CN111329818A - 一种改良的牙膏 - Google Patents
一种改良的牙膏 Download PDFInfo
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- CN111329818A CN111329818A CN202010085524.0A CN202010085524A CN111329818A CN 111329818 A CN111329818 A CN 111329818A CN 202010085524 A CN202010085524 A CN 202010085524A CN 111329818 A CN111329818 A CN 111329818A
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- extract
- sleep
- toothpaste
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Abstract
一种改良的牙膏,包含2%~18%的活性成分和82%~98%的牙膏基质成分,其特征在于:活性成分包含氨基酸复合物和一种以上的中药提取物;牙膏基质成分至少包含用于增加口腔粘膜对活性物中的吸收量,提高活性物中氨基酸复合物利用度的透皮吸收促进剂;氨基酸复合物包含色氨酸、氨基丁酸;中药提取物包含酸枣仁提取物、柏子仁、缬草、元胡、夜交藤、天麻、茯神、远志、肉桂等提取物。本发明除具有清洁口腔牙齿外,养心安神中药和助眠氨基酸活性成分通过口腔粘膜的吸收,助眠氨基酸可刺激大脑分泌睡眠因子有效的调节人体中枢神经平衡;养心安神中药活性成分可起到养心安神、健脑、镇静助眠的特殊功效,开辟一条既洁齿又可安神调理、恢复健康睡眠的新途径。
Description
技术领域
本发明涉及一种改良的牙膏,具体说是涉及一种具有安神调理、改善睡眠的养心安神中药和氨基酸复合助眠牙膏,属于口腔清洁、保健调理领域。
背景技术
人生大约有三分之一的时间在睡眠中度过,良好的睡眠对于健康至关重要。由于现代生活节奏的加快,工作压力与生活压力的增大,以及不规律的作息习惯等因素影响,失眠的人越来越多。据中国睡眠研究会发布的一项调查显示,我国成年人失眠的发生率高达38%以上,长期失眠不仅影响工作和生活,还会诱发其他疾病,睡眠障碍造成了相当一部分人群处于“亚健康”状态,睡眠障碍往往引起人体免疫力低下、精神烦躁,同时还容易引发高血压、神经衰弱、心脑血管意外以及心理疾患等。睡眠障碍给日常工作和生活带来的威胁也是十分可怕的,据统计,30-50%的意外事故由瞌睡引起。据两位美国学者对7000人为期5年半的研究表明,在影响人类寿命的7种因素中,睡眠是重要的一项。睡眠障碍也会导致大量经济损失,美国睡眠障碍研究所一项调查表明,在美国一年因睡眠障碍造成的经济损失达430至560亿美元。
常用的治疗睡眠障碍药物包括化学合成类和天然药物,化学合成类药物包括巴比妥类、苯二氮卓类及非苯二氮卓类短效药物,这些安眠药疗效确切,但成瘾性和反弹性失眠等不良反应严重。与化学合成类药物相比,天然药物以其药源广泛、副作用和依赖性小等优势日益受到人们关注。我国有着丰富的植物资源,并有中医中药宝贵基础,在此优越条件下进行新产品开发,无疑能为丰富当前改善睡眠类产品做出贡献。排除睡眠障碍、保障睡眠健康成为一大健康课题,“大健康中国”正式升级成为国家战略,鼓励开发大健康保健产品,本发明以养心安神中药和助眠氨基酸为活性成分制成具有助眠功效牙膏,睡前通过刷牙经口腔粘膜吸收,助眠氨基酸作为抑制性神经递质起到抑制脑神经兴奋、调节精神节律、改善睡眠,养心安神中药调理恢复健康睡眠,所以利用中药调理作用改善睡眠,越来越受到睡眠障碍者的青睐。
