablet comprises the following steps:
step 1, preparing bamboo leaf flavonoid powder, namely cleaning fresh lophatherum gracile, crushing, adding water, decocting and concentrating; freeze drying the concentrated juice, pulverizing, and sieving to obtain bamboo leaf flavone powder;
step 2, red date powder is prepared by selecting, cleaning, removing cores, pulping, decocting red dates to paste, freeze-drying at low temperature, crushing and sieving to obtain red date powder for later use;
step 3, preparing bamboo leaf flavone granules: preparing bamboo leaf flavone granules: uniformly stirring and mixing the bamboo leaf flavonoid powder, the sweetening agent, the adhesive, the stabilizer and the acid agent in a stirrer, adding 95% ethanol after uniformly stirring and mixing in the stirrer, mixing for 20 minutes, carrying out wet granulation, and drying for 3 hours at 50 ℃ to obtain the bamboo leaf flavonoid granules;
step 4, preparation of red date granules: uniformly stirring and mixing red date powder, a sweetening agent, an adhesive, a stabilizer and an alkaline agent in a stirrer, adding 95% ethanol, mixing for 20 minutes, performing wet granulation, and drying at 50 ℃ for 3 hours to obtain red date granules;
and 5, uniformly mixing the bamboo leaf flavone granules, the red date granules and the lubricant, and tabletting to obtain the bamboo leaf flavone and red date effervescent tablets.
Example 2: bamboo leaf flavone red date effervescent tablet
The raw materials comprise, by mass, 15 parts of bamboo leaf flavone, 20 parts of red date, 1 part of sweetener (stevioside 0.5 part, liquiritigenin 0.5 part), 1 part of adhesive (maltodextrin 0.2 part, carrageenan 0.8 part), 0.5 part of lubricant (polyethylene glycol 60000.3 part, sodium dodecyl sulfate 0.2 part), 5 parts of acid agent (citric acid 4 part, malic acid 1 part), and 5 parts of alkali agent (sodium carbonate 4 part, sodium bicarbonate 1 part).
The sweetener is formed by compounding stevioside and liquiritigenin;
the adhesive is formed by compounding two types of maltodextrin and carrageenan;
the lubricant is formed by compounding polyethylene glycol 6000 and lauryl sodium sulfate;
the acid agent is formed by compounding citric acid and malic acid;
the alkaline agent is formed by compounding two types of sodium carbonate and sodium bicarbonate.
The preparation method of the bamboo leaf flavone red date effervescent tablet comprises the following steps:
step 1, preparing bamboo leaf flavonoid powder, namely cleaning fresh lophatherum gracile, crushing, adding water, decocting and concentrating; freeze drying the concentrated juice, pulverizing, and sieving to obtain bamboo leaf flavone powder;
step 2, red date powder is prepared by selecting, cleaning, removing cores, pulping, decocting red dates to paste, freeze-drying at low temperature, crushing and sieving to obtain red date powder for later use;
step 3, preparing bamboo leaf flavone granules: preparing bamboo leaf flavone granules: uniformly stirring and mixing the bamboo leaf flavone powder, the sweetening agent, the adhesive, the stabilizer and the acid agent in a stirrer, adding 70% ethanol, mixing for 40 minutes, carrying out wet granulation, and then drying for 5 hours at 50 ℃ to obtain the bamboo leaf flavone granules;
step 4, preparation of red date granules: uniformly stirring and mixing red date powder, a sweetening agent, an adhesive, a stabilizer and an alkaline agent in a stirrer, adding 95% ethanol, mixing for 40 minutes, carrying out wet granulation, and evaporating ethanol in the subsequent drying process to obtain red date granules;
and 5, uniformly mixing the bamboo leaf flavone granules, the red date granules and the lubricant, and tabletting to obtain the bamboo leaf flavone and red date effervescent tablets.
Example 3: bamboo leaf flavone red date effervescent tablet
The raw materials comprise, by mass, 20 parts of bamboo leaf flavone, 15 parts of red date, 6 parts of sweetening agents (xylitol 2 parts, sucralose 2 parts and sorbitol 2 parts), 4 parts of binding agents (xanthan gum 1 part, maltodextrin 1 part and sodium carboxymethylcellulose 2 parts), 3 parts of lubricating agents (magnesium stearate 1 part, silicon dioxide 1 part and sodium lauryl sulfate 1 part), 15 parts of acid agents (citric acid 5 parts, lactic acid 5 parts and fumaric acid 5 parts), and 15 parts of alkaline agents (potassium carbonate 5 parts, potassium bicarbonate 5 parts and calcium carbonate 5 parts).
The sweetener is formed by compounding xylitol, xylitol and sorbitol;
the adhesive is formed by compounding xanthan gum, maltodextrin and sodium carboxymethylcellulose
The lubricant is formed by compounding magnesium stearate, silicon dioxide and sodium dodecyl sulfate;
the acid agent is formed by compounding three components of citric acid, lactic acid and fumaric acid;
the alkaline agent is formed by compounding potassium carbonate, potassium bicarbonate and calcium carbonate.
