CN108553549A

CN108553549A - Jujube Qi effervescent tablet and preparation method thereof

Info

Publication number: CN108553549A
Application number: CN201810710119.6A
Authority: CN
Inventors: 刘洪生; 胡晓娟; 张荣培; 李跃克
Original assignee: ZHENGZHOU BOKAI MEDICINE & HEALTH-CARE PRODUCTS Co Ltd
Current assignee: ZHENGZHOU BOKAI MEDICINE & HEALTH-CARE PRODUCTS Co Ltd
Priority date: 2018-07-02
Filing date: 2018-07-02
Publication date: 2018-09-21

Abstract

The present invention provides a kind of jujube Qi effervescent tablets and preparation method thereof, are related to effervescent tablet technical field.Jujube Qi effervescent tablet includes the raw material components of following parts by weight：100 300 parts of red date powder, 50 150 parts of wolfberry fruit powder, 50 150 parts of vitamin C, 1 10 parts of NaFeEDTA sodium, sour 1,500 2000 parts of agent, 800 1500 parts of alkaline agent.Jujube Qi effervescent tablet provided by the invention takes safety for a long time, influences each other between each component, obtain synergistic effect, have the effect of significant enriching the blood and tonifying qi using the red date powder of scientific matching, wolfberry fruit powder, injection Vitamin B_6 DTA ferrisodiums, sour agent and alkaline agent as primary raw material.

Description

Jujube Qi effervescent tablet and preparation method thereof

Technical field

The present invention relates to effervescent tablet technical fields, more particularly, to a kind of jujube Qi effervescent tablet and preparation method thereof.

Background technology

The deficiency of vital energy in insufficiency of vital energy and blood, that is, traditional Chinese medicine and the deficiency of blood.The result of insufficiency of vital energy and blood can lead to the decline of viscera function, draw Play early ageing.The deficiency of vital energy, that is, viscera function decline disease resistance is poor.The deficiency of vital energy then aversion to cold and cold limbs, spontaneous perspiration, dizziness and tinnitus, apathetic, tired Tired inability, palpitation, hypoevolutism.The visible lusterless complexion of the deficiency of blood is sallow, dry skin, hair is withered, nail is dry and cracked, regards object It is dim-sighted, numb in every limb, insomnia and dreamful sleep, forgetful palpitaition, absent-minded.Frequent body is frequent especially in QiXueXuZheng female life Phenomena such as will appear dizzy tired out, dim complexion, Hypomenorrhea dysmenorrhoea.Currently, there is the medicine of various enriching the blood and tonifying qi in the market Object and nutriment, but enriching the blood and tonifying qi effect is not notable, also some products can generate side effect to human body.

In view of this, special propose the present invention.

Invention content

The first object of the present invention is to provide a kind of jujube Qi effervescent tablet, to alleviate enriching the blood and tonifying qi existing in the prior art Effect is poor, there is the technical problems such as side effect.

Jujube Qi effervescent tablet provided by the invention, includes the raw material components of following parts by weight：100-300 parts of red date powder, Chinese holly 50-150 parts of Qi powder, 50-150 parts of vitamin C, 1-10 parts of NaFeEDTA sodium, sour 1500-2000 parts of agent, 800-1500 parts of alkaline agent.

Further, include the raw material components of following parts by weight：150-300 parts of red date powder, 60-150 parts of wolfberry fruit powder, dimension Raw 60-150 parts of element C, 2-10 parts of NaFeEDTA sodium, sour 1600-2000 parts of agent, 900-1500 parts of alkaline agent.

Further, further include the raw material components of following parts by weight：10-50 parts of hedgehog hydnum mushroom powder, radix rehmanniae preparata extract 10-50 Part, 10-50 parts of deer antler extract, 10-50 parts of Herba Lycopi extract；

Preferably, further include the raw material components of following parts by weight：15-50 parts of hedgehog hydnum mushroom powder, radix rehmanniae preparata extract 15-50 Part, 15-50 parts of deer antler extract, 15-50 parts of Herba Lycopi extract.

Further, include the raw material components of following parts by weight：150-250 parts of red date powder, 60-140 parts of wolfberry fruit powder, dimension Raw 60-140 parts of element C, 2-9 parts of NaFeEDTA sodium, 15-45 parts of hedgehog hydnum mushroom powder, 15-45 parts of radix rehmanniae preparata extract, deer antler extract 15- 45 parts, 15-45 parts of Herba Lycopi extract, sour 1600-1900 parts of agent, 900-1400 parts of alkaline agent.

Further, further include 200-800 parts of filler；

Preferably, the filler is at least one of starch, glucose, maltodextrin, lactose and crystallite fibre, into one Step is preferably maltodextrin and lactose.

Further, include the raw material components of following parts by weight：160-250 parts of red date powder, 70-140 parts of wolfberry fruit powder, dimension Raw 70-140 parts of element C, 3-9 parts of NaFeEDTA sodium, 20-45 parts of hedgehog hydnum mushroom powder, 20-45 parts of radix rehmanniae preparata extract, deer antler extract 20- 45 parts, 20-45 parts of Herba Lycopi extract, sour 1700-1900 parts of agent, 1000-1400 parts of alkaline agent, 300-800 parts of filler.

Further, the sour agent is at least one of citric acid, DL-malic acid, tartaric acid and fumaric acid, preferably Citric acid.