中药牙膏具有清洁牙齿和辅助口腔保健的功能。随着中药学、药代学、口腔学的发展,中药应用领域不断扩大,也为更多中药应用于口腔清洁护理产品提供了强有力的理论依据和技术支持。近年来,口腔黏膜(舌下黏膜和颊黏膜)给药途径越来越受到重视,如心肌梗塞舌下含硝酸甘油片可起到快速缓解的急救功效,由于口腔黏膜部位血液循环丰富,药物通过口腔黏膜 (颊黏膜与舌下黏膜)吸收直接进入血液循环系统,能避开肝脏首过效应、胃酸及消化酶的破坏,提高了药物的生物利用度。正是由于口腔黏膜具有较好的给药依从性,所以中药牙膏要突破传统口腔保健功能,寻求新的人体保健项目,增加保健途径。
目前市场上的中药牙膏种类很多,但还未见同时利用养心安神中药和氨基酸复合助眠牙膏,对脑、心、血、神四方面综合调理,达到镇静催眠、养心开郁、养血安神、安神定志作用的中药牙膏。因此,开发一种养心安神中药和氨基酸复合助眠牙膏,必定具有广阔的市场前景。
发明内容
本发明的目的旨在提供一种集清洁口腔、安神助眠于一体的改良的牙膏。具体是利用具助眠功效的色氨酸、氨基丁酸抑制脑神经兴奋、调节精神节律、改善睡眠,养心安神中药酸枣仁、柏子仁、缬草、元胡、夜交藤、天麻、茯神、远志八种中药提取物的不同安神助眠机理以及相互协同增效作用,通过对人体脑、心、血、神四方面综合调理,达到镇静助眠,养心开郁、养血安神、安神定志作用。
为了解决上述问题,本发明的目的是这样实现的。
按此目的设计的一种改良的牙膏,包含2%~18%的活性成分和82%~ 98%的牙膏基质成分,活性成分包含用于助眠氨基酸复合物和一种以上具有养心安神的中药提取物;牙膏基质成分至少包含用于增加口腔粘膜对活性物中的吸收量,提高活性物生物利用度的透皮吸收促进剂。
氨基酸复合物包含色氨酸、氨基丁酸;中药提取物包含酸枣仁提取物、柏子仁提取物、缬草提取物、元胡提取物、夜交藤提取物、天麻提取物、茯神提取物、远志提取物、肉桂提取物。
活性成分按重量百分比计包含:0.01~2%色氨酸、0.3~3%氨基丁酸、 0.3~3%酸枣仁提取物、0.3~3%的柏子仁提取物、0.05~3%缬草提取物、 0.05~2%元胡提取物、0.05~2%夜交藤提取物、0.05~2%天麻提取物、0.05~2%茯神提取物、0.05~2%远志提取物、0.001~0.1%肉桂提取物。
色氨酸至少为L-色氨酸,添加量为0.02~1.5%;L-色氨酸别名为L-2- 氨基-3-吲哚基丙酸;
氨基丁酸至少为γ-氨基丁酸,添加量为0.5~2.5%;γ-氨基丁酸别名为4-氨基丁酸(简称GABA)。GABA(γ-氨基丁酸)是中枢神经系统中重要的神经传导物质,主要存在于脑和脊髓中,并在人体大脑皮质、海马、丘脑、基底神经节和小脑中起重要作用,并对机体的多种功能具有调节作用。人体约有50%的中枢突触是以GABA为递质的。
本发明除具有清洁口腔牙齿外,养心安神中药和助眠氨基酸活性成分通过口腔粘膜的吸收,助眠氨基酸可刺激大脑分泌睡眠因子有效的调节人体中枢神经平衡;养心安神中药活性成分可起到养心安神、健脑、镇静助眠的特殊功效,开辟一条既洁齿又可安神调理、恢复健康睡眠的新途径。
