CN111333680B - 一种膦配体其制备方法及应用 - Google Patents
一种膦配体其制备方法及应用 Download PDFInfo
- Publication number
- CN111333680B CN111333680B CN202010250875.2A CN202010250875A CN111333680B CN 111333680 B CN111333680 B CN 111333680B CN 202010250875 A CN202010250875 A CN 202010250875A CN 111333680 B CN111333680 B CN 111333680B
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- Prior art keywords
- phosphine
- reaction
- salt
- phosphine ligand
- fluoride
- Prior art date
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- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 title claims abstract description 89
- 239000003446 ligand Substances 0.000 title claims abstract description 45
- 229910000073 phosphorus hydride Inorganic materials 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 238000006243 chemical reaction Methods 0.000 claims abstract description 68
- HEBMCVBCEDMUOF-UHFFFAOYSA-N isochromane Chemical class C1=CC=C2COCCC2=C1 HEBMCVBCEDMUOF-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 11
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 5
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 5
- 125000000304 alkynyl group Chemical group 0.000 claims abstract description 5
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims abstract description 5
- 125000001624 naphthyl group Chemical group 0.000 claims abstract description 5
- 125000005561 phenanthryl group Chemical group 0.000 claims abstract description 5
- 125000001153 fluoro group Chemical class F* 0.000 claims abstract 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 36
- 238000003786 synthesis reaction Methods 0.000 claims description 30
- 238000003756 stirring Methods 0.000 claims description 29
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 28
- 239000002904 solvent Substances 0.000 claims description 25
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 14
- 238000004321 preservation Methods 0.000 claims description 13
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 8
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 8
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 claims description 8
- OUMZKMRZMVDEOF-UHFFFAOYSA-N tris(trimethylsilyl)phosphane Chemical group C[Si](C)(C)P([Si](C)(C)C)[Si](C)(C)C OUMZKMRZMVDEOF-UHFFFAOYSA-N 0.000 claims description 8
- MOVBJUGHBJJKOW-UHFFFAOYSA-N methyl 2-amino-5-methoxybenzoate Chemical compound COC(=O)C1=CC(OC)=CC=C1N MOVBJUGHBJJKOW-UHFFFAOYSA-N 0.000 claims description 7
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 5
- XJHCXCQVJFPJIK-UHFFFAOYSA-M caesium fluoride Chemical compound [F-].[Cs+] XJHCXCQVJFPJIK-UHFFFAOYSA-M 0.000 claims description 4
- PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Chemical compound [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 claims description 4
- 239000003880 polar aprotic solvent Substances 0.000 claims description 4
- 235000003270 potassium fluoride Nutrition 0.000 claims description 4
