CN111315370A - 一种具有抗炎症性肠病作用的药物及其制备方法和应用 - Google Patents

一种具有抗炎症性肠病作用的药物及其制备方法和应用 Download PDF

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CN111315370A
CN111315370A CN201880070394.4A CN201880070394A CN111315370A CN 111315370 A CN111315370 A CN 111315370A CN 201880070394 A CN201880070394 A CN 201880070394A CN 111315370 A CN111315370 A CN 111315370A
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inflammatory bowel
formula
bowel disease
compound
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CN111315370B (zh
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邓世平
曹宇
李志�
俞云会
张奎
张敏洁
袁高纲
徐涛
鱼刚
江传亮
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Suzhou Pharmavan Cancer Research Center Co ltd
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    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12Acetic acid esters
    • C07C69/14Acetic acid esters of monohydroxylic compounds
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    • C07C69/157Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
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    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/255Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract

本申请提供了一种具有抗炎症性肠病作用的药物及其制备方法和应用,所述药物具有如式I或式II所示的结构,本申请所提供的药物及其药学上可接受的盐、溶剂合物、前药、互变异构体、立体化学异构体或药物组合物均对于炎症性肠病有良好的作用效果,可用于制备炎症性肠病的治疗药物,具有重要的临床意义和广泛的应用前景。

Description

PCT国内申请,说明书已公开。

Claims (15)

  1. PCT国内申请,权利要求书已公开。
CN201880070394.4A 2018-07-28 2018-07-28 一种具有抗炎症性肠病作用的药物及其制备方法和应用 Active CN111315370B (zh)

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PCT/CN2018/097685 WO2020024078A1 (zh) 2018-07-28 2018-07-28 一种具有抗炎症性肠病作用的药物及其制备方法和应用

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CN111315370A true CN111315370A (zh) 2020-06-19
CN111315370B CN111315370B (zh) 2023-09-29

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US (1) US11602514B2 (zh)
EP (1) EP3756660A4 (zh)
JP (2) JP7332167B2 (zh)
CN (1) CN111315370B (zh)
WO (1) WO2020024078A1 (zh)

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CN115505021B (zh) * 2021-06-23 2023-08-15 沈阳药科大学 具有炎症性肠病治疗作用的乌苏酸衍生物及其制备方法和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1646473A (zh) * 2002-04-17 2005-07-27 北卡罗来纳查佩尔山大学 新的姜黄素类似物和其用途
CN105198714A (zh) * 2015-08-14 2015-12-30 浙江省中医药研究院 杨梅醇衍生物及其制备方法和应用

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Publication number Priority date Publication date Assignee Title
WO2009078444A1 (ja) * 2007-12-18 2009-06-25 Meiji Seika Kaisha, Ltd. 炎症性腸疾患の予防または治療剤
WO2012012798A2 (en) 2010-07-23 2012-01-26 University Of South Florida Materials and methods for reduction of protein tau and treatment of neurodegenerative diseases
CN102552243A (zh) 2012-02-29 2012-07-11 浙江省中医药研究院 杨梅醇和/或杨梅酮在制备抗肿瘤药物中的应用
CN108434127B (zh) * 2018-06-14 2020-01-17 苏州沪云肿瘤研究中心股份有限公司 一种杨梅醇和/或杨梅酮在制备具有预防和/或治疗炎症性肠病的药物中的应用

Patent Citations (2)

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CN1646473A (zh) * 2002-04-17 2005-07-27 北卡罗来纳查佩尔山大学 新的姜黄素类似物和其用途
CN105198714A (zh) * 2015-08-14 2015-12-30 浙江省中医药研究院 杨梅醇衍生物及其制备方法和应用

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DECNE. KO, HA NA 等: "Anti-Inflammatory Constituents from the Branches of Pourthiaea villosa (Thunb.)", 《BULLETIN OF THE KOREAN CHEMICAL SOCIETY》 *
IBRAHIM, SABRIN R. M. 等: "Alnuheptanoid B: a new cyclic diarylheptanoid from Alnus japonica stem bark.", 《RECORDS OF NATURAL PRODUCTS》 *
WHITING, DONALD A等: "Cyclization of 1, 7-diarylheptanoids through oxidative, reductive, and photochemical radical processes: total synthesis of the m, m-bridged biaryls myricanone and (±)-myricanol, and a related diaryl ether.", 《TETRAHEDRON LETTERS》 *
WHITING, DONALD A等: "Total syntheses of the meta, meta-bridged biphenyls (±)-myricanol and myricanone, and of an isomeric biphenyl ether, a 14-oxa[7, l]metaparacyclophane.", 《JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY (1972-1999)》 *
YOSHIMURA, MORIO等: "Diarylheptanoid sulfates and related compounds from Myrica rubra bark.", 《JOURNAL OF NATURAL PRODUCTS》 *

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EP3756660A4 (en) 2021-10-13
EP3756660A1 (en) 2020-12-30
CN111315370B (zh) 2023-09-29
US11602514B2 (en) 2023-03-14
JP2022089845A (ja) 2022-06-16
JP7332167B2 (ja) 2023-08-23
WO2020024078A1 (zh) 2020-02-06
JP2021501171A (ja) 2021-01-14
US20210015780A1 (en) 2021-01-21

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