CN111264531A

CN111264531A - Composition containing abamectin

Info

Publication number: CN111264531A
Application number: CN201811479408.6A
Authority: CN
Inventors: 钟良坤; 胡冬松; 许天明; 邢家华; 黄红英; 魏优昌
Original assignee: Zhejiang Chemical Industry Research Institute Co Ltd; Sinochem Corp; Sinochem Lantian Co Ltd
Current assignee: Zhejiang Chemical Industry Research Institute Co Ltd; Sinochem Corp; Sinochem Lantian Co Ltd
Priority date: 2018-12-05
Filing date: 2018-12-05
Publication date: 2020-06-12

Abstract

The invention discloses a composition comprising abamectin and pyraclostrobin, wherein the weight ratio of the abamectin to the pyraclostrobin is 1-50: 50-1. The composition provided by the invention has the characteristics of high efficiency, low toxicity and long lasting period, and is suitable for preventing and treating mite pests.

Description

Composition containing abamectin

Technical Field

The invention belongs to the field of pesticides, and relates to a composition containing abamectin and pyrazofen-ethyl.

Background

The agricultural pest mites are small in size, fast in propagation, strong in adaptability and easy to generate resistance, mainly damage leaves, young shoots, buds and fruits, and when the number of pest mites is increased sharply, plants can be fallen off leaves, growth is inhibited and even withered, so that the pest mites are one of pests which are difficult to control. And the harmful mites are easy to generate drug resistance after long-term use of a chemical agent.

For example, abamectin is a hexadecimal macrolide compound, has the action mechanism of interfering the neurophysiological activity of insects and mites to cause death, has stomach toxicity and contact poisoning effects on the insects and the mites, has good broad spectrum and quick action, and can show high biological activity on the mites, armyworms, diamond back moths, rice leaf rollers, rice planthoppers, aphids and the like. If the abamectin is used for preventing and controlling the pest mites for a long time, the pest mites are easy to generate drug resistance to the pest mites, so that the prevention and control effect of the abamectin is increasingly poor.

In the field of pesticides, in order to alleviate the drug resistance of pests to a specific pesticide, a common technical method comprises the step of compounding and combining different pesticides to obtain a more efficient compound pesticide formula for controlling pests.

Therefore, in order to slow down the drug resistance of pests such as pest mites to abamectin as much as possible and improve the control effect of the pests such as pest mites, the research on the compound composition of the abamectin pesticide is necessary.

Disclosure of Invention

The invention aims to provide a composition containing abamectin, which has the characteristics of high efficiency, low toxicity and long lasting period and can effectively prevent and control pest mites in crops.

The oxapyrile acarbonitrile has a chemical structural formula shown as the following (I):

the inventor finds that the pyrazofen-ethyl miticide is an acrylonitrile miticide, the action mechanism of the pyrazofen-ethyl miticide is that the pyrazofen-ethyl miticide acts on an electron transfer chain of a respiratory system by being converted into a hydroxyl compound through metabolism, and the normal effect of mitochondria is inhibited by disturbing the action of succinate dehydrogenase, so that the effect of preventing and treating pest mites is achieved, and the pyrazofen-ethyl miticide has higher biological activity on adult mites, nymph mites and eggs.

The inventor of the application prepares the composition containing the oxazote and the abamectin by compounding the oxazote and the abamectin which are different from the abamectin action mechanism, and the composition can be used for preventing and treating pest such as pest mites.

The invention provides a composition comprising abamectin and pyraclostrobin.

In the composition provided by the invention, the ratio of the abamectin to the oxazofen is satisfied, so that the composition is more favorable for preventing and controlling the mites. Preferably, the weight ratio of the abamectin to the oxazofen is 1-50: 50-1. More preferably, the weight ratio of the abamectin to the oxazofen is 1-30: 30-1. More preferably, the weight ratio of the abamectin to the oxazofen is 1-10: 10-1.

