WO2014032362A1

WO2014032362A1 - Use of fungicide composition for preventing rice diseases

Info

Publication number: WO2014032362A1
Application number: PCT/CN2012/084372
Authority: WO
Inventors: 仲汉根
Original assignee: 江苏辉丰农化股份有限公司
Priority date: 2012-09-03
Filing date: 2012-11-09
Publication date: 2014-03-06
Also published as: CN102823609A; CN102823609B

Abstract

A use of a fungicide composition for preventing rice fungal diseases. The composition consists of two active substances and agriculturally acceptable pesticide auxiliary agents. The active component a is epoxiconazole, the active component b is prochloraz or its agriculturally acceptable metal salt compounds, and the weight ratio of epoxiconazole to prochloraz is 0.03 to 65, and preferably 0.05 to 55. The fungicide composition can be used for effectively preventing rice blast diseases, rice sheath blight diseases and rice brown spot diseases. The composition obtained by compounding the component a and the component b has positive effects in aspects of fungal resistance delay, and prevention effect improvement.

Description

Use of fungicide composition for controlling rice diseases

Technical field

The invention relates to the use of a synergistic fungicide composition for controlling rice blast, rice sheath blight and rice husk, which has protective and therapeutic effects on crops and exhibits strong antibacterial activity. And bactericidal activity. The invention belongs to the field of agricultural plant protection.

technical background

Rice blast, rice sheath blight and rice husk are common diseases in rice. These diseases have become the main diseases that restrict rice growth and harvest. The commonly used agents for these diseases are methyl thiophanate, oxytetracycline and Conventional pharmaceuticals such as oxazolone and carbendazim, since these agents have been widely promoted since the 1970s, long-term continuous high-dose use of chemical germicides with a variety or a single mode of action easily affects drug residues, environmental pollution, and Problems such as the development of drug-resistant fungi. Both epoxiconazole and prochloraz are very effective fungicides for agricultural production. Fluconazole is a new type of important triazole-based fluorocide, which not only has good protection, treatment and eradication activity, but also has better systemic activity, which can be quickly absorbed by plants and transmitted to susceptible parts. The disease infestation stops immediately. Since the compound introduces fluoride ions, it has a particularly bactericidal activity against rice fungal diseases, but since the cost of fluoxazole is high, it is difficult to promote it in a large area. Prochloraz is a broad-spectrum fungicide and is the most active of the carbamyl imidazoles. It has good conductivity and is comparable to various diseases caused by ascomycetes, basidiomycetes, and deuteromycetes. The good effect is also good for rice fungal diseases, and the price is moderate, easy to promote, but long-term application, the problem of fungal resistance is also increasingly prominent. For such problems, the currently commonly used method is to screen out mixtures of compounds of different activities to control harmful fungi. By this method, 3⁄4: sexual production can be delayed, the application amount can be reduced, the control effect can be improved, and the prevention cost can be reduced.

Summary of the invention

OBJECTS OF THE INVENTION: In view of the above-mentioned deficiencies, by combining two effective active ingredients such as epoxiconazole and guanidine (or an agriculturally acceptable metal salt compound thereof) and supplemented with agrochemical adjuvants, A fungicide composition having synergistic effect on controlling rice fungal pathogens. The test results show that the synergistic effect of the composition of the present invention is obvious, and the application amount is reduced, the number of application is reduced, and there is no cross-resistance between epoxiconazole and prochloraz.

Prochloraz (English name Prochloraz), chemical name (formula I): propyl -N-[2-

The metal ion of the prochloraz metal salt compound suitable for the present invention may be selected from the first to second exogenous elements of the periodic table, particularly manganese, iron, zinc, copper; and the second main group element, especially Calcium and magnesium ions; and third and fourth main elements, especially aluminum ions. Metal ions may, if appropriate, be present at various valences that they may present. For example, a salt compound of metal ion manganese (such as hydrazine), gp, N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1-H-imidazole is selected. - 1-carboxamide-manganese chloride.

