CN111419782A - Small water diversion of agilawood and preparation method thereof - Google Patents
Small water diversion of agilawood and preparation method thereof Download PDFInfo
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- CN111419782A CN111419782A CN202010223657.XA CN202010223657A CN111419782A CN 111419782 A CN111419782 A CN 111419782A CN 202010223657 A CN202010223657 A CN 202010223657A CN 111419782 A CN111419782 A CN 111419782A
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- extract
- agilawood
- small water
- extraction
- water diversion
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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Abstract
The invention provides agilawood small water diversion and a preparation method thereof, and the small water diversion comprises the following raw materials in percentage by weight: 8-12% of butanediol, 0.3-0.7% of agilawood extract, 1-3% of compound amino acid, 0.5-1% of lactobacillus/eriodictyon fermentation product extract, 10.3-0.8% of ceramide, 0.6-1.3% of skin conditioner, 0.08-0.12% of dipotassium glycyrrhizinate, 0.08-0.12% of PEG-40 hydrogenated castor oil, 0.1-0.5% of p-hydroxyacetophenone, 0.5-1.3% of 1, 2-hexanediol, 0.2-0.5% of sodium hyaluronate and the balance of water.
Description
Technical Field
The invention relates to the field of cosmetics, and particularly relates to agilawood low-moisture and a preparation method thereof.
Background
Skin aging is a continuous and progressive physiological process that directly affects the appearance and function of skin. The moisture of skin cell tissues is easy to lose, and the lack of sufficient moisture can cause the dehydration of the skin, so that the skin is dry, dry and dull, along with the improvement of the life quality of people, in recent years, the anti-aging compact anti-wrinkle cosmetic for improving the skin due to water shortage by using natural physiological active substances is more and more emphasized by people, and the safety and the efficacy of the anti-aging compact anti-wrinkle cosmetic naturally become the key points of attention of consumers and manufacturers.
However, in the existing moisturizing cosmetics, some irritant components are added to ensure the moisturizing effect, even if the moisturizing components are contained, the skin cuticle can keep a certain water content, but the phenomena of skin allergy and the like are caused, and the traditional extraction method is adopted in the extraction process of the moisturizing components, so that the active ingredients of natural plants cannot be completely utilized, and the resource waste is caused.
Disclosure of Invention
In view of the above, the invention provides agilawood small water diversion and a preparation method thereof, and solves the above problems.
The technical scheme of the invention is realized as follows: a small water diversion of agilawood: comprises the following components in percentage by weight:
further, the agilawood small water-dividing agent comprises the following components in percentage by weight:
further, the skin conditioner comprises an extract of centella asiatica root, an extract of polygonum cuspidatum, an extract of astragalus membranaceus, an extract of tea, an extract of glycyrrhiza glabra root, an extract of chamomile flower, and an extract of rosemary leaf.
Further, the compound amino acid comprises one or more of valine, leucine, isoleucine, threonine, methionine, lysine, tryptophan, glycine, alanine, arginine, cystine, proline, serine, tyrosine, aspartic acid, histidine, glycerol, sodium lactate, potassium hydroxide, citric acid, monosodium citrate and pyrrolidone carboxylic acid.
Further, the agilawood extract is obtained by soaking agilawood log chips in water at the temperature of 40-60 ℃, distilling after soaking for 15-28 h, distilling at the temperature of 700-1000 ℃ for 48-60 h, and cooling.
Further, the extraction method of the asiatic centella root extract and the giant knotweed rhizome extract comprises the steps of processing the asiatic centella root and the giant knotweed rhizome into filaments, mixing with calcium oxide, adding 1-3 times of water for decomposition for 1-4 h, wherein the volume ratio of the asiatic centella root to the giant knotweed rhizome extract to the calcium oxide is 1: 0.5-0.9: 0.1-0.3, carrying out water extraction twice, controlling the temperature to be 40-60 ℃, extracting for 2-4 h, and combining the two extracted filtrates to obtain the asiatic pennywort root extract and the giant knotweed rhizome extract.