The invention also provides an acaricide, which contains the composition. The content of the composition in the acaricide meets the requirement that the acaricide is more beneficial to preventing and controlling insects and mites. Preferably, the acaricide comprises 1-90% of the composition by weight percentage, and the balance of acceptable carriers and auxiliaries in pesticide preparations. More preferably, the acaricide comprises 5-40% of the composition by weight percentage, and the balance of acceptable carriers and auxiliaries in pesticide preparations.

The carrier used in the acaricide of the present invention may be a solid or a liquid, and may be any carrier commonly used in the field of pesticide formulations.

By way of example, suitable solid supports include: minerals, plants, synthetic fillers and inorganic salt carriers. Wherein the mineral carrier comprises silicate, carbonate, sulfate and oxide. Silicate carriers, such as kaolin, sepiolite, nacrite, montmorillonite, mica, vermiculite, pyrophyllite, talc. Carbonate-based carriers, for example: calcium carbonate and dolomite. Sulfates such as ammonium sulfate, sodium sulfate, calcium sulfate. Oxide-based carriers such as quicklime, magnesia lime, diatomaceous earth. Plant-based vectors, for example: citrus pulp, corn cob cores, rice hull powder, rice hulls, soybean straw powder, tobacco powder, walnut shells and sawmilling powder. Synthetic filler carriers such as precipitated calcium carbonate hydrate, precipitated calcium carbonate and white carbon black. Inorganic salt carriers, such as potassium chloride, sodium chloride.

The liquid carrier includes water and an organic solvent. By way of example, suitable organic solvents include: aromatic hydrocarbons such as benzene, xylene, trimethylbenzene, toluene; chlorinated aliphatic hydrocarbons such as chloroform, dichloromethane, chloroform, carbon tetrachloride and polychlorinated ethane; aliphatic hydrocarbons such as petroleum fractions, cyclohexane, light mineral oil, and paraffin wax; alcohols such as methanol, ethanol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, glycerol, fatty alcohols, and the like; ethers such as propylene glycol ethyl ether, propylene glycol methyl ether, petroleum ether and the like; ketones such as acetone, cyclohexanone, and isophorone, N-methyl-pyrrolidone, N-octyl pyrrolidone, etc.; specialty solvents, such as dimethylformamide, dimethyl sulfoxide, polyethylene glycol, hexanenitrile; vegetable oils and methylated vegetable oils. The organic solvent may be used alone, may be used in combination, or may be used in combination with water.

The auxiliary agent used in the acaricide can comprise one or more of a surfactant, an antifoaming agent, a thickening agent, a suspending agent and an antifreezing agent according to requirements, and can also comprise other auxiliary agents commonly used in the industry according to requirements.

By way of example, the surfactant may be an emulsifier, dispersant or wetting agent. The emulsifier includes nonionic emulsifier and anionic emulsifier. The nonionic emulsifier is preferably nonylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, styrylphenyl polyoxyethylene ether, alkylphenol formaldehyde resin polyoxyethylene ether, hydroxyl-terminated polyoxyethylene polyoxypropylene ether, styrylphenol formaldehyde resin polyoxyethylene polyoxypropylene ether, and castor oil polyoxyethylene ether. The anionic emulsifier mainly comprises calcium dodecyl benzene sulfonate, ammonium triphenethyl phenol polyoxyethylene ether phosphate, ammonium nonylphenol polyoxyethylene ether phosphate and ammonium castor oil polyoxyethylene ether phosphate.

The dispersant of the invention comprises: one or more of acrylic acid homopolymer sodium salt, maleic acid disodium salt, naphthalene sulfonic acid formaldehyde condensate sodium salt, rosin block polyoxyethylene ether polyoxypropylene ether sulfonate, hydroxyl-terminated polyoxyethylene polyoxypropylene ether block copolymer, triphenyl ethyl phenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphoric acid and p-hydroxyphenyl lignin sulfonic acid sodium salt.

The wetting agent of the present invention comprises: one or more of fatty alcohol-polyoxyethylene ether, naphthalene sulfonate, sodium dodecyl sulfate and alkylphenol resin polyoxyethylene ether sulfate.

