CN111417727A - 用于靶向核酸编辑的系统、方法和组合物 - Google Patents

用于靶向核酸编辑的系统、方法和组合物 Download PDF

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Publication number
CN111417727A
CN111417727A CN201880048361.XA CN201880048361A CN111417727A CN 111417727 A CN111417727 A CN 111417727A CN 201880048361 A CN201880048361 A CN 201880048361A CN 111417727 A CN111417727 A CN 111417727A
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protein
adenosine deaminase
sequence
cpf1
mutation
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Chinese (zh)
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F·张
D·B·T·科克斯
J·戈滕贝格
O·O·阿布达耶
B·蔡彻
J·斯特雷克
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Massachusetts Institute of Technology
Broad Institute Inc
Harvard University
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Massachusetts Institute of Technology
Broad Institute Inc
Harvard University
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)
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CN201880048361.XA 2017-05-18 2018-05-18 用于靶向核酸编辑的系统、方法和组合物 Pending CN111417727A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762508293P 2017-05-18 2017-05-18
US62/508,293 2017-05-18
US201762561663P 2017-09-21 2017-09-21
US62/561,663 2017-09-21
US201762568133P 2017-10-04 2017-10-04
US62/568,133 2017-10-04
US201762609957P 2017-12-22 2017-12-22
US62/609,957 2017-12-22
PCT/US2018/033394 WO2018213708A1 (en) 2017-05-18 2018-05-18 Systems, methods, and compositions for targeted nucleic acid editing

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US (2) US11866697B2 (https=)
EP (1) EP3625343B1 (https=)
JP (2) JP7364472B2 (https=)
KR (1) KR102678809B1 (https=)
CN (1) CN111417727A (https=)
AU (1) AU2018270088B2 (https=)
CA (1) CA3063739A1 (https=)
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CN111328290A (zh) * 2017-06-26 2020-06-23 博德研究所 用于靶向核酸编辑的基于crispr/cas-腺嘌呤脱氨酶的组合物、系统和方法
CN112111471A (zh) * 2020-09-25 2020-12-22 中国科学院微生物研究所 广谱识别PAM序列的FnCpf1突变体及其应用
CN113667734A (zh) * 2021-07-16 2021-11-19 四川大学华西医院 Shank3片段序列甲基化检测试剂在制备精神分裂症诊断试剂盒中的用途
CN114729381A (zh) * 2019-09-05 2022-07-08 本森希尔股份有限公司 修饰基因组的组合物和方法
CN114934031A (zh) * 2022-05-25 2022-08-23 广州瑞风生物科技有限公司 新型Cas效应蛋白、基因编辑系统及用途
CN114958920A (zh) * 2021-02-25 2022-08-30 北京中因科技有限公司 一种新型CRISPR-Cas9系统载体及其制备方法和应用
CN115786456A (zh) * 2022-08-24 2023-03-14 中国科学技术大学 一种单链悬突双链核酸供体的制备方法及应用
CN116217741A (zh) * 2023-02-27 2023-06-06 河北科技大学 一种高效率且低脱靶率的精确基因编辑方法
CN117844780A (zh) * 2024-01-22 2024-04-09 广东省农业科学院设施农业研究所 CaPTPMKP1基因对瓜类疫霉和辣椒疫霉的抗性及应用
WO2024156085A1 (en) * 2023-01-27 2024-08-02 Syngenta Crop Protection Ag Mb2cas12a variants with enhanced efficiency
WO2024156084A1 (en) * 2023-01-27 2024-08-02 Syngenta Crop Protection Ag Variants of cpf1 (cas12a) with improved activity
CN118685428A (zh) * 2024-08-21 2024-09-24 昆明理工大学 一种岷江百合cyclophilin抗菌蛋白基因LrCYP1及应用

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