CN114190387A

CN114190387A - Acaricide composition

Info

Publication number: CN114190387A
Application number: CN202010986967.7A
Authority: CN
Inventors: 赵灵杰; 侯建宇; 胡冬松; 郁季平; 邢家华
Original assignee: Zhejiang Chemical Industry Research Institute Co Ltd; Sinochem Lantian Co Ltd
Current assignee: Zhejiang Chemical Industry Research Institute Co Ltd; Sinochem Lantian Co Ltd
Priority date: 2020-09-18
Filing date: 2020-09-18
Publication date: 2022-03-18

Abstract

The invention discloses an acaricidal composition, oxacillin and propargite are active ingredients, and the mass ratio of oxacillin to propargite in the acaricidal composition is 1-50: 50 to 1. The invention also provides an acaricide containing the acaricidal composition. The acaricidal composition and the acaricide provided by the invention are suitable for preventing and treating common pest mites in crops, such as panonychus citri, tetranychus cinnabarinus, red spider mites on apples, red spider mites on cotton, tetranychus urticae koch and the like. The acaricidal composition and the acaricide provided by the invention are better than single agents in quick-acting property and lasting property, reduce the using dosage and the application cost of pesticides, and are beneficial to environmental protection and comprehensive treatment of agricultural pest mites.

Description

Acaricide composition

Technical Field

The invention belongs to the field of pesticides, and particularly relates to an acaricidal composition.

Background

The agricultural pest mites are small in size, fast in propagation, strong in adaptability and easy to generate resistance, are one of pests which are difficult to control, damage leaves, tender tips, buds and fruits of plants, and can cause leaf fall and even wither after the number of pests is increased sharply.

In order to more effectively control the harmful mites and delay the resistance of plants to acaricides, the acaricides with different action mechanisms are compounded and combined in a better way, so that a more efficient product formula is obtained for controlling the harmful mites.

The pyraclonil has the following structural formula (I), is a novel acrylonitrile acaricide, and is an acaricide which is developed by chemical research institute of Zhejiang province and has independent intellectual property rights (grant No: CN108570008B, grant date: 7/28/2020). The action mechanism is that the harmful mites are converted into hydroxyl compounds in the harmful mites through metabolism, so that the action of succinate dehydrogenase is inhibited, the succinate dehydrogenase further acts on a complex II in an electron transfer chain of a respiratory system, energy synthesis is damaged, the effect of preventing and treating the harmful mites is achieved, the mite-forming, nymph and ovum have high biological activity, and the structural formula is as follows:

propargite belongs to an efficient, low-toxicity and broad-spectrum organic sulfur acaricide, and can kill various harmful mites. The product has effects of contact killing and stomach poisoning, and can stop feeding and reduce oviposition immediately after pest mites contact with effective dose of medicament, and has good preventing and treating effects on adult mites and nymph mites, and has poor ovicidal effect. The product can be widely used for the comprehensive control of resistant mites, and is safe to most natural enemies. Has no systemic and osmotic conduction effect.

Although the oxazofen has higher biological activity on adult mites, nymphs and eggs, the acarid still easily generates resistance to the acarid if being used for a long time, so that the control effect of the acarid is increasingly poor. In order to maintain or even improve the control effect of the pyrazofen-ethyl, delay the generation of the drug resistance of harmful mites and prolong the service life of the medicament, the pyrazofen-ethyl and other miticides are compounded, so that the method is a better method.

Therefore, there is a need for technical improvements to oxazofen, and in particular for further research into oxazofen-containing acaricide compositions.

Disclosure of Invention

The invention aims to provide an acaricide composition containing pyrazofen-ethyl cyanide, which has the advantages of high efficiency, low toxicity and long lasting period, can effectively prevent and treat common pest mites in plants, and is beneficial to comprehensive control of the pest mites.

The invention provides an acaricide composition, which contains pyrazofen and propargite.

According to the acaricide composition provided by the invention, oxazofen and propargite are active ingredients, and the mass ratio of oxazofen to propargite is (1-50): 50-1; preferably, the mass ratio of oxazofen to propargite is 1-30: 30-1; more preferably, the mass ratio of oxazofen to propargite is 1-10: 10 to 1.