- 239000011698 potassium fluoride Substances 0.000 claims description 4
- POSYVRHKTFDJTR-UHFFFAOYSA-M tetrapropylazanium;fluoride Chemical compound [F-].CCC[N+](CCC)(CCC)CCC POSYVRHKTFDJTR-UHFFFAOYSA-M 0.000 claims description 4
- 230000035484 reaction time Effects 0.000 claims description 3
- DDQMTQUVWRTBIV-UHFFFAOYSA-N tris(triethylsilyl)phosphane Chemical compound CC[Si](CC)(CC)P([Si](CC)(CC)CC)[Si](CC)(CC)CC DDQMTQUVWRTBIV-UHFFFAOYSA-N 0.000 claims description 3
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 2
- 229960001701 chloroform Drugs 0.000 claims description 2
- 239000012299 nitrogen atmosphere Substances 0.000 claims description 2
- 239000012266 salt solution Substances 0.000 claims description 2
- 235000013024 sodium fluoride Nutrition 0.000 claims description 2
- 239000011775 sodium fluoride Substances 0.000 claims description 2
- XLQDGYFCACBBIS-UHFFFAOYSA-N bis(trimethylsilyl)-triphenylsilylphosphane Chemical compound C=1C=CC=CC=1[Si](C=1C=CC=CC=1)(P([Si](C)(C)C)[Si](C)(C)C)C1=CC=CC=C1 XLQDGYFCACBBIS-UHFFFAOYSA-N 0.000 claims 1
- 238000007037 hydroformylation reaction Methods 0.000 abstract description 36
- 150000001336 alkenes Chemical class 0.000 abstract description 25
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 abstract description 19
- 239000003054 catalyst Substances 0.000 abstract description 15
- 239000010948 rhodium Substances 0.000 abstract description 15
- 229910052703 rhodium Inorganic materials 0.000 abstract description 9
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract description 9
- 229910017052 cobalt Inorganic materials 0.000 abstract description 7
- 239000010941 cobalt Substances 0.000 abstract description 7
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 abstract description 7
- 229910052799 carbon Inorganic materials 0.000 abstract description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract description 5
- 229910052751 metal Inorganic materials 0.000 abstract description 4
- 239000002184 metal Substances 0.000 abstract description 4
- 125000003118 aryl group Chemical group 0.000 abstract description 3
- 150000002739 metals Chemical class 0.000 abstract description 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 44
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 37
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 27
- 230000015572 biosynthetic process Effects 0.000 description 26
- 239000000243 solution Substances 0.000 description 26
- 229910052757 nitrogen Inorganic materials 0.000 description 25
- 239000007789 gas Substances 0.000 description 18
- -1 aldehyde compounds Chemical class 0.000 description 17
- IAQRGUVFOMOMEM-UHFFFAOYSA-N but-2-ene Chemical compound CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 17
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 14
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical compound CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 11
