CN111417720B - 用于选择性扩增表达具有鼠恒定区的tcr的细胞的方法 - Google Patents
用于选择性扩增表达具有鼠恒定区的tcr的细胞的方法 Download PDFInfo
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- CN111417720B CN111417720B CN201880076862.9A CN201880076862A CN111417720B CN 111417720 B CN111417720 B CN 111417720B CN 201880076862 A CN201880076862 A CN 201880076862A CN 111417720 B CN111417720 B CN 111417720B
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4203—Receptors for growth factors
- A61K40/4205—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
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- A61K40/42—Cancer antigens
- A61K40/4238—Regulators of development
- A61K40/424—Apoptosis related proteins, e.g. survivin or livin
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- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4271—Melanoma antigens
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
- A61K2239/28—Expressing multiple CARs, TCRs or antigens
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C12N2501/20—Cytokines; Chemokines
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2312—Interleukin-12 (IL-12)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
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- C12N2501/2321—Interleukin-21 (IL-21)
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- C12N2510/00—Genetically modified cells
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- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Oncology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762568339P | 2017-10-05 | 2017-10-05 | |
| US62/568,339 | 2017-10-05 | ||
| PCT/US2018/052432 WO2019070435A1 (en) | 2017-10-05 | 2018-09-24 | METHODS FOR SELECTIVE EXPANSION OF CELLS EXPRESSING A TCR WITH A CONSTANT MURINE REGION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111417720A CN111417720A (zh) | 2020-07-14 |
| CN111417720B true CN111417720B (zh) | 2025-02-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880076862.9A Active CN111417720B (zh) | 2017-10-05 | 2018-09-24 | 用于选择性扩增表达具有鼠恒定区的tcr的细胞的方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12227554B2 (enExample) |
| EP (2) | EP3692140B1 (enExample) |
| JP (2) | JP2020535832A (enExample) |
| KR (1) | KR102757789B1 (enExample) |
| CN (1) | CN111417720B (enExample) |
| AU (1) | AU2018345400B2 (enExample) |
| CA (1) | CA3077595A1 (enExample) |
| ES (1) | ES2960313T3 (enExample) |
| FI (1) | FI3692140T3 (enExample) |
| IL (1) | IL273698B2 (enExample) |
| MA (1) | MA50748A (enExample) |
| SG (1) | SG11202003112QA (enExample) |
| WO (1) | WO2019070435A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3202874A1 (en) * | 2020-12-22 | 2022-06-30 | Carsten LINNEMANN | Peptide markers to track genetically engineered cells |
| US20240175047A1 (en) | 2021-02-25 | 2024-05-30 | Alaunos Therapeutics, Inc. | Recombinant Vectors Comprising Polycistronic Expression Cassettes and Methods of Use Thereof |
| US20250145950A1 (en) * | 2022-02-01 | 2025-05-08 | Alaunos Therapeutics, Inc. | Methods for Activation and Expansion of T Cells |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766886A (en) * | 1991-12-13 | 1998-06-16 | Xoma Corporation | Modified antibody variable domains |
| CN104968675A (zh) * | 2012-09-14 | 2015-10-07 | 美国政府卫生与公众服务部 | 识别mhc ii类限制性mage-a3的t细胞受体 |
| CN105452288A (zh) * | 2013-07-15 | 2016-03-30 | 美国卫生和人力服务部 | 抗人乳头瘤病毒16 e6 t细胞受体 |
| CN106661098A (zh) * | 2014-05-29 | 2017-05-10 | 美国卫生和人力服务部 | 抗人乳头瘤病毒16 e7的t细胞受体 |
| CN107075479A (zh) * | 2014-10-02 | 2017-08-18 | 美国卫生和人力服务部 | 分离对癌症特异性突变具有抗原特异性的t细胞的方法 |
| CN107109369A (zh) * | 2014-11-20 | 2017-08-29 | Umc乌德勒支控股有限公司 | 用于富集具有外源性免疫受体的工程化t细胞的抗体的用途和用于清除工程化t细胞的抗体 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997009419A1 (en) | 1995-09-05 | 1997-03-13 | The General Hospital Corporation | Monoclonal lymphocytes and methods of use |
| DE19905048A1 (de) | 1999-02-08 | 2000-08-10 | Gsf Forschungszentrum Umwelt | Verwendung depletorisch oder mitogen wirkender Antikörper in der Immuntherapie |
| JP2003274960A (ja) * | 2000-02-03 | 2003-09-30 | Japan Science & Technology Corp | 可溶性t細胞受容体タンパク質およびその作成方法 |
| JP2003276960A (ja) * | 2002-03-26 | 2003-10-02 | Mitsubishi Electric Corp | エレベーター制御システム |
| DK1545204T3 (en) | 2002-09-06 | 2016-11-14 | The Government Of The Us Secretary Dept Of Health And Human Services | Immunotherapy with in vitro selected antigen-specific lymphocytes following non-myeloablative lymphodepletive chemotherapy |