Further, the alkaline agent is in sodium carbonate, potassium carbonate, calcium carbonate, sodium bicarbonate, saleratus and calcium bicarbonate At least one, preferably sodium carbonate.

The second object of the present invention is to provide a kind of preparation method of jujube Qi effervescent tablet, and this method is simple for process, operation Convenient, production efficiency is high, is suitable for large-scale production.

The preparation method of jujube Qi effervescent tablet provided by the invention, includes the following steps：

(a) wolfberry fruit powder, red date powder, NaFeEDTA sodium, alkaline agent and optional filler are mixed, first is obtained through granulation Grain；

(b) sour agent, remaining wolfberry fruit powder and red date powder and optional remaining filler are mixed and obtains second through granulation Particle；

(c) optional hedgehog hydnum mushroom powder, optional radix rehmanniae preparata extract, optional deer antler extract and optional Herba Lycopi are extracted Object mixes, and third particle is obtained through granulation；

(d) the first particle, the second particle and optional third particle are mixed, jujube Qi effervescent tablet is made through tabletting.

Further, through wet method system after the wolfberry fruit powder, red date powder, NaFeEDTA sodium, alkaline agent and the mixing of optional filler Grain obtains the first wet granular, and first wet granular obtains the first particle through drying, whole grain；

Preferably, the drying temperature of first wet granular is 55-60 DEG C, and the drying time of first wet granular is 0.5-1h；

It is obtained through wet granulation after the acid agent, remaining wolfberry fruit powder and red date powder and the mixing of optional remaining filler Second wet granular, second wet granular obtain the second particle through drying, whole grain；

Preferably, the drying temperature of second wet granular is 55-60 DEG C, and the drying time of second wet granular is 0.5-1h；

After the hedgehog hydnum mushroom powder, radix rehmanniae preparata extract, deer antler extract and Herba Lycopi extract mixing the is obtained through wet granulation Three wet granulars, the third wet granular obtain third particle through drying, whole grain；

Preferably, the drying temperature of the third wet granular is 55-60 DEG C, and the drying time of the third wet granular is 0.5-1h。

Compared with prior art, the invention has the advantages that：

Jujube Qi effervescent tablet provided by the invention is with the red date powder of scientific matching, wolfberry fruit powder, injection Vitamin B_6 DTA ferrisodiums, sour agent It is primary raw material with alkaline agent, takes safety for a long time, influence each other between each component, obtain synergistic effect, have and significantly enrich blood The effect of QI invigorating.

The preparation method of jujube Qi effervescent tablet provided by the invention, this method is simple for process, easy to operate, and production efficiency is high, Suitable for large-scale production.

Description of the drawings

It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art Embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, in being described below Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor It puts, other drawings may also be obtained based on these drawings.

The preparation technology flow chart for the jujube Qi effervescent tablet that Fig. 1 is provided by the embodiment of the present invention one to three.

The preparation technology flow chart for the jujube Qi effervescent tablet that Fig. 2 is provided by the embodiment of the present invention four to seven.

Specific implementation mode

Technical scheme of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill The every other embodiment that personnel are obtained without making creative work, shall fall within the protection scope of the present invention. The person that is not specified actual conditions in embodiment, carries out according to conventional conditions or manufacturer's recommended conditions.Agents useful for same or instrument are not Production firm person is indicated, is the conventional products that can be obtained by commercially available purchase.

According to the first aspect of the invention, the present invention provides a kind of jujube Qi effervescent tablet, including following parts by weight Raw material components：100-300 parts of red date powder, 50-150 parts of wolfberry fruit powder, 50-150 parts of vitamin C, 1-10 parts of NaFeEDTA sodium, sour agent 1500-2000 parts, 800-1500 parts of alkaline agent.

Jujube is sage's product of benefiting qi and nourishing blood, has the effect of nourishment for vitality, rich in nutrition, invigorating spleen and reinforcing stomach, nourishing blood and tranquilization, red Rich in the ingredients such as abundant protein, carrotene, vitamin B, vitamin C, citrin and phosphorus, calcium, iron in jujube, wherein tieing up Raw element C content comes out at the top in fruit kind, there is the laudatory title of " natural complex ball " and " treasured of woman ".

Matrimony vine is mild-natured, sweet in flavor, has the effect of nourishing the liver, nourshing kidney, moistening lung, is suitable for consumption consumptive loss, soreness and weakness of waist and knees, dizziness ear The diseases such as ring, Heat Diabetes, blood deficiency chlorosis, blurred vision.

Vitamin C is also known as ascorbic acid, is a kind of antioxidant in vivo, body can be protected from oxidant It threatens.Vitamin C is that antibody and collagen are formed, tissue repairing's (including certain redoxes), phenylalanine, tyrosine, The metabolism of folic acid, the utilization of iron, carbohydrate, the synthesis of fat, protein maintain immune function, hydroxylation and hydroxytryptamine, protect The complete of blood vessel is held, promotes the institute such as nonheme iron absorption required.Meanwhile vitamin C is also equipped with anti-oxidant, Green Tea Extract, suppression The formation of tyrosinase processed, to reach whitening, the effect of light spot.In addition, vitamin C also has the function of removing toxic substances, anti-cancer.

