CN111265671A - Method for improving hot-melt wall adhesion of spray drying of traditional Chinese medicine or food raw materials - Google Patents
Method for improving hot-melt wall adhesion of spray drying of traditional Chinese medicine or food raw materials Download PDFInfo
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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Abstract
The invention relates to a method for improving the hot-melt wall adhesion of spray drying of traditional Chinese medicine or food raw materials, which comprises the following steps: adding any one or more than one small molecular peptide as an auxiliary material into the solution to be dried with the solid content of 2-50%, adding the auxiliary material with the dosage of 5-30% of the solid content of the solution to be dried, uniformly stirring and dispersing, and carrying out spray drying under the stirring condition. The invention has safe auxiliary materials, no interference to the release of the main components of the medicine, wide application range and good dissolubility of the obtained product, and can effectively improve the problem of hot-melt wall adhesion in the spray drying process. The invention also provides application of the small molecular peptide in improving the spray drying hot-melt wall adhesion of traditional Chinese medicines or food raw materials.
Description
Technical Field
The invention belongs to the technical field of drying processes, and particularly relates to a method for improving spray drying hot-melt wall adhesion of a traditional Chinese medicine or food raw material by using auxiliary materials; in particular to a method for improving the hot-melt wall adhesion of spray drying of traditional Chinese medicine or food raw materials by using plant-derived natural small molecular peptides.
Background
Spray drying is a common drying method for traditional Chinese medicine extracting solution and food raw material solution, and has the advantages of instant drying, good quality of dried products, simple drying process and the like. However, due to the nature of the material itself, hot melt wall adhesion often occurs during spray drying. The main phenomenon generated by the method is that liquid drop-shaped agglomerates are formed on the inner wall of the spray dryer, the agglomerates are firmly combined with the inner wall and cannot be collected, and the agglomerates are mainly adhered to a cyclone separator and a collector. Research is available [ Huanglixin, Zhou Rui Jun, product glass transition in spray drying process is first detected, general machinery, 2005, 12: 14-18; puyu, Zhao Kai Jun, Guangxi Yun, etc., research on the influence of softening point of Chinese medicinal extract on spray drying [ J ], Chinese patent medicine, 2006, 28(1):18-20 ] shows that the phenomenon is caused by the low softening point or glass transition temperature of material powder. If the material is dried by other drying methods, such as atmospheric forced air drying or vacuum drying, the phenomenon is that the material is soft semisolid and can not be crushed into powder, and if the solid is transferred to a low-temperature environment, the soft material becomes hard gradually. The materials mainly appear in traditional Chinese medicines and foods, and the reason that the softening point or the glass transition temperature of the materials is low is probably because the components of the materials are complex and part of the components form eutectic.
At present, the main methods for improving the hot-melt wall adhesion of spray drying are as follows: modifying spray drying equipment, and adding additional devices such as jacket cooling tower wall, low temperature spray drying method [ Wang Xizhou, Yuan, etc. ], spray drying [ M ], Beijing: chemical industry Press, 2003 ]; and adding adjuvants into the extractive solution. Compared with a jacket cooling method and a low-temperature spray drying method, the method for adding the auxiliary materials has the advantages in the aspects of operability and operation economy, so that the method is the most widely applied method for improving powder wall adhesion in the current production. In the method of adding auxiliary materials, the types of the auxiliary materials are common soluble starch and maltodextrin, but when the auxiliary materials are used for improving the hot-melt type wall sticking, the dosage is generally larger, and can generally reach more than 50 percent of the dry paste amount in an extracting solution [ Shaodan, Bianhong, Dahurian angelica root formula particle spray drying process research (J) Chinese herbal medicine 2006, 37(6): 874-. The dosage of the auxiliary materials is large, so that the drug-loading rate of the prescription is inevitably reduced, and the dosage of the preparation after forming is overlarge. Therefore, how to overcome the hot-melt wall adhesion in the spray drying process of the traditional Chinese medicine extracting solution and reduce the dosage of the auxiliary materials is very important.