- 239000000047 product Substances 0.000 description 11
- WGLLSSPDPJPLOR-UHFFFAOYSA-N 2,3-dimethylbut-2-ene Chemical compound CC(C)=C(C)C WGLLSSPDPJPLOR-UHFFFAOYSA-N 0.000 description 10
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 description 10
- ZGEGCLOFRBLKSE-UHFFFAOYSA-N 1-Heptene Chemical compound CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 description 8
- XNMQEEKYCVKGBD-UHFFFAOYSA-N dimethylacetylene Natural products CC#CC XNMQEEKYCVKGBD-UHFFFAOYSA-N 0.000 description 8
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 8
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N pentanal Chemical compound CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- CUJRVFIICFDLGR-UHFFFAOYSA-N acetylacetonate Chemical compound CC(=O)[CH-]C(C)=O CUJRVFIICFDLGR-UHFFFAOYSA-N 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 238000005070 sampling Methods 0.000 description 6
- 229910052723 transition metal Inorganic materials 0.000 description 6
- 150000003624 transition metals Chemical class 0.000 description 6
- GGQQNYXPYWCUHG-RMTFUQJTSA-N (3e,6e)-deca-3,6-diene Chemical compound CCC\C=C\C\C=C\CC GGQQNYXPYWCUHG-RMTFUQJTSA-N 0.000 description 5
- 239000006227 byproduct Substances 0.000 description 5
- 239000012295 chemical reaction liquid Substances 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 239000012043 crude product Substances 0.000 description 5
- 238000002425 crystallisation Methods 0.000 description 5
- 230000008025 crystallization Effects 0.000 description 5
- 239000012065 filter cake Substances 0.000 description 5
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 5
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 5
- 239000011541 reaction mixture Substances 0.000 description 5
- 238000002390 rotary evaporation Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- AIODYCJUHTYCEB-UHFFFAOYSA-N 1,3-dimethyl-3,4-dihydro-1h-isochromene Chemical compound C1=CC=C2C(C)OC(C)CC2=C1 AIODYCJUHTYCEB-UHFFFAOYSA-N 0.000 description 4
- BYGQBDHUGHBGMD-UHFFFAOYSA-N 2-methylbutanal Chemical compound CCC(C)C=O BYGQBDHUGHBGMD-UHFFFAOYSA-N 0.000 description 4
- YGHRJJRRZDOVPD-UHFFFAOYSA-N 3-methylbutanal Chemical compound CC(C)CC=O YGHRJJRRZDOVPD-UHFFFAOYSA-N 0.000 description 4
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 4
- 150000001299 aldehydes Chemical class 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 150000002221 fluorine Chemical class 0.000 description 4
- 239000012046 mixed solvent Substances 0.000 description 4
- NUJGJRNETVAIRJ-UHFFFAOYSA-N octanal Chemical compound CCCCCCCC=O NUJGJRNETVAIRJ-UHFFFAOYSA-N 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 239000012265 solid product Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 239000004305 biphenyl Substances 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 3
- 239000001893 (2R)-2-methylbutanal Substances 0.000 description 2
- ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 2,3-dimethylbutane Chemical compound CC(C)C(C)C ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 0.000 description 2
- QPRQEDXDYOZYLA-UHFFFAOYSA-N 2-methylbutan-1-ol Chemical compound CCC(C)CO QPRQEDXDYOZYLA-UHFFFAOYSA-N 0.000 description 2
- SZBNDYYJXRXQHA-UHFFFAOYSA-N 3,4-dimethylpentanal Chemical compound CC(C)C(C)CC=O SZBNDYYJXRXQHA-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 229940120638 avastin Drugs 0.000 description 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N caprylic alcohol Natural products CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- KVFDZFBHBWTVID-UHFFFAOYSA-N cyclohexanecarbaldehyde Chemical compound O=CC1CCCCC1 KVFDZFBHBWTVID-UHFFFAOYSA-N 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000012847 fine chemical Substances 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
- QVDTXNVYSHVCGW-ONEGZZNKSA-N isopentenol Chemical compound CC(C)\C=C\O QVDTXNVYSHVCGW-ONEGZZNKSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 150000008300 phosphoramidites Chemical class 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- OGNVQLDIPUXYDH-ZPKKHLQPSA-N (2R,3R,4S)-3-(2-methylpropanoylamino)-4-(4-phenyltriazol-1-yl)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid Chemical compound CC(C)C(=O)N[C@H]1[C@H]([C@H](O)[C@H](O)CO)OC(C(O)=O)=C[C@@H]1N1N=NC(C=2C=CC=CC=2)=C1 OGNVQLDIPUXYDH-ZPKKHLQPSA-N 0.000 description 1
- DWGOEAHRHZDVLC-UHFFFAOYSA-N 1,3-diphenylisophosphinoline Chemical compound c1ccc(cc1)-c1cc2ccccc2c(p1)-c1ccccc1 DWGOEAHRHZDVLC-UHFFFAOYSA-N 0.000 description 1
- KAVCPAPEQJQJKH-UHFFFAOYSA-N 1,4-diphenylbut-3-yn-1-one Chemical compound C=1C=CC=CC=1C(=O)CC#CC1=CC=CC=C1 KAVCPAPEQJQJKH-UHFFFAOYSA-N 0.000 description 1
- QCMHBIMNSCDOSH-UHFFFAOYSA-N 1-methyl-3-phenylisophosphinoline Chemical compound CC1=PC(=CC2=CC=CC=C12)C3=CC=CC=C3 QCMHBIMNSCDOSH-UHFFFAOYSA-N 0.000 description 1
- FATLFAJLNPTNIM-UHFFFAOYSA-N 1-phenylpent-4-yn-1-one Chemical compound C#CCCC(=O)C1=CC=CC=C1 FATLFAJLNPTNIM-UHFFFAOYSA-N 0.000 description 1
- FJJYHTVHBVXEEQ-UHFFFAOYSA-N 2,2-dimethylpropanal Chemical compound CC(C)(C)C=O FJJYHTVHBVXEEQ-UHFFFAOYSA-N 0.000 description 1
- DHEKCFIOOSCJRW-UHFFFAOYSA-N 2-methylheptanal Chemical compound CCCCCC(C)C=O DHEKCFIOOSCJRW-UHFFFAOYSA-N 0.000 description 1
- SVJNECJVNWTYQG-UHFFFAOYSA-N 3,4-dimethylpentan-1-ol Chemical compound CC(C)C(C)CCO SVJNECJVNWTYQG-UHFFFAOYSA-N 0.000 description 1
- UHEFACWYBYZURZ-UHFFFAOYSA-N 4-phenylnaphthalen-2-ol Chemical compound C=12C=CC=CC2=CC(O)=CC=1C1=CC=CC=C1 UHEFACWYBYZURZ-UHFFFAOYSA-N 0.000 description 1
- BZAWNVWURVLDAT-UHFFFAOYSA-N CC(C=C1)=CC=C1C#CC(C1=CC(C2=CC=CC=C2)=C(C)C=C1)=O Chemical compound CC(C=C1)=CC=C1C#CC(C1=CC(C2=CC=CC=C2)=C(C)C=C1)=O BZAWNVWURVLDAT-UHFFFAOYSA-N 0.000 description 1