Further, the astragalus extract is prepared by crushing astragalus, sieving the crushed astragalus with a 60-80-mesh sieve, placing the crushed astragalus in a microwave extraction device, adding 40-60% ethanol at the temperature of 40-60 ℃ under the microwave power of 200-400W, extracting for 15-35 min, extracting for 2-4 times, mixing filtrates, adding 3-4 times of distilled water, extracting and concentrating to obtain the astragalus extract.
Further, the glycyrrhiza glabra root extract is prepared by drying glycyrrhiza glabra roots in the shade, freezing and storing at a low temperature of-12 to-2 ℃ for 12 to 24 hours, taking out the glycyrrhiza glabra roots, crushing the glycyrrhiza glabra roots, putting the glycyrrhiza glabra roots into an extraction kettle of a low-temperature continuous phase change extraction device, using butane as an extractant, extracting at a pressure of 0.12 to 0.25MPa and at a temperature of 40 to 60 ℃ for 12 to 50 minutes, and collecting the glycyrrhiza glabra root extract after extraction.
Further, the mother chrysanthemum extract is prepared by soaking mother chrysanthemum in water at 40-60 ℃, soaking for 15-28 h, sieving with a sieve of 80-100 meshes to obtain mother chrysanthemum powder, carrying out ultrasonic-assisted extraction on the mother chrysanthemum powder, and carrying out ultrasonic extraction at 70-90 ℃ for 10-20 min.
Further, the preparation method of the small water-separation agilawood is characterized by comprising the following steps: the method comprises the following steps:
s1, stirring and dissolving butanediol, sodium hyaluronate and water at 85-90 ℃ for 15-20 min according to the weight percentage, and supercooling to 45-47 ℃ while stirring;
s2, adding dipotassium glycyrrhizinate, PEG-40 hydrogenated castor oil, compound amino acid, lactobacillus/eriodictyon fermentation product extract, ceramide 1, skin conditioner, p-hydroxyacetophenone and 1, 2-hexanediol, mixing and stirring for 16-20 min,
and S3, filtering, filling and packaging the mixture obtained in the step S2 to obtain the small water-cut agilawood.
Compared with the prior art, the invention has the beneficial effects that:
the invention adopts pure natural plant extract components as skin conditioner, scientifically mixes the skin conditioner with agilawood extract, compound amino acid, sodium hyaluronate, lactobacillus/eriodictyol grass fermentation product extract and the like, and utilizes the characteristics of strong penetrability, strong solubility and the like of the effective components of each plant to generate the effect by the penetration and absorption of skin cells.
The agilawood extract is combined with the compound amino acid, so that the hyaluronidase can effectively inhibit the decomposition of the hyaluronidase, and the skin conditioner has a good skin moisturizing effect; the lactobacillus/eriodictyon officinalis fermentation product extract contains abundant natural polysaccharide and glycoprotein, has a structure similar to that of glycoprotein of human skin, can provide high skin-friendly property to promote moisture and nutrient absorption under the penetration of a skin conditioner, endows the skin conditioner with moisture retention and sedative and soothing properties, improves the astringent feeling of the polysaccharide and the glycoprotein, and enhances the softness and smoothness; the asiatic centella root extract in the skin conditioner mainly contains asiaticoside, madecassoside and terpenoid, can obviously improve the content of collagen and cell layer fibronectin under the coordination of the giant knotweed rhizome extract, the astragalus extract and the chamomile extract, can participate in the processes of cell migration, adhesion, proliferation, hemostasis, skin tissue repair and the like, can stimulate the generation of collagen for promoting the maturation of scars, reduces the generation of inflammatory reaction, and improves and repairs the barrier function of the skin; therefore, emodin in the giant knotweed rhizome extract, saponin in the astragalus root extract, flavone, rosemary leaf extract, glycyrrhiza glabra root extract and triterpenoid saponin compounds in the centella asiatica extract can be combined with water in an occlusive layer, so that the epidermal barrier capability is improved, the skin moisture is enhanced, and the hydration degree of the horny layer can be obviously increased.