(II)

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Fluodiconazole (English name: epoxiconazole), chemical name (formula III) (2RS, 3RS)-l-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl) )propyl] -1 hydrogen-1,2,4-triazole.

A specific embodiment of the present invention is: a fungicide composition for controlling a fungal disease of rice, comprising the following components: epoxiconazole and prochloraz (or an agriculturally acceptable metal salt thereof) and a conventional pesticide Auxiliary composition.

The prochloraz metal salt compound suitable for the present invention is preferably one of a prochloraz manganese salt, a prolamamine zinc salt, and a prochloraz copper salt.

In the composition of the present invention, the weight ratio of prochloraz to epoxiconazole is 1:50 to 50:1, preferably 1:30 to 30:1.

The mixtures of the present invention are used in the form of compositions which are usually applied together with other adjuvants such as other carriers, surfactants and the like. Suitable additives and carriers may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizer.

A preferred method of applying the compositions of the present invention comprises applying the compositions of the present invention to aerial parts of plants for growth, particularly foliage (foliar application). The frequency of use and the amount applied will depend on the biological and climatic conditions of the pathogen.

The compositions of the present invention can be used in a constant form, or preferably together with additives commonly used in the configuration process, so that these compounds can be formulated in a known manner, for example, as wettable powders, suspending agents, water. Dispersing granules. Depending on the nature of these compositions, application methods such as spraying, misting, spreading, pouring, and the like can be selected depending on the intended purpose and environmental conditions.

As the composition in solid form, the following may be mentioned: Water-dispersible granules (the content of which is generally relatively high, usually between 50% and 90%), usually by a wettable powder type composition The dosage form is prepared by agglomeration in a suitable particle system.

Wettable powders are generally prepared by the method of containing the active ingredients, in addition to the solid carrier, they generally contain 0-7% wetting agent, 3-10% dispersing agent, and if necessary, further 0-10% of one or more other additives. Such as dyes, colorants, penetrants, adhesives or anti-caking agents.

Suspending agents are prepared by the method of obtaining a stable fluid which does not form deposits, which generally contain 10-85% active ingredient, 0.5-45% surfactant, 0-10% appropriate Additives such as dyes, colorants, anti-foaming agents, corrosion inhibitors, stabilizers and penetrants, and binders, the carrier may be water or an organic liquid, the active ingredient is poorly soluble or insoluble in water, and certain solids may be The organic or inorganic salt is dissolved in the liquid to aid in the formation of deposits or as an antifreeze to water.

Various dosage forms can be prepared by known methods: For example, the active ingredient and a filler such as a solvent, a solid carrier, and if necessary, can be mixed and ground with a surfactant.

Solvents suitable for the invention are: aromatic hydrocarbons, preferably having 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, fat Hydrocarbons, such as cyclohexane or paraffin, alcohols and glycols and their ethers and esters, such as ethanol, ethylene glycol, ethylene glycol monomethyl; ketones, such as cyclohexanone, highly polar solvents such as N -Methyl-2 pyrrolidone, dimethyl sulfoxide or dimethylformamide, and vegetable or vegetable oils such as soybean oil. Solid carriers suitable for the present invention, such as for powders and dispersibles, are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay. Highly dispersible silicic acid or highly dispersible adsorbent polymers can also be added for the management of physical properties. Suitable particulate adsorbent supports are porous, such as pumice, bentonite or bentonite; suitable non-adsorbing supports are, for example, calcite or sand. In addition, a large amount of pre-granulated materials of inorganic or organic nature, in particular dolomite, can be used.