The thickening agent comprises one or more of xanthan gum, magnesium aluminum silicate, sodium alginate, sodium carboxymethylcellulose, Arabic gum, gelatin and polyvinyl alcohol.

The acaricide can be prepared into missible oil, oil suspension, suspending agent, suspoemulsion, wettable powder, water dispersible granules, microcapsule suspending agent and aqueous emulsion according to a general method in the field.

The composition or acaricide provided by the invention is suitable for controlling mite pests. The composition or acaricide provided by the invention is particularly suitable for preventing and controlling at least one pest mite selected from citrus red spider, apple red spider, cotton red spider, tetranychus cinnabarinus, two-class tetranychus, hawthorn leaf mite and tea yellow mite. The composition or acaricide provided by the invention is particularly suitable for preventing and controlling harmful mites on oranges, cotton, apples or vegetables. The composition or acaricide provided by the invention is most suitable for controlling harmful mites on citrus, cotton, apples or vegetables, and the harmful mites are selected from at least one of citrus red mite, apple red mite, cotton red mite, tetranychus cinnabarinus, two-class tetranychus, hawthorn tetranychus and tea yellow mite.

Compared with the prior art, the composition provided by the invention has the following advantages:

(1) the composition shows excellent synergistic effect after two active ingredients are compounded, and compared with a single agent, the acaricidal effect of the mixed composition is obviously improved, and the composition has the characteristics of good quick-acting property and long-lasting effect;

(2) the dosage can be reduced, and the drug cost of farmers can be reduced;

(3) the two active ingredients are reasonably mixed by utilizing different action modes and different action mechanisms of the two active ingredients on pest mites, so that the service life of the pesticide is prolonged, and the generation of drug resistance of the pest mites is delayed.

Detailed Description

The present invention is further illustrated by the following examples, which are not intended to limit the invention to these embodiments. It will be appreciated by those skilled in the art that the present invention encompasses all alternatives, modifications and equivalents as may be included within the scope of the claims.

In the following examples, all percentages are by weight unless otherwise indicated.

The inventor of the application carries out indoor toxicity determination test on the mixture of pyrazofen-ethyl and abamectin. The test refers to the indoor biological determination test criterion of the pesticide (agricultural industry standard NY/T1154.7-2006) and the formulated pesticide biological activity evaluation SOP (pesticide volume), and adopts an immersion method.

The combined effect of the compositions was calculated using the following method:

theoretical virulence index of the mix (TTI) ═ A virulence index x A content in the mix (%)

+ B virulence index x B content in the mix (%);

if the co-toxicity coefficient is more than 120, the synergistic effect is shown; if the content is less than 80, antagonism is indicated; if greater than 80 and less than 120, an additive effect is indicated.

Example 1: composition of abamectin azole and ether mite nitrile

TABLE 1 synergistic effect of the composition on Tetranychus Cinnabarinus by combining Tetranychus Cinnabarinus and Tetranychus Cinnabarinus

As can be seen from Table 1, the composition provided by the application has the co-toxicity coefficient of more than 120 in the range of 1-50: 50-1 by weight of abamectin and pyraclostrobin, and shows a synergistic effect on tetranychus cinnabarinus. The ZJ10665 and the spirotetramat are reasonably mixed and feasible.

Example 2 control of citrus red spider by 31% Carbazin-Avermectin suspension

According to the formula of 30% of pyraclostrobin, 1% of abamectin, 3.5% of triphenylethylphenol polyoxyethylene ether phosphate, 1% of fatty alcohol polyoxyethylene ether, 0.15% of xanthan gum, 0.4% of organic silicon defoamer, 5% of propylene glycol and the balance of deionized water, the components are uniformly mixed, added into a sand mill and ground to a certain particle size, and then mixed through high shear to prepare the 31% pyraclostrobin, acarine and abamectin suspending agent.

