JP2021504384A - Ｌｓｚ１０２及びアルペリシブを含む医薬品の組合せ - Google Patents

Ｌｓｚ１０２及びアルペリシブを含む医薬品の組合せ Download PDF

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Publication number
JP2021504384A
JP2021504384A JP2020529159A JP2020529159A JP2021504384A JP 2021504384 A JP2021504384 A JP 2021504384A JP 2020529159 A JP2020529159 A JP 2020529159A JP 2020529159 A JP2020529159 A JP 2020529159A JP 2021504384 A JP2021504384 A JP 2021504384A
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JP
Japan
Prior art keywords
combination
lsz102
day
amide
pharmaceutically acceptable
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JP2020529159A
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Japanese (ja)
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JP2021504384A5 (https=
Inventor
アブラムス，ティニア
アレクサンダー ガイサー，ラリー
アレクサンダー ガイサー，ラリー
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ノバルティス アーゲー
ノバルティス アーゲー
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Publication of JP2021504384A publication Critical patent/JP2021504384A/ja
Publication of JP2021504384A5 publication Critical patent/JP2021504384A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020529159A 2017-12-01 2018-11-29 Ｌｓｚ１０２及びアルペリシブを含む医薬品の組合せ Pending JP2021504384A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762593760P 2017-12-01 2017-12-01
US62/593,760 2017-12-01
US201862771757P 2018-11-27 2018-11-27
US62/771,757 2018-11-27
PCT/IB2018/059470 WO2019106604A1 (en) 2017-12-01 2018-11-29 Pharmaceutical combination comprising lsz102 and alpelisib

Publications (2)

Publication Number Publication Date
JP2021504384A true JP2021504384A (ja) 2021-02-15
JP2021504384A5 JP2021504384A5 (https=) 2022-01-06

Family

ID=64901034

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020529159A Pending JP2021504384A (ja) 2017-12-01 2018-11-29 Ｌｓｚ１０２及びアルペリシブを含む医薬品の組合せ

Country Status (6)

Country Link
US (2) US10695333B2 (https=)
EP (1) EP3716969A1 (https=)
JP (1) JP2021504384A (https=)
CN (1) CN111386113A (https=)
TW (1) TW201924675A (https=)
WO (1) WO2019106604A1 (https=)

Cited By (1)

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JP2023516951A (ja) * 2020-02-27 2023-04-21 サノフイ アルペリシブおよび６－（２，４－ジクロロフェニル）－５－［４－［（３ｓ）－１－（３－フルオロプロピル）ピロリジン－３－イル］オキシフェニル］－８，９－ジヒドロ－７ｈ－ベンゾ［７］アヌレン－２－カルボン酸を含む組合せ物

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EP3709997A1 (en) 2017-11-16 2020-09-23 Novartis AG Pharmaceutical combination comprising lsz102 and ribociclib
BR112021003440A2 (pt) 2018-09-07 2021-05-18 Sanofi sais de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil) pirrolidin-3-il]oxifenil]-8,9-di-hidro-7h-benzo[7]anuleno-2-carboxilato de metila e seu processo de preparação
EP3849545A1 (en) * 2018-09-10 2021-07-21 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of neurofibromatosis
EP4037768B1 (en) 2019-10-01 2023-10-11 Sanofi Novel substituted 6,7-dihydro-5h-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof
AU2020399168A1 (en) 2019-12-09 2022-07-28 Sanofi Crystalline form of a 7H-benzo[7]annulene-2-carboxylic acid derivative
TW202233572A (zh) 2020-10-19 2022-09-01 法商賽諾菲公司 新穎之經取代的6,7-二氫-5h-苯並[7]輪烯衍生物，其製備方法及其治療用途
WO2022084280A1 (en) 2020-10-19 2022-04-28 Sanofi Substituted 6,7-dihydro-5h-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof

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JP2016509022A (ja) * 2013-02-19 2016-03-24 ノバルティス アーゲー 選択的エストロゲン受容体ディグレーダーとしてのベンゾチオフェン誘導体およびその組成物
WO2017077445A1 (en) * 2015-11-02 2017-05-11 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor

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US20080306057A1 (en) 2005-10-11 2008-12-11 Laboratories Serono Sa P13K Inhibitors for the Treatment of Endometriosis
UA104147C2 (uk) 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
EP2650401A1 (de) 2012-04-10 2013-10-16 Siemens Aktiengesellschaft Kraftwerk basiertes Methanisierungssystem
EA031077B1 (ru) * 2013-06-19 2018-11-30 Серагон Фармасьютикалз, Инк. Модулятор рецептора эстрогена и его применения
CN105828822B (zh) 2013-08-14 2019-10-18 诺华股份有限公司 用于治疗癌症的组合疗法
WO2015028409A1 (de) 2013-08-27 2015-03-05 Bayer Pharma Aktiengesellschaft 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
JP6223154B2 (ja) 2013-11-29 2017-11-01 ロッテ アドバンスト マテリアルズ カンパニー リミテッド ポリアミド樹脂およびその製造方法
WO2015136016A2 (en) 2014-03-13 2015-09-17 F. Hoffmann-La Roche Ag Therapeutic combinations with estrogen receptor modulators
KR20250152679A (ko) 2015-04-29 2025-10-23 래디어스 파마슈티컬스, 인코포레이티드 암을 치료하는 방법
HK1249866A1 (zh) * 2015-06-29 2018-11-16 豪夫迈‧罗氏有限公司 用他塞利昔布进行治疗的方法
WO2017168303A1 (en) * 2016-03-29 2017-10-05 Novartis Ag Reaction medium containing water-surfactant mixture
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EP3709997A1 (en) * 2017-11-16 2020-09-23 Novartis AG Pharmaceutical combination comprising lsz102 and ribociclib

Patent Citations (2)

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JP2016509022A (ja) * 2013-02-19 2016-03-24 ノバルティス アーゲー 選択的エストロゲン受容体ディグレーダーとしてのベンゾチオフェン誘導体およびその組成物
WO2017077445A1 (en) * 2015-11-02 2017-05-11 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor

Non-Patent Citations (1)

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Title
樋口智子、三好康雄: "分子標的薬の治療標的と作用メカニズム", 日本内分泌・甲状腺外科学会雑誌, vol. 第32巻 第2号, JPN6023006750, 2015, pages 74 - 79, ISSN: 0004995578 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023516951A (ja) * 2020-02-27 2023-04-21 サノフイ アルペリシブおよび６－（２，４－ジクロロフェニル）－５－［４－［（３ｓ）－１－（３－フルオロプロピル）ピロリジン－３－イル］オキシフェニル］－８，９－ジヒドロ－７ｈ－ベンゾ［７］アヌレン－２－カルボン酸を含む組合せ物

Also Published As

Publication number Publication date
US20210000810A1 (en) 2021-01-07
WO2019106604A1 (en) 2019-06-06
CN111386113A (zh) 2020-07-07
EP3716969A1 (en) 2020-10-07
US10695333B2 (en) 2020-06-30
US20190167652A1 (en) 2019-06-06
TW201924675A (zh) 2019-07-01

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