Through research, the applicant has developed a method for improving hot-melt wall adhesion in the spray drying process of traditional Chinese medicine extract, and has applied for invention patents with patent numbers as follows: ZL201010108021.7, the method can achieve the effect of improving the spray drying hot melt wall adhesion by adding a small amount of auxiliary materials (namely light magnesium oxide and microcrystalline cellulose) in a certain range, and is proved by a plurality of experiments. However, the auxiliary materials used in the method have certain limitation on the human body intake, so the auxiliary materials are only suitable for being added into medicines, and cannot be added into food at will. In addition, through a great deal of experimental research, the auxiliary material cannot solve all the hot-melt wall sticking problems. The applicant develops another method for improving the spray drying hot-melt wall adhesion of the traditional Chinese medicine or food raw materials by using auxiliary materials, and the patent numbers are as follows: ZL201010298981.4, the method utilizes the semi-synthetic cellulose with higher safety as the auxiliary material, realizes the high-efficiency spray drying hot-melt-resistant wall-sticking-resistant method, and the method is a pure physical wall-sticking-resistant method, has higher safety, wider application range and less influence on the physicochemical property of the feed liquid. However, the auxiliary materials used in the method have certain viscosity, and if the requirement on the water redissolution speed of the dried product is higher, the method has no advantages. In addition, the spray drying process parameter of the method has a small applicable window, the process parameter needs to be accurately optimized, and the control requirement on instrument and equipment is high. There is a risk that, once the process parameters are not appropriate, incomplete drying will occur or hot melt sticking of the walls will occur again. Accordingly, the present inventors have continued to conduct research to find more advantageous spray drying wall-sticking resistant solutions.
Disclosure of Invention
The invention aims to solve the technical problem of providing a method for improving the hot-melt wall adhesion of spray drying of traditional Chinese medicine or food raw materials. The invention has the advantages of small using amount of auxiliary materials, no side effect, no interference on the release of the main components of the medicine, good reproducibility and strong applicability, and can effectively improve the hot-melt wall adhesion problem in the spray drying process.
In order to solve the technical problems, the technical scheme provided by the invention is as follows:
a method for improving the hot-melt wall adhesion of spray drying of traditional Chinese medicine or food raw materials comprises the following steps: adding any one or more than one small molecular peptide as an auxiliary material into the solution to be dried with the solid content of 2-50%, adding the auxiliary material with the dosage of 5-30% of the solid content of the solution to be dried, uniformly stirring and dispersing, and carrying out spray drying under the stirring condition.
The source of the small molecule peptide is food raw materials of plant sources, namely ready-to-use plants, and the food raw materials of plant sources comprise but are not limited to soybeans, peas, corns, rice and walnuts.
Preferably, the small molecule peptide consists of 2-15 amino acids.
The solution to be dried is traditional Chinese medicine extract or food raw material solution.
Preferably, the amount of the added auxiliary materials is 10-20% of the solid content of the solution to be dried, the solid content refers to the solid content of the solution to be dried, namely the dry paste content in the solution to be dried, and the percentage of the solid content refers to the mass/volume percentage.
The invention also provides application of the small molecular peptide in improving the spray drying hot-melt wall adhesion of traditional Chinese medicines or food raw materials, wherein the small molecular peptide consists of 2-15 amino acids.
The auxiliary materials adopted by the invention are small molecular peptides, wherein the small molecular peptides are compounds formed by connecting α -amino acids through peptide bonds, have molecular weights between amino acids and proteins, and are intermediate products of protein hydrolysis, wherein the small molecular peptides consisting of 2-15 amino acids are called small molecular peptides or small peptides.
Compared with the prior art, the invention has the beneficial effects that: (1) the auxiliary material micromolecule peptide used in the invention is obtained by pure natural extraction or enzymolysis, the constituent unit is amino acid, and the invention is safe to human body, has no side effect and has certain nutritive value. The additive can be used for adding medicines and food, and the dosage is not limited; the safety level is improved, and the application value is wider; (2) the invention solves the unsolved problem of ZL201010108021.7 patent application, namely, the method has more universal applicability to improving hot-melt wall sticking, and researches to date, the method can solve the problem of spray drying hot-melt wall sticking in most foods or medicines, for example, the method recorded in ZL201010108021.7 patent application cannot improve the hot-melt wall sticking problem of Chinese date extract, and the hot-melt wall sticking phenomenon can be completely solved by applying the method; (3) the product obtained by the method has low water content, good powder property, good water redissolution property, low viscosity of the aqueous solution and good clarity, solves the problems of slow redissolution of ZL201010298981.4 water and high viscosity of the aqueous solution, is favorable for expanding the further application range of the dried product, and has higher application value; (4) the auxiliary materials used in the invention have no interference to the release of the main components of the medicine or food, and have good reproducibility and strong applicability.