酸枣仁为鼠李科植物酸枣的种子提取的活性成分,主要为脂肪油和蛋白质,并有两种甾醇,添加量为0.5~2.5%;
柏子仁为柏科植物侧柏的干燥成熟种仁提取的活性成分,主要为脂肪油及少量挥发油,并含皂甙,添加量为0.5~2.5%;
缬草提取物为败酱科缬草属植物缬草的干燥根及根茎里提取的活性成分,主要为缬草酸,添加量为0.08~2.5%;
元胡为罂粟科紫堇属多年生草本植物的扁球状块茎提取的活性成分并含有多种生物碱,添加量为0.08~1.8%;元胡又名为延胡索、玄胡;
夜交藤为蓼科植物何首乌的藤茎或带叶的藤茎提取的活性成分,主要为蒽醌类,添加量为0.08~1.8%;
天麻为兰科植物天麻的干燥块茎提取的活性成分,主要含天麻苷、天麻苷元,添加量为0.08~1.8%;
茯神为多孔菌科卧孔属植物茯苓的菌核中夹有松根的白色部分提取的活性成分,主要为多糖类,茯苓酸,添加量为0.08~1.8%;
远志为远志科远志属植物提取的活性成分,主要含植物皂甙,添加量为 0.08~1.8%;
肉桂为樟目樟科植物肉桂树皮提取的活性成分,主要成分为肉桂醛,本发明主要利用肉桂抗菌防口臭功效,添加量为提取物0.002~0.08%。
透皮吸收促进剂为氮酮、薄荷醇、丙二醇中的一种或两种。
牙膏基质成分还包含磨擦剂、保湿剂、增稠剂、表面活性剂、甜味剂、防腐剂、香精、纯化水。
牙膏基质成分按重量百分比计包含:10~45%磨擦剂、10~30%保湿剂、 0.8~3%增稠剂、0.5~3%透皮吸收促进剂、1.5~3%的表面活性剂、0.3~3%的甜味剂、0.1~0.8%的防腐剂、0.8~2%的香精、纯化水添加至100%。
保湿剂为山梨醇、甘油、聚乙二醇中的一种或多种混合物;
磨擦剂为碳酸钙、磷酸氢钙、二氧化硅中的一种或两种混合物;
增稠剂为羧甲基纤维素钠、黄原胶、瓜尔胶、卡拉胶中的一种或多种混合物;
表面活性剂为月桂醇硫酸钠、月桂酰肌氨酸钠、月桂酰谷氨酸钠、中的一种或多种混合物;
甜味剂为糖精钠、白糖、安赛蜜中的一种或两种;
防腐剂为苯甲酸钠、羟苯乙酯、羟苯丙酯、山梨醇钾中的一种或多种;
牙膏中还包含添加剂,添加剂为焦磷酸钠、氟化物、钛白粉中的一种或两种以上。
本发明的有益效果如下:
a、本发明利用具助眠功效的色氨酸、氨基丁酸抑制脑神经兴奋、调节精神节律、改善睡眠,养心安神中药酸枣仁、柏子仁、缬草、元胡、夜交藤、天麻、茯神、远志八种中药提取物的不同安神助眠机理以及相互协同增效作用,既发挥了单味中药的活性,又使八味中药相辅相成,协同增效。同时添加透皮吸收促进剂,增加了口腔粘膜对活性成分的吸收量,提高了活性物的生物利用度。
b、本发明具体是利用具助眠功效的色氨酸、氨基丁酸抑制脑神经兴奋、调节精神节律、改善睡眠;通过酸枣仁、柏子仁的养心安神作用,缓解心烦不眠所致的失眠;通过缬草、元胡、远志对大脑皮层的抑制作用,降低反射兴奋性来达到镇静催眠作用;通过夜交藤、养血安神作用,缓解阴虚血少所致的失眠;通过天麻、茯神的理气解郁、和血、宁心作用,缓解心神不安、忧郁所致的失眠。八种中药共同调理,达到镇静催眠,养心开郁、养血安神、安神定志的作用。
c、本发明的改良的牙膏,所添加的养心安神中药和助眠氨基酸活性成分可以通过刷牙过程吸收和刷牙后在口腔中的残留吸收,直接通过口腔粘膜和舌下静脉进入血液循环系统,避免肝脏的首过效应、胃肠道酶和酸的降解作用,提高了活性物的吸收利用度,更好更快地发挥安神助眠保健作用。