| US8772451B2 (en) * | 2003-11-10 | 2014-07-08 | Altor Bioscience Corporation | Soluble TCR molecules and methods of use |
| WO2007131092A2 (en) * | 2006-05-03 | 2007-11-15 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Chimeric t cell receptors and related materials and methods of use |
| WO2008089053A2 (en) | 2007-01-12 | 2008-07-24 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Gp100-specific t cell receptors and related materials and methods of use |
| WO2010088160A1 (en) | 2009-01-28 | 2010-08-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors and related materials and methods of use |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| CN103124740B (zh) | 2010-09-21 | 2015-09-02 | 美国卫生和人力服务部 | 抗-ssx-2t细胞受体和相关材料及使用方法 |
| US20120244133A1 (en) | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| ES2835200T3 (es) | 2012-05-22 | 2021-06-22 | Us Health | Uso médico de células que comprenden receptores de células T anti-NY-ESO-1 |
| PL3223850T3 (pl) | 2014-11-26 | 2020-08-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Receptory limfocytów t przeciwko zmutowanemu kras |
| EP3901169A1 (en) | 2015-09-15 | 2021-10-27 | The United States of America, as represented by the Secretary, Department of Health and Human Services | T cell receptors recognizing hla-cw8 restricted mutated kras |
| AU2017258745B2 (en) | 2016-04-26 | 2022-03-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-KK-LC-1 T cell receptors |
| LT3494133T (lt) | 2016-08-02 | 2022-12-12 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Anti-kras-g12d t ląstelės receptoriai |
-
2018
- 2018-09-24 AU AU2018345400A patent/AU2018345400B2/en active Active
- 2018-09-24 ES ES18786145T patent/ES2960313T3/es active Active
- 2018-09-24 US US16/652,948 patent/US12227554B2/en active Active
- 2018-09-24 IL IL273698A patent/IL273698B2/en unknown
- 2018-09-24 KR KR1020207012314A patent/KR102757789B1/ko active Active
- 2018-09-24 JP JP2020519092A patent/JP2020535832A/ja active Pending
- 2018-09-24 WO PCT/US2018/052432 patent/WO2019070435A1/en not_active Ceased
- 2018-09-24 FI FIEP18786145.5T patent/FI3692140T3/fi active
- 2018-09-24 CN CN201880076862.9A patent/CN111417720B/zh active Active
- 2018-09-24 MA MA050748A patent/MA50748A/fr unknown
- 2018-09-24 EP EP18786145.5A patent/EP3692140B1/en active Active
- 2018-09-24 EP EP23185846.5A patent/EP4269595A3/en active Pending
- 2018-09-24 CA CA3077595A patent/CA3077595A1/en active Pending
- 2018-09-24 SG SG11202003112QA patent/SG11202003112QA/en unknown
-
2023
- 2023-12-26 JP JP2023220106A patent/JP7747724B2/ja active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766886A (en) * | 1991-12-13 | 1998-06-16 | Xoma Corporation | Modified antibody variable domains |
| CN104968675A (zh) * | 2012-09-14 | 2015-10-07 | 美国政府卫生与公众服务部 | 识别mhc ii类限制性mage-a3的t细胞受体 |
| CN105452288A (zh) * | 2013-07-15 | 2016-03-30 | 美国卫生和人力服务部 | 抗人乳头瘤病毒16 e6 t细胞受体 |
| CN106661098A (zh) * | 2014-05-29 | 2017-05-10 | 美国卫生和人力服务部 | 抗人乳头瘤病毒16 e7的t细胞受体 |
| CN107075479A (zh) * | 2014-10-02 | 2017-08-18 | 美国卫生和人力服务部 | 分离对癌症特异性突变具有抗原特异性的t细胞的方法 |
| CN107109369A (zh) * | 2014-11-20 | 2017-08-29 | Umc乌德勒支控股有限公司 | 用于富集具有外源性免疫受体的工程化t细胞的抗体的用途和用于清除工程化t细胞的抗体 |
Non-Patent Citations (2)
| Title |
|---|
| Drew C Deniger, et al..Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System.The American Society of Gene & Cell Therapy.2016,第24卷(第6期),1078-1089. * |
| Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System;Drew C Deniger, et al.;The American Society of Gene & Cell Therapy;第24卷(第6期);1078-1089 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MA50748A (fr) | 2020-08-12 |
| SG11202003112QA (en) | 2020-05-28 |
| CN111417720A (zh) | 2020-07-14 |
| ES2960313T3 (es) | 2024-03-04 |
| EP4269595A2 (en) | 2023-11-01 |
| EP3692140B1 (en) | 2023-07-19 |
| AU2018345400A1 (en) | 2020-05-07 |
| IL273698B2 (en) | 2025-07-01 |
| JP7747724B2 (ja) | 2025-10-01 |
| US12227554B2 (en) | 2025-02-18 |
| JP2024050551A (ja) | 2024-04-10 |
| US20200254018A1 (en) | 2020-08-13 |
| KR102757789B1 (ko) | 2025-01-20 |
| AU2018345400B2 (en) | 2024-06-20 |
| IL273698B1 (en) | 2025-03-01 |
| WO2019070435A1 (en) | 2019-04-11 |
| KR20200064107A (ko) | 2020-06-05 |
| EP3692140A1 (en) | 2020-08-12 |
| IL273698A (en) | 2020-05-31 |
| EP4269595A3 (en) | 2023-12-06 |
| WO2019070435A8 (en) | 2020-01-30 |
| CA3077595A1 (en) | 2019-04-11 |
| FI3692140T3 (fi) | 2023-10-11 |
| JP2020535832A (ja) | 2020-12-10 |
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