- UTRRHKAMUNWASW-UHFFFAOYSA-N COC(C1=C(C2=CC=CC=C2)C(C#CC2=CC(OC)=CC=C2)=CC=C1)=O Chemical compound COC(C1=C(C2=CC=CC=C2)C(C#CC2=CC(OC)=CC=C2)=CC=C1)=O UTRRHKAMUNWASW-UHFFFAOYSA-N 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 125000005103 alkyl silyl group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- GGRQQHADVSXBQN-FGSKAQBVSA-N carbon monoxide;(z)-4-hydroxypent-3-en-2-one;rhodium Chemical compound [Rh].[O+]#[C-].[O+]#[C-].C\C(O)=C\C(C)=O GGRQQHADVSXBQN-FGSKAQBVSA-N 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000003889 chemical engineering Methods 0.000 description 1
- 239000007810 chemical reaction solvent Substances 0.000 description 1
- VSSAZBXXNIABDN-UHFFFAOYSA-N cyclohexylmethanol Chemical compound OCC1CCCCC1 VSSAZBXXNIABDN-UHFFFAOYSA-N 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000001282 iso-butane Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N n-Octanol Natural products CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- UIUWNILCHFBLEQ-UHFFFAOYSA-N pent-3-enoic acid Chemical compound CC=CCC(O)=O UIUWNILCHFBLEQ-UHFFFAOYSA-N 0.000 description 1
- ZDMBWRVNJKHIAV-UHFFFAOYSA-N phenyl-[2-(2-phenylethynyl)phenyl]methanone Chemical compound C=1C=CC=C(C#CC=2C=CC=CC=2)C=1C(=O)C1=CC=CC=C1 ZDMBWRVNJKHIAV-UHFFFAOYSA-N 0.000 description 1
- 150000003003 phosphines Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 230000036632 reaction speed Effects 0.000 description 1
- BDDWSAASCFBVBK-UHFFFAOYSA-N rhodium;triphenylphosphane Chemical compound [Rh].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 BDDWSAASCFBVBK-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65683—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
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Abstract
Description
技术领域
本发明属于精细化工和特种营养品领域,具体涉及一种快速、高效合成的新型膦配体、其制备方法,以及所得膦配体在烯烃氢甲酰化反应中的应用。
背景技术
醛是一类常见的有机化合物,广泛地存在天然产物和精细化学品中,在人们的生产、生活中有着广泛的应用。合成醛类化合物有多种方法,如伯醇的氧化、酯和酰胺的还原、烯烃的氢甲酰化等,这些合成方法中,烯烃氢甲酰化由于起始原料简单易得、反应原子经济性高、三废少等优点,是目前醛类化合物合成中应用最多的方法。根据催化剂形态不同,烯烃氢甲酰化反应可分为均相氢甲酰化和非均相氢甲酰化,目前工业应用最多的是均相氢甲酰化,据估计,全世界每年有超过700万吨的醛类化合物通过均相氢甲酰化反应合成。
烯烃均相氢甲酰化反应的催化剂一般是钴或铑,反应体系中一般需要加入膦配体,膦配体不但可以稳定金属离子,防止催化剂失活,而且还可以提高直链醛产物的选择性,目前生产中最常用的配体是三苯基膦或者苯环含有取代基的三芳基膦。对于低碳数的单取代端烯烃,铑-三苯基膦是非常有效的催化体系,但是该催化剂对于高碳数的烯烃、内烯烃、三取代或者四取代烯烃催化效果较差,反应速度很慢(J.Falbe.New Syntheses withcarbon monoxide,Springer,Berlin,1980.);此外,由于三苯基膦配体会在氢甲酰化反应条件下会缓慢降解,造成氢甲酰化催化剂缓慢活性;所以近年来人们致力于发展新型的膦配体,改善上述已有膦配体的缺陷。
Beller等人发现亚磷酰胺配体可以提高铑催化剂活性,实现2-丁烯和3-戊烯酸酯等内烯烃的氢甲酰化,但是亚磷酰胺对水敏感,限制了这类的配体的广泛应用(M.Belleret al.J.Mol.Catal.1995,104,17)。专利WO9746507发现还有取代基的膦杂苯配体可以很好用于铑催化的氢甲酰化反应。B.Breit等人合成一系列的膦杂苯配体并将这些配体应用烯烃氢甲酰化反应,TOF最高可达45370h-1,端烯烃和内烯烃都是合适的底物(B.Breit etal.Chem.Eur.J.2001,7,3106)。专利US20040106512A2将膦杂环己烷或者桥联的膦杂环己烷配体应用于钴或铑催化的氢甲酰化反应中,取得不错的反应效果,但是该体系对内烯烃和多取代烯烃效果一般。
综上所述,烯烃氢甲酰化反应是合成醛类化合物最有效的方法之一,虽然目前钴和铑催化的均相氢甲酰化反应已经获得了大规模的应用,但是目前所使用的配体存在化学稳定性差、对内烯烃活性低等多种问题,制约氢甲酰化反应进一步发展和应用。目前需要发展新型氢甲酰化反应膦配体,不但要具有较高的催化活性,而且在苛刻反应条件下稳定性好,促进氢甲酰化反应的进一步应用。
发明内容
本发明的目的在于提供一种膦配体及快速、高效合成该膦配体的制备方法。
本发明的另一目的还在于提供所得膦配体在氢甲酰化反应中的应用,例如丙烯、1-丁烯、2-丁烯、异丁烯和异戊烯醇等烯烃底物氢甲酰化反应中的应用。