d、本发明的改良的牙膏,增加了睡眠障碍者的保健途径,不再局限于药品治疗或其他口服保健,在睡前口腔清洁护理的同时就能得到调理,缓解睡眠障碍,保障睡眠健康,避免口服安眠药带来的毒副作用,为睡眠障碍患者提供安全、方便的大健康保健产品。
以下为本发明涉及到的几种中药养心安神和助眠氨基酸作用机理的简要表述:
L-色氨酸,是人体重要的神经递质-5-羟色胺的前体,是人体的必需氨基酸之一;可作为安神药,调节精神紧张节律、改善睡眠。
γ-氨基丁酸(简称GABA),GABA作为一种抑制性神经递质起到分子信号的作用,具有多种生理功能,在提神安宁以及提高睡眠质量和记忆力等生理层面也有比较突出的表现,包括对神经细胞以及脑细胞等,抑制脑神经兴奋、调节精神节律、改善睡眠。
酸枣仁:现代药理实验证明酸枣仁煎剂给大白鼠口服或腹腔注射均表现镇静及催眠作用,广泛用于养肝,宁心,安神,治虚烦不眠,惊悸怔忡。
柏子仁具有养心安神等功效,用于血不养心的惊悸怔忡、虚烦不眠,思虑过度等症。
缬草又名睡草,是自然对人类的怜悯恩赐,更是从古到今东西方极为常用的珍贵草药。许多经典的医药文献中对缬草均有记载。如《本草纲目》上记载缬草的功效为:“安神,理气,止痛”。早在十六世纪,欧洲民间就会用缬草煎茶喝来帮助入眠、延年益寿。现代药理实验证明缬草有镇静作用,能加强大脑皮层的抑制过程,减低反射兴奋性,能安心神,主心神不安,心悸失眠,故有镇静、催眠、解痉、镇痛作用。
元胡为又名延胡索,动物实验证明,延胡索乙素有显著的镇痛、镇静作用。
夜交藤具有安神养血作用,用于阴虚血少所致的失眠、多梦,虚烦不眠等睡眠障碍症。
天麻水、醇提取物及不同制剂,均能使小鼠自发性活动明显减少,且能延长巴比妥钠、环己烯巴比妥钠引起的小鼠睡眠时间,
茯神,用于宁心,安神,治心虚惊悸,健忘,失眠。
远志,用于安神益智,解郁,治神经衰弱,健忘心悸,多梦失眠
具体实施方式
第一实施例
一种改良的牙膏,按重量百分比计,包含以下原料组分:
L-色氨酸0.1%,γ-氨基丁酸0.5%,酸枣仁提取物0.5%,柏子仁提取物 0.5%,缬草提取物0.5%,元胡提取物0.3%,夜交藤提取物0.3%,天麻提取物0.3%,茯神提取物0.3%,远志提取物0.2%,肉桂提取物0.002%,糖精钠 0.3%,白糖2%,月桂醇硫酸钠2%,山梨醇5%,羧甲基纤维素钠0.5%,黄原胶0.5%,碳酸钙30%,磷酸氢钙5%,焦磷酸钠0.2%,羟苯乙酯0.05%,山梨醇钾0.2%,氮酮1%,薄荷醇0.5%,薰衣草精油0.02%,留兰香精0.2%,纯化水加至100%。
制作工艺如下:
1)将羟苯乙酯、薄荷醇、薰衣草精油、氮酮、留兰香精、肉桂提取物称量后加入容器A中搅拌溶解,备用;
2)将纯化水、山梨醇加入预混锅中,再加入酸枣仁提取物,柏子仁提取物,缬草提取物,元胡提取物,夜交藤提取物,天麻提取物,茯神提取物,远志提取物加热搅拌溶解,并加热至100℃保温灭菌10分钟,冷却至80℃然后加入色氨酸,氨基丁酸,糖精钠、白糖,焦磷酸钠,山梨醇钾并搅拌溶解,备用;
3)将碳酸钙、磷酸氢钙、羧甲基纤维素钠、黄原胶、月桂醇硫酸钠加入混粉器混合均匀,备用;
4)将预混锅中的液料在真空状态下吸入制膏机,然后开动刮板和搅拌,吸入混粉器中的粉料,粉料进完后打开均质,均质脱气25~30分钟;
5)真空脱气25~30分钟后,吸入容器A中的原料,再均质脱气10分钟,检验合格后方可出膏。
