CN111419789A

CN111419789A - Influenza prevention bag

Info

Publication number: CN111419789A
Application number: CN202010332889.9A
Authority: CN
Inventors: 王彤略
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-04-24
Filing date: 2020-04-24
Publication date: 2020-07-17

Abstract

The invention relates to an influenza prevention bag which is convenient to use and can slowly release active ingredients of the bag, and the bag comprises a barrier layer and an active ingredient layer; the effective components in the effective component layer are inhalable volatile extracts of traditional Chinese medicines; the set of barrier layers is a multi-layer odor barrier film. The invention utilizes the volatile components in the corydalis bungeana extractive to play a better role in preventing influenza and has the efficacies of clearing away heat and toxic material, eliminating phlegm, relieving cough and relieving asthma; convenient use, easy manufacture and storage and low cost.

Description

Influenza prevention bag

Technical Field

The invention relates to a membrane for preventing influenza, in particular to an influenza prevention bag which is convenient to use and can slowly release active ingredients of the influenza prevention bag.

Background

The traditional Chinese medicine belongs to the categories of epidemic diseases and epidemic febrile diseases, the traditional Chinese medicine always pays attention to the prevention of epidemic diseases, the yellow emperor's internal classic in late stage of the warring country clearly proposes ' no cure of existing diseases and no cure of diseases ', and rich prevention methods are accumulated in the long-term struggle process with the epidemic diseases, wherein the traditional Chinese medicine is mainly fumigated by aromatic medicines and has the effects of avoiding dirt, detoxifying and dissolving turbidity, and expelling pathogenic factors and preventing epidemic.

The traditional Chinese medicine sachet is one of the common methods for preventing epidemic diseases, has a good effect on preventing influenza, and has two effects as proved by modern medical research: 1. the smell of the traditional Chinese medicine powder contained in the sachet can stimulate the respiratory mucosa of a human body to generate secretory immunoglobulin A, and the antibody has strong killing effect on viruses and bacteria, so that the viruses cannot survive on the upper respiratory mucosa; 2. the smell of the traditional Chinese medicine powder contained in the sachet can change the acid-base environment of the oral and nasal mucosa, and effectively inhibit the invasion of influenza virus.

The traditional Chinese medicine air disinfectant sold in the market is also developed according to the effect of killing germs and viruses of aromatic traditional Chinese medicines, is used for killing germs and viruses in the air, is safe and effective for preventing influenza, and has no side effect.

The traditional Chinese medicine sachet and the traditional Chinese medicine air disinfectant are used for preventing influenza from two aspects of enhancing immunity and blocking virus infection, but have the obvious defects that:

1. the traditional Chinese medicine sachet can not directly kill germs and viruses, and the traditional Chinese medicine air disinfectant has no obvious effect on enhancing the immunity of human bodies. The aromatic traditional Chinese medicines in the traditional Chinese medicine sachet are only processed into powder, and the volatile oil emitted out cannot reach a certain concentration in the air, so that the germs and viruses in the air cannot be killed. The traditional Chinese medicine air disinfectant can effectively kill germs and viruses in the air, but volatilizes quickly and cannot act on respiratory organs for a long time to enhance immunity.

2. The traditional Chinese medicine sachet and the traditional Chinese medicine air disinfectant can not promote the physical and mental balance of people and enhance the resistance to influenza.

3. The traditional Chinese medicine sachet and the traditional Chinese medicine air disinfectant have strong bad smell, and most people do not want to use the traditional Chinese medicine air disinfectant.

4. It is inconvenient to use. The clothes-wearing habits of people are greatly different from the ancient times, inconvenience is brought to people when the sachets are hung, and particularly, the sachets hung on the necks of children are easily injured when the children play. The traditional Chinese medicine air disinfectant is inconvenient to carry, needs to be hung for a long time, and can pollute clothes when in use.

The patent with publication number CN102824586A discloses a cold prevention spray, which takes the following raw materials in parts by weight and formula: 1-3 parts of eupatorium, 1-3 parts of ligusticum wallichii, 1-3 parts of galangal, 3-5 parts of clove, 3-5 parts of borneol, 4-7 parts of magnolia flower, 4-7 parts of divaricate saposhnikovia root and 6-10 parts of angelica dahurica. Cleaning the raw materials according to the proportion, crushing, putting into a distiller, adding distilled water for soaking for a certain time, distilling, collecting distillate, dissolving with 1% ethanol, adding a proper amount of cosolvent and preservative, bottling and sealing. The compatibility mechanism of the invention is not clear; the tolerance is poor when the composition is used as a spray; the use of ethanol is easy to stimulate the skin, and the audience range is reduced; and a cosolvent and other substances are required to be added to influence the exertion of the drug effect.

