CN111278809B - 二环砜类和亚砜类、以及其使用方法 - Google Patents

二环砜类和亚砜类、以及其使用方法 Download PDF

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Publication number
CN111278809B
CN111278809B CN201880070578.0A CN201880070578A CN111278809B CN 111278809 B CN111278809 B CN 111278809B CN 201880070578 A CN201880070578 A CN 201880070578A CN 111278809 B CN111278809 B CN 111278809B
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China
Prior art keywords
dihydro
pyrrolo
fluoro
triazole
phenyl
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CN201880070578.0A
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Chinese (zh)
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CN111278809A (zh
Inventor
S·帕特尔
G·汉密尔顿
C·斯蒂瓦拉
陈慧芬
B·达涅尔斯
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201880070578.0A 2017-10-31 2018-10-30 二环砜类和亚砜类、以及其使用方法 Active CN111278809B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762579392P 2017-10-31 2017-10-31
US62/579,392 2017-10-31
PCT/EP2018/079772 WO2019086494A1 (en) 2017-10-31 2018-10-30 Bicyclic sulfones and sulfoxides and methods of use thereof

Publications (2)

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CN111278809A CN111278809A (zh) 2020-06-12
CN111278809B true CN111278809B (zh) 2024-06-25

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US (2) US11072617B2 (enExample)
EP (1) EP3704097B1 (enExample)
JP (1) JP2021501183A (enExample)
KR (1) KR20200083515A (enExample)
CN (1) CN111278809B (enExample)
AR (1) AR113811A1 (enExample)
AU (1) AU2018360270A1 (enExample)
BR (1) BR112020008446A2 (enExample)
CA (1) CA3078688A1 (enExample)
CL (1) CL2020001062A1 (enExample)
CO (1) CO2020003475A2 (enExample)
CR (1) CR20200168A (enExample)
IL (1) IL273847A (enExample)
MA (1) MA50503A (enExample)
MX (1) MX2020003451A (enExample)
PE (1) PE20211247A1 (enExample)
PH (1) PH12020550537A1 (enExample)
RU (1) RU2020115915A (enExample)
SG (1) SG11202002877RA (enExample)
TW (1) TW201922748A (enExample)
WO (1) WO2019086494A1 (enExample)

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US11071721B2 (en) 2016-12-02 2021-07-27 Genentech, Inc. Bicyclic amide compounds and methods of use thereof
CN119613408A (zh) 2017-07-14 2025-03-14 豪夫迈·罗氏有限公司 二环酮化合物及其使用方法
MX2020003451A (es) 2017-10-31 2020-08-03 Hoffmann La Roche Sulfonas y sulfoxidos biciclicos y metodos de uso de los mismos.
CN113302193B (zh) 2019-01-11 2026-05-29 豪夫迈·罗氏有限公司 双环吡咯并三唑酮化合物及其使用方法
TW202214617A (zh) 2020-06-02 2022-04-16 法商賽諾菲公司 作為ｒｉｐｋ１抑制劑之異㗁唑啶及其用途
CN118510775A (zh) 2021-11-11 2024-08-16 建新公司 作为ripk1抑制剂的异噁唑烷及其用途

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Also Published As

Publication number Publication date
EP3704097A1 (en) 2020-09-09
PH12020550537A1 (en) 2021-03-22
EP3704097C0 (en) 2023-10-25
CO2020003475A2 (es) 2020-04-24
CA3078688A1 (en) 2019-05-09
AU2018360270A1 (en) 2020-03-26
MX2020003451A (es) 2020-08-03
US20190127382A1 (en) 2019-05-02
WO2019086494A1 (en) 2019-05-09
IL273847A (en) 2020-05-31
TW201922748A (zh) 2019-06-16
EP3704097B1 (en) 2023-10-25
CR20200168A (es) 2020-07-12
RU2020115915A (ru) 2021-12-01
SG11202002877RA (en) 2020-04-29
AR113811A1 (es) 2020-06-10
US11072617B2 (en) 2021-07-27
KR20200083515A (ko) 2020-07-08
US12338241B2 (en) 2025-06-24
RU2020115915A3 (enExample) 2022-05-06
CN111278809A (zh) 2020-06-12
CL2020001062A1 (es) 2020-08-21
MA50503A (fr) 2020-09-09
PE20211247A1 (es) 2021-07-13
BR112020008446A2 (pt) 2020-12-29
US20230002391A1 (en) 2023-01-05
JP2021501183A (ja) 2021-01-14

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