According to the chemical properties of the two components of the present invention, suitable surfactants are alkali metal salts of ligninsulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, dibutylnaphthalenesulfonic acid, alkaline earth metal salts and amine salts, alkyl aromatic Sulfonates, alkyl sulfates, mercaptosulfonates, mercaptosulfonates, fatty alcohol sulfates, fatty acids and sulfated fatty alcohol glycol ethers, as well as sulfonated naphthalene and naphthalene derivatives and formaldehyde Condensate, condensate of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, polyoxyethylene octylphenyl ether, ethoxylated isooctylphenol, octylphenol, nonylphenol, mercaptoaryl polyethylene glycol Ether, tributyl benzene polyglycol ether, tristearyl phenyl polyglycol ether, mercapto aryl polyether alcohol, ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensate , ethoxylated polyoxypropylene, lauric acid polyethylene glycol ether acetal, sorbitol ester, lignin sulfite waste liquid and methyl cellulose.

In the composition of the present invention, when two components are co-administered, an effect of superposition (equal to synergy) occurs. The activity of this composition is more significant than the expected expected activity of a single compound, as well as the individual activity of a single compound. The synergistic effect allows for a reduction in the application rate, a quick effect on the effect, and a more durable control effect, which can better control the harmful fungi of the plant by only one or a few applications.

The other characteristics exhibited by the bactericidal composition of the present invention are mainly as follows: 1. Since the chemical composition of the two single agents of the present composition is very different, there is no cross-resistance, and the anti-resistance generated by the two single agents can be delayed. Sexual problems; 2. The composition of the invention is safe and effective against crops. It has been proved by experiments that the bactericidal composition of the invention has stable chemical properties and remarkable synergistic effect, and exhibits obvious synergistic effect and complementary effect on the control object; 3. The dosage is reduced, thereby reducing the cost and reducing the environmental pollution. In order to make the objects, technical solutions and advantages of the present invention more comprehensible, the present invention will be further described in detail below with reference to the embodiments. It should be understood that the specific embodiments described herein are intended to be illustrative of the invention, and are not to be construed as limiting the invention, any modifications, equivalents, Within the scope of protection of the present invention.

The percentages in all formulations in the following examples are percentages by weight. Addition of various preparations of the composition of the present invention The processes are all prior art and can vary depending on the situation.

First, the dosage form preparation example

(4) Processing and examples of water emulsion

The active ingredients a and b, the solvent and the auxiliary agent are uniformly mixed under mechanical stirring, then the emulsifier and the stabilizer are uniformly stirred, and finally water is added, and the mixture is stirred at 10 to 30,000 rpm for 10-30 to make it Become a homogeneous milky product.

Example 1: 30% prochloraz fluorocyclazole water emulsion

5% prochloraz, epoxiconazole 25% polyoxyethylene block copolymer 4%, 2% propylene glycol, xanthan gum, _30/0, polyisobutylene anhydride - 4% polyethylene glycol copolymer, a silicone Defoamer 2%, 7 make up to 100%.

In the case of Example 1, the present example can also be prepared by substituting prochlorazin, prochlorazin or prodamine zinc salt for prochloraz.

Cat Case 2: 30% Prochloraz & Fluodiazole Water Emulsion

Microfiber 25%, flucyclazole 5%, N-dodecylpyrrolidone 3%, castor oil polyoxyethylene ether 2%, glycerol 2%, polyvinyl alcohol 3%, sodium benzoate 3%, isooctanol 2%, zK complements to 100%.

In Example 2, this example can also be prepared by substituting prochloraz, a prochlorazinium salt, or a prolamamine zinc salt for prochloraz.

(2) Processing and examples of suspending agents

The active ingredients a and b, the dispersing agent, the wetting agent, the thickening, the water and the like are uniformly mixed according to the formula, and after the sanding and/or high-speed shearing, the semi-finished product is obtained, and the water is uniformly mixed after the analysis. Filter to get the finished product.

Example 3: 42% prochlorazin copper salt, fluorocyclovir

Prochlorazin copper salt 40%, epoxiconazole 2%, sodium lignosulfonate 8%, white carbon black 2%, ethylene glycol 5%, xanthan gum 2%, water to 100%.