NaFeEDTA sodium is a kind of nutrition fortifier of supplement minerals iron.NaFeEDTA sodium has effects that following：NaFeEDTA sodium For stable chelate, no gastrointestinal irritation, there is special duodenal absorption, be tightly combined under one's belt, into duodenum Afterwards, iron is just released and absorbs；The absorptivity of NaFeEDTA sodium is high, is avoided that the obstruction that phytic acid etc. absorbs chalybeate, research shows that The absorptivity of its iron is 2-3 times of ferrous sulfate, and seldom causes the change of food color and taste；NaFeEDTA sodium has suitable steady Qualitative and dissolving out capability, and releasing Fe³⁺Afterwards, ligand ethylenediamine tetra-acetic acid (EDTA) will not to body generate side effect and Toxicity is listed in " it is generally acknowledged that safety " (GRAS).In absorption process EDTA can also with harmful element in conjunction with rapid excretion and Play the role of antidote；NaFeEDTA sodium has the function of promoting other sources of iron or endogenous source of iron in diet to absorb, simultaneously also It can promote the absorption of zinc, and on the absorption of calcium without influence.

Disintegrant of the sour agent as effervescent tablet, sour agent generate great amount of carbon dioxide after meeting water with alkaline agent and keep effervescent tablet fast Speed disintegration so that drug effect is rapid, and bioavilability is high.

Disintegrant of the alkaline agent as effervescent tablet, alkaline agent generate great amount of carbon dioxide after meeting water with sour agent and keep effervescent tablet fast Speed disintegration so that drug effect is rapid, and bioavilability is high.

Wherein, red date powder for example can be, but be not limited to 100 parts, 110 parts, 120 parts, 130 parts, 140 parts, 150 parts, 160 Part, 170 parts, 180 parts, 190 parts, 200 parts, 210 parts, 220 parts, 230 parts, 240 parts, 250 parts, 260 parts, 270 parts, 280 parts, 290 parts or 300 parts；Wolfberry fruit powder for example can be, but be not limited to 50 parts, 60 parts, 70 parts, 80 parts, 90 parts, 100 parts, 110 parts, 120 parts, 130 parts, 140 parts or 150 parts；Vitamin C for example can be, but be not limited to 50 parts, 60 parts, 70 parts, 80 parts, 90 parts, 100 parts, 110 parts, 120 parts, 130 parts, 140 parts or 150 parts；NaFeEDTA sodium for example can be, but be not limited to 1 part, 2 parts, 3 parts, 4 Part, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts；Sour agent for example can be, but be not limited to 1500 parts, 1600 parts, 1700 parts, 1800 Part, 1900 parts or 2000 parts；Alkaline agent for example can be, but be not limited to 800 parts, 900 parts, 1000 parts, 1100 parts, 1200 parts, 1300 parts, 1400 parts or 1500 parts.

In one preferred embodiment, the jujube Qi effervescent tablet includes the raw material components of following parts by weight：Jujube 150-300 parts of powder, 60-150 parts of wolfberry fruit powder, 60-150 parts of vitamin C, 2-10 parts of NaFeEDTA sodium, sour 1600-2000 parts of agent, alkali 900-1500 parts of agent.

The present invention is given full play to the synergistic effect between each component, is had by the proportioning between rationally adjusting each component The effect of mending iron, QI invigorating, blood-nourishing, significant effect.

In a preferred embodiment of present embodiment, the jujube Qi effervescent tablet further includes the original of following parts by weight Expect component：10-50 parts of hedgehog hydnum mushroom powder, 10-50 parts of radix rehmanniae preparata extract, 10-50 parts of deer antler extract, 10-50 parts of Herba Lycopi extract.

Hericium erinaceus is mild-natured, sweet in flavor, relieving the five internal organs, aid digestion, has that stomach invigorating, qi-restoratives, anticancer, kidney-nourishing be smart, antifatigue, antioxygen Change, anti-mutation, reducing blood lipid, anti-aging, strengthen the spleen and stomach, qi and blood of supplementing nutrition, improve immunity of organisms the effect of, cure mainly anorexia and loose stool, The illnesss such as gastric and duodenal ulcer, superficial gastritis, neurasthenia, cancer of the esophagus, gastric cancer, dizziness, impotence, and to treating intestinal cancer There is booster action.

Radix rehmanniae preparata is warm-natured, sweet in flavor, has the effect of nourishing yin and supplementing blood, beneficial to spirit and marrow.

Pilose antler has antioxidation, can significantly increase SOD activity, and it is horizontal to reduce MDA, in addition also cure mainly kidney deficiency, dizziness, The deaf, diseases such as mesh is dark, impotence, involuntary emission, uterus cold infertile, thin thin and prolonged illness are deficient.

Herba Lycopi slightly warm in nature, bitter, pungent, Return liver, the spleen channel have the effect of promoting blood circulation and removing blood stasis, line water detumescence, removing toxicity for eliminating carbuncles.

Wherein, hedgehog hydnum mushroom powder for example can be, but be not limited to 10 parts, 20 parts, 30 parts, 40 parts or 50 parts；Radix rehmanniae preparata extract Such as can be, but it is not limited to 10 parts, 20 parts, 30 parts, 40 parts or 50 parts；Deer antler extract for example can be, but be not limited to 10 Part, 20 parts, 30 parts, 40 parts or 50 parts；Herba Lycopi extract for example can be, but be not limited to 10 parts, 20 parts, 30 parts, 40 parts or 50 Part.

Jujube Qi effervescent tablet provided by the invention is based on red date powder, wolfberry fruit powder, injection Vitamin B_6 DTA ferrisodiums, sour agent and alkaline agent Raw material is wanted, then is arranged in pairs or groups with hedgehog hydnum mushroom powder, radix rehmanniae preparata extract, deer antler extract and Herba Lycopi extract science, between each component mutually It influences, energy and blood of human body can be made vigorous, it is energetic, alleviate the sub-health state of body, enhances immunity of organisms.