Disclosure of Invention

In view of the above, the present invention provides an influenza prevention pack which is convenient to store and use and allows the active ingredient thereof to be slowly released.

In order to solve the problems, the invention adopts the following technical scheme:

an influenza prevention pack comprises a barrier layer and an active ingredient layer;

the effective components in the effective component layer are inhalable volatile extracts of traditional Chinese medicines;

the set of barrier layers is a multi-layer odor barrier film.

Preferably, the active ingredient is a corydalis extract.

Corydalis edulis, school name: corydalis pallida (Thunb.) Pers, a gray-green clump of annual herbs with malodor. The height is 20-60 cm. One or more stems are from axilla of basal leaf with arris and branch at the upper part. Most basal leaves are rosette-like and withered in flowering phase. Total flower tops and axillary, sometimes on phyllanthus, sparse florescence and or long or short rachis. The bract is coated with needle to be long round. Yellow to yellowish, thicker and flat. The sepals are nearly circular and are rooted in the center. Ovary shape, capsule shape, moniliform. Black and bright seeds, cap-shaped seed fun. It is produced in most areas of China and grows on wall corners, stone seams, lawn low marshy land on the side of a mountain ditch, and the like.

The corydalis used in the present invention may be a plant of the genus corydalis of the family corydalis, such as corydalis edulis, corydalis pachylon, etc.

It is bitter and sweet in taste, cold in nature, and can clear away heat and toxic material. Hepatitis, pneumonia; carbuncle, swelling, sore and furuncle; bite by poisonous snake.

The volatile components in the corydalis bungeana are extracted, the main chemical components are alcohol, ester and ketone compounds which contain 3, 7-dimethyl-1, 6-octadiene-3-ol, 2-aminobenzoic acid-3, 7-dimethyl-1, 6-octadiene-3 ester, 4-methyl-1- (1-methylethyl) -3-cyclohexene-1-ol, α -terpineol, β -myrcene and the like, wherein β -myrcene has the functions of eliminating phlegm and relieving cough, and α -terpineol has the remarkable effect of relieving asthma.

Preferably, the active ingredient layer is prepared by: mixing the corydalis extract with bacterial cellulose, and vacuum filtering to obtain membrane. The corydalis edulis extract and the bacterial cellulose are mixed to prepare the membranous effective component layer, because the bacterial cellulose has high purity, a fiber net structure, good air permeability, high porosity and no peculiar smell, the membrane can absorb volatile components, the volatile components are locked in the bacterial cellulose after the surface of the membrane is coated with the separation layer, and the volatile components are released after the separation layer is opened.

Preferably, the method for preparing the active ingredient layer comprises:

(1) preparing homogenate, namely cutting the bacterial cellulose membrane into small blocks of 1cm × 3cm after cleaning, putting the small blocks into a high-speed homogenizer at the rotating speed of 0.5Wrpm, crushing and homogenizing for 3 times, 15 minutes each time, putting the homogenate into an ultrasonic crusher, and crushing for 2 hours for the second time to obtain the bacterial cellulose homogenate with soft and smooth texture and uniform dispersion;

(2) mixing and suction filtering: adding the corydalis extract into the bacterial cellulose homogenate obtained in the step (1), mixing uniformly, and performing suction filtration to obtain a membranous effective component layer.

Preferably, the weight ratio of the corydalis extract to the bacterial cellulose is 1: 6-1: 10.

preferably, the effective component layer is prepared by coating the extract of corydalis edulis on activated carbon nonwoven fabric or activated carbon cotton.

The activated carbon non-woven fabric or the activated carbon cotton has good adsorption performance, good air permeability and no peculiar smell.

Preferably, the adsorption capacity of the corydalis edulis extract on the activated carbon non-woven fabric or activated carbon cotton is 10 to 30g per square meter.

Preferably, the group interlayer is a PE layer, an EVOH layer and a PE layer in this order.

Preferably, the flu prevention bag is characterized in that the group partition layer wraps the upper surface and the lower surface of the effective component layer under the vacuum condition, and an easily torn tape is led out from the contact part of the group partition layer and the effective component layer; when in use, the easy-to-tear tape is pulled, and the effective component layer is placed in nostril for breathing.