In Example 3, this example can also be prepared by replacing prochlorazinyl salt with prochloraz, prochloraz, and glycerin salt.

Town example 4: 42% fresh salt salt · Fluorine ring float agent

Prochlorazin copper salt 2%, flucyclazole 40%, white carbon black 2%, monthly fatty alcohol polyoxyethylene ether phosphate 6%, benzamidine 3%, glycerol 7%, 7] C complement To 100%.

- In Example 4, this example can also be prepared by substituting prochloraz, prochloraz, and prochlorazin in place of prochlorazin.

(1) Processing and examples of water-dispersible granules The active ingredients 3 and 1), the auxiliary agent and the filler are uniformly mixed according to the formula, and are pulverized into a wettable powder by a jet stream, and then added with a certain amount of water to be mixed and extruded, and then sieved to obtain a water-dispersible granule. product.

Example 5: 75% prochloraz manganese salt · Fluconazole water dispersible granules

Prochlorazamine manganese salt 2%, epoxiconazole 73%, seaweed meal 4%, methylnaphthalene sulfonate formaldehyde condensate 2%, thioxa 2%, organic silicone 2%, bentonite supplement to 100% o

In Example 5, this example can also be prepared by using prochlorazin copper salt, prochlorazin or prochloraz as a substitute for prochloraz manganese salt.

Example 6: 80% prochloraz zinc salt · Fluconazole water dispersible granules

Prochloraz zinc salt 78%, epoxiconazole 2%, sodium lignosulfonate 4%, carboxymethyl lake fi l°/. , sodium dodecyl sulfonate 2%, xanthan gum 4%, attapulgite to 100%.

In Example 6, this example can also be prepared by using prochlorazin copper salt, prochlorazin or prochloraz as a substitute for prochlorazin.

(3) Processing and examples of wettable powders

The active ingredient is thoroughly mixed with b, various auxiliaries and fillers, and pulverized by an ultrafine pulverizer to obtain a "hidden agent".

Example 7: S5% prochlorazin copper salt · Fluconazole wettable powder

Amic brain salt 78%, flucyclazole 7%, lignin sulfonate with 6%, bentonite 3%, polyoxyethylene octyl 3⁄4 ether 4%, attapulgite to make up to 100%.

In Example 7, this example can also be prepared by replacing the prochloraz copper wire with prochloraz, prochloraz or imipenem.

Hungry case 8: 50% prochloraz copper salt · Fluconazole wet leg

Prochlorazin copper salt 25%, anthracycline 25%, lignin sulfonate 4%, white carbon black 8%, dodecylbenzene sulfonate 3%, attapulgite to make up to 100%.

In Example 8, this example can also be prepared by replacing the prochlorazin copper salt with prochloraz, manganese or myramine salt.

Example 9: 55% of fresh salt and salt · epoxiconazole wettable powder

Prochloraz manganese salt 5%, 50% epoxiconazole, polyoxyethylene octylphenyl ether 6 ⁰ A 7% sodium lignosulfonate, 15% silica, silicon made up to pin%.

In Example 9, this example can also be prepared by substituting proguanamine copper salt, cilostatin or prochloraz in place of prochloraz manganese salt. (1) Indoor biological activity determination Co-toxicity coefficient of the invention

The control effect is converted into the probability value (y), the drug concentration (ug/ml) is converted into the logarithm value (X), the virulence equation is calculated by the least squares method, and the neutral concentration EC50 is suppressed. The virulence index of the drug is calculated by the method of Sun Yunpei. Co-toxicity coefficient (CTC). The virulence test results are shown in Table 1.