Further include the raw material components of following parts by weight in a preferred embodiment of present embodiment：Hericium erinaceus 15-50 parts of powder, 15-50 parts of radix rehmanniae preparata extract, 15-50 parts of deer antler extract, 15-50 parts of Herba Lycopi extract.

In one preferred embodiment, the jujube Qi effervescent tablet includes the raw material components of following parts by weight：It is red 150-250 parts of date powder, 60-140 parts of wolfberry fruit powder, 60-140 parts of vitamin C, 2-9 parts of NaFeEDTA sodium, 15-45 parts of hedgehog hydnum mushroom powder, 15-45 parts of radix rehmanniae preparata extract, 15-45 parts of deer antler extract, 15-45 parts of Herba Lycopi extract, sour 1600-1900 parts of agent, alkaline agent 900-1400 parts.

In one preferred embodiment, the jujube Qi effervescent tablet further includes 200-800 parts of filler.

Filler can make effervescent tablet forming, no sticking be uniformly dispersed, stablize after dissolving, and disintegration rate is fast, biology profit Expenditure is high.

Wherein, filler for example can be, but be not limited to 200 parts, 300 parts, 400 parts, 500 parts, 600 parts, 700 parts or 800 parts.

In a preferred embodiment of present embodiment, the filler is starch, glucose, maltodextrin, breast At least one of sugar and crystallite fibre.

In a more preferable embodiment of present embodiment, the filler is maltodextrin and lactose.

Maltodextrin and lactose can make effervescent tablet forming, no sticking be uniformly dispersed after dissolving, surely as filler Fixed, disintegration rate is fast, and bioavilability is high.

In one preferred embodiment, the jujube Qi effervescent tablet includes the raw material components of following parts by weight：It is red 160-250 parts of date powder, 70-140 parts of wolfberry fruit powder, 70-140 parts of vitamin C, 3-9 parts of NaFeEDTA sodium, 20-45 parts of hedgehog hydnum mushroom powder, 20-45 parts of radix rehmanniae preparata extract, 20-45 parts of deer antler extract, 20-45 parts of Herba Lycopi extract, sour 1700-1900 parts of agent, alkaline agent 1000-1400 parts, 300-800 parts of filler.

Jujube Qi effervescent tablet forming provided by the invention, no sticking are uniformly dispersed after dissolving, stablize, and disintegration rate is fast, raw Object availability is high, has good taste flavor, has good promotion and antifatigue effect.

In one preferred embodiment, the sour agent is in citric acid, DL-malic acid, tartaric acid and fumaric acid At least one, preferably citric acid and DL-malic acid.

When sour agent is citric acid, the disintegration rate of effervescent tablet obtained is fast, and dissolved solution clarification is stablized.

In one preferred embodiment, the alkaline agent is sodium carbonate, potassium carbonate, calcium carbonate, sodium bicarbonate, bicarbonate At least one of potassium and calcium bicarbonate, preferably sodium carbonate.

When alkaline agent is sodium carbonate, the disintegration rate of effervescent tablet obtained is fast, and dissolved solution clarification is stablized.

According to the second aspect of the invention, the present invention provides a kind of preparation method of jujube Qi effervescent tablet, including it is as follows Step：

In one preferred embodiment, the wolfberry fruit powder, red date powder, NaFeEDTA sodium, alkaline agent and optional filler The first wet granular is obtained through wet granulation after mixing, first wet granular obtains the first particle through drying, whole grain.

Particle made of wet method have passed through moistened surface, have granular mass good, and good appearance, wearability is stronger, compression The advantages that good moldability, is most widely used in medical industry.Dry, whole grain can avoid wet granular from luming, and be convenient for tabletting.

In a preferred embodiment of present embodiment, the drying temperature of first wet granular is 55-60 DEG C, institute The drying time for stating the first wet granular is 0.5-1h.

It is more preferable to the drying effect of wet granular when drying temperature is 55-60 DEG C, and drying time is 0.5-1h, dry effect Rate higher.

Wherein, drying temperature for example can be, but be not limited to 55 DEG C, 56 DEG C, 57 DEG C, 58 DEG C, 59 DEG C or 60 DEG C；When dry Between for example can be but to be not limited to 0.5h, 0.6h, 0.7h, 0.8h, 0.9h or 1h.

In one preferred embodiment, the sour agent, remaining wolfberry fruit powder and red date powder and optionally remaining are filled out It fills after agent mixing and obtains the second particle through wet granulation, second wet granular obtains the second particle through drying, whole grain.

In a preferred embodiment of present embodiment, the drying temperature of second wet granular is 55-60 DEG C, institute The drying time for stating the second wet granular is 0.5-1h.

In one preferred embodiment, the hedgehog hydnum mushroom powder, radix rehmanniae preparata extract, deer antler extract and Herba Lycopi extract Third wet granular is obtained through wet granulation after mixing, the third wet granular obtains third particle through drying, whole grain.

In a preferred embodiment of present embodiment, the drying temperature of the third wet granular is 55-60 DEG C, institute The drying time for stating third wet granular is 0.5-1h.

In order to contribute to the clearer understanding present invention, below in conjunction with embodiment and comparative example to the technical side of the present invention Case is described further.