The preparation method of the bamboo leaf flavone red date effervescent tablet comprises the following steps:
step 1, preparation of bamboo leaf flavonoid powder: cleaning fresh herba Lophatheri, pulverizing, decocting in water, and concentrating; freeze drying the concentrated juice, pulverizing, and sieving to obtain bamboo leaf flavone powder;
step 2, red date powder is prepared by selecting, cleaning, removing cores, pulping, decocting red dates to paste, freeze-drying at low temperature, crushing and sieving to obtain red date powder for later use;
step 3, preparing bamboo leaf flavone granules: uniformly stirring and mixing the bamboo leaf flavonoid powder, the sweetening agent, the adhesive, the stabilizer and the acid agent in a stirrer, adding 80% ethanol after uniformly stirring and mixing in the stirrer, mixing for 30 minutes, carrying out wet granulation, and drying for 4 hours at 50 ℃ to obtain the bamboo leaf flavonoid granules;
step 4, preparation of red date granules: uniformly stirring and mixing red date powder, a sweetening agent, an adhesive and an alkaline agent in a stirrer, adding 90% ethanol, mixing for 30 minutes, carrying out wet granulation, and evaporating the ethanol in the subsequent drying process to obtain red date granules;
and 5, uniformly mixing the bamboo leaf flavone granules, the red date granules and the lubricant, and tabletting to obtain the bamboo leaf flavone and red date effervescent tablets.
Example 4: bamboo leaf flavone red date effervescent tablet
The raw materials comprise, by mass, 25 parts of bamboo leaf flavone, 15 parts of red date, 5 parts of sweetening agent (stevioside 2 parts, maltitol 2 parts and sorbitol 1 part), 4 parts of adhesive (cyclodextrin 2 parts, microcrystalline cellulose 1 part and carrageenan 1 part), 4 parts of lubricant (magnesium stearate 2 parts, calcium stearate 1 part and talcum powder 1 part), 12 parts of acid agent (citric acid 5 parts, malic acid 5 parts and lactic acid 2 parts), and 12 parts of alkaline agent (sodium carbonate 5 parts, sodium bicarbonate 5 parts and potassium bicarbonate 2 parts).
The sweetener is formed by compounding stevioside, maltitol and sorbitol;
the adhesive is formed by compounding three components of cyclodextrin, microcrystalline cellulose and carrageenan;
the lubricant is formed by compounding magnesium stearate, calcium stearate and talcum powder;
the acid agent is formed by compounding citric acid, malic acid and lactic acid;
the alkaline agent is formed by compounding three components of sodium carbonate, sodium bicarbonate and potassium bicarbonate.
The preparation method of the bamboo leaf flavone red date effervescent tablet comprises the following steps:
step 1, preparing bamboo leaf flavonoid powder, namely cleaning fresh lophatherum gracile, crushing, adding water, decocting and concentrating; freeze drying the concentrated juice, pulverizing, and sieving to obtain bamboo leaf flavone powder;
step 2, red date powder is prepared by selecting, cleaning, removing cores, pulping, decocting red dates to paste, freeze-drying at low temperature, crushing and sieving to obtain red date powder for later use;
step 3, preparing bamboo leaf flavone granules: preparing bamboo leaf flavone granules: uniformly stirring and mixing the bamboo leaf flavone powder, the sweetening agent, the adhesive, the stabilizer and the acid agent in a stirrer, adding 85% ethanol, mixing for 25 minutes, carrying out wet granulation, and then drying for 4 hours at 50 ℃ to obtain the bamboo leaf flavone granules;
step 4, preparation of red date granules: uniformly stirring and mixing red date powder, a sweetening agent, an adhesive, a stabilizer and an alkaline agent in a stirrer, adding 90% ethanol, mixing for 35 minutes, carrying out wet granulation, and evaporating ethanol in the subsequent drying process to obtain red date granules;
and 5, uniformly mixing the bamboo leaf flavone granules, the red date granules and the lubricant, and tabletting to obtain the bamboo leaf flavone and red date effervescent tablets.
The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited by the above embodiments, and all technical solutions obtained by using equivalent alternatives or equivalent variations fall within the protection scope of the present invention.
Claims (10)
1. The bamboo leaf flavone and red date effervescent tablet is characterized by comprising the following raw materials in percentage by mass: 15-30 parts of bamboo leaf flavone, 10-20 parts of red dates, 1-8 parts of sweetening agent, 1-6 parts of adhesive, 0.5-4 parts of lubricant, 5-20 parts of acid agent and 5-20 parts of alkaline agent.
