CN104604920A - Sterilization composition containing prochloraz nantokite and triazole bactericide as well as application thereof - Google Patents
Sterilization composition containing prochloraz nantokite and triazole bactericide as well as application thereof Download PDFInfo
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- CAWGOZKIZLWQHE-UHFFFAOYSA-N CCCC(CC[n]1ncnc1)c(c(Cl)c1)ccc1Cl Chemical compound CCCC(CC[n]1ncnc1)c(c(Cl)c1)ccc1Cl CAWGOZKIZLWQHE-UHFFFAOYSA-N 0.000 description 1
- STMIIPIFODONDC-UHFFFAOYSA-N CCCCC(C[n]1ncnc1)(c(ccc(Cl)c1)c1Cl)O Chemical compound CCCCC(C[n]1ncnc1)(c(ccc(Cl)c1)c1Cl)O STMIIPIFODONDC-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention discloses a sterilization composition containing prochloraz nantokite and triazole bactericide as well as an application thereof, which belong to the technical field of pesticide. The sterilization composition contains prochloraz nantokite (A) and one (B)of the following triazole bactericides; propiconazole, difenoconazole, triticonazole, cyproconazole, epoxiconazole, fluquinconazole, flutriafol, hexaconazole, ipconazole, metconazole, myclobutanil, penconazole, prothioconazole, tebuconazole and triadimenol, wherein weight ratio of A to B is 1-70: 1-60. The sterilization composition can be used for preventing and controlling fungous diseases such as cereal, fruit or vegetable crops, The composition has high cooperative synergism effect, and can overcome and delay the resistance of pathogen as well as enlarge a controlling spectrum, the sterilization speed is fast, persistent period is long, application cost is reduced, and the controlling effect of the composition is obviously better than that of a single dose.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition and uses thereof, especially a kind of with the one (B) in prochloraz nantokite (A) and following triazole bactericidal agent: propiconazole, Difenoconazole, triticonazole, Cyproconazole, epoxiconazole, Fluquinconazole, Flutriafol, own azoles alcohol, kind bacterium azoles, metconazole, nitrile bacterium azoles, penconazole, prothioconazoles, Tebuconazole, Triadimenol are bactericidal composition and the application thereof of main active.
Background technology
Prochloraz nantokite (prochloraz), chemical name: N-propyl group-N-[2-(2,4,6-Trichlorophenoxy) ethyl]-1H imidazoles-1-formamide-copper chloride, the following (CuR of structural formula
ncan be CuCl
2, CuSO
4deng):
Prochloraz nantokite is the slaine derivative compound of Prochloraz, a kind of wide spectrum, low toxicity bactericide, to the disease that various crop is caused by sac fungi and imperfect fungus, there is obvious preventive effect, also can be mixed with most of bactericide, bactericide, Insecticides (tech) & Herbicides (tech), all there is good control efficiency.Prochloraz nantokite has Uptake and translocation, prevention & protection, the multiple actions such as treatment, to field crop, fruit and vegetable, multiple diseases on turf and ornamental plants has treatment and eradicant action, the conventional use water prevention rice bakanae disease, rice blast, false smut, citrus anthracnose, blossom-end rot, penicilliosis, green mould, banana anthracnose, leaf spot, mango anthracnose, leaf spot of peanut, capsicum, eggplant, muskmelon, the vegetables anthracnose such as tomato, Strawberry anthracnose, sclerotinia rot of colza, leaf spot, mushroom brown spot, apple anthracnose, pear scab etc., prochloraz nantokite can be widely used in the fields such as fruit freshness preserving.Extensive gradually along with Prochloraz application, prochloraz nantokite usage amount also will increase year by year, and in order to further expanding prevention scope, alleviate the problems such as resistance, composite exploitation has very important significance.
Propiconazole (Propiconazole), chemical name: 1-[2-(2,4-dichlorophenyl)-4-propyl group-DOX-2-methyl]-1 hydrogen-1,2,4-triazole, structural formula is as follows:
Propiconazole is triazole type systemic fungicide.There is protection and therapeutic action, belong to the biosynthetic inhibitor of ergosterol.Ergosterol plays an important role in the formation of fungal cell membrane, and propiconazole is by interference C
14-demethylation and hinder the biosynthesis of ergosterol in fungus body, thus destroy the growth and breeding of fungi, play protection and therapeutic action.Propiconazole is except invalid to phycomycete disease, the multiple diseases caused on cereal crops, veterinary antibiotics and ornamental plants Saccharomyces, Basidiomycotina, Dendrochium fungi is effective, particularly to root rotof flax, powdery mildew, bakanae disease of rice, various rust, leaf spot, glume blight, net smut etc., there is good control efficiency, but invalid to ovum mattress disease.The longevity of residure reaches 3 ~ 5 weeks.It is reported in addition, for wheat rust increase yield significantly.In addition, also can be used for the multiple diseases such as powdery mildew of cucumber, bean powdery mildew, tomato powdery mildew, apple mildew, scab, mould corruption material disease and peanut, soybean, coffee.