Measured virulence index (ATI) = (standard drug EC50/test drug EC50)*100

Theoretical virulence index (TTI) = A drug virulence index * A quantity of A in the mixture + β drug virulence index * Amount of Β in the mixture

Co-toxicity coefficient (CTC) = [mixture measured virulence index (ATI) / mixed theory virulence index (TTI)] * 100 CTC ^ SO, the composition showed antagonism, 80 < CTC < 120, composition performance For additive effect, CTC

^120, the composition appears to be synergistic.

1. Indoor biological activity determination The co-toxicity coefficient of the composition of the invention for rice blast disease test object: 7] C rice blast fungus (taken from the field and isolated and purified)

Table 1 Analysis of the results of the determination of the strength of rice scorpion virus by the combination of prochloraz and epoxiconazole and their different ratios

The results (Table 1) indicate that prochloraz and epoxiconazole have synergistic effects on the control of rice blast in the ratio of 50:1~1:50, especially between 30:1~1:30. The synergistic effect is significant, and the co-toxicity coefficient is above 1-50, indicating that the synergistic effect of prochloraz and epoxiconazole on rice blast is obvious.

2. Determination of the co-toxicity coefficient of the composition of the present invention for rice sheath blight by laboratory bioactivity assay object: 7j f Xiezhan pathogen

Table 2 Analysis of the results of the determination of prochloraz and epoxiconazole and their different ratios against rice strain

The results of the determination (Table 2) indicate that prochloraz and epoxiconazole have synergistic effects on the control of rice sheath blight at a ratio of 50:1 to 1:50, especially at 30:1 to 1:30. Among them, the synergistic effect is particularly significant, and the co-toxicity coefficient is above 165.

3. Indoor biological activity determination The co-toxicity coefficient of the composition of the present invention on rice leaf spot disease Table 3 Analysis of the virulence determination results of the different ratios of the fresh amine and the fluorine ring

The results of the determination (Table 3) show that promethamine and fluororing have a synergistic effect on the control of rice leaf spot in the ratio of 50:1~1:50, especially at 30:1~1:30. In addition, the synergy effect is particularly significant, and the co-toxicity coefficient is above 135.

(ii) Field efficacy test (using a parallel test method to verify the composition of the invention) Field trials and control effects of rice blast, sheath blight and flax spot

ο 31 Method: In the early stage of the disease, immediately spray, and apply the second time after 7 days, each level

Each of the 4 cells is processed, and each cell is 20 square meters. The incidence of the disease was investigated 10 days after the first dose of the drug. Each plot was nicknamed 5 points, and 5 rice plants were investigated at each point. The whole rice was investigated. The area of lesions per leaf or leaf sheath accounted for the percentage of leaf area and graded. The calculation of the condition refers to the prevention and treatment effect.

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Anticipated effect (%) = X+Y XY/100 (hence, X, Υ is a single-agent control)

Grading standards:

No lesions;

The number of leaf lesions is less than 5, and the length is less than lcm;

Leaf lesions 6 '10, part of the lesion length is greater than 1cm;

There were 1 '1 25 leaf lesions, some of which were connected into pieces, and the area of lesions accounted for 10 25% of the leaf area; 7th level: more than 26 leaf lesions, the lesions were connected into pieces, and the area of lesions accounted for the leaf area. 26 50%; Grade 9: The lesions are connected into pieces, and the area of the lesions accounts for more than 50% of the leaf area or the whole leaves die.

(1) Field efficacy test analysis of the composition of the invention on rice blast

Table 4 Results of field control trials of prochloraz and epoxicone in combination with rice blast

30% prochloraz fluoxazole water emulsion

150 2.88 3.46 92.5 (Mimiline · Fluorine ring P sitting ratio = 25:5)

25% prochloraz emulsifiable concentrate 143 2.69 17.41 59.6 Example 3 12.5% epoxiconazole suspending agent 7 2.79 39.41 11.8 Expected control effect after mixing ― ― ― 64.4

42% prochlorazin copper salt · epoxiconazole suspension

150 2.72 4.97 88.6 (Prochlorin copper salt: epoxiconazole = 40:2)