The prepared 31% oxazofen-abamectin suspending agent is applied to prevention and treatment of citrus red spiders. The test site is the northern area of Ningbo city in Zhejiang province. The control effect of the 30% oxazofen mite nitrile avermectin suspending agent on citrus red spiders is 96.7%, 96.5% and 93.6% respectively in the dose of 80mg/kg of active ingredients after 3 days, 14 days and 30 days after the pesticide application. The control medicament 20% oxaziclovir hydrochloride suspending agent has the control effects on citrus red spiders of 90.7%, 95.8% and 91.5% respectively in the dose of 80mg/kg of active ingredient after 3 days, 14 days and 30 days. The control medicament 1.8% avermectin emulsifiable concentrate has the control effects on citrus red spiders of 86.2%, 83.5% and 40.9% respectively in the dosage of 80mg/kg of active ingredients after 3 days, 14 days and 30 days. After the pyraclostrobin and the abamectin are compounded, the synergistic effect is remarkable, and the quick-acting performance and the lasting period are obviously better than those of a contrast agent.

Example 3 prevention and treatment of cotton spider mite with 45% Azolofen-Avermectin Water dispersible granule

According to the formula of 40% of oxazofen-acarine nitrile, 5% of abamectin, 3% of sodium dodecyl sulfate, 4% of acrylic acid homopolymer sodium salt and the balance of kaolin, the components are subjected to dry grinding, granulation, drying and screening to obtain the 45% oxazofen-acarine-abamectin water dispersible granule.

The prepared 45% oxazofen-abamectin water dispersible granule is applied to cotton red spiders. The test site is Anyang city, Henan province. The 45% oxazofen-acarbonitrile-abamectin water dispersible granule has the control effects on cotton red spiders of 95.4%, 97.3% and 95.8% respectively in the dose of 80mg/kg of active ingredients after being applied for 3 days, 14 days and 30 days. The control medicament 20% oxaziclovir hydrochloride suspending agent has the control effects on cotton red spiders of 91.3%, 95.6% and 90.7% respectively in the dose of 80mg/kg of active ingredient after 3 days, 14 days and 30 days. The control medicament 1.8% avermectin emulsifiable concentrate has control effects on cotton red spiders of 83.8%, 75.4% and 43.5% respectively in the dosage of 80mg/kg of active ingredients after 3 days, 14 days and 30 days. After the pyraclostrobin and the abamectin are compounded, the synergistic effect is remarkable, and the quick-acting performance and the lasting period are obviously better than those of a contrast agent.

Example 4 prevention and control of apple Red spider by 55% Azolofen-Chlorfenapyr-Avermectin suspension

According to the formula of 50% of pyraclostrobin, 5% of abamectin, 4% of maleic acid homopolymer sodium salt, 2% of ethylene oxide propylene oxide block copolymer, 0.15% of xanthan gum, 0.4% of organic silicon defoamer, 5% of propylene glycol and the balance of deionized water, the components are uniformly mixed, added into a sand mill and ground to a certain particle size, and subjected to high shear mixing to prepare the 55% pyraclostrobin-abamectin suspending agent.

The 55% oxazofen-abamectin suspending agent is applied to prevention and treatment of apple red spiders. The test site is Shandong province tobacco stage city. The 55% oxazofen-acaricidal nitrile-avermectin suspending agent has the control effects on apple red spiders of 96.8%, 99.7% and 96.3% respectively in the dose of 80mg/kg of active ingredients after 3 days, 14 days and 30 days. The control medicament 20% oxaziclovir hydrochloride suspending agent has the control effects on apple red spiders of 91.8%, 93.7% and 91.2% respectively in the dose of 80mg/kg of active ingredient after 3 days, 14 days and 30 days. The control medicament 1.8% avermectin emulsifiable concentrate has the control effects on apple red spiders of 81.7%, 76.2% and 40.7% respectively in the dosage of 80mg/kg of active ingredients after 3 days, 14 days and 30 days. After the pyraclostrobin and the abamectin are compounded, the synergistic effect is remarkable, and the quick-acting performance and the lasting period are obviously better than those of a contrast agent.