The invention has the beneficial effects that the volatile components in the corydalis bungeana extractive are utilized, so that the effect of better preventing influenza is achieved, and the corydalis bungeana extractive has the effects of clearing away heat and toxic materials, eliminating phlegm, relieving cough and relieving asthma; the use is convenient, the manufacture and the storage are easy, and the cost is low; the product of the invention is convenient to use and store, and only needs to inhale normal breath when in use;

the volatile components in the corydalis bungeana extractive can promote the generation of human immunoglobulin and improve the resistance of a human body after being absorbed by a respiratory tract mucous membrane, and meanwhile, the odor molecules of the essential oil can stimulate olfactory cells of the human body, inhibit the activity by exciting cerebral cortex, regulate the metabolism of the whole body, balance the functions of vegetative nerves and achieve the relative stability of physiological and psychological functions.

Drawings

FIG. 1 is a schematic of the present invention.

In the figure, 1, PE layer; 2. an EVOH layer; 3. an active ingredient layer; 4. an easy-to-tear tape.

Detailed Description

The invention will be further explained with reference to the drawings and the embodiments, but the invention is not limited to the embodiments.

In the present invention, unless otherwise specified, all methods used are conventional methods.

The corydalis extract can be prepared by the following method: cleaning fresh herba corydalis edulis with clear water, squeezing to obtain concentrated juice, continuously squeezing grass residue to obtain juice, mixing multiple squeezed juices, filtering, adding ethanol, extracting with ethanol, refrigerating, ultrafiltering, reflux-extracting the filtrate for multiple times, mixing extractive solutions, recovering ethanol, concentrating under reduced pressure, and vacuum drying to obtain paste or spray drying.

Can also be prepared by the following method: 1) steam explosion: cleaning the whole corydalis edulis, drying in a 55 ℃ oven for 12h, soaking 1 part by weight of dried corydalis edulis in 2 parts by weight of tartaric acid solution with the mass fraction of 5% for 2h, then soaking in 3 parts by weight of caffeic acid solution with the mass fraction of 1-3% for 3h, and then placing in a steam explosion machine to carry out explosion treatment on the raw materials, wherein the pressure of the steam explosion is 2 MPa;

2) microwave and ultrasonic assisted acid leaching: placing the corydalis edulis wrapped by diatomite and subjected to blasting treatment in an acetic acid solution according to the mass ratio of the material liquid of 1: 2-4, performing microwave treatment for 50s at the microwave power of 600W, and performing ultrasonic treatment for 60min at the ultrasonic power of 500W;

3) elution and adsorption: eluting diatomaceous earth with deionized water for 2-4 times, and collecting eluate and residue; purifying the eluent by using conventional macroporous resin to obtain purified eluent;

4) residue extraction and condensation: performing ultrasonic extraction on the residue in absolute ethyl alcohol at 50-70 ℃ to obtain an extracting solution, combining the extracting solution and the purified eluent obtained in the step 3), and then condensing to obtain crude oil;

5) and 4) refining the crude oil obtained in the step 4) to obtain a final corydalis extract.

Example 1

Referring to fig. 1, an influenza prevention pack includes a barrier layer and an active ingredient layer 3; the effective components in the effective component layer 3 are inhalable volatile extracts of traditional Chinese medicines; the group of interlayer comprises a PE layer 1, an EVOH layer 2 and a PE layer 1 in sequence. The flu-prevention bag is manufactured under vacuum conditions, and the PE layer 1, the EVOH layer 2, the effective component layer 3, the EVOH layer 2 and the PE layer 1 are sequentially manufactured into a square shape of about 3cmX3cm or a round shape with similar area size. An easy-to-tear tape 4 is arranged at the contact part of the EVOH layer 2 and the effective component layer 3.

The preparation method of the effective component layer comprises the following steps:

(1) preparing homogenate, namely, cleaning and shearing 0.108g of bacterial cellulose membrane into small blocks of 1cm × 3cm, putting the small blocks into a high-speed homogenizer at the rotating speed of 0.5Wrpm, crushing and homogenizing for 3 times, 15 minutes each time, putting the homogenate into an ultrasonic crusher, and crushing for 2 hours for the second time to obtain the bacterial cellulose homogenate with soft and smooth texture and uniform dispersion;

(2) mixing and suction filtering: adding the corydalis extract into the bacterial cellulose homogenate obtained in the step (1), mixing uniformly, and performing suction filtration to obtain a membranous effective component layer; the weight ratio of the corydalis extract to the bacterial cellulose is 1: 6-1: 10, preferably 1: 6.

When the mask is used, the easy-to-tear tape is pulled, the wrapped EVOH layer and the wrapped PE layer are torn, and the mask is placed at the nostril and breathed slowly.

Example 2

The difference between the embodiment and the embodiment 1 is that the carrier of the effective component layer is activated carbon non-woven fabric or activated carbon cotton, and the adsorption quantity is 10-30g per square meter, preferably 20g per square meter.