Difenoconazole (Difenoconazole), chemical name: suitable, the chloro-4-of trans-3-[4-methyl-2-(1H-1,2,4-triazol-1-yl methyl)-1,3-bis-Evil pentane-2-base] phenyl 4-chlorphenyl ether, structural formula is as follows:
Difenoconazole belongs to triazole bactericidal agent, and having protection, treatment and systemic activity, is sterol demethylation inhibitors, and the biosynthesis of T suppression cell wall sterol stops the growth of fungi.Fungicidal spectrum is wide, and leaf surface treatment or seed treatment can improve output and the guaranteed quality of crop.To Ascomycetes, Basidiomycetes and the imperfect fungus comprising Alternaria, Ascochyta, the mould genus of tail spore, Colletotrichum, ball Cuo Pseudomonas, Phoma, Ramularia, Septoria, Venturia, Erysiphaceae, Uredinales and some Seedborne pathogen have lasting protection and therapeutic action.Simultaneously to cercospora leaf spot of sugar beet, wheat glume blotch, leaf blight, rust and by several cause a disease microbial mildew, apple scab, powdery mildew, grape powdery mildew, target, leaf spot of peanut, net blotch etc. all have good result for the treatment of.Also fine to bitter rot or anthracnose of grape, white rot effect.
Triticonazole (Triticonazole), chemical name: (E)-5-(4-chlorine benzal)-2,2-dimethyl-1-(1H-1,2,4-triazol-1-yl methyl) cyclopentanol, structure is as follows:
The triticonazole mechanism of action is the precursor of sterol in Antifungi-the demethylation effect on lanosterol or the liquor-saturated l4 position of 24-methylene dihydro Mi hair, i.e. demethylation inhibitors (DMIs).Not only there is good systemic activity, excellent protection, treat and root out activity, and the lasting period is long.Mainly be used as seed treatment, also can spray by cauline leaf, the lasting period reaches 4 ~ 6 weeks.Mainly be applicable to cereal crop, legume, fruit diseases, have special efficacy to seed-borne disease.Under recommended dose to crop safety, without poisoning.The disease such as powdery mildew, rust, apple scab, the net blotch etc. that cause for sickle spore (mould) genus, Puccinia, wheat class nuclear cavity Pseudomonas, Ustilago, Tilletia, Erysiphe, circle nuclear cavity bacteria, Septoria, Ramularia etc. have good control efficiency.
Cyproconazole (cyproconazole), chemical name 2-(4-chlorphenyl)-3-cyclopropyl-1-(1,2,4-triazol-1-yl) fourth-2-alcohol, chemical structural formula is as follows:
Cyproconazole is racemic mixture, and sterling is colourless crystallization body, and this medicine is steroids demethylation (ergosterol biosynthesis) inhibitor, can be partially absorbed and mainly shift to top by plant is vegetative rapidly.Cyproconazole has prevention, treatment, systemic action, main as cauline leaf process, suitable for crop comprises wheat, barley, oat, rye, corn, Chinese sorghum, beet, apple, pears, apple, coffee, lawn etc., can be used for preventing and treating Erysiphe, Puccinia, beak is full to be belonged to, nuclear cavity Pseudomonas, the disease caused is as wheat powdery mildew, loose smut of wheat, wheat sharp eyespot, wheat snow mold, take-all, the bunt of wheat, barley leaf blotch, maize head smut, stem rot of beet, coffee rust, alternaria leaf spot of apple, pear scab etc.Cyproconazole is the triazole bactericidal agent product developed in recent years, but germ produces the speed of resistance to it, and use can cause poisoning phenomenon to crops continuously, and therefore the composite exploitation of Cyproconazole and application technology have great importance.