Drawings
FIG. 1A is the scanning electron microscope image of the spray-dried powder added with HPMC in example 3, and FIG. 1B is the scanning electron microscope image of the spray-dried powder added with rice peptide powder in example 3.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. These examples are to be construed as merely illustrative and not limitative of the remainder of the disclosure in any way whatsoever. After reading the description of the invention, one skilled in the art can make various changes and modifications to the invention, and such equivalent changes and modifications also fall into the scope of the invention defined by the claims.
Example 1: comparative example for improving spray-drying hot-melt wall adhesion of hawthorn extract
The hawthorn belongs to food with homology of medicine and food, the water extract of the hawthorn is often used alone or added into other medicines or foods, but the extract generates serious hot melt type wall sticking in the spray drying process.
Extracting fructus crataegi, concentrating to obtain extractive solution (solid content 20%), dividing into two parts, adding soybean peptide powder (type: soybean protein isolate, manufactured by Pinus koraiensis bioproduct Co., Ltd., meeting the first-level standard of physicochemical index of soybean peptide powder in GB/T22492-3H). The sample without the soybean peptide powder is subjected to hot melting type wall sticking, and the powder collection rate is zero; the yield of the sample powder added with the soybean peptide powder reaches 70 percent. Therefore, the method can improve the spray drying hot-melt wall sticking problem of the hawthorn extract.
Example 2: comparative example for improving hot melt type wall sticking of spray drying of jujube extract
The Chinese dates belong to food with homology of medicine and food, and the water extract of the Chinese dates has serious hot-melt wall adhesion in the spray drying process.
Extracting fructus Jujubae to obtain extractive solution, adjusting solid content to 2%, and dividing into four parts. Adding corresponding adjuvants (magnesium oxide content is 5% of the dry extract content of the extractive solution, HPMC F5 content is 15% and semen Pisi Sativi peptide powder content is 15%) according to Table 1 respectively, stirring to disperse uniformly, and spray drying under stirring (BUCHI-B290 spray drier with process parameters of inlet air temperature of 140 deg.C, atomizing pressure of 1.05bar, inlet liquid velocity of 9mL/min and inlet air volume of 35 m)3H). Pure jujube water extract and extract added with magnesium oxide can not be sprayed and dried to obtain powdery products, and the hot melt is serious in wall adhesion. HPMC F5 and semen Pisi Sativi peptide powder (type: semen Pisi Sativi peptide, manufacturer: Chinese food)Duqing (Shandong) Biotechnology Co., Ltd.) improved the wall adhesion. Therefore, for the Chinese date extract, the effect of the spray drying of the invention on anti-sticky wall is equivalent to that of the ZL201010298981.4 patent.
TABLE 1 jujube extract adjuvant adding method and spray drying yield
Example 3: improved Qianglining extracting solution spray drying hot melt type wall sticking
The Qianglining is a collection of 2 Chinese herbs, acanthopanax and wolfberry fruit, recorded in volume 10 of the "Standard Chinese medicine Chengfang preparation of Ministry of health". In the experiment, the extract liquid is found to generate hot-melt wall sticking when being spray-dried.
Comparing the difference in properties between the method of patent ZL201010298981.4 and the product obtained by the method of the patent: extracting and concentrating the Qianglining to obtain Qianglining extracting solution (solid content: 10%); the first part is directly spray-dried, the second part is added with HPMC E3 accounting for 20% of the solid content of the extracting solution, the third part is added with rice peptide powder (model: rice peptide powder, manufacturer: Zhongshidu Chongqing (Shandong) biotechnology limited) accounting for 20% of the solid content of the extracting solution, the mixture is respectively stirred to be dissolved and uniformly dispersed, and spray-dried under the stirring condition (BUCHI-B290 spray-drying instrument, the technological parameters are set as that the air inlet temperature is 140 ℃, the atomizing pressure is 1.05bar, the liquid inlet speed is 9mL/min, and the air inlet amount is 35m3H), the physical and chemical properties of the spray-dried powder obtained were evaluated.
1) Solubility: according to the soluble granule inspection method under the item of 0104 granules in general rules of the four parts of Chinese pharmacopoeia of 2015 edition, 10g of dry powder is taken and heated to 200mL of water, stirred, and the phenomenon and the time for complete dissolution are recorded. As a result, the powder with rice peptide powder as adjuvant is completely dissolved within 2min, and the powder added with HPMC is still significantly adhered to the bottom of the cup and floats or sinks after stirring for 5 min.