The invention also provides an acaricide, which comprises 1.0-90.0% of the acaricide composition by weight, and the balance of acceptable carriers and auxiliary agents in pesticide preparations.

As a preferred embodiment, the acaricide comprises 5.0-40.0% of the acaricide composition by weight, and the rest is acceptable carriers and auxiliary agents in pesticide preparations.

The carrier used in the formulation of the acaricide in the dosage form can be any carrier used in the development and production process of pesticide preparations, and can be a solid carrier or a liquid carrier.

The solid support comprises: minerals, plants, synthetic fillers and inorganic salts. Wherein the minerals include silicates, carbonates, sulfates, and oxides. Preferably, the silicate is at least one selected from kaolin, sepiolite, nacrite, montmorillonite, mica, vermiculite, pyrophyllite and talc; the carbonate is selected from calcium carbonate or dolomite; the sulfate is at least one of ammonium sulfate, sodium sulfate and calcium sulfate; the oxide is selected from at least one of quicklime, magnesium lime and diatomite; the plant is selected from at least one of Mandarin orange residue, corn cob core, testa oryzae, soybean straw powder, tobacco powder, Juglandis shell, and sawdust powder; the synthetic filler is selected from at least one of precipitated calcium carbonate hydrate, precipitated calcium carbonate and white carbon black; the inorganic salt is selected from potassium chloride or sodium chloride.

The liquid carrier includes water and an organic solvent. The organic solvent is at least one selected from aromatic hydrocarbon, chlorinated aliphatic hydrocarbon, alcohol, ether, ketone, special solvent, vegetable oil and methylated vegetable oil. Preferably, the aromatic hydrocarbon is selected from at least one of benzene, xylene, trimethylbenzene and toluene; the chlorinated aliphatic hydrocarbon is selected from at least one of trichloromethane, dichloromethane, chloroform, carbon tetrachloride and polychlorinated ethane; the aliphatic hydrocarbon is at least one selected from petroleum fractions, cyclohexane, light mineral oil and paraffin; the alcohol is selected from at least one of methanol, ethanol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, glycerol and fatty alcohol; the ether is at least one selected from propylene glycol ethyl ether, propylene glycol methyl ether and petroleum ether; the ketone is selected from at least one of acetone, cyclohexanone, isophorone, N-methyl-pyrrolidone and N-octyl pyrrolidone; the special solvent is at least one selected from dimethylformamide, dimethyl sulfoxide, polyethylene glycol and hexanenitrile; the vegetable oil is at least one selected from peanut oil, soybean oil, linseed oil, castor oil and rapeseed oil; the methylated vegetable oil is selected from at least one of vegetable methyl oleate, animal methyl oleate, methyl laurate, methyl stearate, methyl myristate, methyl palmitate, methyl caprylate/caprate, methyl cocoate, and mixed fatty acid methyl ester.

The organic solvent may be used alone, may be used in combination, or may be used in combination with water.

The adjuvant used in the preparation of the acaricide can be the adjuvant commonly used in the industry. Preferably, the adjuvant comprises at least one of a surfactant, an antifoaming agent, a thickening agent, a suspending agent, or an anti-freezing agent.

Preferably, the surfactant is selected from at least one of an emulsifier, a dispersant, and a wetting agent.

The emulsifier includes a nonionic emulsifier and an anionic emulsifier. Preferably, the non-ionic emulsifier is selected from at least one of nonylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, styryl phenyl polyoxyethylene ether, alkylphenol formaldehyde resin polyoxyethylene ether, hydroxyl-terminated polyoxyethylene polyoxypropylene ether, styryl phenol formaldehyde resin polyoxyethylene polyoxypropylene ether and castor oil polyoxyethylene ether; the anionic emulsifier is at least one selected from calcium dodecyl benzene sulfonate, ammonium triphenethyl phenol polyoxyethylene ether phosphate, ammonium nonylphenol polyoxyethylene ether phosphate and ammonium castor oil polyoxyethylene ether phosphate.

Preferably, the dispersing agent is at least one selected from the group consisting of a sodium salt of an acrylic acid homopolymer, a disodium salt of maleic acid, a sodium salt of a formaldehyde condensate of naphthalene sulfonic acid, a rosin block polyoxyethylene ether polyoxypropylene ether sulfonate, a hydroxyl-terminated polyoxyethylene polyoxypropylene ether block copolymer, a triphenylethyl phenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphoric acid and a sodium salt of p-hydroxyphenyl lignosulfonate.