In addition, the invention also combines the property characteristics of each raw material, reasonably adjusts the optimal extraction process, extracts natural active ingredients under the control of pressure, power, particle size and the like, reasonably adds the extracting agent according to the proportion to ensure that the extraction rate is high, the stability is good, impurities are not generated, and the skin conditioner is free from stimulation.
Detailed Description
In order to better understand the technical content of the invention, specific examples are provided below to further illustrate the invention.
The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.
The materials, reagents and the like used in the examples of the present invention can be obtained commercially without specific description.
Example 1
The agilawood water cut comprises the following components in percentage by weight:
the skin conditioner comprises Asiatic pennywort root extract, giant knotweed rhizome extract, astragalus extract, tea extract, glabrous greenbrier root extract, chamomile flower extract and rosemary leaf extract;
the compound amino acid comprises valine, leucine, isoleucine, threonine, methionine, lysine, tryptophan, glycine, alanine, arginine, cystine, proline, serine, tyrosine, aspartic acid, histidine, glycerol, sodium lactate, potassium hydroxide, citric acid, monosodium citrate, pyrrolidone carboxylic acid;
the lignum Aquilariae Resinatum extract is prepared by soaking lignum Aquilariae Resinatum log pieces in 40 deg.C water for 15 hr, distilling at 700 deg.C for 48 hr, and cooling to obtain lignum Aquilariae Resinatum extract;
the extraction method of the asiatic centella root extract and the giant knotweed rhizome extract comprises the steps of processing the asiatic centella root and the giant knotweed rhizome into filaments, mixing with calcium oxide, adding 1 time of water for decomposition for 1 hour, wherein the volume ratio of the asiatic centella root to the giant knotweed rhizome extract to the calcium oxide is 1: 0.5: 0.1, carrying out water extraction twice, controlling the temperature to be 40 ℃, extracting for 2h, and combining the two extracted filtrates to obtain an asiatic pennywort root extract and a giant knotweed rhizome extract;
the astragalus extract is prepared by crushing astragalus, sieving with a 60-mesh sieve, placing in a microwave extraction device, extracting for 15min by adding 40% ethanol at 40 ℃ under the microwave power of 200W for 2 times, mixing filtrates, adding 3 times of distilled water, extracting, and concentrating to obtain the astragalus extract;
the glycyrrhiza glabra root extract is prepared by drying glycyrrhiza glabra roots in the shade, freezing and storing at-12 ℃ for 12 hours, taking out the glycyrrhiza glabra roots, crushing, putting into an extraction kettle of a low-temperature continuous phase change extraction device, using butane as an extractant, extracting for 12 minutes at the extraction pressure of 0.12MPa and the extraction temperature of 40 ℃, and collecting the glycyrrhiza glabra root extract after extraction is finished;
the flos Matricariae Chamomillae extract is prepared by soaking flos Matricariae Chamomillae in 40 deg.C water for 15 hr, sieving with 80 mesh sieve to obtain flos Matricariae Chamomillae powder, performing ultrasonic-assisted extraction on the flos Matricariae Chamomillae powder, and performing ultrasonic extraction at 70 deg.C for 10min to obtain flos Matricariae Chamomillae extract.