为实现上述目的和达到上述技术效果,本发明采用如下技术方案:
一种膦配体,其结构式为:
其中,R、R1、R2和R3相同或不同,各自独立的选自C1~C40烷基、烯基、炔基、苯基、取代苯基、萘基、蒽基、菲基或者其他更高碳数的芳环和芳杂环取代基。
本发明还提供上述膦配体的制备方法,将异色满盐、三硅基膦和氟盐在加热条件下一步反应得到膦配体,即异磷啉配体衍生物。
本发明中,所述异色满盐的结构式如下:
其中,R、R1、R2和R3相同或不同,各自独立的选自C1~C40烷基、烯基、炔基,以及苯基、取代苯基、萘基、蒽基、菲基或者其他更高碳数的芳环和芳杂环取代基。
本发明所述膦配体合成路线如下所示:
本发明中,所述三硅基膦结构为磷连接三个硅原子取代基的化合物,可以是三(三甲基硅基)膦、三(三乙基硅基)膦、二-(三甲基硅基)三苯基硅基膦或者其他更高碳数的烷基硅基取代的膦,三硅基膦的摩尔用量为异色满盐的1.5~3.0倍。
本发明中,所述氟盐可以是氟化锂、氟化钠、氟化钾、氟化铯、四甲基氟化铵、四丙基氟化铵、四丁基氟化铵等中的一种或多种,优选四甲基氟化铵,氟盐的用量为三硅基膦摩尔量的2.0~3.0倍。
本发明的制备方法中,所述膦配体的合成反应在极性非质子型溶剂中进行,所述极性非质子型溶剂选自四氢呋喃、乙腈、N,N-二甲基甲酰胺、二氯甲烷、三氯甲烷、二氯乙烷中的一种或多种,优选为四氢呋喃。
本发明的制备方法中,所述膦配体合成反应的温度为70~100℃,反应压力为常压,反应时间2~4小时;
优选的,膦配体的制备方法为:在氮气氛围中,室温下依次加入异色满盐、三硅基膦和极性非质子型溶剂,升温至70~100℃,快速搅拌下,缓慢加入氟盐溶液,保温反应2-4小时。
本发明中,根据所述的方法制备的膦配体,可以和过渡金属尤其是VIII族金属配位,优选的,其可以用于和钴、铑配位。
本发明还提供该膦配体的应用,其可以和过渡金属尤其是VIII族金属配位,优选的,其可以用于和钴、铑配位得配合物,所得配合物可以用于催化烯烃的氢甲酰化反应。
本发明中,在所述的氢甲酰化反应中,所述膦配体和过渡金属配位,二者的摩尔比为1~20:1,优选2~10:1,过渡金属的用量为烯烃底物的0.01~0.1mol%。
本发明中,所述烯烃底物可以是端烯烃、内烯烃、三取代烯烃或四取代烯烃等烯烃,例如丙烯、1-丁烯、2-丁烯、异丁烯、异戊烯醇等。
本发明中,所述氢甲酰化反应中,溶剂可以是苯、甲苯、四氢呋喃、二氯甲烷、丙酮或者目标产物,优选甲苯或目标产物作为反应溶剂。
本发明中,所述氢甲酰化反应的反应温度为70~150℃,优选80~100℃;反应时间2~8小时;和/或反应压力为1.0~10.0MPa。
本发明采用上述技术方案,具有如下积极效果:
1、原料异色满盐、三硅基膦简单易得、性质稳定、操作方便,本发明在二者的反应中加入氟盐,可以有效促进反应进行,快速、高效的得到异磷啉配体衍生物;
2、所得异磷啉配体衍生物不但化学性质稳定,而且具有较强的配位能力,能很好的与钴、铑等过渡金属配位,所得配合物催化氢甲酰化反应活性高,催化剂用量少,反应条件温和,高收率得到直链醛产物。
3、所得异磷啉配体与铑配位,所得配合物可以实现内烯烃氢甲酰化反应,例如2-丁烯、环己烯、2,3-二甲基-2-丁烯等。
4、异磷啉配体与金属配位物结构稳定,120℃仍能问题存在、不分解,完成催化反应。
具体实施方式
下面通过实施例详述本发明,但本发明并不限于下述的实施例。
主要原料信息如下:
1,3-二苯基异色满三氟甲磺酸盐(C22H15F3O4S,432.412)、1,3-二对甲苯基异色满三氟甲磺酸盐(C24H19F3O4S,460.465)、1,3-二间甲氧基苯基异色满三氟甲磺酸盐(C24H19F3O6S,492.464)、1-甲基-3-苯基异色满高氯酸盐(C16H13ClO5,320.724)、1,3-二甲基异色满高氯酸盐(C11H11ClO5,258.654)等根据文献报道方法合成;三(三甲基硅基)膦、三(三乙基硅烷基)膦,阿尔德里奇试剂,99%;四甲基氟化铵、四丙基氟化铵、四丁基氟化铵、氟化钾,阿拉丁试剂,98-99%;无水四氢呋喃、乙腈、N,N-二甲基甲酰胺、甲苯等溶剂,阿尔德里奇试剂,色谱纯%;1-丁烯、2-丁烯、异丁烯、1-庚烯,自制,纯度>99.5%;[Rh(acac)(CO)2]、环己烯、2,3-二甲基-2-丁烯,阿拉丁,99%。
本发明的用于监测反应转化率和选择性的气相色谱测试条件如下:
仪器型号:Agilent GC;色谱柱:Agilent DB-5(30m×0.25mm×0.25μm);柱温:起始温度为50℃,以5℃/min的速率升温至100℃,然后以10℃/min的速率升温酯200℃,最后以15℃/min的速率升温至230℃,保持3min;进样器进样口温度:280℃;FID检测器温度为:300℃;分流进样,分流比30:1;进样量:1.5μL;H2流量:40mL/min;空气流量:320mL/min。
实施例1:1,3-二苯基异色满三氟甲磺酸盐合成(C22H15F3O4S,432.412)
空气中,室温下向装有磁力搅拌子的100mL三口烧瓶加入(2-苯乙炔基)-二苯甲酮(C21H14O,282.335)(2.82g,10.0mmol),用氮气置换瓶内空气3次,然后加入溶剂二氯甲烷(20mL),开启搅拌,用恒压滴液漏斗逐滴、缓慢加入三氟甲磺酸(7.50g,50.0mmol),加毕,室温反应2小时。后处理,向反应液加入溶剂乙醚(20mL),继续搅拌10分钟后,将三口烧瓶密封,放入-10℃的冰箱中,冷冻结晶1小时。将反应液从冰箱取出,快速过滤反应液,乙醚洗涤滤饼,得到纯净的1,3-二苯基异色满三氟甲磺酸盐2.98g,纯度>99%,收率69.0%。
实施例2:1,3-二对甲苯基异色满三氟甲磺酸盐(C24H19F3O4S,460.465)
空气中,室温下向装有磁力搅拌子的100mL三口烧瓶加入(2-对甲苯乙炔基)苯基-对甲苯基甲酮(C23H18O,310.388)(3.10g,10.0mmol),用氮气置换瓶内空气3次,然后加入溶剂二氯甲烷(20mL),开启搅拌,用恒压滴液漏斗逐滴、缓慢加入三氟甲磺酸(7.50g,50.0mmol),加毕,室温反应2小时。后处理,向反应液加入溶剂乙醚(20mL),继续搅拌10分钟后,将三口烧瓶密封,放入-10℃的冰箱中,冷冻结晶1小时。将反应液从冰箱取出,快速过滤反应液,乙醚洗涤滤饼,得到纯净的1,3-二对甲苯基异色满三氟甲磺酸盐2.90g,纯度>99%,收率63.0%
实施例3:1,3-二间甲氧基苯基异色满三氟甲磺酸盐(C24H19F3O6S,492.464)