Preferably, the wetting agent is selected from at least one of fatty alcohol-polyoxyethylene ether, naphthalene sulfonate, sodium dodecyl sulfate and alkylphenol resin polyoxyethylene ether sulfate.

Preferably, the defoaming agent is at least one selected from silicone oil, C8-10 fatty alcohol compounds or C10-20 saturated fatty acid compounds.

Preferably, the thickening agent is at least one selected from xanthan gum, magnesium aluminum silicate, sodium alginate, sodium carboxymethylcellulose, acacia, gelatin and polyvinyl alcohol.

Preferably, the suspending agent is selected from at least one of polyvinyl alcohol, sodium alginate, magnesium aluminum silicate and sodium methyl cellulose.

Preferably, the antifreeze is selected from at least one of ethylene glycol, propylene glycol, glycerol or urea.

The acaricide provided by the invention can be prepared into any dosage form suitable for agriculture according to a method commonly used in the field. Preferably, the acaricide is missible oil, oil suspension, suspending agent, suspoemulsion, wettable powder, water dispersible granule, microcapsule suspending agent or aqueous emulsion.

The acaricidal composition and the acaricide provided by the invention are suitable for controlling acarids. Preferably, the acaricidal composition and the acaricide are suitable for the mites for controlling the acaricidal composition to be selected from at least one of panonychus citri, tetranychus cinnabarinus, red spider mites on apples, red spider mites on cotton, tetranychus urticae koch or yellow tea mites.

The acaricidal compositions and acaricides are suitable for controlling mites on plants; preferably, the acaricidal compositions and acaricides are suitable for controlling mites on citrus, cotton, apples, vegetables or flowers.

Compared with the prior art, the acaricidal composition has the following advantages:

(1) the two active ingredients in the composition show excellent synergistic effect in a proportioning range, the acaricidal effect is obviously improved compared with that of a single agent, and the composition also has the characteristics of good quick action and long lasting effect;

(2) the dosage is reduced, the pesticide cost of farmers is reduced, and the acaricide composition is an environment-friendly acaricide composition;

(3) the two active ingredients are reasonably mixed by utilizing different action modes and different action mechanisms of the two active ingredients on pest mites, so that the service life of the acaricidal composition is prolonged, and the generation of drug resistance of the pest mites is delayed.

Detailed Description

The present invention is further illustrated by the following examples, which are not intended to limit the invention to these embodiments. It will be appreciated by those skilled in the art that the present invention encompasses all alternatives, modifications and equivalents as may be included within the scope of the claims.

The material formulation selection in the following examples can be made according to local conditions, without substantial effect on the results. In these examples, all percentages are by weight unless otherwise indicated.

First, indoor toxicity determination

The applicant carried out indoor toxicity test tests on the mixture of the acaricidal composition containing the oxazofen and the propargite. The test refers to the indoor biological determination test criterion of the pesticide (agricultural industry standard NY/T1154.7-2006) and the formulated pesticide biological activity evaluation SOP (pesticide volume), and adopts an immersion method.

The combined effect was calculated using the following method:

theoretical virulence index of the mix (TTI) ═ A virulence index x A content in the mix (%)

+ B virulence index x B content in the mix (%);

co-toxicity coefficient: if the content is more than 120, the synergistic effect is shown; if the content is less than 80, antagonism is indicated; if greater than 80 and less than 120, an additive effect is indicated.

Example 1 Combined synergistic Effect of Metronidazole and propargite on Tetranychus cinnabarinus

TABLE 1 Combined synergistic Effect of acaricidal composition of Metronidazole and propargite on Tetranychus Cinnabarinus

As can be seen from the table 1, the pyrazofen and the propargite have the co-toxicity coefficients of more than 120 and have synergistic effect on tetranychus cinnabarinus within the mass ratio of 1: 50-50: 1. The compounding of the oxazofen and the propargite has rationality and feasibility.