Example 2
The agilawood water cut comprises the following components in percentage by weight:
the skin conditioner comprises Asiatic pennywort root extract, giant knotweed rhizome extract, astragalus extract, tea extract, glabrous greenbrier root extract, chamomile flower extract and rosemary leaf extract;
the compound amino acid comprises valine, leucine, isoleucine, threonine, methionine, lysine, tryptophan, glycine, alanine, arginine, cystine, proline, serine, tyrosine, aspartic acid, histidine, glycerol, sodium lactate, potassium hydroxide, citric acid, monosodium citrate, pyrrolidone carboxylic acid;
the lignum Aquilariae Resinatum extract is prepared by soaking lignum Aquilariae Resinatum log pieces in 60 deg.C water for 28 hr, distilling at 1000 deg.C for 60 hr, and cooling;
the extraction method of the asiatic centella root extract and the giant knotweed rhizome extract comprises the steps of processing the asiatic centella root and the giant knotweed rhizome into filaments, mixing with calcium oxide, adding 3 times of water for decomposition for 4 hours, wherein the volume ratio of the asiatic centella root to the giant knotweed rhizome extract to the calcium oxide is 1: 0.9: 0.3, carrying out water extraction twice, controlling the temperature to be 60 ℃, extracting for 4h, and combining the two extracted filtrates to obtain an asiatic pennywort root extract and a giant knotweed rhizome extract;
the astragalus extract is prepared by crushing astragalus, sieving with a 80-mesh sieve, placing in a microwave extraction device, extracting for 35min by adding 60% ethanol at the temperature of 60 ℃ under the microwave power of 400W for 4 times, mixing filtrates, adding 3-4 times of distilled water, extracting, and concentrating to obtain the astragalus extract;
the glycyrrhiza glabra root extract is prepared by drying glycyrrhiza glabra roots in the shade, freezing and storing at-2 ℃ for 24 hours, taking out the glycyrrhiza glabra roots, crushing, putting into an extraction kettle of a low-temperature continuous phase change extraction device, using butane as an extractant, extracting at 0.25MPa and 60 ℃ for 50min, and collecting the glycyrrhiza glabra root extract after extraction is finished;
the flos Matricariae Chamomillae extract is prepared by soaking flos Matricariae Chamomillae in 60 deg.C water for 28 hr, sieving with 100 mesh sieve to obtain flos Matricariae Chamomillae powder, performing ultrasonic-assisted extraction on the flos Matricariae Chamomillae powder, and performing ultrasonic extraction at 90 deg.C for 20min to obtain flos Matricariae Chamomillae extract.
Example 3
The agilawood water cut comprises the following components in percentage by weight:
the skin conditioner comprises Asiatic pennywort root extract, giant knotweed rhizome extract, astragalus extract, tea extract, glabrous greenbrier root extract, chamomile flower extract and rosemary leaf extract;
the compound amino acid comprises valine, leucine, isoleucine, threonine, methionine, lysine, tryptophan, glycine, alanine, arginine, cystine, proline, serine, tyrosine, aspartic acid, histidine, glycerol, sodium lactate, potassium hydroxide, citric acid, monosodium citrate and pyrrolidone carboxylic acid.
The lignum Aquilariae Resinatum extract is prepared by soaking lignum Aquilariae Resinatum log pieces in 50 deg.C water for 21 hr, distilling at 850 deg.C for 54 hr, and cooling;
the extraction method of the asiatic centella root extract and the giant knotweed rhizome extract comprises the steps of processing the asiatic centella root and the giant knotweed rhizome into filaments, mixing with calcium oxide, adding 2 times of water for decomposition for 3 hours, wherein the volume ratio of the asiatic centella root to the giant knotweed rhizome extract to the calcium oxide is 1: 0.7: 0.2, carrying out water extraction twice, controlling the temperature to be 50 ℃, extracting for 3h, and combining the two extracted filtrates to obtain an asiatic pennywort root extract and a giant knotweed rhizome extract;