25% prochloraz emulsifiable concentrate 7 2.85 43.55 4.6

12.5% epoxiconazole suspension 143 2.98 9.02 81.1 Example 4 Expected control after mixing the two 82.0

42% prochlorazin copper salt · epoxiconazole suspension

150 2.83 3.26 92.8 (Prochlorin copper salt: epoxiconazole = 2:40)

25% prochloraz cream 4 2.76 42.75 3.3

12.5% epoxiconazole suspending agent 146 3.04 8.42 82.7 Example 5 Anti-effect expected after mixing the two ― ― ― 83.3

75% prochloraz manganese salt · flucyclazole water dispersible granules

150 2.93 3.61 92.3 (Mimiline manganese salt: epoxiconazole = 2:73)

25% prochloraz emulsifiable concentrate 146 3.0 18.40 61.7

12.5% epoxiconazole suspension 4 2.87 42.66 7.2 Example 6 Expected control after mixing the two 64.46

80% prochloraz zinc salt · flucyclazole water dispersible granules

150 2.91 4.80 89.7 (Mimiline manganese salt: epoxiconazole = 78:2)

25% prochloraz emulsifiable concentrate 137 2.79 19.93 55.4

12.5% epoxiconazole suspension 13 2.85 30.81 32.5 Example 7 Expected control after mixing the two 69.9

85% prochloraz copper salt · flucyclazole wettable powder

150 3.02 4.89 89.9 (Prochlorin copper salt: epoxiconazole = 78:7)

25% prochloraz emulsifiable concentrate 75 2.68 28.85 32.8

12.5% epoxiconazole suspension 75 2.89 24.95 46.1 Example 8

Expected effect after mixing the two - ― 63.8

50% prochlorazin copper salt epoxiconazole wettable powder 150 2.75 2.82 93.6 (Prochlorin copper salt: epoxiconazole = 25:25)

25% prochloraz emulsifiable concentrate 13 2.87 40.22 12.5

12.5% epoxiconazole suspension 137 2.93 11.22 76.1 Example 9 Anti-effects expected after mixing - 79.1

55% prochloraz manganese salt · epoxiconazole wettable powder

150 2.85 4.47 90.2 (Mimiline manganese salt: epoxiconazole = 5:50)

Clear water pair

― ― 2.93 46.93

Photo (CK)

The results of the determination (Table 4) indicate that the combination of prochloraz or prochloraz, manganese salt, prochlorazin and flucyclazole significantly improved the control of rice blast, indicating that the two K-inch rice disease has a significant synergistic effect.

(2) Field efficacy test analysis of the composition of the present invention on rice sheath blight

Table 5 Results of field control trials of prochloraz and epoxiconazole against rice sheath blight

Dosage After the second drug, 11 days before the drug

No. Treatment agent ( a.i.g/ disease prevention effect disease index

Ha) Index (%)

25% prochloraz cream 25 2.81 33.25 12.3

12.5% epoxiconazole suspension 125 2.74 8.73 76.4 Example 1 Anti-effects expected after mixing the two 79.3

30% prochloraz · · flucyclazole water emulsion

150 3.06 3.01 92.7 (mimiline 'epoxicycline ratio = 5:25)

25% prochloraz cream 125 2.92 19.86 49.6

12.5% epoxiconazole suspending agent 25 2.85 24.19 37.1 Example 2 Expected control after mixing of the two 68.3

30% prochloraz fluoxazole water emulsion

150 2.81 4.89 87.1 (Mimiline · Fluorine ring Ρ sitting ratio = 25:5)

25% prochloraz cream 143 2.76 18.17 51.2 Example 3 12.5% epoxiconazole suspension 7 2.84 33.68 12.1 Expected control after mixing 57.1

42°/. Prochlorazin copper salt · epoxiconazole suspension

150 2.88 4.43 88.6 (Prochlorin copper salt: epoxiconazole = 40:2) 25% prochloraz emulsifiable concentrate 7 2.85 36.34 5.5

