CN111281909A

CN111281909A - Hair growth composition and method for producing the same

Info

Publication number: CN111281909A
Application number: CN202010277313.7A
Authority: CN
Inventors: 曾钦台; 曾祥辉
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-04-10
Filing date: 2020-04-10
Publication date: 2020-06-16

Abstract

The invention discloses a hair growth composition and a preparation method thereof, belonging to the technical field of traditional Chinese medicine compositions, and the hair growth composition comprises the following active substances in parts by weight: 12-15 parts of fructus forsythiae, 12-15 parts of wrinkled gianthyssop herb, 10-15 parts of Chinese honeylocust fruit, 12-15 parts of garden balsam stem, 12-15 parts of polygala root, 12-15 parts of platycladus orientalis and 12-15 parts of rosemary. The hair growth composition is a pure traditional Chinese medicine preparation, has small irritation to scalp, is simple in composition components, does not need solvent extraction, can reduce the generation of allergy, is suitable for long-term use, and can effectively promote the regeneration of hair. The preparation method of the hair-growing composition provided by the invention is simple and easy for industrial production, and the obtained product is in spray package, is fresh and cool, is not greasy, does not need to be cleaned twice, and is more convenient to use.

Description

Hair growth composition and method for producing the same

Technical Field

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a composition for hair growth and a preparation method thereof.

Background

Alopecia is no longer a trouble of the elderly alone, and with the progress of society and the increase of social pressure, more and more young people enter the alopecia line. There are data indicating that about 2 million people in china have trouble with hair loss. The hair of the balder is pathologically shed, the hair is sparse or the baldness plaque is formed, and the hair can be seriously shed all the hair of the head. At present, the cause of the disease is not clear, and the cause of the disease is complex. Androgenetic alopecia, seborrheic alopecia, chemical alopecia, hereditary alopecia, nutritional alopecia, and the like are known at present. However, it is obvious that the phenomenon of alopecia is more and more serious and common due to the accelerated pace of life and the mental stress from all aspects of people as society develops. The common treatment in Western medicine is finasteride (Baofanti) oral administration or minoxidil (tendril) external application. However, the two western medicines have slow effect, long use period, easy rebound and obvious side effect, and the relapse phenomenon still occurs even after the western medicines are stopped or used for a long time. The traditional Chinese medicine therapy is also commonly used in China, the traditional Chinese medicine means or traditional Chinese medicines are used for treating alopecia, but no unified theory or therapy exists, some traditional Chinese medicines have irritation or bad smell and poor use feeling, part of products adopt traditional Chinese medicine extraction components and need to be extracted by organic solvents, toxic and harmful solvent residues easily exist, even the skin allergy phenomenon caused by overhigh concentration can occur, and part of important preparations have complex formula and are not targeted to alopecia treatment and hair growth, so the problem of poor effect is caused.

Disclosure of Invention

In order to overcome the defects of the prior art, the technical problems to be solved by the invention are as follows: provides a Chinese medicinal composition special for hair growth.

In order to solve the technical problems, the invention adopts the technical scheme that: a composition for hair growth comprises the following active substances in parts by weight: 12-15 parts of fructus forsythiae, 12-15 parts of wrinkled gianthyssop herb, 10-15 parts of Chinese honeylocust fruit, 12-15 parts of garden balsam stem, 12-15 parts of polygala root, 12-15 parts of platycladus orientalis and 12-15 parts of rosemary.

The other technical scheme adopted by the invention is as follows: a method for preparing a composition for promoting hair growth comprises the following steps:

step 1, weighing fructus forsythiae, wrinkled gianthyssop herb, Chinese honeylocust fruit, garden balsam stem, polygala root, arborvitae and rosemary, soaking, fishing out, adding water, decocting and filtering to obtain medicinal liquid;

step 2, adding 9% of acetic acid, salicylic acid, sodium deoxyacetate and a dispersing agent into the medicine juice obtained in the step 1 and stirring;

wherein, calculated by weight portion, 12 to 15 portions of forsythia, 12 to 15 portions of ageratum, 10 to 15 portions of saponin, 12 to 15 portions of garden balsam stem, 12 to 15 portions of polygala root, 12 to 15 portions of arborvitae and 12 to 15 portions of rosemary;

according to the weight percentage, the medicine juice is 84 percent, 9 percent of acetic acid is 15 percent, salicylic acid is 0.4 percent, sodium deoxyacetate is 0.3 percent, and dispersant is 0.3 percent.