Second, field efficacy test

Example 240% Azolofen Chlorfenapyr propargite suspoemulsion

20% of pyraclonil, 20% of propargite, 4% of triphenylethylphenol polyoxyethylene ether phosphate, 21% of fatty alcohol polyoxyethylene ether, 8% of trimethyl benzene, 0.15% of xanthan gum, 0.3% of an organic silicon defoamer, 5% of propylene glycol and deionized water to make up to 100%. The formula is prepared into the 40% oxadixyl acaricidal nitrile propargite suspoemulsion according to the processing technology of the suspoemulsion.

This example applies to the control of panonychus citri. The test site is a northern area of Nibo city in Zhejiang province, and 40% of oxaziclotrimazole-propargite suspension emulsion is prepared at a dosage of 80mg/kg of effective components. The control effect on panonychus citri 3 days, 14 days and 30 days after the application is 96.2%, 97.3% and 92.8% respectively. The control medicament 20% oxazofen mite nitrile suspending agent has the control effects on panonychus citri for 3 days, 14 days and 30 days respectively of 90.7%, 94.8% and 91.5% under the dosage of 80mg/kg of effective components; the control medicament 730 g/l propargite emulsifiable solution has the control effects on panonychus citri 3 days, 14 days and 30 days after application of 61.8%, 65.2% and 50.4% respectively under the dosage of 200mg/kg of active ingredients.

After the pyraclonil and the propargite are compounded, the synergistic effect is obvious, and the quick-acting performance and the lasting period are obviously better than those of a contrast medicament.

Example 330% Azole Ether mite nitrile propargite emulsifiable concentrate

The composition is prepared from 10% of oxacillin, 20% of propargite, 4% of calcium dodecyl benzene sulfonate, 15% of styryl phenyl polyoxyethylene ether and S-150# to be 100%. The formula is mixed and stirred according to the proportion until the mixture is transparent, and then the 30 percent oxadixyl acaricidal nitrile propargite missible oil can be prepared.

This example applies to cotton spider mites. The test site is Anyang city, Henan province, and 30% of pyraclostrobin nitrile propargite emulsifiable concentrate is prepared under the dosage of 80mg/kg of effective components. The control effect on cotton red spiders 3 days, 14 days and 30 days after the pesticide is 97.4%, 98.6% and 94.3% respectively. The control medicament 20% oxadixyl mite nitrile suspending agent has the control effects on cotton red spiders of 93.2%, 94.7% and 92.1% respectively in 3 days, 14 days and 30 days after the application of 80mg/kg of the effective component, and the control medicament 730 g/L propargite missible oil has the control effects on cotton red spiders of 45.9%, 61.3% and 57.2% respectively in 3 days, 14 days and 30 days after the application of 200mg/kg of the effective component.

Example 425% Oxyether Acarinil propargite aqueous emulsion

5% of pyraclonil, 20% of propargite, 3% of ethylene oxide propylene oxide block copolymer, 0.15% of xanthan gum, 0.4% of organic silicon defoamer, 5% of propylene glycol and deionized water to make up to 100%. The formula is mixed according to the processing technology of the aqueous emulsion, and then the mixture is subjected to high shear to prepare the 25% oxadixyl-acarus-propargite aqueous emulsion.

This example is applied to control apple red spiders. The test place is Shandong province tobacco stage city, and the 25% oxadixyl-acarine-nitrile-propargite aqueous emulsion has the dosage of 100mg/kg of effective components. The control effect on apple red spiders 3 days, 14 days and 30 days after the application is 94.5%, 97.8% and 95.7% respectively. The control medicament 20% oxadixyl mite nitrile suspending agent has the control effects on apple red spiders of 91.2%, 93.6% and 90.4% respectively in 3 days, 14 days and 30 days after the application of the suspending agent under the dosage of 100mg/kg of active ingredients, and the control medicament 730 g/L propargite missible oil has the control effects on apple red spiders of 56.8%, 67.4% and 61.5% respectively in 3 days, 14 days and 30 days after the application of the suspending agent under the dosage of 200mg/kg of the active ingredients.

After the pyrazofen and the propargite are compounded, the synergistic effect is obvious, the quick-acting performance and the lasting period are obviously better than those of a contrast medicament, the medicament cost can be reduced, the medicament efficiency is improved, and the like.