the astragalus extract is prepared by crushing astragalus, sieving with a 70-mesh sieve, placing in a microwave extraction device, extracting for 3 times by adding 50% ethanol at 50 ℃ under the microwave power of 300W for 25min, mixing filtrates, adding 3 times of distilled water, extracting, and concentrating to obtain the astragalus extract;
the glycyrrhiza glabra root extract is prepared by drying glycyrrhiza glabra roots in the shade, freezing and storing at-5 ℃ for 18h, taking out, crushing, putting into an extraction kettle of a low-temperature continuous phase change extraction device, using butane as an extractant, extracting for 30min at the extraction pressure of 0.18MPa and the extraction temperature of 50 ℃, and collecting the glycyrrhiza glabra root extract after extraction is finished;
the mother chrysanthemum extract is prepared by soaking mother chrysanthemum in 50 deg.C water for 20h, sieving with 90 mesh sieve to obtain mother chrysanthemum powder, performing ultrasonic-assisted extraction on the mother chrysanthemum powder, and performing ultrasonic extraction at 80 deg.C for 15min to obtain mother chrysanthemum extract;
example 1-3 method for preparing a small amount of water, comprising the steps of:
s1, stirring and dissolving the butanediol, the sodium hyaluronate and the water at 88 ℃ for 18min according to the weight percentage, and cooling to 46 ℃ while stirring;
s2, adding dipotassium glycyrrhizinate, PEG-40 hydrogenated castor oil, compound amino acid, lactobacillus/eriodictyon fermentation product extract, ceramide 1, skin conditioner, p-hydroxyacetophenone, and 1, 2-hexanediol, mixing and stirring for 18min,
and S3, filtering, filling and packaging the mixture obtained in the step S2 to obtain the small water-cut agilawood.
Example 4
In this embodiment, the raw materials in example 3 are used in percentage by weight, and the preparation method of the agilawood small water-dividing product is as follows:
s1, stirring and dissolving butanediol, sodium hyaluronate and water at 85 ℃ for 15min according to the weight percentage, and cooling to 45 ℃ while stirring;
s2, adding dipotassium glycyrrhizinate, PEG-40 hydrogenated castor oil, compound amino acids, lactobacillus/eriodictyon fermentation product extract, ceramide 1, skin conditioner, p-hydroxyacetophenone, and 1, 2-hexanediol, mixing, stirring for 16min,
and S3, filtering, filling and packaging the mixture obtained in the step S2 to obtain the small water-cut agilawood.
Example 5
In this embodiment, the raw materials in example 3 are used in percentage by weight, and the preparation method of the agilawood small water-dividing product is as follows:
s1, stirring and dissolving butanediol, sodium hyaluronate and water at 90 ℃ for 20min according to the weight percentage, and cooling to 47 ℃ while stirring;
s2, adding dipotassium glycyrrhizinate, PEG-40 hydrogenated castor oil, compound amino acids, lactobacillus/eriodictyon fermentation product extract, ceramide 1, skin conditioner, p-hydroxyacetophenone, and 1, 2-hexanediol, mixing, stirring for 20min,
and S3, filtering, filling and packaging the mixture obtained in the step S2 to obtain the small water-cut agilawood.
Example 6
The difference between this example and example 3 is that the agilawood extract is obtained by immersing the wood chips of agilawood in water at 30 ℃, distilling after 30h of immersion, distilling at 500 ℃ for 40h, and cooling.
Example 7
The difference between this example and example 3 is that the asiatic centella root extract and the giant knotweed rhizome extract are extracted by processing the asiatic centella root and the giant knotweed rhizome into filaments, performing water extraction twice, controlling the temperature at 50 ℃, extracting for 3 hours, and combining the two extracted filtrates to obtain the asiatic centella root extract and the giant knotweed rhizome extract.
Example 8
The difference between the embodiment and the embodiment 3 is that the glycyrrhiza glabra root extract is obtained by crushing glycyrrhiza glabra root, putting the crushed glycyrrhiza glabra root into an extraction kettle of a low-temperature continuous phase change extraction device, using butane as an extractant, extracting at 50 ℃ for 30min under 0.18MPa, and collecting the glycyrrhiza glabra root extract after extraction.