The invention has the beneficial effects that: according to the hair growth composition provided by the application, a pure traditional Chinese medicine preparation is used as an active ingredient, the hair growth composition has small irritation to scalp, has no medicine residue, and is suitable for long-term use; rosemary is adopted for soothing the nerves and reducing dryness; the polygala root, the garden balsam stem and the wrinkled gianthyssop herb can not achieve the effect of promoting the hair growth basically when being used alone, but the polygala root, the garden balsam stem and the wrinkled gianthyssop herb can play a role in improving the drug effect, expelling wind heat, healing wound and the like after being matched with the components, and can obviously enhance the effect of promoting the hair growth of the composition; the composition has simple components, no need of solvent extraction, reduced allergy, and remarkable hair growth promoting effect. According to the preparation method of the hair growth composition, acetic acid, salicylic acid, sodium deoxyacetate, a dispersing agent and the medicine juice are matched, the scalp grease removing, sterilizing and bacteriostasis effects of the composition can be improved, the method is simple and convenient, the method is suitable for industrial production, the obtained hair growth composition is used for preparing the spray type hair growth agent, the hair growth promoting effect can be effectively achieved, the use is convenient, the skin feeling is fresh, and secondary cleaning is not needed.

Detailed Description

In order to explain the technical content, the objects and the effects of the present invention in detail, the following description will be given with reference to the embodiments.

The most key concept of the invention is as follows: through years of research and practice, the inventor finds that the main reason of alopecia is head dryness heat caused by yang hyperactivity, and hair follicle necrosis is caused by a large amount of grease and toxin generated by the dryness heat, so that the alopecia becomes inevitable. The invention selects forsythia, Chinese honeylocust fruit, arborvitae and rosemary as components for detoxifying, sterilizing and removing grease, and combines with polygala tenuifolia, garden balsam stem and agastache as components for growing hair, thereby achieving the synergistic effect of growing hair.

The invention provides a hair growth composition, which comprises the following active substances in parts by weight: 12-15 parts of fructus forsythiae, 12-15 parts of wrinkled gianthyssop herb, 10-15 parts of Chinese honeylocust fruit, 12-15 parts of garden balsam stem, 12-15 parts of polygala root, 12-15 parts of platycladus orientalis and 12-15 parts of rosemary.

From the above description, the beneficial effects of the present invention are: according to the hair growth composition, a pure traditional Chinese medicine preparation is used as an active ingredient, the hair growth composition has small irritation to scalp, has no medicine residue, and is suitable for long-term use; rosemary is adopted for soothing the nerves and reducing dryness; the polygala root, the garden balsam stem and the wrinkled gianthyssop herb can not achieve the effect of promoting the hair growth basically when being used alone, but the polygala root, the garden balsam stem and the wrinkled gianthyssop herb can play a role in improving the drug effect, expelling wind heat, healing wound and the like after being matched with the components, and can obviously enhance the effect of promoting the hair growth of the composition; the composition has simple components, no need of solvent extraction, reduced allergy, and remarkable hair growth promoting effect.

Further, the hair growth composition comprises the following active substances in parts by weight: 15 parts of fructus forsythiae, 15 parts of wrinkled gianthyssop herb, 11 parts of Chinese honeylocust fruit, 12 parts of garden balsam stem, 15 parts of polygala root, 15 parts of oriental arborvitae and 15 parts of rosemary.

From the above description, the above mixture ratio is the best mixture ratio obtained after single factor test and orthogonal test.

Further, the composition for hair growth is an external preparation for skin.

Furthermore, the composition for hair growth is a spray, an emulsion, an ointment, a cream or a gel.

The preparation method of the hair growth composition provided by the invention comprises the following steps:

step 2, adding 9% of acetic acid, salicylic acid, sodium deoxyacetate and a dispersing agent into the medicine juice obtained in the step 1, and stirring;

From the above description, the beneficial effects of the present invention are: the spray type hair growth agent prepared by the method can effectively play a role in promoting hair growth, is convenient to use, has fresh skin feel and does not need to be washed for two times.

Further, the step 1 is as follows: weighing fructus forsythiae, herba Agastaches, fructus Gleditsiae Abnormalis, herba Speranskiae Tuberculatae, cortex et radix Polygalae, cacumen Platycladi, and herba Rosmarini officinalis, soaking for 60min, taking out, decocting with 8 times of water for 60min, and filtering to obtain medicinal liquid.

The contents of active substances contained in the hair growth compositions of examples 1 to 6 are shown in table 1.