Embodiment one

A kind of jujube Qi effervescent tablet is present embodiments provided, the raw material components of following parts by weight are included：200 parts of red date powder, 100 parts of wolfberry fruit powder, 100 parts of vitamin C, 6 parts of NaFeEDTA sodium, 1600 parts of citric acid, 935 parts of sodium carbonate.

Embodiment two

A kind of jujube Qi effervescent tablet is present embodiments provided, the raw material components of following parts by weight are included：100 parts of red date powder, 50 parts of wolfberry fruit powder, 50 parts of vitamin C, 1 part of NaFeEDTA sodium, 1500 parts of citric acid, 800 parts of sodium carbonate.

Embodiment three

A kind of jujube Qi effervescent tablet is present embodiments provided, the raw material components of following parts by weight are included：300 parts of red date powder, 150 parts of wolfberry fruit powder, 150 parts of vitamin C, 10 parts of NaFeEDTA sodium, 2000 parts of citric acid, 1500 parts of sodium carbonate.

The formula for the jujube Qi effervescent tablet that embodiment one to three is provided is mixed with filler, colorant and corrigent, is made Obtain jujube Qi effervescent tablet.Wherein, filler is 459 parts of maltodextrin, 100 parts of lactose.

The preparation method for the jujube Qi effervescent tablet that embodiment one to three is provided, includes the following steps：

(1) wolfberry fruit powder, red date powder, NaFeEDTA sodium and maltodextrin are mixed to get the first mixed powder, then are sieved with 80 mesh are crossed Sodium carbonate mixing 3-5min afterwards obtains the second mixed powder, 80% ethyl alcohol is added into the second mixed powder, the first softwood, mistake is made 16 mesh sieve, and obtain the first wet granular, and the first wet granular crosses 16 mesh sieves, obtain the first particle after 58 DEG C of dry 0.8h；

(2) remaining matrimony vine date powder and red date powder are mixed to get third mixed powder with lactose, then are sieved with crushing, crossing 80 mesh Citric acid mixing 3-5min afterwards obtains the 4th mixed powder, 80% ethyl alcohol is added into the four or three mixed powder, the second softwood is made, 16 mesh sieve is crossed, the second wet granular is obtained, the second wet granular crosses 16 mesh sieves, obtain the second particle after 58 DEG C of dry 0.8h；

(3) by the first particle and the second particle mixing 30min, the jujube Qi effervescent tablet of 3.5g/ pieces is made through tabletting.

(4) it picks, inner packing；

(5) outer packing, quality inspection, storage.

Concrete technology flow process is as shown in Figure 1.

Example IV

A kind of jujube Qi effervescent tablet is present embodiments provided, the raw material components of following parts by weight are included：200 parts of red date powder, 100 parts of wolfberry fruit powder, 100 parts of vitamin C, 6 parts of NaFeEDTA sodium, 25 parts of hedgehog hydnum mushroom powder, 25 parts of radix rehmanniae preparata extract, deer antler extract 25 parts, 25 parts of Herba Lycopi extract, 1600 parts of citric acid, 935 parts of sodium carbonate.

Embodiment five

A kind of jujube Qi effervescent tablet is present embodiments provided, the raw material components of following parts by weight are included：150 parts of red date powder, 60 parts of wolfberry fruit powder, 60 parts of vitamin C, 2 parts of NaFeEDTA sodium, 10 parts of hedgehog hydnum mushroom powder, 10 parts of radix rehmanniae preparata extract, deer antler extract 10 Part, 10 parts of Herba Lycopi extract, 1600 parts of citric acid, 900 parts of sodium carbonate.

Embodiment six

A kind of jujube Qi effervescent tablet is present embodiments provided, the raw material components of following parts by weight are included：250 parts of red date powder, 140 parts of wolfberry fruit powder, 140 parts of vitamin C, 9 parts of NaFeEDTA sodium, 50 parts of hedgehog hydnum mushroom powder, 50 parts of radix rehmanniae preparata extract, deer antler extract 50 parts, 50 parts of Herba Lycopi extract, 1900 parts of citric acid, 1400 parts of sodium carbonate.

Embodiment seven

A kind of jujube Qi effervescent tablet is present embodiments provided, the raw material components of following parts by weight are included：160 parts of red date powder, 70 parts of wolfberry fruit powder, 70 parts of vitamin C, 3 parts of NaFeEDTA sodium, 15 parts of hedgehog hydnum mushroom powder, 15 parts of radix rehmanniae preparata extract, deer antler extract 15 Part, 15 parts of Herba Lycopi extract, 1700 parts of citric acid, 1000 parts of sodium carbonate.

The formula for the jujube Qi effervescent tablet that example IV to seven is provided is mixed with filler, jujube Qi effervescent tablet is made.Its In, filler is 459 parts of maltodextrin, 100 parts of lactose.

The preparation method for the jujube Qi effervescent tablet that example IV is provided to seven, includes the following steps：

(3) 95% ethyl alcohol will be added in the mixture of hedgehog hydnum mushroom powder, radix rehmanniae preparata extract, deer antler extract and Herba Lycopi extract Third softwood is made, crosses 16 mesh sieve, obtains third wet granular, third wet granular crosses 16 mesh sieves after 58 DEG C of dry 0.8h, Obtain third particle；

(4) by the first particle, the second particle and third particle mixing 30min, the jujube Qi effervesce of 3.5g/ pieces is made through tabletting Piece；

(5) it picks, inner packing；

(6) outer packing, quality inspection, storage.