Example 5 control of Tetranychus urticae mite-Mimex Avermectin wettable powder by 50% Azole Ether mite nitrile

According to the formula of 45% of pyraclostrobin, 5% of abamectin, 2.5% of sodium dodecyl sulfate, 8% of sodium naphthalene sulfonate formaldehyde condensate and the balance of kaolin, all the components are mixed and crushed to prepare the 50% pyraclostrobin-acarine-abamectin wettable powder.

The prepared 50% oxadixyl acaricidal nitrile-abamectin wettable powder is applied to prevention and treatment of citrus red spiders. The test site is the northern area of Ningbo city in Zhejiang province. The 50% oxadixyl acaricidal nitrile-abamectin wettable powder has the control effects on citrus red spiders of 96.7%, 97.8% and 93.7% in the dosage of 80mg/kg of active ingredients after being applied for 3 days, 14 days and 30 days. The control medicament 20% oxaziclovir hydrochloride suspending agent has the control effects on citrus red spiders of 90.7%, 95.8% and 91.5% respectively in the dose of 80mg/kg of active ingredient after 3 days, 14 days and 30 days. The control medicament 1.8% avermectin emulsifiable concentrate has control effects on citrus red spiders of 84.2%, 85.3% and 46.7% respectively in the dosage of 80mg/kg of active ingredients after 3 days, 14 days and 30 days. After the pyraclostrobin and the abamectin are compounded, the synergistic effect is remarkable, and the quick-acting performance and the lasting period are obviously better than those of a contrast agent.

Example 6 control of Oriental spider mite with 10% Azolofen-Avermectin emulsifiable concentrate

According to the formula of 9.5% of pyrazofen-mite nitrile, 0.5% of abamectin, 6% of calcium dodecyl benzene sulfonate, 6% of fatty alcohol-polyoxyethylene ether, 8% of NMP and the balance of 150# solvent oil, the components are mixed and stirred uniformly to obtain the 10% pyrazofen-abamectin emulsifiable oil.

The prepared 10% oxazofen-abamectin emulsifiable concentrate is applied to controlling citrus red spiders. The test site is the northern area of Ningbo city in Zhejiang province. The 20% oxazofen mite nitrile-abamectin emulsifiable concentrate has the control effects on citrus red spiders of 95.7%, 98.3% and 93.7% respectively in 3 days, 14 days and 30 days after application under the dosage of 80mg/kg of active ingredients. The control medicament 20% oxaziclovir hydrochloride suspending agent has the control effects on citrus red spiders of 90.7%, 95.8% and 91.5% respectively in the dose of 80mg/kg of active ingredient after 3 days, 14 days and 30 days. The control medicament 1.8% avermectin emulsifiable concentrate has control effects on citrus red spiders of 83.7%, 79.6% and 43.5% respectively in the dosage of 15mg/kg of active ingredient after 3 days, 14 days and 30 days. After the pyraclostrobin and the abamectin are compounded, the synergistic effect is remarkable, and the quick-acting performance and the lasting period are obviously better than those of a contrast agent.

Example 7 prevention and treatment of Tetranychus cinnabarinus by 55% Azole Ether mite nitrile-Avermectin suspension

The prepared 55% oxadixyl-mite nitrile-abamectin suspending agent is applied to prevention and treatment of tetranychus cinnabarinus. The test site is the northern area of Ningbo city in Zhejiang province. The 55% oxadixyl mite nitrile-abamectin suspending agent has the control effects on tetranychus cinnabarinus of 92.7%, 96.1% and 96.9% respectively in the dose of 80mg/kg of active ingredients and 3 days, 14 days and 30 days after the suspending agent is applied. The control medicament 20% oxadixyl mite nitrile suspending agent has the control effects on tetranychus cinnabarinus of 82.5%, 84.8% and 85.1% respectively in the dose of 80mg/kg of active ingredient after 3 days, 14 days and 30 days. The control agent 1.8% avermectin emulsifiable solution has control effects on tetranychus cinnabarinus of 72.4%, 73.2% and 73.6% respectively in the dose of 80mg/kg of active ingredients and 3 days, 14 days and 30 days after the control agent is applied. After the pyraclostrobin and the abamectin are compounded, the synergistic effect is remarkable, and the quick-acting performance and the lasting period are obviously better than those of a contrast agent.