TABLE 1

Component (g)	Example 1	Example 2	Example 3	Example 4	Example 5	Example 6
							Forsythia fruit	150	120	26	140	150	36
Agastache rugosus	150	120	30	120	130	42
							Chinese honey locust	110	100	26	110	140	45
Caulis et folium Gaultheriae Yunnanensis	120	120	28	130	110	45
							Root of Polygala	150	120	28	150	130	36
Arborvitae	150	120	24	150	140	39
							Rosemary	150	120	30	140	120	39

Example 1:

a hair growth composition comprising an active substance shown in example 1 of table 1.

The hair growth composition of example 1 is a spray.

The preparation method of the hair growing composition comprises the following steps:

step 1, weighing fructus forsythiae, agastache rugosus, saponin, garden balsam stem, polygala tenuifolia, platycladus orientalis and rosemary according to the table 1, soaking, taking out, adding 10 times of water, decocting to 6 times of juice, and filtering solid substances to obtain medicinal juice;

the weight of the liquid is 100 percent, and the weight percentage is 84 percent of the medicine juice, 15 percent of 9 percent of acetic acid, 0.4 percent of salicylic acid, 0.3 percent of sodium deoxyacetate and 0.3 percent of dispersant.

Example 2:

a hair growth composition comprising an active substance shown in example 2 of table 1.

The hair growth composition of example 2 is a spray;

the hair growth composition was prepared in the same manner as in example 1, except that 9% acetic acid was used in an amount of 10%, and the balance was purified water.

Example 3:

a hair growth composition comprising an active substance shown in example 3 of table 1.

The hair growth composition of example 3 is a spray;

the above hair growth composition was prepared in the same manner as in example 1.

Example 4:

a hair growth composition comprising an active substance shown in example 4 of table 1.

The hair growth composition of example 4 is a gel, and other adjuvants are the same as those of a general gel except for the active substance, and the content of the active substance needs to be more than 68% in order to ensure the effect, and the gel is suitable for patients with large-area hair loss and bare scalp.

Example 5:

a hair growth composition comprising an active substance shown in example 5 of table 1.

The hair growth composition of example 5 is an emulsion, and the other adjuvants are the same as those of a general emulsion except for the active substance, and the content of the active substance needs to be more than 75% in order to ensure the effect, and the emulsion is suitable for patients with large-area hair loss and bare scalp.

Example 6:

a hair growth composition comprising an active substance shown in example 6 of table 1.

The hair growth composition of example 6 was a shampoo, and the other auxiliary agents were the same as those of a general shampoo except for the active material, but it was found that the effect was general when a shampoo was used alone, and it was necessary to use the spray, gel or emulsion of examples 1 to 5 in combination.

Experimental example 1:

1 blank group, 1 experimental group and 4 control groups are set, and the control group 1 is only different from the embodiment 1 in that the hair growth composition does not contain polygala tenuifolia and garden balsam stem; control 2 differs from example 1 only in that the hair growth promoting composition used does not contain garden balsam stem and wrinkled giant hyssop; control 3 differs from example 1 only in that the hair growth promoting composition used does not contain wrinkled giant hyssop and thinleaf milkwort root; the control group 4 differed from example 1 only in that the hair growth promoting composition used did not contain wrinkled giant hyssop, thinleaf milkwort root-bark and garden balsam stem.

Taking 90 experimental male mice weighing 25-30g, each group containing 15 mice, anesthetizing the mice before the experiment, depilating the back of the mice with rosin and paraffin (1:1), wherein the depilated area is about 2.5x3cm²。

The method comprises the following steps of respectively administering the medicines to each group of mice in the morning and at night (eight spots in the morning and eight spots in the evening) in an experimental period, spraying and rubbing physiological saline on the unhairing part of a blank group of mice, respectively spraying and rubbing equal amount of hair growing compositions on an experimental group and a control group, observing the growth condition of hair of each mouse in the experimental period, killing the mice after 28 days (29 days), taking new hairs in a unhairing area, counting the length and weight of the new hairs, counting the number of hair follicles in the unhairing area, and simultaneously observing whether the unhairing of the mice has redness or allergy in the experimental process. The results are shown in Table 2. Wherein, the hair growth time represents the hair growth time of the first mouse in each group which has new hair.