Concrete technology flow process is as shown in Figure 2.

Embodiment eight

A kind of jujube Qi effervescent tablet is present embodiments provided, the raw material components of following parts by weight are included：180 parts of red date powder, 90 parts of wolfberry fruit powder, 90 parts of vitamin C, 53 parts of NaFeEDTA sodium, 30 parts of hedgehog hydnum mushroom powder, 30 parts of radix rehmanniae preparata extract, deer antler extract 30 Part, 30 parts of Herba Lycopi extract, 1750 parts of tartaric acid, 1200 parts of potassium carbonate, 500 parts of glucose.

Embodiment nine

A kind of jujube Qi effervescent tablet is present embodiments provided, the raw material components of following parts by weight are included：200 parts of red date powder, 120 parts of wolfberry fruit powder, 120 parts of vitamin C, 7 parts of NaFeEDTA sodium, 35 parts of hedgehog hydnum mushroom powder, 35 parts of radix rehmanniae preparata extract, deer antler extract 35 parts, 35 parts of Herba Lycopi extract, 1850 parts of fumaric acid, 1300 parts of calcium carbonate, 600 parts of glucose.

The preparation method for the jujube Qi effervescent tablet that embodiment eight to nine is provided, with example IV to seven identical.

Comparative example one

This comparative example provides a kind of jujube Qi effervescent tablet, what is different from the first embodiment is that the content of each component is not at this Within the protection domain of invention.

This comparative example provides a kind of jujube Qi effervescent tablet, includes the raw material components of following parts by weight：50 parts of red date powder, Chinese holly 200 parts of Qi powder, 200 parts of vitamin C, 0.5 part of NaFeEDTA sodium, 1000 parts of citric acid, 500 parts of sodium carbonate.

Comparative example two

This comparative example provides a kind of jujube Qi effervescent tablet, what is different from the first embodiment is that being free of red date powder.

This comparative example provides a kind of jujube Qi effervescent tablet, includes the raw material components of following parts by weight：100 parts of wolfberry fruit powder, 100 parts of vitamin C, 6 parts of NaFeEDTA sodium, 1600 parts of citric acid, 935 parts of sodium carbonate.

Comparative example three

This comparative example provides a kind of jujube Qi effervescent tablet, what is different from the first embodiment is that being free of wolfberry fruit powder.

This comparative example provides a kind of jujube Qi effervescent tablet, includes the raw material components of following parts by weight：200 parts of red date powder, 100 parts of vitamin C, 6 parts of NaFeEDTA sodium, 1600 parts of citric acid, 935 parts of sodium carbonate.

Comparative example four

This comparative example provides a kind of jujube Qi effervescent tablet, what is different from the first embodiment is that being free of vitamin C.

This comparative example provides a kind of jujube Qi effervescent tablet, includes the raw material components of following parts by weight：200 parts of red date powder, 100 parts of wolfberry fruit powder, 6 parts of NaFeEDTA sodium, 1600 parts of citric acid, 935 parts of sodium carbonate.

Comparative example five

This comparative example provides a kind of jujube Qi effervescent tablet, what is different from the first embodiment is that being free of NaFeEDTA sodium.

This comparative example provides a kind of jujube Qi effervescent tablet, includes the raw material components of following parts by weight：200 parts of red date powder, 100 parts of wolfberry fruit powder, 100 parts of vitamin C, 1600 parts of citric acid, 935 parts of sodium carbonate.

Comparative example six

This comparative example provides a kind of jujube Qi effervescent tablet, what is different from the first embodiment is that being free of citric acid.

This comparative example provides a kind of jujube Qi effervescent tablet, includes the raw material components of following parts by weight：200 parts of red date powder, 100 parts of wolfberry fruit powder, 100 parts of vitamin C, 6 parts of NaFeEDTA sodium, 935 parts of sodium carbonate.

Comparative example seven

This comparative example provides a kind of jujube Qi effervescent tablet, what is different from the first embodiment is that not containing sodium carbonate.

This comparative example provides a kind of jujube Qi effervescent tablet, includes the raw material components of following parts by weight：200 parts of red date powder, 100 parts of wolfberry fruit powder, 100 parts of vitamin C, 6 parts of NaFeEDTA sodium, 1600 parts of citric acid.

The formula for the jujube Qi effervescent tablet that comparative example one to seven is provided is mixed with functional auxiliary material, jujube Qi effervesce is made Piece.Wherein, filler is 459 parts of maltodextrin, 100 parts of lactose.

The preparation method for the jujube Qi effervescent tablet that comparative example one to seven is provided is identical as embodiment one.

Test example one

The jujube Qi effervescent tablet that embodiment one to nine and comparative example one to seven are provided is tested for the property, test result is shown in Table 1.

1 the performance test results of table

By data in table 1 it is found that the jujube Qi effervescent tablet provided using the embodiment of the present invention one to nine and comparative example one to The seven jujube Qi effervescent tablets provided are compared, and piece type is good, no sticking, and the pH of solution is in 4.1-4.3, and disintegration is rapid, and disintegration time exists 180-184s, clear after solution dissolving, mouthfeel is stablized within 3 months time, and each main ingredient component content is stablized.

In addition, the jujube Qi effervescent tablet provided to the embodiment of the present invention one to nine and comparative example one to seven is January, 2 months With carried out microbioassay March, do not find the presence of microorganism.