Comparative example 1
The agilawood water comprises the following components in percentage by weight:
the skin conditioner comprises Asiatic pennywort root extract, giant knotweed rhizome extract, astragalus extract, tea extract, glabrous greenbrier root extract, chamomile flower extract and rosemary leaf extract;
the compound amino acid comprises one or more of valine, leucine, isoleucine, threonine, methionine, lysine, tryptophan, glycine, alanine, arginine, cystine, proline, serine, tyrosine, aspartic acid, histidine, glycerol, sodium lactate, potassium hydroxide, citric acid, monosodium citrate and pyrrolidone carboxylic acid;
the lignum Aquilariae Resinatum extract is prepared by soaking lignum Aquilariae Resinatum log pieces in 50 deg.C water for 21 hr, distilling at 850 deg.C for 54 hr, and cooling;
the extraction method of the asiatic centella root extract and the giant knotweed rhizome extract comprises the steps of processing the asiatic centella root and the giant knotweed rhizome into filaments, mixing with calcium oxide, adding 2 times of water for decomposition for 3 hours, wherein the volume ratio of the asiatic centella root to the giant knotweed rhizome extract to the calcium oxide is 1: 0.7: 0.2, carrying out water extraction twice, controlling the temperature to be 50 ℃, extracting for 3h, and combining the two extracted filtrates to obtain an asiatic pennywort root extract and a giant knotweed rhizome extract;
the astragalus extract is prepared by crushing astragalus, sieving with a 70-mesh sieve, placing in a microwave extraction device, extracting for 3 times by adding 50% ethanol at 50 ℃ under the microwave power of 300W for 25min, mixing filtrates, adding 3 times of distilled water, extracting, and concentrating to obtain the astragalus extract;
the glycyrrhiza glabra root extract is prepared by drying glycyrrhiza glabra roots in the shade, freezing and storing at-5 ℃ for 18h, taking out, crushing, putting into an extraction kettle of a low-temperature continuous phase change extraction device, using butane as an extractant, extracting for 30min at the extraction pressure of 0.18MPa and the extraction temperature of 50 ℃, and collecting the glycyrrhiza glabra root extract after extraction is finished;
the flos Matricariae Chamomillae extract is prepared by soaking flos Matricariae Chamomillae in 50 deg.C water for 20 hr, sieving with 90 mesh sieve to obtain flos Matricariae Chamomillae powder, performing ultrasonic-assisted extraction on the flos Matricariae Chamomillae powder, and performing ultrasonic extraction at 80 deg.C for 15min to obtain flos Matricariae Chamomillae extract.
Comparative example 2
This comparative example differs from example 3 in that the agilawood extract was replaced with a commercially available agilawood extract, brand name borlin biotechnology limited.
Comparative example 3
The comparative example differs from example 3 in that the asiatic centella root extract and giant knotweed rhizome extract of the skin conditioner are commercially available asiatic centella root extract and giant knotweed rhizome extract, brand name: Baichuan Biotech limited.
Comparative example 4
The comparative example differs from example 3 in that the licorice root extract of the skin conditioner is a commercially available licorice root extract, with a brand name of Baichuan Biotech limited.
Comparative example 5
This comparative example differs from example 3 in that the small aliquot of agilawood is free of lactobacillus/eriodictyon fermentation product extract.
Detection of physical and chemical properties
1. Stability test
Cold resistance: and (3) placing the small amount of the agilawood into a low-temperature refrigerator with the temperature of minus 10 +/-1 ℃, taking out the agilawood after 24 hours, placing the agilawood for a certain time to the room temperature, and observing whether the layering phenomenon exists or not. Parallel 3 times.
Heat resistance: and (3) placing the small amount of water of the agilawood into a thermostat with the temperature of 40 +/-1 ℃, taking out the agilawood after 24 hours, returning to the room temperature, and observing whether the layering phenomenon exists or not. Parallel 3 times.