空气中,室温下向装有磁力搅拌子的100mL三口烧瓶加入(2-间甲氧基苯乙炔基)苯基-甲氧基苯基甲酮(C23H18O3,342.387)(3.42g,10.0mmol),用氮气置换瓶内空气3次,然后加入溶剂二氯甲烷(20mL),开启搅拌,用恒压滴液漏斗逐滴、缓慢加入三氟甲磺酸(7.50g,50.0mmol),加毕,室温反应2小时。后处理,向反应液加入溶剂乙醚(20mL),继续搅拌10分钟后,将三口烧瓶密封,放入-10℃的冰箱中,冷冻结晶1小时。将反应液从冰箱取出,快速过滤反应液,乙醚洗涤滤饼,得到纯净的1,3-二间甲氧基苯基异色满三氟甲磺酸盐3.05g,纯度>99%,收率62.0%
实施例4:1-甲基-3-苯基-异色满高氯酸盐(C16H13ClO5,320.724)
空气中,室温下向装有磁力搅拌子的100mL三口烧瓶加入(2-苯乙炔基)-苯乙酮(C16H12O,220.266)(2.20g,10.0mmol),用氮气置换瓶内空气3次,然后加入溶剂二氯甲烷(20mL),开启搅拌,用恒压滴液漏斗逐滴、缓慢加入高氯酸(7.50g,50.0mmol),加毕,室温反应2小时。后处理,向反应液加入溶剂乙醚(20mL),继续搅拌10分钟后,将三口烧瓶密封,放入-10℃的冰箱中,冷冻结晶1小时。将反应液从冰箱取出,快速过滤反应液,乙醚洗涤滤饼,得到纯净的1-甲基-3-苯基-异色满高氯酸盐2.44g,纯度>99%,收率76.0%
实施例5:1,3-二甲基异色满高氯酸盐(C11H11ClO5,258.655)
空气中,室温下向装有磁力搅拌子的100mL三口烧瓶加入(2-丙炔基)-苯乙酮(C11H10O,158.197)(1.58g,10.0mmol),用氮气置换瓶内空气3次,然后加入溶剂二氯甲烷(20mL),开启搅拌,用恒压滴液漏斗逐滴、缓慢加入高氯酸(7.50g,50.0mmol),加毕,室温反应2小时。后处理,向反应液加入溶剂乙醚(20mL),继续搅拌10分钟后,将三口烧瓶密封,放入-10℃的冰箱中,冷冻结晶1小时。将反应液从冰箱取出,快速过滤反应液,乙醚洗涤滤饼,得到纯净的1,3-二甲基异色满高氯酸盐1.89g,纯度>99%,收率73.0%
实施例6:
1,3-二苯基异磷啉合成(1,3-diphenylisophosphinoline)
空气中,室温下向200mL敞口的高压釜加入1,3-二苯基异色满三氟甲磺酸盐(8.65g,20.0mmol),加毕,密封高压釜,氮气置换釜内空气三次,每次1.0MPa,最后充入1.0MPa氮气验漏,确定高压釜密封性良好后,用平流泵一次性加入三(三甲硅基)膦(10.02g,40.0mmol)的四氢呋喃(40mL)溶液。开启搅拌和加热,待反应釜内温升高至80℃时,用平流泵缓慢加入四甲基氟化铵(11.18g,120.0mmol)的四氢呋喃(40mL)溶液,加毕,保温反应3小时。后处理,将反应釜降至室温,取出反应液,旋转蒸发除去溶剂,得固体粗产物,采用二氯甲烷和乙醚混合溶剂结晶得到纯净的1,3-二苯基异磷啉固体产物4.98g,收率83.4%。HRMS-EI M+calcd for C21H15P:298.0911,found 298.0910。
实施例7:
1,3-二对甲苯基异磷啉合成(1,3-di-p-tolylisophosphinoline)
空气中,室温下向200mL敞口的高压釜加入1,3-二对甲苯基异色满三氟甲磺酸盐(9.21g,20.0mmol),加毕,密封高压釜,氮气置换釜内空气三次,每次1.0MPa,最后充入1.0MPa氮气验漏,确定高压釜密封性良好后,用平流泵一次性加入三(三甲硅基)膦(7.52g,30.0mmol)的四氢呋喃(40mL)溶液。开启搅拌和加热,待反应釜内温升高至80℃时,用平流泵缓慢加入四甲基氟化铵(8.38g,90.0mmol)的四氢呋喃(40mL)溶液,加毕,保温反应4小时。后处理,将反应釜降至室温,取出反应液,旋转蒸发除去溶剂,得固体粗产物,采用二氯甲烷和乙醚混合溶剂结晶得到纯净的1,3-二对甲苯基异磷啉固体产物5.01g,收率76.7%。HRMS-EI M+calcd for C23H19P:326.1224,found 326.1226。
实施例8:
1,3-二间甲氧基苯基异磷啉合成(1,3-bis(3-methoxyphenyl)isophosphinoline)空气中,室温下向200mL敞口的高压釜加入1,3-二间甲氧基苯基异色满三氟甲磺酸盐(9.85g,20.0mmol),加毕,密封高压釜,氮气置换釜内空气三次,每次1.0MPa,最后充入1.0MPa氮气验漏,确定高压釜密封性良好后,用平流泵一次性加入三(三甲硅基)膦(10.02g,40.0mmol)的四氢呋喃(40mL)溶液。开启搅拌和加热,待反应釜内温升高至80℃时,用平流泵缓慢加入四丙基氟化铵(24.64g,120.0mmol)的四氢呋喃(80mL)溶液,加毕,保温反应4小时。后处理,将反应釜降至室温,取出反应液,旋转蒸发除去溶剂,得固体粗产物,采用二氯甲烷和乙醚混合溶剂结晶得到纯净的1,3-二间甲氧基苯基异磷啉固体产物6.10g,收率85.1%。HRMS-EI M+calcd for C23H19O2P:358.1123,found 358.1121。
实施例9:
1-甲基-3-苯基异磷啉合成(1-methyl-3-phenylisophosphinoline)
空气中,室温下向200mL敞口的高压釜加入1-甲基-3-苯基-异色满高氯酸盐(6.41g,20.0mmol),加毕,密封高压釜,氮气置换釜内空气三次,每次1.0MPa,最后充入1.0MPa氮气验漏,确定高压釜密封性良好后,用平流泵一次性加入三(三甲硅基)膦(10.02g,40.0mmol)的四氢呋喃(40mL)溶液。开启搅拌和加热,待反应釜内温升高至80℃时,用平流泵缓慢加入四丁基氟化铵(20.92g,80.0mmol)的四氢呋喃(40mL)溶液,加毕,保温反应3小时。后处理,将反应釜降至室温,取出反应液,旋转蒸发除去溶剂,得固体粗产物,采用二氯甲烷和乙醚混合溶剂结晶得到纯净的1-甲基-3-苯基异磷啉固体产物2.92g,收率61.9%。HRMS-EI M+calcd for C16H13P:236.0755,found 236.0755。实施例10:
1,3-二甲基异磷啉合成(1,3-dimethylisophosphinoline)
空气中,室温下向200mL敞口的高压釜加入1,3-二甲基异色满高氯酸盐(5.17g,20.0mmol),加毕,密封高压釜,氮气置换釜内空气三次,每次1.0MPa,最后充入1.0MPa氮气验漏,确定高压釜密封性良好后,用平流泵一次性加入三(三甲硅基)膦(15.03g,60.0mmol)的无水N,N-二甲基甲酰胺(40mL)溶液。开启搅拌和加热,待反应釜内温升高至100℃时,用平流泵缓慢加入氟化钾(8.72g,150mmol)的N,N-二甲基甲酰胺(60mL)溶液,加毕,保温反应4小时。后处理,将反应釜降至室温,取出反应液,旋转蒸发除去溶剂,得浅黄色液体粗产物,采用硅胶柱层析分离的方法得到纯净的1,3-二甲基异磷啉固体液体2.04g,收率58.6%。HRMS-EI M+calcd for C11H11P:174.0598,found 174.0596。