2) Surface morphology: the apparent physical form of the spray-dried powder was observed by scanning with an electron microscope, see fig. 1. The powder prepared from rice peptide powder is smooth sphere, and the powder prepared from HPMC is irregular shrinkage. The powder added with the rice peptide powder shows different flowability in powder due to the difference of the powder surface, and the powder flowability is remarkably superior to that of HPMC powder.
3) Water content: the measurement is carried out by adopting a water content measuring method of 0832 according to the general rule of the four parts of the Chinese pharmacopoeia of 2015 edition, the result is shown in table 2, and the water content of the powder added with the rice peptide powder is obviously lower than that of the HPMC powder.
4) Viscosity: taking 10g of the dry powder, adding 100mL of water to fully dissolve the dry powder to obtain a compound solution, and measuring the rotational viscosity of the compound solution by using a rotational viscometer, wherein the result is shown in Table 2, and the viscosity of the powder compound solution added with the rice peptide powder is obviously lower than that of the HPMC powder compound solution.
5) Dissolution rate: the dissolution rate of the main component syringin in the Qianglining extracting solution spray-dried powder is investigated by adopting a small cup method of 0931 third method of the general rule of the four parts of the Chinese pharmacopoeia of 2015 edition, the result is shown in table 2, and the dissolution rate of the powder added with the rice peptide powder is obviously higher than that of the HPMC powder.
TABLE 2
Example 4: comparative example for improving hot melt type wall adhesion of spray drying of dark plum extract
The dark plum medicinal material contains more micromolecular organic acid and micromolecular saccharide components, and the water extract of the dark plum medicinal material has serious hot-melt wall adhesion in the spray drying process.
Extracting mume fructus, concentrating to obtain extractive solution (solid content 50%), dividing into two parts, adding corn peptide powder (type: corn oligopeptide, manufacturer: Zhongshidu Chongqing (Shandong) biotechnology Co., Ltd.) in one part of the extractive solution, stirring to disperse uniformly, and spray drying under stirring (BUCHI-B290 spray dryer, with process parameters of inlet air temperature 140 deg.C, atomization pressure 1.05bar, inlet liquid speed 9mL/min, and inlet air volume 35m3H). The sample without the corn peptide powder is subjected to hot melting type wall sticking, and the powder collection rate is zero; the yield of the sample powder added with the corn peptide powder is 65 percent. Due to the fact thatThe method can improve the problem of spray drying hot melt type wall sticking of the dark plum extract.
Example 5: comparative example for improving spray-drying hot-melt wall adhesion of Xiaoying-Jian extract
The classic formula Xiaoying decoction contains medicinal materials which are easy to generate hot melt type wall sticking, such as prepared rehmannia root, medlar and the like, and the water extract of the formula also has obvious hot melt type wall sticking in the spray drying process.
The Xiaoying decoction is properly extracted and concentrated to obtain an extracting solution (the solid content is 30 percent), the extracting solution is averagely divided into two parts, one part of the extracting solution is added with walnut peptide powder (the model: the walnut peptide powder, the manufacturer: Zhongshidu Chongqing (Shandong) biotechnology limited) accounting for 10 percent of the dry paste amount of the extracting solution, the mixture is stirred to be uniformly dispersed, and spray drying is carried out under the stirring condition (a BUCHI-B290 spray dryer, the technological parameters are set as the air inlet temperature of 140 ℃, the atomizing pressure of 1.05bar, the liquid inlet speed of 9mL/min and the air inlet air amount of3H). The samples without walnut peptide powder are subjected to hot-melt wall adhesion, and the powder collection rate is 26%; the yield of the sample powder added with the walnut peptide powder is 70 percent. Therefore, for small-fried extract, the method can achieve the effect of improving the spray drying hot-melt wall sticking problem.
The above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (9)
1. A method for improving the hot-melt wall adhesion of spray drying of traditional Chinese medicine or food raw materials is characterized by comprising the following steps: adding any one or more than one small molecular peptide as an auxiliary material into the solution to be dried with the solid content of 2-50%, adding the auxiliary material with the dosage of 5-30% of the solid content of the solution to be dried, uniformly stirring and dispersing, and carrying out spray drying under the stirring condition.
2. The method for improving the hot-melt type wall adhesion of spray drying of traditional Chinese medicine or food materials according to claim 1, wherein the source of the small molecule peptide is a food material of plant origin.