12.5% epoxiconazole suspending agent 143 2.79 5.57 85.2 Example 4 Anti-effects expected after mixing the two 84.3

42% prochlorazin copper salt · epoxiconazole suspension

150 2.89 2.53 93.5 (prochlorazide copper salt: epoxiconazole = 2:40)

25% prochloraz cream 4 2.91 37.97 3.3

12.5% epoxiconazole suspension 146 3.12 5.43 87.1 Example 5 Expected control after mixing the two ― ― ― 87.5

75% prochloraz manganese salt · flucyclazole water dispersible granules

150 3.03 3.11 92.4 (Mimiline manganese salt: epoxiconazole = 2:73)

25% prochloraz emulsifiable concentrate 146 2.76 16.95 54.5

12.5% flucyclazole suspension 4 3.17 38.97 8.9 Example 6 Expected control after mixing the two 58.5

80% prochloraz zinc salt · flucyclazole water dispersible granules

150 2.99 4.76 88.2 (Mimiline manganese salt: epoxiconazole = 78:2)

25% prochloraz emulsifiable concentrate 137 3.19 22.64 47.4

12.5% epoxiconazole suspending agent 13 3.05 35.48 13.8 Example 7 Anti-effect expected after mixing the two ― ― ― 54.7

85°/. Prochlorazin copper salt · epoxiconazole wettable powder

150 2.89 4.89 89.9 (Prochlorin copper salt: epoxiconazole = 78:7)

25% prochloraz cream 75 3.02 28.20 30.8

12.5% epoxiconazole suspension 75 2.68 16.96 53.1 Example 8 Expected control after mixing the two 67.5

50% prochlorazin copper salt · epoxiconazole wettable powder

150 2.89 4.21 89.2 (prochlorazide copper salt: epoxiconazole = 25:25)

25% prochloraz emulsifiable concentrate 13 2.82 35.58 6.5

12.5% epoxiconazole suspending agent 137 2.75 6.98 81.2 Example 9 Expected control effect after mixing ― 82.4

55°/. Promethamine manganese salt · epoxiconazole wettable powder

150 3.11 3.69 91.2 (Mimiline manganese salt: epoxiconazole = 5: 50)

Clear water control 3.06 41.29 The results (Table 5) indicate that the combination of prochloraz or prochloraz, manganese salt, prochlorazin and flucyclazole significantly improved the control of rice sheath blight, indicating that the two There is a significant synergistic effect of Κ Κ 纹。.

(3) Analysis of the field efficacy test of the composition of the invention on rice leaf spot of rice

Table 6 Results of field control trials of prochloraz and epoxiconazole in combination with rice husk spot No. Treatment agent used drug After drug 21 days after the second drug

(a.i. pre-disease condition disease control g/ha) index index (%) Example 1 25% prochloraz cream 25 3.22 26.08 14.1

12.5% epoxiconazole suspension 125 3.51 8.21 75.2 Expected control after mixing the two 78.7

30% prochloraz & epoxiconazole water emulsion 150 3.25 2.82 90.8 (prochlorazin · epoxizole ratio = 5:25)

Example 2 25% prochloraz cream 125 3.12 15.53 47.2

12.5% epoxiconazole suspension 25 3.45 20.56 36.8 Expected control after mixing 66.6

30% prochloraz & epoxiconazole water emulsion 150 3.52 3.68 88.9 (prochloraz & epoxizole ratio = 25:5)

25% prochloraz cream 143 3.52 15.73 52.6 Example 3 12.5% epoxiconazole suspending agent 7 3.52 27.65 16.7 Expected control after mixing - ― 60.5

42% prochlorazin copper salt · epoxiconazole suspension agent 150 3.61 4.60 86.5 (prochlorazamine copper salt: epoxiconazole = 40:2)