第二实施例
一种改良的牙膏,按重量百分比计,包含以下原料组分:
L-色氨酸0.2%,γ-氨基丁酸0.8%,酸枣仁提取物0.8%,柏子仁提取物 1%,缬草提取物1%,元胡提取物0.5%,夜交藤提取物0.5%,天麻提取物0.5%,茯神提取物0.5%,远志提取物0.3%,肉桂提取物0.002%,糖精钠0.3%,安赛蜜0.2%,月桂醇硫酸钠2%,山梨醇5%,羧甲基纤维素钠0.5%,瓜尔胶0.5%,碳酸钙30%,二氧化硅5%,氟化钠0.2%,羟苯乙酯0.05%,苯钾酸钠0.2%,氮酮1.5%,薄荷醇0.5%,丙二醇5%,薰衣草精油0.02%,薄荷香精0.2%,纯化水加至100%。
制作工艺如下:
1)将羟苯乙酯、薄荷醇、薰衣草精油、氮酮、薄荷香精、肉桂提取物称量后加入容器A中搅拌溶解,备用;
2)将纯化水、山梨醇、丙二醇加入预混锅中,加入酸枣仁提取物,柏子仁提取物,缬草提取物,元胡提取物,夜交藤提取物,天麻提取物,茯神提取物,远志提取物加热搅拌溶解,并加热至100℃保温灭菌10分钟,冷却至 80℃然后加入色氨酸,氨基丁酸,糖精钠,安赛蜜,氟化钠,苯钾酸钠并搅拌溶解,备用;
3)将将碳酸钙、二氧化硅、羧甲基纤维素钠、瓜尔胶、月桂醇硫酸钠加入混粉器混合均匀,备用;
4)将预混锅中的液料在真空状态下吸入制膏机,然后开动刮板和搅拌,吸入混粉器中的粉料,粉料进完后打开均质,均质脱气25~30分钟;
5)真空脱气25~30分钟后,吸入容器A中的原料,再均质脱气10分钟,检验合格后方可出膏。
第三实施例
一种改良的牙膏,按重量百分比计,包含以下原料组分:
L-色氨酸0.3%,γ-氨基丁酸1%,酸枣仁提取物1%,柏子仁提取物1%,缬草提取物1.5%,元胡提取物1%,夜交藤提取物0.8%,天麻提取物0.8%,茯神提取物0.8%,远志提取物0.3%,肉桂提取物0.002%,糖精钠0.3%,安赛蜜0.2%,月桂醇硫酸钠1%,月桂酰谷氨酸钠1%、山梨醇5%,甘油3%,羧甲基纤维素钠1.5%,碳酸钙25%,二氧化硅15%,氟化钠0.2%,羟苯丙酯0.05%,苯钾酸钠0.2%,氮酮2%,薄荷醇0.5%,丙二醇5%,薰衣草精油0.03%,留兰香精0.2%,纯化水加至100%。
制作工艺如下:
1)将羟苯乙酯、薄荷醇、薰衣草精油、氮酮、留兰香精、肉桂提取物称量后加入容器A中搅拌溶解,备用;
2)将纯化水、山梨醇、甘油、丙二醇加入预混锅中1中,加入酸枣仁提取物,柏子仁提取物,缬草提取物,元胡提取物,夜交藤提取物,天麻提取物,茯神提取物,远志提取物加热搅拌溶解,并加热至100℃保温灭菌10分钟,冷却至80℃然后加入色氨酸,氨基丁酸,糖精钠,安赛蜜,月桂酰谷氨酸钠,氟化钠,苯钾酸钠并搅拌溶解,备用;
3)将将碳酸钙、二氧化硅、羧甲基纤维素钠、月桂醇硫酸钠加入混粉器混合均匀,备用;
4)将预混锅中的液料在真空状态下吸入制膏机,然后开动刮板和搅拌,吸入混粉器中的粉料,粉料进完后打开均质,均质脱气25~30分钟;
5)真空脱气25~30分钟后,吸入容器A中的原料,再均质脱气10分钟,检验合格后方可出膏。
第四实施例
一种改良的牙膏,按重量百分比计,包含以下原料组分:
L-色氨酸0.25%,γ-氨基丁酸0.8%,酸枣仁提取物1.5%,柏子仁提取物1.5%,缬草提取物1.5%,元胡提取物1%,夜交藤提取物1%,天麻提取物 0.8%,茯神提取物0.8%,远志提取物0.5%,肉桂提取物0.002%,糖精钠0.3%,安赛蜜0.25%,月桂醇硫酸钠1%,月桂酰肌氨酸钠0.5%、山梨醇5%,聚乙二醇3%,羧甲基纤维素钠1%,黄原胶0.5%,碳酸钙20%,二氧化硅18%,钛白粉0.2%,羟苯乙酯0.05%,苯钾酸钠0.2%,氮酮1.5%,薄荷醇0.5%,丙二醇5%,薰衣草精油0.01%,留兰香精0.5%,纯化水加至100%。
制作工艺如下:
1)将羟苯乙酯、薄荷醇、薰衣草精油、氮酮、留兰香精、肉桂提取物称量后加入容器A中搅拌溶解,备用;
2)将纯化水、山梨醇、聚乙二醇、丙二醇加入预混锅中1中,加入酸枣仁提取物,柏子仁提取物,缬草提取物,元胡提取物,夜交藤提取物,天麻提取物,茯神提取物,远志提取物加热搅拌溶解,并加热至100℃保温灭菌 10分钟,冷却至80℃然后加入色氨酸,氨基丁酸,糖精钠,安赛蜜,月桂酰肌氨酸钠、苯钾酸钠并搅拌溶解,备用;
3)将将碳酸钙、二氧化硅、羧甲基纤维素钠、黄原胶、月桂醇硫酸钠、钛白粉加入混粉器混合均匀,备用;
4)将预混锅1中的液料在真空状态下吸入制膏机,然后开动刮板和搅拌,吸入混粉器中的粉料,粉料进完后打开均质,均质脱气25~30分钟;
5)真空脱气25~30分钟后,吸入容器A中的原料,再均质脱气10分钟,检验合格后方可出膏。
为检测本发明的活性成分能否通过口腔粘膜吸收与临床试验效果,进行以下试验:
1.透皮吸收试验
以第三实施例样品,并与没有加入氮酮、薄荷醇和丙二醇透皮吸收促进剂的对照样品进行比较。
采用体外透皮吸收试验法,以猪腹部皮作离体动物供试皮肤,用0.9%的生理盐水作为渗透接收液,采用高效液相色谱法(HPLC),检测接收液中的γ-氨基丁酸含量,计算其透皮渗透量(mg/cm2),结果如下表2所示。
表一γ-氨基丁酸的透皮吸收试验结果
时间 | 30min | 1h | 2h | 4h | 6h | 8h |
第三实施例 | 1.0365 | 2.1341 | 3.1431 | 4.4135 | 5.3141 | 6.4135 |
对照品 | 0.7143 | 1.4151 | 2.1131 | 3.1341 | 3.7311 | 4.3134 |
由表一的试验结果可见,第三实施例的30min(分钟)至8h(小时)透皮渗透量优于对照品,表明通过添加透皮吸收促进剂,能够促进γ-氨基丁酸的透皮吸收。
2.效果试验例
一种改良的牙膏效果试验(以第四实施例为例):利用匹兹堡睡眠质量指数PSQI值进行测试。
匹兹堡睡眠质量指数使用和统计方法:PSQI值用于评定被试者最近一个月的睡眠质量(分第1天、第15天、第30天三次评分综合而成),被试者完成试问需要5~10分钟。它由19个自评条目(组成9个自评问题)和5 个他评条目组成,计分时只计自评问题的得分。19个条目组成7个因子,每个按0~3等级计分,“0”指没有困难,“1”指轻度困难,“2”指中度困难,“3”指重度困难。累积各因子成份得分为PSQI总分,总分范围在0~ 2l,得分越高,表示睡眠质量越差。“0”分指没有困难,“21”分指在所有方面都非常困难。各个因子:主观睡眠质量;睡眠潜伏期;睡眠持续性;习惯性睡眠效率;睡眠紊乱;使用睡眠药物;白天功能紊乱。自评条目中各选项计分为:①计0分,②计1分,③计2分,④计3分。PSQI≥8为睡眠质量差,以总分=7为分界值,用该量表判断病人与正常人的灵敏度为98.3%。