实施例11:
1-丁烯氢甲酰化合成正戊醛
手套箱中,室温下依次称取[Rh(acac)(CO)2](25.8mg,0.1mmol)和实施例6制备的1,3-二苯基异磷啉(149.2mg,0.5mmol),放入带有磁力搅拌子的单口瓶中,然后加入溶剂甲苯(20mL),室温下搅拌配位20分钟后,密封单口瓶,从手套箱中取出,氮气保护下,用平流泵打入250mL高压釜中,高压釜已提前用氮气和合成气置换三次,保压验漏没有问题后,釜内充满合成气,压力为常压。催化剂溶液加入完毕,用1-丁烯储罐向反应釜充入1-丁烯(56.1g,1.0mol),最后向反应釜内充入合成气,使反应釜内压至3.0MPa。开启高压釜搅拌(400rpm)和伴热,使反应釜的内温达到80℃,保温、保压反应3小时后,取样分析,GC检测,原料1-丁烯的转化率>99.5%,产物正戊醛的选择性93.1%,2-甲基丁醛选择性5.6%,其它为丁烷、正戊醇等副产物。
实施例12:
2-丁烯氢甲酰化合成戊醛混合物
手套箱中,室温下依次称取[Rh(acac)(CO)2](51.6mg,0.2mmol)和实施例7制备的1,3-二对甲苯基异磷啉456.9mg,1.4mmol),放入带有磁力搅拌子的单口瓶中,然后加入溶剂甲苯(20mL),室温下搅拌配位20分钟后,密封单口瓶,从手套箱中取出,氮气保护下,用平流泵打入250mL高压釜中,高压釜已提前用氮气和合成气置换三次,保压验漏没有问题后,釜内充满合成气,压力为常压。催化剂溶液加入完毕,用2-丁烯储罐向反应釜充入2-丁烯(56.1g,1.0mol),最后向反应釜内充入合成气,使反应釜内压至5.0MPa。开启高压釜搅拌(400rpm)和伴热,使反应釜的内温达到120℃,保温、保压反应5小时后,取样分析,GC检测,原料2-丁烯的转化率>99.0%,产物正戊醛的选择性33.0%,2-甲基丁醛选择性55.6%,正戊醇和2-甲基丁醇8.5%。
实施例13:
异丁烯氢甲酰化合成异戊醛
手套箱中,室温下依次称取[Rh(acac)(CO)2](51.6mg,0.2mmol)和实施例8制备的1,3-二-间甲氧苯基异膦啉(358.4mg,1.0mmol),放入带有磁力搅拌子的单口瓶中,然后加入溶剂甲苯(20mL),室温下搅拌配位20分钟后,密封单口瓶,从手套箱中取出,氮气保护下,用平流泵打入250mL高压釜中,高压釜已提前用氮气和合成气置换三次,保压验漏没有问题后,釜内充满合成气,压力为常压。催化剂溶液加入完毕,用异丁烯储罐向反应釜充入异丁烯(56.1g,1.0mol),最后向反应釜内充入合成气,使反应釜内压至4.0MPa。开启高压釜搅拌(400rpm)和伴热,使反应釜的内温达到90℃,保温、保压反应3小时后,取样分析,GC检测,原料异丁烯的转化率>99.5%,产物异戊醛的选择性98.1%,特戊醛选择性0.45%,其它为异丁烷等副产物。
实施例14:
环己烯氢甲酰化合成环己基甲醛
手套箱中,室温下依次称取[Rh(acac)(CO)2](258mg,1mmol)和实施例9制备的1-甲基-3-苯基异磷啉(236.2mg,1mmol),放入带有磁力搅拌子的单口瓶中,然后加入溶剂甲苯(20mL),室温下搅拌配位20分钟后,密封单口瓶,从手套箱中取出,氮气保护下,用平流泵打入250mL高压釜中,高压釜已提前用氮气和合成气置换三次,保压验漏没有问题后,釜内充满合成气,压力为常压。催化剂溶液加入完毕,向反应釜加入环己烯(82.1g,1.0mol),最后向反应釜内充入合成气,使反应釜内压至4.0MPa。开启高压釜搅拌(400rpm)和伴热,使反应釜的内温达到90℃,保温、保压反应4小时后,取样分析,GC检测,原料环己烯的转化率>99.5%,产物环己基甲醛的选择性99.1%,环己基甲醇选择性0.31%,其它为环己烷等副产物。
实施例15:
2,3-二甲基-2-丁烯氢甲酰化合成3,4-二甲基戊醛
手套箱中,室温下依次称取[Rh(acac)(CO)2](129.0mg,0.5mmol)和实施例10制备的1,3-二甲基异磷啉(435.4mg,2.5mmol),放入带有磁力搅拌子的单口瓶中,然后加入溶剂甲苯(20mL),室温下搅拌配位20分钟后,密封单口瓶,从手套箱中取出,氮气保护下,用平流泵打入250mL高压釜中,高压釜已提前用氮气和合成气置换三次,保压验漏没有问题后,釜内充满合成气,压力为常压。催化剂溶液加入完毕,向反应釜加入2,3-二甲基-2-丁烯(84.2g,1.0mol),最后向反应釜内充入合成气,使反应釜内压至6.0MPa。开启高压釜搅拌(400rpm)和伴热,使反应釜的内温达到120℃,保温、保压反应8小时后,取样分析,GC检测,原料2,3-二甲基-2-丁烯的转化率>99.5%,产物3,4-二甲基戊醛的选择性96.1%,3,4-二甲基戊醇选择性3.4%,其它为2,3-二甲基丁烷等副产物。
实施例16:
1-庚烯氢甲酰化合成正辛醛
手套箱中,室温下依次称取[Rh(acac)(CO)2](25.8mg,0.1mmol)和实施例6制备的1,3-二苯基异磷啉(298.3mg,1.0mmol),放入带有磁力搅拌子的单口瓶中,然后加入溶剂甲苯(20mL),室温下搅拌配位20分钟后,密封单口瓶,从手套箱中取出,氮气保护下,用平流泵打入250mL高压釜中,高压釜已提前用氮气和合成气置换三次,保压验漏没有问题后,釜内充满合成气,压力为常压。催化剂溶液加入完毕,向反应釜加入1-庚烯(112.2g,1.0mol),最后向反应釜内充入合成气,使反应釜内压至3.0MPa。开启高压釜搅拌(400rpm)和伴热,使反应釜的内温达到80℃,保温、保压反应3小时后,取样分析,GC检测,原料1-庚烯的转化率>99.5%,产物正辛醛的选择性92.7%,2-甲基庚醛选择性5.8%,其它为庚烷、正辛醇等副产物。
Claims (7)
2.根据权利要求1所述的制备方法,其特征在于,三硅基膦的用量为异色满盐摩尔量的1.5~3.0倍。
3.根据权利要求1所述的制备方法,其特征在于,所述氟盐为四甲基氟化铵,氟盐的用量为三硅基膦摩尔量的2.0~3.0倍。
4.根据权利要求1所述的制备方法,其特征在于,所述膦配体合成反应在极性非质子型溶剂中进行,所述溶剂选自四氢呋喃、乙腈、N,N-二甲基甲酰胺、二氯甲烷、三氯甲烷、二氯乙烷中的一种或多种。
5.根据权利要求4所述的制备方法,其特征在于,所述溶剂为四氢呋喃。
6.根据权利要求1所述的制备方法,其特征在于,所述膦配体制备的反应的温度为70~100℃,反应压力为常压,反应时间2~4小时。
7.根据权利要求1所述的制备方法,其特征在于,氮气氛围中,室温下依次加入异色满盐、三硅基膦和溶剂,升温至70~100℃,快速搅拌下,加入氟盐溶液,保温反应2-4小时。
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