2. The bamboo leaf flavonoid red date effervescent tablet as claimed in claim 1 and the preparation method thereof are characterized in that the ingredients are mixed according to the proportion of claim 1, and the preparation method comprises the following steps:
step 1, preparing bamboo leaf flavonoid powder, namely cleaning fresh lophatherum gracile, crushing, adding water, decocting and concentrating; freeze drying the concentrated juice, pulverizing, and sieving to obtain bamboo leaf flavone powder;
step 2, red date powder is prepared by selecting, cleaning, removing cores, pulping, decocting red dates to paste, freeze-drying at low temperature, crushing and sieving to obtain red date powder for later use;
step 3, preparing bamboo leaf flavone granules: uniformly stirring and mixing the bamboo leaf flavone powder, the sweetening agent, the adhesive, the stabilizer and the acid agent in a stirrer, adding ethanol, mixing, performing wet granulation, and drying at 50 ℃ to obtain the bamboo leaf flavone granules;
step 4, preparation of red date granules: uniformly stirring and mixing red date powder, a sweetening agent, an adhesive, a stabilizer and an alkaline agent in a stirrer, adding ethanol, mixing, performing wet granulation, and evaporating the ethanol in the subsequent drying process to obtain red date granules;
and 5, uniformly mixing the bamboo leaf flavone granules, the red date granules and the lubricant, and tabletting to obtain the bamboo leaf flavone and red date effervescent tablets.
3. The bamboo leaf flavonoid red date effervescent tablet and the preparation method thereof according to claim 1, wherein the sweetener: one or more of stevioside, glycyrrhizin, maltitol, xylitol, sucralose and sorbitol; preferably, the sweetener is one or two of stevioside and liquiritigenin.
4. The method for preparing the bamboo leaf flavonoid tablet according to claim 1, wherein the adhesive comprises: one or more than one of xanthan gum, maltodextrin, cyclodextrin, microcrystalline cellulose, carrageenan and sodium carboxymethylcellulose; preferably, the adhesive is formed by compounding one or two of xanthan gum and maltodextrin.
5. The bamboo leaf flavonoid red date effervescent tablet as claimed in claim 1, wherein the lubricant comprises: one or more of magnesium stearate, silicon dioxide, stearic acid, talcum powder, polyethylene glycol 6000, sodium dodecyl sulfate and magnesium dodecyl sulfate; preferably, the lubricant is formed by compounding one or two of magnesium stearate and sodium lauryl sulfate.
6. The bamboo leaf flavonoid red date effervescent tablet and the preparation method thereof according to claim 1, wherein the acid agent is one or more of citric acid, malic acid, tartaric acid, lactic acid and fumaric acid; preferably, the acid agent is one or two of citric acid and apple.
7. The bamboo leaf flavonoid red date effervescent tablet and the preparation method thereof according to claim 1, wherein the alkaline agent is one or more of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and calcium carbonate; preferably, the alkaline agent is formed by compounding one or two of sodium carbonate and sodium bicarbonate.
8. The bamboo leaf flavonoid red date effervescent tablet as claimed in claim 2, and the steps 3 and 4 of the preparation method thereof, are characterized in that the mixing time is 20-40 minutes, and the drying time is 3-5 hours.
9. The bamboo leaf flavonoid red date effervescent tablet as claimed in claim 2, and the steps 3 and 4 of the preparation method thereof, are characterized in that the mixing time is 3-5 hours.
10. The bamboo leaf flavonoid red date effervescent tablet as claimed in claim 2, and the steps 3 and 4 of the preparation method thereof, are characterized in that the ethanol concentration is 70% -95%.
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| CN202010399027.8A CN111436610A (en) | 2020-05-12 | 2020-05-12 | Bamboo leaf flavone red date effervescent tablet and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1359614A (en) * | 1971-04-06 | 1974-07-10 | Dev Et De Rech Soc Fr De | Method for the manufacture of effervescent tablets |
| CN103169131A (en) * | 2013-03-12 | 2013-06-26 | 太原市素有苦荞食品有限公司 | Red jujube, hawthorn and walnut effervescent tablet |
| CN108553549A (en) * | 2018-07-02 | 2018-09-21 | 郑州博凯医药保健品有限公司 | Jujube Qi effervescent tablet and preparation method thereof |
-
2020
- 2020-05-12 CN CN202010399027.8A patent/CN111436610A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1359614A (en) * | 1971-04-06 | 1974-07-10 | Dev Et De Rech Soc Fr De | Method for the manufacture of effervescent tablets |
| CN103169131A (en) * | 2013-03-12 | 2013-06-26 | 太原市素有苦荞食品有限公司 | Red jujube, hawthorn and walnut effervescent tablet |
| CN108553549A (en) * | 2018-07-02 | 2018-09-21 | 郑州博凯医药保健品有限公司 | Jujube Qi effervescent tablet and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 吴丽娜等: "竹叶大麦泡腾片固体饮料的研制", 《食品工业》 * |
| 李秋艳: "《养心就是养命》", 30 November 2016 * |
| 郑丹丹等: "竹叶提取物泡腾片的制备工艺优化及其质量分析", 《食品科学》 * |
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Application publication date: 20200724 |