Epoxiconazole (Epoxiconazol), chemical name: (2RS, 3SR)-1-[3-(2-chlorphenyl)-2,3-oxo bridge-2-(4-fluorophenyl) propyl group]-1H-1,2,4-triazole, molecular formula: C
17h
13clFN
3o, chemical structural formula:
Epoxiconazole, fusing point: 136.2 DEG C; Density: 1.384g/mL (25 DEG C); Vapour pressure: <1.0 × 10
-5pa (25 DEG C); Solvability (20 DEG C/mg/litre): water 6.63, acetone 14.4, carrene 29.1.Stability: be not hydrolyzed for 12 days under pH value is 7 and pH value is the condition of 9.Epoxiconazole is a kind of interior absorption triazole bactericidal agent, its active component epoxiconazole suppresses the synthesis of germ ergosterol, hinder the formation of germ cell wall, and epoxiconazole molecule has powerful compatibility to a kind of fungal enzyme (14-dencthylase), compared with bactericide known at present, can more effectively suppress germ fungal pathogens.Epoxiconazole can improve the chitinase activity of crop, causes the contraction of fungi haustorium, and suppress germ to invade, this is epoxiconazole unique characteristic in all triazole type products.Good preventive effect is had to the disease such as anthracnose, white rot on leaf spot, damping off, powdery mildew, rust and the grape on the crops such as banana, green onion garlic, celery, Kidney bean, melon, asparagus, peanut, beet, paddy rice, Wheat And Barley.
Fluquinconazole (Fluquinconazole), the fluoro-2-of 3-(2,4-dichlorophenyl)-6-(1H-1,2,4-triazol-1-yl) quinazoline-4-(3H)-one, chemical structural formula is as follows:
Fluquinconazole is a kind of quinazoline ditosylate salt bactericide with triazole structure, have good inhibitory action to the biosynthesis of ergosterol, foliage-spray can be prevented and treated by the important disease on the fungus-caused multiple broad-leaved of Ascomycetes, deuteromycetes and Basidiomycetes and cereal crop.Excellent preventive effect is had to the Major Diseases apple scab on apple and apple mildew.Can also prevent and treat simultaneously other pathogens as powdery mildew, chain sclerotinia sclerotiorum, the mould genus of tail spore, Phoma, Septoria, bury the fungus-caused plant diseases such as Sclerotinia, Puccinia, hunchbacked spore Rust and Sclerotinia.Have protection, treatment and interior absorption concurrently, and very safe to crop.
Flutriafol (Flutriafol), the triazole bactericidal agent of Syngenta Co., Ltd's exploitation.Chemical name: (RS)-2,4'-bis-chloro-a-(1H-1,2,4-triazole-1-methyl) benzohydrol.Structural formula is as follows:
Flutriafol is a kind of triazole bactericidal agent; belong to sterol demethylation inhibitors; effectively can suppress the biosynthesis of ergosterol; fungal cell wall can be caused to break; to basidiomycetes and the microbial many diseases of ascus, there is good protection and therapeutic action; and have certain fumigation action concurrently, but to oomycetes and bacterium non-activity.Former medicine is clear crystal, stable in acid, alkali, heat and moist environment, and have the bactericidal activity of wide spectrum, interior absorption is strong, to top conduction in plant corpus, has protection and therapeutic action to disease.Cereal crop (mainly comprising wheat, barley, rye, corn etc.) cauline leaf, fringe portion disease and soil-borne disease and seed-borne disease can be prevented and treated, as powdery mildew, rust, moire disease, leaf spot, net blotch, smut etc.Meanwhile, also soil and seed-borne disease can be prevented and treated.Have special efficacy to cereal powdery mildew, especially have eradicant action to the sorus of powdery mildew of wheat and barley, after medication 5 ~ 10 days, the scab originally formed can disappear.Under recommended dose, to crop safety, without key phenomenon, but single use, and resistance problem must draw attention.
Own azoles alcohol (hexaconazole), chemical name: (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-own-2-alcohol, structural formula is as follows:
Own azoles alcohol belongs to azoles fungicide, sterol demethylation inhibitors, and the disease caused fungi especially Basidiomycota and Ascomycota has protection and the therapeutic action of broad spectrum activity.The biosynthesis of the cell membrane important composition composition ergosterol of destruction and prevention germ, causes cell membrane not formed, and makes germ dead.There is interior suction, protection and therapeutic activity.Own azoles alcohol can prevent and treat disease caused by sac fungi, basidiomycetes and imperfect fungus effectively; especially excellent protection and eradicant action is had to disease such as powdery mildew, rust, scab, brown spot, anthracnose etc. that Basidiomycetes and Ascomycetes cause; good preventive effect is had to rice sheath blight disease; be widely used in paddy rice, apple, grape, banana at present; vegetables (melon and fruit, capsicum etc.); peanut, coffee, cereal crop and ornamental plants etc.Use under recommended dose, to environment, crop safety.As an old bactericide kind, resistance problem must be solved.In addition, own azoles alcohol high concentration uses and has obvious poisoning to manifest to crops such as apples to resemble, need to arouse attention.