3. The method for improving the spray-dried hot-melt type wall adhesion of Chinese herbal or food materials as claimed in claim 2, wherein said plant-derived food materials comprise soybean, pea, corn, rice, walnut.
4. The method for improving the hot-melt type wall sticking of spray drying of Chinese herbal medicines or food ingredients as claimed in claim 1, wherein the solution to be dried is Chinese herbal medicine extract or food ingredient solution.
5. The method for improving the hot-melt wall adhesion in spray drying of traditional Chinese medicines or food raw materials according to claim 1, wherein the amount of the added auxiliary materials is 10-20% of the solid content of the solution to be dried.
6. The method for improving the spray drying hot-melt wall adhesion of the traditional Chinese medicine or food raw material according to any one of claims 1 to 3, wherein the small molecule peptide consists of 2 to 15 amino acids.
7. The application of the small molecular peptide in improving the spray drying hot-melt wall adhesion of traditional Chinese medicines or food raw materials is characterized in that the small molecular peptide consists of 2-15 amino acids.
8. The use according to claim 7, wherein the source of small molecule peptides is a food material of plant origin.
9. Use according to claim 8, characterized in that the food raw materials of vegetable origin comprise soy, pea, corn, rice, walnut.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006079420A1 (en) * | 2005-01-31 | 2006-08-03 | Nestec S.A. | Process for preparing nutritional products |
| CN101518323A (en) * | 2009-04-07 | 2009-09-02 | 江南大学 | Preparation method for taste base peptide for steamed savory flavoring |
| CN101816431A (en) * | 2010-04-30 | 2010-09-01 | 浙江省医学科学院 | Precious peptide bone-strengthening capsules or tablets with function of improving osteoporosis and increasing bone mineral density and preparation method thereof |
| CN104719993A (en) * | 2015-02-11 | 2015-06-24 | 浙江海洋学院 | Application method of hydrolysate after squid tentacles peeled through enzymic method and seafood-flavor seasoning prepared through method |
| CN104904988A (en) * | 2015-06-17 | 2015-09-16 | 山东省农业科学院农产品研究所 | Method for processing peanut protein powder with high polypeptide content |
| CN106581685A (en) * | 2016-12-13 | 2017-04-26 | 广州市香雪制药股份有限公司 | Method and auxiliary composition for improving wall adhesion of traditional Chinese medicine extract in spray drying |
| CN106755233A (en) * | 2016-12-05 | 2017-05-31 | 东北农业大学 | A kind of method that aqueous enzymatic method Soy hydrolysate prepares protein peptide powder |
-
2020
- 2020-01-21 CN CN202010070883.9A patent/CN111265671B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006079420A1 (en) * | 2005-01-31 | 2006-08-03 | Nestec S.A. | Process for preparing nutritional products |
| CN101518323A (en) * | 2009-04-07 | 2009-09-02 | 江南大学 | Preparation method for taste base peptide for steamed savory flavoring |
| CN101816431A (en) * | 2010-04-30 | 2010-09-01 | 浙江省医学科学院 | Precious peptide bone-strengthening capsules or tablets with function of improving osteoporosis and increasing bone mineral density and preparation method thereof |
| CN104719993A (en) * | 2015-02-11 | 2015-06-24 | 浙江海洋学院 | Application method of hydrolysate after squid tentacles peeled through enzymic method and seafood-flavor seasoning prepared through method |
| CN104904988A (en) * | 2015-06-17 | 2015-09-16 | 山东省农业科学院农产品研究所 | Method for processing peanut protein powder with high polypeptide content |
| CN106755233A (en) * | 2016-12-05 | 2017-05-31 | 东北农业大学 | A kind of method that aqueous enzymatic method Soy hydrolysate prepares protein peptide powder |
| CN106581685A (en) * | 2016-12-13 | 2017-04-26 | 广州市香雪制药股份有限公司 | Method and auxiliary composition for improving wall adhesion of traditional Chinese medicine extract in spray drying |
Non-Patent Citations (2)
| Title |
|---|
| KRZYSZTOF SOLLOHUB ET AL: "Spray Drying Technique: II. Current Applications in Pharmaceutical Technology", 《JOURNAL OF PHARMACEUTICAL SCIENCES》 * |
| 周鸿翔 等: "葛根核桃肽复合饮料喷雾干燥工艺研究", 《中国酿造》 * |
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