Example 4 25% prochloraz cream 7 3.42 30.86 4.3

12.5% epoxiconazole suspension 143 3.71 6.26 82.1 Expected control after mixing the two 82.9

42% prochlorazin copper salt · epoxiconazole suspension agent 150 3.29 3.38 89.1 (prochlorazamine copper salt: epoxiconazole = 2:40)

Example 5 25% prochloraz cream 4 2.98 27.23 3.1

12.5% epoxiconazole suspension 146 3.41 5.56 82.7 Expected control after mixing - ― 83.2 75% prochloraz manganese salt · gas cyclic azole water dispersible granule 150 3,12 3.71 874 (B fresh amine manganese salt: epoxiconazole = 2:73)

Example 6 25% prochloraz emulsifiable concentrate 146 3.71 14.94 57.3

12.5% epoxiconazole suspending agent 4 3.28 27,77 10.2 Expected control after mixing both 61,7

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Example 7 25% 1 «Fresh amine cream 137 3.42 16,32 49.4

12.5% epoxiconazole suspension 13 3,18 25.55 14,8 Anti-effects expected after mixing in both warehouses 56,9

85% prochlorazin copper salt "aerobicazole wettable powder 150 329 3,75 87,9 (B fresh amine copper salt: epoxiconazole = 78:7)

Example 8 25% prochloraz cream 75 3.42 23.44 27.3

12,5% fluorocycloazole suspension 75 3,18 14.39 52 Expected control after mixing. 65,1

50% guanidine salt 氟 epoxiconazole wettable powder 150 3,29 3,69 88,1 (imitian copper salt: gas cyclic azole = 25:25)

Example 9 25% 1 «Fresh amine emulsifiable concentrate 13 2.89 25 Λ 2 7.8

12.5% epoxiconazole suspending agent 137 3.71 9.79 72 Expected control after mixing of both 74,2

55% prochloraz and manganese salt "aerobicazole wettable powder 150 352 458 862 (B fresh amine manganese salt: epoxiconazole = 5:50)

Clear water pair 3,36 31.68

Photo (CK)

The results of the determination (Table 6) indicate that the combination of prochloraz or prochloraz, manganese salt, prochlorazin, and flucyclazole significantly improved the control effect against rice mayard. There is a significant synergistic effect on the complexation of flax.

Claims

The use of a synergistic fungicidal composition for controlling rice blast, rice sheath blight and rice husk disease fungi, characterized in that the composition comprises two active components, wherein the active Component a is prochloraz or an agriculturally acceptable metal salt compound, and active component b is epoxiconazole, and the weight ratio between the two components is 1:50 to 50:1.

The use according to claim 1, characterized in that the prochloraz metal salt compound is selected from the group consisting of a prochloraz manganese salt, a prolamamine zinc salt or a prochloraz copper salt.

The use according to Claim 1, characterized in that the weight ratio of the active component a to the active component b in the composition is from 1:30 to 30:1.

The use according to claim 1, characterized in that the prochloraz metal salt compound is a prochloraz copper salt.

The use according to claim 2, characterized in that the prochloraz metal salt compound is a prochloraz manganese salt.

The use according to claim 2, characterized in that the prochloraz metal salt compound is a prolamamine zinc salt.

The use according to Claim 3, characterized in that the weight ratio of the active ingredient prochlorazin copper salt to the active ingredient epoxiconazole is from 1:30 to 30:1.

The use according to Claim 3, characterized in that the weight ratio of the active ingredient prochloraz and the active ingredient epoxiconazole is from 1:30 to 30:1.

The use according to Claim 3, characterized in that the weight ratio of the active ingredient prochlorazin salt to the active ingredient epoxiconazole is from 1:30 to 30:1.

0. Use according to claim 1, characterized in that the rice disease is rice blast. Use according to claim 1, characterized in that the rice disease is rice sheath blight. 2. Use according to claim 1, characterized in that the rice disease is rice flax.