测试对象:选取80名睡眠障碍者纳入测试对象,其中40名男性,40 名女性,年龄在30~65岁。
测试统计方法:第1天在未使用本发明的养心安神中药和氨基酸复合助眠牙膏时,对80名测试对象按匹兹堡睡眠质量表进行问卷测试,汇总出男、女平均PSQI值,然后使用第四实施例的牙膏刷牙,分别在第15天和第30 天进行测试。
测试者使用统一的牙刷及上述指定的牙膏,要求晚上睡觉前半小时内刷牙1次,每次不少于3分钟,使用膏体约为1.5cm~2cm,整个实验期间晚上禁止摄取咖啡、茶等含有咖啡因的饮品或食物。
PSQI值统计如下表二所示。
第1天 | 第15天 | 第30天 | |
PSQI值(男平均值) | 13.1 | 6.2 | 4.1 |
PSQI值(女平均值) | 14.3 | 6.5 | 4.3 |
PSQI值(总平均值) | 13.7 | 6.35 | 4.2 |
以表二的实验结果表明,在连续使用本发明的益晚安神中药牙膏1个月后,PSQI值明显下降,说明本发明具有缩短入睡时间、延长睡眠时间,降低睡眠障,有效地改善睡眠质量,达到养心安神的效果。
上述为本发明的优选方案,显示和描述了本发明的基本原理、主要特征和本发明的优点。本领域的技术人员应该了解本发明不受上述实施例的限制,上述实施例和说明书中描述的只是说明本发明的原理,在不脱离本发明精神和范围的前提下本发明还会有各种变化和改进,这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等同物界定。
Claims (10)
1.一种改良的牙膏,包含2%~18%的活性成分和82%~98%的牙膏基质成分,其特征在于:活性成分包含用于助眠氨基酸复合物和一种以上具有养心安神的中药提取物;牙膏基质成分至少包含用于增加口腔粘膜对活性物中的吸收量,提高活性物中氨基酸复合物利用度的透皮吸收促进剂。
2.根据权利要求1所述改良的牙膏,其特征在于:氨基酸复合物包含色氨酸、氨基丁酸;中药提取物包含酸枣仁提取物、柏子仁提取物、缬草提取物、元胡提取物、夜交藤提取物、天麻提取物、茯神提取物、远志提取物、肉桂提取物。
3.根据权利要求1所述改良的牙膏,其特征在于:所述活性成分按重量百分比计包含:0.01~2%色氨酸、0.3~3%氨基丁酸、0.3~3%酸枣仁提取物、0.3~3%的柏子仁提取物、0.05~3%缬草提取物、0.05~2%元胡提取物、0.05~2%夜交藤提取物、0.05~2%天麻提取物、0.05~2%茯神提取物、0.05~2%远志提取物、0.001~0.1%肉桂提取物。
4.根据权利要求2或3所述改良的牙膏,其特征在于:色氨酸至少为L-色氨酸,添加量为0.02~1.5%;
氨基丁酸至少为γ-氨基丁酸,添加量为0.5~2.5%。
5.根据权利要求2或3所述改良的牙膏,其特征在于:酸枣仁为鼠李科植物酸枣的种子提取的活性成分,添加量为0.5~2.5%;
柏子仁为柏科植物侧柏的干燥成熟种仁提取的活性成分,添加量为0.5~2.5%;
缬草提取物为败酱科缬草属植物缬草的干燥根及根茎里提取的活性成分,添加量为0.08~2.5%;
元胡为罂粟科紫堇属多年生草本植物的扁球状块茎提取的活性成分,添加量为0.08~1.8%;
夜交藤为蓼科植物何首乌的藤茎或带叶的藤茎提取的活性成分,添加量为0.08~1.8%;
天麻为兰科植物天麻的干燥块茎提取的活性成分,添加量为0.08~1.8%;