Example 550% Oxyeleofen propargite aqueous emulsion

10% of oxacillin, 40% of propargite, 5% of triphenylethylphenol polyoxyethylene ether, 10% of S-150# solvent oil, 0.15% of xanthan gum, 3% of propylene glycol and deionized water, wherein the balance is up to 100%. The formula is subjected to high-shear mixing according to the processing technology of the aqueous emulsion to prepare the 50% oxadixyl-acarine nitrile-propargite aqueous emulsion.

This example is applied to control Panonychus citri. The test site is a northern area of Nibo city in Zhejiang province, and 50% of the oxaziclotrimazole-propargite aqueous emulsion is prepared at the dosage of 100mg/kg of the effective components. The control effect on panonychus citri 3 days, 14 days and 30 days after the application is respectively 94.3%, 97.2% and 93.8%. The control medicament 20% oxapyrile mite nitrile suspending agent has the control effects on panonychus citri 3 days, 14 days and 30 days after application of 100mg/kg of effective component dose of 90.7%, 95.8% and 91.5% respectively, and the control medicament 730 g/L propargite emulsifiable concentrate has the control effects on panonychus citri 3 days, 14 days and 30 days after application of 200mg/kg of effective component dose of 63.5%, 71.6% and 65.4% respectively.

Example 645% Azolofen propargite suspoemulsion

30% of pyraclonil, 15% of propargite, 5% of maleic acid disodium salt, 2% of fatty alcohol-polyoxyethylene ether, 10% of trimethylbenzene, 0.15% of xanthan gum, 0.4% of an organic silicon defoamer, 5% of propylene glycol and the balance of deionized water to 100%. The formula is prepared into the 45% oxadixyl acaricidal nitrile propargite suspoemulsion according to the processing technology of the suspoemulsion.

The embodiment is applied to the prevention and treatment of strawberry tetranychus urticae. The test site is Shaoxing city in Zhejiang province, and the 45% oxaziridinium-propargite suspension emulsion has the effective component dosage of 100 mg/kg. The control effect on strawberry tetranychus urticae 3 days, 14 days and 30 days after the application is 97.1%, 98.6% and 92.3% respectively. The control medicament 20% oxadixyl mite nitrile suspending agent has the control effects on strawberry tetranychus urticae koch of 92.4%, 94.5% and 86.2% respectively in 3 days, 14 days and 30 days after the application under the dosage of 100mg/kg of the effective components, and the control medicament 730 g/L propargite missible oil has the control effects on strawberry tetranychus urticae koch of 71.0%, 65.1% and 58.7% respectively in 3 days, 14 days and 30 days after the application under the dosage of 200mg/kg of the effective components.

Claims

1. An acaricide composition characterized by: the acaricide composition contains oxacillin and propargite, and the mass ratio of oxacillin to propargite is (1-50): 50 to 1.

2. An acaricide composition according to claim 1, characterized in that: the mass ratio of oxazofen to propargite is 1-30: 30 to 1.

3. An acaricide composition according to claim 1, characterized in that: the mass ratio of oxazofen to propargite is 1-10: 10 to 1.

4. An acaricide characterized by: the acaricide comprises 1.0-90.0% by mass of the acaricidal composition according to claim 1, and the balance of carriers and auxiliaries acceptable in pesticide preparations.

5. An acaricide according to claim 4, characterized in that: the acaricide comprises 5.0-40.0% of the acaricidal composition by mass, and the balance of carriers and auxiliaries acceptable in pesticide preparations.

6. An acaricide according to claim 4 or 5, characterized in that: the acaricide can be missible oil, oil suspension, suspending agent, suspoemulsion, wettable powder, water dispersible granule, microcapsule suspending agent or aqueous emulsion.

7. Use of an acaricidal composition according to claim 1, characterized in that: the acaricidal composition is used for controlling mites.

8. Use of the acaricidal composition according to claim 7, characterized in that: the acarid used for preventing and treating the acarid composite is selected from at least one of panonychus citri, tetranychus cinnabarinus, red spider mites of apples, red spider mites of cotton, tetranychus urticae koch, tetranychus crataegi or yellow tea mites.

9. Use of an acaricidal composition according to claim 1, characterized in that: the acaricidal composition is used for controlling mites on citrus, cotton, apples, vegetables or flowers.