And (4) centrifugal test, namely taking 40m L small portions of agilawood, setting the centrifugal rotation speed to be 2000, 3000 and 4000r/min respectively, centrifuging for 30min, and observing whether layering occurs or not, wherein the layering is performed for 3 times.
2. Determination of the content of oxygen-containing Compounds
Measuring the content of the oxygen-containing compound with small water content in the agilawood by GC/MS analysis
3. Determination of solute content
The test results were as follows:
from the results, the prepared small water diversion is scientific in proportioning, the components supplement each other, and beneficial and effective substances are extracted by adjusting the extraction process according to the properties of the raw materials, so that the prepared small water diversion is high in stability, high in oxygen-containing compound and free of solute.
Second, evaluation of skin irritation response
The agilawood small-water-diversion test of examples 1-8 and comparative examples 1-5 is adopted to carry out a skin irritation test on the rabbits.
(1) Test animal
The experimental rabbit 130 is only used for an acute skin irritation test and weighs 2-3 kg. During the test period the animals were fed normally, with free access to water and food intake.
(2) Experimental methods and scoring standards
The skin irritation test method and the steps are carried out according to the cosmetic hygiene standards
Third, moisture retention efficacy determination
140 (40 male and female) volunteers 25-50 years old are organized into 14 groups at random, the experimental time is 12 hours, the temperature is (25 +/-2) DEG C, the humidity is 40% -50%, the inner sides of the left arm and the right arm of each volunteer are respectively marked with a tested part (4cm × 4cm), the tested sample and the contrast are randomly distributed on the left arm and the right arm, each tested part is coated with a 0.05m L sample, after coating, a multifunctional skin tester is adopted to measure the skin moisture content of the tested sample area and the contrast area in 5 time periods, and the original skin moisture content of all experimenters is 25-28%.
EXAMPLES 1 TO 8 AND COMPARATIVE EXAMPLES 1 TO 5 Aquilaria agallocha Small Water sample skin moisture content (%)
(the reference substance is commercially available moisturizing water)
| Time (h) | 2 | 8 | 10 | 12 |
| Example 1 | 52.4 | 51.0 | 43.6 | 39.4 |
| Example 2 | 52.3 | 46.9 | 42.1 | 39.1 |
| Example 3 | 58.3 | 51.4 | 49.3 | 40.5 |
| Example 4 | 52.3 | 43.3 | 45.9 | 36.2 |
| Example 5 | 53.3 | 43.5 | 46.9 | 39.6 |
| Example 6 | 54.3 | 41.6 | 40.3 | 38.9 |
| Example 7 | 50.3 | 42.0 | 41.1 | 39.7 |
| Example 8 | 53.1 | 42.1 | 40.2 | 38.5 |
| Comparative example 1 | 37.9 | 33.1 | 31.9 | 29.6 |
| Comparative example 2 | 39.8 | 32.6 | 29.3 | 26.9 |
| Comparative example 3 | 40.1 | 32.0 | 30.1 | 29.7 |
| Comparative example 4 | 41.0 | 34.0 | 31.2 | 29.8 |
| Reference substance | 35.8 | 32.1 | 30.2 | 28.5 |
Therefore, the micro-water prepared by the invention can be well mixed and stabilized by adopting a specific process, and the moisture-preserving and moisturizing active elements and the soothing elements are fully mixed to fully promote the absorption of skin, so that the micro-water has good moisture-preserving and moisturizing effects, can well soothe skin and reduce skin irritation, and is suitable for people of all ages.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. The agilawood small water diversion is characterized in that: comprises the following components in percentage by weight:
2. the small water diversion agilawood according to claim 1, characterized in that: comprises the following components in percentage by weight:
3. the small water diversion agilawood according to claim 1, characterized in that: the skin conditioner comprises Asiatic pennywort root extract, giant knotweed rhizome extract, astragalus extract, tea extract, glabrous greenbrier root extract, chamomile flower extract and rosemary leaf extract.
