CN111386113A - 包含lsz102和阿培利司的药物组合 - Google Patents
包含lsz102和阿培利司的药物组合 Download PDFInfo
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- CN111386113A CN111386113A CN201880076600.2A CN201880076600A CN111386113A CN 111386113 A CN111386113 A CN 111386113A CN 201880076600 A CN201880076600 A CN 201880076600A CN 111386113 A CN111386113 A CN 111386113A
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- lsz102
- amide
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762593760P | 2017-12-01 | 2017-12-01 | |
| US62/593,760 | 2017-12-01 | ||
| US201862771757P | 2018-11-27 | 2018-11-27 | |
| US62/771,757 | 2018-11-27 | ||
| PCT/IB2018/059470 WO2019106604A1 (en) | 2017-12-01 | 2018-11-29 | Pharmaceutical combination comprising lsz102 and alpelisib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111386113A true CN111386113A (zh) | 2020-07-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880076600.2A Pending CN111386113A (zh) | 2017-12-01 | 2018-11-29 | 包含lsz102和阿培利司的药物组合 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10695333B2 (https=) |
| EP (1) | EP3716969A1 (https=) |
| JP (1) | JP2021504384A (https=) |
| CN (1) | CN111386113A (https=) |
| TW (1) | TW201924675A (https=) |
| WO (1) | WO2019106604A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3709997A1 (en) | 2017-11-16 | 2020-09-23 | Novartis AG | Pharmaceutical combination comprising lsz102 and ribociclib |
| BR112021003440A2 (pt) | 2018-09-07 | 2021-05-18 | Sanofi | sais de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil) pirrolidin-3-il]oxifenil]-8,9-di-hidro-7h-benzo[7]anuleno-2-carboxilato de metila e seu processo de preparação |
| EP3849545A1 (en) * | 2018-09-10 | 2021-07-21 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of neurofibromatosis |
| EP4037768B1 (en) | 2019-10-01 | 2023-10-11 | Sanofi | Novel substituted 6,7-dihydro-5h-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof |
| AU2020399168A1 (en) | 2019-12-09 | 2022-07-28 | Sanofi | Crystalline form of a 7H-benzo[7]annulene-2-carboxylic acid derivative |
| TW202146007A (zh) | 2020-02-27 | 2021-12-16 | 法商賽諾菲公司 | 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合 |
| TW202233572A (zh) | 2020-10-19 | 2022-09-01 | 法商賽諾菲公司 | 新穎之經取代的6,7-二氫-5h-苯並[7]輪烯衍生物，其製備方法及其治療用途 |
| WO2022084280A1 (en) | 2020-10-19 | 2022-04-28 | Sanofi | Substituted 6,7-dihydro-5h-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof |
Citations (1)
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| JP2016523253A (ja) * | 2013-06-19 | 2016-08-08 | セラゴン ファーマシューティカルズ， インク． | エストロゲン受容体モジュレーター及びその使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080306057A1 (en) | 2005-10-11 | 2008-12-11 | Laboratories Serono Sa | P13K Inhibitors for the Treatment of Endometriosis |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| EP2650401A1 (de) | 2012-04-10 | 2013-10-16 | Siemens Aktiengesellschaft | Kraftwerk basiertes Methanisierungssystem |
| ES2671516T3 (es) * | 2013-02-19 | 2018-06-06 | Novartis Ag | Derivados de benzotiofeno y composiciones de los mismos como degradantes selectivos de los receptores de estrógeno |
| CN105828822B (zh) | 2013-08-14 | 2019-10-18 | 诺华股份有限公司 | 用于治疗癌症的组合疗法 |
| WO2015028409A1 (de) | 2013-08-27 | 2015-03-05 | Bayer Pharma Aktiengesellschaft | 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
| JP6223154B2 (ja) | 2013-11-29 | 2017-11-01 | ロッテ アドバンスト マテリアルズ カンパニー リミテッド | ポリアミド樹脂およびその製造方法 |
| WO2015136016A2 (en) | 2014-03-13 | 2015-09-17 | F. Hoffmann-La Roche Ag | Therapeutic combinations with estrogen receptor modulators |
| KR20250152679A (ko) | 2015-04-29 | 2025-10-23 | 래디어스 파마슈티컬스, 인코포레이티드 | 암을 치료하는 방법 |
| HK1249866A1 (zh) * | 2015-06-29 | 2018-11-16 | 豪夫迈‧罗氏有限公司 | 用他塞利昔布进行治疗的方法 |
| RU2018119085A (ru) * | 2015-11-02 | 2019-12-04 | Новартис Аг | Схема введения ингибитора фосфатидилинозитол-3-киназы |
| WO2017168303A1 (en) * | 2016-03-29 | 2017-10-05 | Novartis Ag | Reaction medium containing water-surfactant mixture |
| MX2019008158A (es) | 2017-01-06 | 2019-12-09 | G1 Therapeutics Inc | Terapia de combinacion para el tratamiento del cancer. |
| EP3709997A1 (en) * | 2017-11-16 | 2020-09-23 | Novartis AG | Pharmaceutical combination comprising lsz102 and ribociclib |
-
2018
- 2018-11-29 CN CN201880076600.2A patent/CN111386113A/zh active Pending
- 2018-11-29 EP EP18826816.3A patent/EP3716969A1/en not_active Withdrawn
- 2018-11-29 US US16/204,471 patent/US10695333B2/en not_active Expired - Fee Related
- 2018-11-29 JP JP2020529159A patent/JP2021504384A/ja active Pending
- 2018-11-29 WO PCT/IB2018/059470 patent/WO2019106604A1/en not_active Ceased
- 2018-12-03 TW TW107143297A patent/TW201924675A/zh unknown
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2020
- 2020-05-07 US US16/869,450 patent/US20210000810A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016523253A (ja) * | 2013-06-19 | 2016-08-08 | セラゴン ファーマシューティカルズ， インク． | エストロゲン受容体モジュレーター及びその使用 |
Non-Patent Citations (1)
| Title |
|---|
| CLINICALTRIALS.GOV: "Phase I/Ib Trial of LSZ102 Single Agent or LSZ102 + LEE011 or LSZ102 + BYL719 in ER+ Breast Cancers", 《HTTPS://CLINICALTRIALS.GOV/CT2/SHOW/NCT02734615》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20210000810A1 (en) | 2021-01-07 |
| WO2019106604A1 (en) | 2019-06-06 |
| EP3716969A1 (en) | 2020-10-07 |
| US10695333B2 (en) | 2020-06-30 |
| JP2021504384A (ja) | 2021-02-15 |
| US20190167652A1 (en) | 2019-06-06 |
| TW201924675A (zh) | 2019-07-01 |
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