Example 8 control of Tetranychus viennensis by 55% Azole Ether mite nitrile-Avermectin suspension

The prepared 55% oxazofen-abamectin suspending agent is applied to control tetranychus viennensis. The test site is Taian city, Shandong province. The 55% oxazofen mite nitrile abamectin suspending agent has the control effects on the tetranychus viennensis 3 days, 14 days and 30 days after the pesticide is applied under the dosage of 80mg/kg of active ingredients, namely 91.3%, 93.6% and 95.1% respectively. The control medicament 20% oxazoetoxyfen suspending agent has the control effects on the tetranychus viennensis 3 days, 14 days and 30 days after the application of 80mg/kg of active ingredient of 81.7%, 86.3% and 88.9% respectively. The control agent 1.8% avermectin emulsifiable solution has control effect on tetranychus viennensis for 3 days, 14 days and 30 days of pesticide application of 76.8%, 79.2% and 82.9% respectively under the dosage of 80mg/kg of active ingredient. After the pyraclostrobin and the abamectin are compounded, the synergistic effect is remarkable, and the quick-acting performance and the lasting period are obviously better than those of a contrast agent.

Example 9 control of Tetranychus urticae by 55% Azole Ether mite nitrile-Avermectin suspension

The prepared 55% oxazofen-abamectin suspending agent is applied to prevention and control of yellow tea mites. The test site is Hangzhou city in Zhejiang province. The 55% oxazofen mite nitrile abamectin suspending agent has the control effects on the tea yellow mites of 88.7%, 89.6% and 90.2% respectively in the dose of 80mg/kg of active ingredients and 3 days, 14 days and 30 days after the application. The control medicament 20% oxaziclovir hydrochloride suspending agent has the control effects on the tea yellow mites of 86.7%, 88.3% and 89.3% respectively in the dose of 80mg/kg of active ingredient after 3 days, 14 days and 30 days. The control agent 1.8% avermectin emulsifiable solution has control effect on tea yellow mites of 73.8%, 78.7% and 81.5% respectively in the dosage of 80mg/kg of active ingredient after 3 days, 14 days and 30 days. After the pyraclostrobin and the abamectin are compounded, the synergistic effect is remarkable, and the quick-acting performance and the lasting period are obviously better than those of a contrast agent.

Claims

1. A composition characterized by: the composition comprises abamectin and pyraclostrobin chlorfenapyr, and the weight ratio of the abamectin to the pyraclostrobin chlorfenapyr is 1-50: 50-1.

2. The composition of claim 1, wherein: the weight ratio of the abamectin to the pyraclostrobin is 1-30: 30-1.

3. The composition of claim 2, wherein: the weight ratio of the abamectin to the pyraclostrobin is 1-10: 10-1.

4. The composition of claim 2, wherein: the weight ratio of the abamectin to the pyraclostrobin is 1-4: 4-1.

5. An acaricide characterized by: the acaricide comprises the composition as defined in claim 1, and the acaricide comprises 1-90% of the composition by weight percentage, and the balance of acceptable carriers and auxiliary agents in pesticide preparations.

6. An acaricide according to claim 5, characterized in that: the acaricide comprises 5-40% of the composition in percentage by weight, and the balance of carriers and auxiliaries acceptable in pesticide preparations.

7. An acaricide according to claim 5, characterized in that: the acaricide is selected from missible oil, oil suspension, suspending agent, suspoemulsion, wettable powder, water dispersible granule, microcapsule suspending agent or aqueous emulsion.

8. Use of a composition according to claim 1, characterized in that: the composition is used for controlling mite pests.

9. Use of a composition according to claim 8, characterized in that: the composition is used for preventing and treating at least one pest mite selected from citrus red mite, apple red mite, cotton red mite, tetranychus cinnabarinus, two-class spider mite, hawthorn leaf mite and tea yellow mite.

10. Use of a composition according to claim 8, characterized in that: the composition is used for controlling pest mites on citrus, cotton, apples or vegetables.