4. The small water diversion agilawood according to claim 1, characterized in that: the compound amino acid comprises valine, leucine, isoleucine, threonine, methionine, lysine, tryptophan, glycine, alanine, arginine, cystine, proline, serine, tyrosine, aspartic acid, histidine, glycerol, sodium lactate, potassium hydroxide, citric acid, monosodium citrate and pyrrolidone carboxylic acid.
5. The small water diversion agilawood according to claim 1, characterized in that: the agilawood extract is prepared by soaking agilawood log chips in water at the temperature of 40-60 ℃, distilling after soaking for 15-28 h, distilling at the temperature of 700-1000 ℃ for 48-60 h, and cooling.
6. The small water diversion agilawood according to claim 3, characterized in that: the extraction method of the asiatic centella root extract and the giant knotweed rhizome extract comprises the steps of processing the asiatic centella root and the giant knotweed rhizome into filaments, mixing with calcium oxide, adding 1-3 times of water for decomposition for 1-4 h, wherein the volume ratio of the asiatic centella root to the giant knotweed rhizome extract to the calcium oxide is 1: 0.5-0.9: 0.1-0.3, carrying out water extraction twice, controlling the temperature to be 40-60 ℃, extracting for 2-4 h, and combining the two extracted filtrates to obtain the asiatic pennywort root extract and the giant knotweed rhizome extract.
7. The small water diversion agilawood according to claim 3, characterized in that: the astragalus extract is prepared by crushing astragalus, sieving the crushed astragalus with a 60-80-mesh sieve, placing the crushed astragalus in a microwave extraction device, adding 40-60% ethanol at the microwave power of 200-400W and the temperature of 40-60 ℃, extracting for 15-35 min for 2-4 times, mixing filtrates, adding 3-4 times of distilled water, extracting and concentrating to obtain the astragalus extract.
8. The small water diversion agilawood according to claim 3, characterized in that: the glycyrrhiza glabra root extract is prepared by drying glycyrrhiza glabra roots in the shade, freezing and storing at a low temperature of-12 to-2 ℃ for 12 to 24 hours, taking out the glycyrrhiza glabra roots, crushing the glycyrrhiza glabra roots, putting the glycyrrhiza glabra roots into an extraction kettle of a low-temperature continuous phase change extraction device, using butane as an extractant, extracting at a temperature of 40 to 60 ℃ for 12 to 50 minutes under an extraction pressure of 0.12 to 0.25MPa, and collecting the glycyrrhiza glabra root extract after extraction.
9. The small water diversion agilawood according to claim 3, characterized in that: the mother chrysanthemum extract is prepared by soaking mother chrysanthemum in water at 40-60 ℃, soaking for 15-28 h, sieving with a sieve of 80-100 meshes to obtain mother chrysanthemum powder, carrying out ultrasonic-assisted extraction on the mother chrysanthemum powder, and carrying out ultrasonic leaching at 70-90 ℃ for 10-20 min.
10. The preparation method of the small water-dividing agilawood according to claim 1, characterized by comprising the following steps: the method comprises the following steps:
s1, stirring and dissolving butanediol, sodium hyaluronate and water at 85-90 ℃ for 15-20 min according to the weight percentage, and supercooling to 45-47 ℃ while stirring;
s2, adding dipotassium glycyrrhizinate, PEG-40 hydrogenated castor oil, compound amino acid, lactobacillus/eriodictyon fermentation product extract, ceramide 1, skin conditioner, p-hydroxyacetophenone and 1, 2-hexanediol, mixing and stirring for 16-20 min,
and S3, filtering, filling and packaging the mixture obtained in the step S2 to obtain the small water-cut agilawood.
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| CN113583755A (en) * | 2021-08-17 | 2021-11-02 | 海口楠脂香业有限公司 | Extraction method of agilawood essential oil |
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| CN108379155A (en) * | 2018-04-20 | 2018-08-10 | 安徽怡人生物科技有限公司 | A kind of acne eliminating cream and preparation method thereof |
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