Test example two

400 SPF grades of SD rats are chosen, rat is placed in laboratory environment and adapted to 5 days, given later by weight 70-90g Low iron feed and mineral water, the hemoglobin (Hb) of blood sampling detection rat after 20 days, using rats of the Hb less than 100g/L as battalion It nourishs one's nature Anemia model animal.It therefrom chooses 360 Anemia in Rats stochastic averaginas and is divided into 18 groups, every group is 20, as unit of group, Every group feeds the sample that embodiment one to nine, comparative example one to seven, blank control group and positive controls are provided respectively, continuously 30 days, detect iron content in hemoglobin (Hb), red blood cell (RBC), packed cell volume (HCT) and liver, the spleen tissue of rat.

Wherein, the amount of feeding for the jujube Qi effervescent tablet that embodiment one to nine and comparative example one to seven are provided is each daily morning and evening 1 time, 1 tablet once, is brewed using 40-60 DEG C of warm water, continuous 30 days；The sample that blank control group is provided is mineral water；Sun Property control group to be provided be ferrous sulfate, the amount of feeding of ferrous sulfate is each 1 time, each 2.0mg/kg daily morning and evening, continuously 30 days.

Biochemical Indexes

Hemoglobin (Hb)：Content of hemoglobin is measured using HemoCue, big rat-tail is taken with 10 μ L quantitative capillary tubes Blood is put into the plastic tube for filling 2.5mL high-potassium ferricyanide reagents, is fully vibrated, so that blood is dissolved out completely, avoid light place 15min Afterwards, it is measured with Hemoglobin Meter, while measuring hemoglobin standard and primary standard substance.

Packed cell volume (HCT)：Blood is taken with 9 μ L quantitative capillary tubes, one end is sealed with plasticine, using packed cell volume Analyzer measures, and is read after 2min as a result, measuring reference data blood sample simultaneously.

Red blood cell number (RBC)：It is measured with full-automatic blood counting instrument.

Iron content in liver, spleen tissue：After the test, about 0.2g tissues is taken to be put into the glass examination through hydrochloric acid dry cleansing Nitric acid: perchloric acid=4: 1 mixed acid 2mL after digestion, is settled to 5mL or 10mL, using flame with deionized water is added in Guan Zhong Atomization measures iron content in tissue, measures use beef liver powder (National Bureau of Standards NBS1577a) as Quality Control object every time Matter.

Table 2 tests front and back rat Biochemical Indexes result

By data in table 2 it is found that after feeding jujube Qi effervescent tablet that the embodiment of the present invention one to nine is provided 30 days to rat, Hemoglobin (Hb) concentration of rat, red blood cell (RBC) count, iron content is aobvious in cell pack (HCT) value and liver, spleen tissue It writes and is higher than blank control group；The blood red of the rat for the jujube Qi effervescent tablet that the embodiment of the present invention one to nine is provided has been fed after experiment Before iron content is all remarkably higher than experiment in albumen (Hb), red blood cell (RBC), cell pack (HCT) and liver, spleen tissue；With sun Property control group is compared, and the jujube Qi effervescent tablet that the embodiment of the present invention one to nine is provided is to hemoglobin (Hb) concentration of rat, red Iron content has significant facilitation in cell (RBC) number, cell pack (HCT) value and liver, spleen tissue.Wherein, embodiment Due to being added to hedgehog hydnum mushroom powder, radix rehmanniae preparata extract, deer antler extract and Herba Lycopi extraction in four to the nine jujube Qi effervescent tablets provided Object, with the mutual coordinated of other components, bioavailability higher, to hemoglobin (Hb) concentration of rat, red blood cell (RBC) The facilitation of iron content is more notable in number, cell pack (HCT) value and liver, spleen tissue.

Test example three

Choose the female patient of the symptoms such as dizzy tired out, dim complexion, irregular menstruation caused by 425 insufficiency of vital energy and blood, year Age 35-55 Sui, stochastic averagina are divided into 17 groups, and every group is taken embodiment one to nine, comparative example respectively for 25 people as unit of group One to seven and mineral water (as a control group), adhere to taking 3 months, and observe curative effect after 3 months, the results are shown in Table 3.

Drinking method：Each 1 time daily morning and evening, 1 tablet once, is brewed using 40-60 DEG C of warm water, is used in conjunction 3 months.

Evaluation criterion：(1) significantly：Dizzy exhaustion syndrome disappears, and has rosy cheeks, is glossy, eumenorrhea, without dysmenorrhoea；

(2) effectively：Dizzy exhaustion syndrome is alleviated, and complexion is glossy, and dysmenorrhoea disappears substantially；

(3) invalid：Have no any of the above described effect.

Wherein, total effective rate=(notable number of cases+effective number of cases)/total number of cases × 100%.

3 each group patient of table takes the testing result of jujube Qi effervescent tablet

From the data in table 3, female patient takes the jujube Qi effervescent tablet 3 months that the embodiment of the present invention one to nine is provided Afterwards, the symptoms such as dizziness is tired out, dim complexion, irregular menstruation disappear or completely disappear substantially, and effect is significantly better than that blank pair According to group, illustrate jujube Qi effervescent tablet that the embodiment of the present invention one to nine is provided to the dizzy tired out, face caused by insufficiency of vital energy and blood Color is dark and gloomy, irregular menstruation has significant curative effect so that the symptom of female patient be improved significantly.Wherein, example IV is to nine Due to being added to hedgehog hydnum mushroom powder, radix rehmanniae preparata extract, deer antler extract and Herba Lycopi extract in the jujube Qi effervescent tablet provided, with it The mutual coordinated of its component, bioavailability higher, enriching the blood and tonifying qi are better.