TABLE 2

Experimental example 2:

80 male volunteers and 20 female volunteers, wherein 20 volunteers are 20 in 20-29 years old, 20 in 30-39 years old, 35 in 40-49 years old, 15 in 50-55 years old and 100 volunteers all have alopecia problems of different degrees, but all have no alopecia and the area of alopecia is within 85%. According to the hair loss degree of the volunteers, the hair loss treatment method comprises three groups of mild, moderate and severe degrees, wherein the mild group is characterized in that hair lines at the temples and the forehead obviously move backwards, the moderate group is characterized in that the hair lines at the temples and the forehead obviously move backwards, the hair at the top of the head is obviously sparse, the severe group is characterized in that the scalp at the top and two sides of the head is obviously naked, and 20 female volunteers all suffer from mild hair loss. Volunteers sprayed the hair growth composition of example 1 on the scalp once a day (rubbing after spraying) once in the morning and evening, and massaged after spraying until absorption, wherein the head was washed before spraying every night for 180 days continuously, and the results of observing the degree of hair thinning of the subjects before and after spraying are shown in table 3. Wherein, the effect shows that the sparse part or the scalp bare part has new hair growth compared with the hair growth before use; effectively shows that compared with the scalp before use, the scalp at the sparse part or the naked part of the scalp is covered and cannot be exposed in a natural state; cure indicates that the amount of hair in the volunteer returned to the pre-baldness state. Each volunteer can only belong to one state, and statistics are not repeated. The effective rate is counted by the sum of the number of effective people, the number of effective people and the number of cured people.

TABLE 3

Degree of hair loss	Number of people	Number of effective people	Number of effective persons	The number of people cured	Effective rate (%)
						Mild degree of	64	3	22	39	100％
Of moderate degree	23	6	11	4	91.3％
						Severe degree	13	6	3	0	69.2％

In conclusion, in the hair growth composition provided by the invention, a pure traditional Chinese medicine preparation is used as an active ingredient, the stimulation to scalp is small, no medicine residue is generated, and the hair growth composition is suitable for long-term use; rosemary is adopted for soothing the nerves and reducing dryness; the polygala root, the garden balsam stem and the wrinkled gianthyssop herb can not achieve the effect of promoting the hair growth basically when being used alone, but the polygala root, the garden balsam stem and the wrinkled gianthyssop herb can play a role in improving the drug effect, expelling wind heat, healing wound and the like after being matched with the components, and can obviously enhance the effect of promoting the hair growth of the composition; the composition has simple components, no need of solvent extraction, reduced allergy, and remarkable hair growth promoting effect. According to the preparation method of the hair growth composition, acetic acid, salicylic acid, sodium deoxyacetate, a dispersing agent and the medicine juice are matched, the scalp grease removing, sterilizing and bacteriostasis effects of the composition can be improved, the method is simple and convenient, the method is suitable for industrial production, the obtained hair growth composition is used for preparing the spray type hair growth agent, the hair growth promoting effect can be effectively achieved, the use is convenient, the skin feeling is fresh, and secondary cleaning is not needed.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent modifications made by the present invention in the specification or directly or indirectly applied to the related technical field are included in the scope of the present invention.

Claims

1. The hair growth composition is characterized by comprising the following active substances in parts by weight: 12-15 parts of fructus forsythiae, 12-15 parts of wrinkled gianthyssop herb, 10-15 parts of Chinese honeylocust fruit, 12-15 parts of garden balsam stem, 12-15 parts of polygala root, 12-15 parts of platycladus orientalis and 12-15 parts of rosemary.

2. The hair growth composition according to claim 1, comprising the following active substances in parts by weight: 15 parts of fructus forsythiae, 15 parts of wrinkled gianthyssop herb, 11 parts of Chinese honeylocust fruit, 12 parts of garden balsam stem, 15 parts of polygala root, 15 parts of oriental arborvitae and 15 parts of rosemary.

3. The hair growth composition according to any one of claims 1 to 2, wherein the hair growth composition is an external skin preparation.

4. The hair growth composition according to any one of claims 1 to 2, wherein the hair growth composition is a spray, an emulsion, an ointment, a cream or a gel.

5. A method for preparing a hair growth composition, which is characterized by comprising the following steps:

6. The method for preparing a hair growth composition according to claim 5, wherein the step 1 is: weighing fructus forsythiae, herba Agastaches, fructus Gleditsiae Abnormalis, herba Speranskiae Tuberculatae, cortex et radix Polygalae, cacumen Platycladi, and herba Rosmarini officinalis, soaking for 60min, taking out, decocting with 10 times of water for 60min, and filtering to obtain medicinal liquid.