茯神为多孔菌科卧孔属植物茯苓的菌核中夹有松根的白色部分提取的活性成分,添加量为0.08~1.8%;
远志为远志科远志属植物提取的活性成分,添加量为0.08~1.8%;
肉桂为樟目樟科植物肉桂树皮提取的活性成分,添加量为提取物0.002~0.08%。
6.根据权利要求1所述改良的牙膏,其特征在于:透皮吸收促进剂为氮酮、薄荷醇、丙二醇中的一种或两种。
7.根据权利要求1所述改良的牙膏,牙膏基质成分还包含磨擦剂、保湿剂、增稠剂、表面活性剂、甜味剂、防腐剂、香精、纯化水。
8.根据权利要求1或7所述改良的牙膏,牙膏基质成分按重量百分比计包含:10~45%磨擦剂、10~30%保湿剂、0.8~3%增稠剂、0.5~3%透皮吸收促进剂、1.5~3%的表面活性剂、0.3~3%的甜味剂、0.1~0.8%的防腐剂、0.8~2%的香精、纯化水添加至100%。
9.根据权利要求8所述改良的牙膏,其特征在于:保湿剂为山梨醇、甘油、聚乙二醇中的一种或多种混合物;
磨擦剂为碳酸钙、磷酸氢钙、二氧化硅中的一种或两种混合物;
增稠剂为羧甲基纤维素钠、黄原胶、瓜尔胶、卡拉胶中的一种或多种混合物;
表面活性剂为月桂醇硫酸钠、月桂酰肌氨酸钠、月桂酰谷氨酸钠、中的一种或多种混合物;
甜味剂为糖精钠、白糖、安赛蜜中的一种或两种;
防腐剂为苯甲酸钠、羟苯乙酯、羟苯丙酯、山梨醇钾中的一种或多种。
10.根据权利要求1所述改良的牙膏,其特征在于:牙膏中还包含添加剂,添加剂为焦磷酸钠、氟化物、钛白粉中的一种或两种以上。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102727408A (zh) * | 2012-06-14 | 2012-10-17 | 董家华 | 一种生物环保抗病毒防感冒牙膏及其制备方法 |
CN103784611A (zh) * | 2014-01-23 | 2014-05-14 | 云南白药天颐茶品有限公司 | 一种具有改善睡眠帮助缓解压力的组合物及其应用 |
CN105168059A (zh) * | 2015-09-24 | 2015-12-23 | 名臣健康用品股份有限公司 | 一种益晚安神中药牙膏 |
CN109010587A (zh) * | 2018-08-23 | 2018-12-18 | 广西宾阳县紫香缘香业有限公司 | 中药安神养生熏香及其制备方法 |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102727408A (zh) * | 2012-06-14 | 2012-10-17 | 董家华 | 一种生物环保抗病毒防感冒牙膏及其制备方法 |
CN103784611A (zh) * | 2014-01-23 | 2014-05-14 | 云南白药天颐茶品有限公司 | 一种具有改善睡眠帮助缓解压力的组合物及其应用 |
CN105168059A (zh) * | 2015-09-24 | 2015-12-23 | 名臣健康用品股份有限公司 | 一种益晚安神中药牙膏 |
CN109010587A (zh) * | 2018-08-23 | 2018-12-18 | 广西宾阳县紫香缘香业有限公司 | 中药安神养生熏香及其制备方法 |
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