The jujube Qi effervescent tablet that comparative example one to seven is provided changes the content of each component compared with embodiment one, and Not within protection scope of the present invention, or lack some component therein, total effective rate is significantly reduced, further illustrated The component and content of effervescent tablet only can be only achieved the effect of preferable enriching the blood and tonifying qi in the framework of the present definition.

Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution The range of scheme.

Claims

1. a kind of jujube Qi effervescent tablet, which is characterized in that include the raw material components of following parts by weight：100-300 parts of red date powder, Chinese holly 50-150 parts of Qi powder, 50-150 parts of vitamin C, 1-10 parts of NaFeEDTA sodium, sour 1500-2000 parts of agent, 800-1500 parts of alkaline agent.

2. jujube Qi effervescent tablet according to claim 1, which is characterized in that include the raw material components of following parts by weight：It is red 150-300 parts of date powder, 60-150 parts of wolfberry fruit powder, 60-150 parts of vitamin C, 2-10 parts of NaFeEDTA sodium, sour 1600-2000 parts of agent, 900-1500 parts of alkaline agent.

3. jujube Qi effervescent tablet according to claim 1 or 2, which is characterized in that further include the raw material group of following parts by weight Point：10-50 parts of hedgehog hydnum mushroom powder, 10-50 parts of radix rehmanniae preparata extract, 10-50 parts of deer antler extract, 10-50 parts of Herba Lycopi extract；

Preferably, further include the raw material components of following parts by weight：15-50 parts of hedgehog hydnum mushroom powder, 15-50 parts of radix rehmanniae preparata extract, deer Fine and soft extract 15-50 parts, 15-50 parts of Herba Lycopi extract.

4. jujube Qi effervescent tablet according to claim 3, which is characterized in that include the raw material components of following parts by weight：It is red 150-250 parts of date powder, 60-140 parts of wolfberry fruit powder, 60-140 parts of vitamin C, 2-9 parts of NaFeEDTA sodium, 15-45 parts of hedgehog hydnum mushroom powder, 15-45 parts of radix rehmanniae preparata extract, 15-45 parts of deer antler extract, 15-45 parts of Herba Lycopi extract, sour 1600-1900 parts of agent, alkaline agent 900-1400 parts.

5. jujube Qi effervescent tablet according to claim 3, which is characterized in that further include 200-800 parts of filler；

Preferably, the filler is at least one of starch, glucose, maltodextrin, lactose and crystallite fibre, further excellent It is selected as maltodextrin and lactose.

6. jujube Qi effervescent tablet according to claim 5, which is characterized in that include the raw material components of following parts by weight：It is red 160-250 parts of date powder, 70-140 parts of wolfberry fruit powder, 70-140 parts of vitamin C, 3-9 parts of NaFeEDTA sodium, 20-45 parts of hedgehog hydnum mushroom powder, 20-45 parts of radix rehmanniae preparata extract, 20-45 parts of deer antler extract, 20-45 parts of Herba Lycopi extract, sour 1700-1900 parts of agent, alkaline agent 1000-1400 parts, 300-800 parts of filler.

7. jujube Qi effervescent tablet according to claim 1, which is characterized in that the acid agent is citric acid, DL-malic acid, wine At least one of stone acid and fumaric acid, preferably citric acid.

8. jujube Qi effervescent tablet according to claim 1, which is characterized in that the alkaline agent is sodium carbonate, potassium carbonate, carbonic acid At least one of calcium, sodium bicarbonate, saleratus and calcium bicarbonate, preferably sodium carbonate.

9. a kind of method preparing claim 1-8 any one of them jujube Qi effervescent tablets, which is characterized in that including walking as follows Suddenly：

(a) wolfberry fruit powder, red date powder, NaFeEDTA sodium, alkaline agent and optional filler are mixed, the first particle is obtained through granulation；

(b) sour agent, remaining wolfberry fruit powder and red date powder and optional remaining filler are mixed and obtains the second particle through granulation；

(c) optional hedgehog hydnum mushroom powder, optional radix rehmanniae preparata extract, optional deer antler extract and optional Herba Lycopi extract are mixed It closes, third particle is obtained through granulation；

10. the preparation method of jujube Qi effervescent tablet according to claim 9, which is characterized in that the wolfberry fruit powder, red date powder, The first wet granular is obtained through wet granulation after NaFeEDTA sodium, alkaline agent and the mixing of optional filler, first wet granular is through dry Dry, whole grain obtains the first particle；

Preferably, the drying temperature of first wet granular is 55-60 DEG C, and the drying time of first wet granular is 0.5- 1h；

After the acid agent, remaining wolfberry fruit powder and red date powder and the mixing of optional remaining filler second is obtained through wet granulation Wet granular, second wet granular obtain the second particle through drying, whole grain；

Preferably, the drying temperature of second wet granular is 55-60 DEG C, and the drying time of second wet granular is 0.5- 1h；

It is wet that through wet granulation third is obtained after the hedgehog hydnum mushroom powder, radix rehmanniae preparata extract, deer antler extract and Herba Lycopi extract mixing Particle, the third wet granular obtain third particle through drying, whole grain；

Preferably, the drying temperature of the third wet granular is 55-60 DEG C, and the drying time of the third wet granular is 0.5- 1h。