When the product is used, the easy-tearing tape is used for tearing a seam, and the influenza prevention bag is placed in the nostril and is inhaled; after the absorption, the barrier layer is pressed for the next use.

And (3) evaluating the product effect:

selection criteria: 1. 15 people of susceptible population; 2. the elderly population is 15.

The groups were randomly divided into 3 groups of 10 people each, and the comparison was 1-3.

Wherein comparative 1 group used the influenza prevention pack prepared in example 1, comparative 2 group used the influenza prevention pack prepared in example 2, and comparative 3 group did not.

The comparative 1 group and the comparative 2 group were used every 5 days and observed for one month.

The symptoms were observed: aversion to cold, fever, nasal obstruction, watery nasal discharge, headache, sneeze, joint ache, cough, spontaneous perspiration, hypodynamia and anorexia.

As a result:

15 days before observation time

In the observation process of the comparative group 1, one case showed anorexia, one case headache and two cases coughed without other adverse reactions.

In the observation process of the comparative group 2, there were two cases of sneezing, one headache, one cough and one fever without any adverse reaction.

In the observation process of the group 3, five cases showed symptoms of nasal obstruction, nasal discharge and the like, and three cases showed symptoms of cough and fever.

15 days after observation

In the case of the group 1 without additional symptoms, the symptoms of the symptom-appearing cases disappeared.

In the case of the comparative group 2, no symptoms occurred, and the symptoms of the symptom-appearing cases disappeared.

Comparing with 3 groups, 1 new group has symptoms of fever, nasal obstruction, watery nasal discharge and headache, and the symptom is confirmed to be common cold.

Therefore, the application of the influenza prevention bag can effectively prevent the occurrence of influenza, volatile components in the corydalis bungeana extractive can promote the generation of human immunoglobulin and improve the resistance of a human body after being absorbed by respiratory mucosa, and meanwhile, the odor molecules of the essential oil can stimulate olfactory cells of the human body, inhibit the activity by exciting cerebral cortex, regulate the metabolism of the whole body, balance the functions of vegetative nerves and achieve the relative stability of physiological and psychological functions.

The active ingredient layer of the present invention may also be used in the form of a nasal suppository.

The present invention and its embodiments have been described above schematically, without limitation, and what is shown in the drawings is only one of the embodiments of the present invention, and the actual structure is not limited thereto. Therefore, if the person skilled in the art receives the teaching, without departing from the spirit of the invention, the person skilled in the art shall not inventively design the similar structural modes and embodiments to the technical solution, but shall fall within the scope of the invention.

Claims

1. An influenza prevention pack, comprising a barrier layer and an active ingredient layer;

the set of barrier layers is a multi-layer odor barrier film.

2. The influenza prevention pack according to claim 1, wherein the effective ingredient is a corydalis extract.

3. The influenza prevention pack according to claim 1, wherein the effective component layer is prepared by: mixing the corydalis extract with bacterial cellulose, and vacuum filtering to obtain membrane.

4. The influenza prevention pack according to claim 3, wherein the effective component layer is prepared by a method comprising:

(1) preparing homogenate, namely cutting the bacterial cellulose membrane into small blocks of 1cm × 1cm after cleaning, putting the small blocks into a high-speed homogenizer at the rotating speed of 0.5Wrpm, crushing and homogenizing for 3 times, 15 minutes each time, putting the homogenate into an ultrasonic crusher, and crushing for 2 hours for the second time to obtain the bacterial cellulose homogenate with soft and smooth texture and uniform dispersion;

5. The influenza prevention bag according to claim 4, wherein the weight ratio of the corydalis extract to the bacterial cellulose is 1: 6-1: 10.

6. the influenza prevention pack according to claim 1, wherein the effective ingredient layer is prepared by coating the extract of corydalis edulis on an activated carbon nonwoven fabric or an activated carbon cotton.

7. The influenza prevention bag according to claim 6, wherein the adsorption amount of the corydalis impatiens extract on the activated carbon nonwoven fabric or the activated carbon cotton is 10 to 30g per square meter.

8. The influenza prevention bag according to claim 1, wherein the group barrier layer comprises a PE layer, an EVOH layer and a PE layer in this order.

9. The influenza prevention bag according to claim 1, wherein the barrier layer is wrapped on the upper and lower surfaces of the active ingredient layer under vacuum condition, and an easily tearable tape is led out from the contact part of the barrier layer and the active ingredient layer; when in use, the easy-to-tear tape is pulled, and the effective component layer is placed in nostril for breathing.