Plant bacterium azoles (ipconazole), chemical name: 2-((4-chlorphenyl) methyl)-5-(1-Methylethyl)-1-(1H-1,2,4-triazole-1-methyl) cyclopentanol, molecular structural formula is as follows:
Metconazole (metconazole) is developed by Japanese Wu Yu chemical industrial company, and with the novel wide spectrum triazole bactericidal agent of American Cyanamid Company's (being now BASF AG) joint development.
Metconazole toxicity LD
50(mg/kg) rat acute footpath mouth >661, acute through skin >2000.To rabbit no skin irritation, there is minimal irritation to lagophthalmos eyeball.Nontoxic to honeybee, nontoxic to earthworm.To non-target organism low toxicity.Consumption low activity is high, and environment prospect is good.The metconazole mechanism of action: C-14 demethylation inhibitors in ergosterol biosynthesis, although identical with the triazole bactericidal agent mechanism of action, fungicidal spectrum but difference is larger.Two kinds of isomer have bactericidal activity, but Cis activity is higher than the activity of transisomer.The antifungal spectrum of this medicine is widely, and active splendid, and field is used and planted disease to cereal septoria musiva, fusarium and handle rest fungus and have excellent effect, and compared with conventional sterilants, the low cereal of preventing and treating of dosage plants disease wide range.Be mainly used in the crops such as wheat, barley, oat, rye, triticale.Control wheat septoria, fringe sickle-like bacteria, leaf rust, yellow rust, powdery mildew, glume blight; The short shape rust of barley, powdery mildew, Rhynchosporium spp．; Rye Rhynchosporium spp．, leaf rust; Crown hull sugar, triticale (wheat and rye hybridize) leaf rust, septoria musiva.To Septoria and rust superior activity.Have excellent protection and therapeutic action concurrently.Effective especially to the glume blight of wheat, prevention, result for the treatment of are all good.5 ~ 6 weeks lasting periods, without poisoning.
Nitrile bacterium azoles (Myclobutanil), chemical name: 2-(4-chlorphenyl)-2-(1H, 1,2,4-triazole-1-methyl) own nitrile, molecular formula: C
15h
17clN
4, molecular structural formula:
Nitrile bacterium azoles toxicity: rat acute per os LD
50male is 1600mg/kg, and female is 2290mg/kg, and rabbit is acute through skin LD
50>5000mg/kg, has minimal irritation to eyes, to no skin irritation.Nitrile bacterium azoles is the interior absorption triazole bactericidal agent of a class tool protection and therapeutic activity.Mainly inhibitory action is played to the biosynthesis of the ergosterol of pathogen, to sac fungi, basidiomycetes, all there is good control efficiency.This agent lasting period is long, to crop safety, has certain stimulating growth effect.Suitable for crop and safety: apple, pears, drupe, grape, cucurbit, gardening ornamental crops, wheat, barley, oat, cotton and paddy rice etc.To crop safety.To powdery mildew, scab, rot, rust, brown spot, graywall, smut has good preventive effect.
Penconazole (Penconazole), the triazole bactericidal agent of Syngenta Co., Ltd's exploitation.Chemical name: 1-[2-(2,4-dichlorophenyl) amyl group]-1H-1,2,4-triazole, chemical structural formula is as follows:
Penconazole former medicine rat acute per os LD
502125mg/kg, acute through skin LD
50>3000mg/kg, Acute inhalation LC
50(4h) >4000mg/mL; To rabbit eyes and no skin irritation; The Main Function mechanism of penconazole is sterol demethylation inhibitors, and the biosynthesis of the cell membrane important composition composition ergosterol of destruction and prevention germ, causes cell membrane not formed, and makes germ dead.Owing to having absorption well, therefore can promptly be absorbed by plants, and in conducted inside; There is the good protection of armpit and therapeutic activity.This medicine is stable in water; Temperature to 350 DEG C is still stablized, and does not decompose, and is mainly used in fruit tree as apple, grape, pears, banana, vegetables and ornamental plants etc.Use under recommended dose, to environment, crop safety.Effectively can prevent and treat disease caused by sac fungi, basidiomycetes and imperfect fungus and especially to powdery mildew, scab etc., there is excellent preventive effect.Their early stage dispenser.Safety interval is 30d before vintage, and per season, maximum times for spraying was 3 times, to crop safety under recommended dose, has no poisoning and occurs.
Prothioconazoles (prothioconazole), chemical name: 2-[2-(1-chlorine cyclopropyl)-3-(2-chlorphenyl)-2-hydroxypropyl]-1-2-dihydro-3-1,2,4-triazole-3-sulfo-, structural formula is as follows:
Prothioconazoles is low toxicity bactericide, by the demethylation effect of the precursor of sterol in Antifungi, thus plays bactericidal action, and this kind not only has good systemic activity, excellent protection, treats and root out activity, and the lasting period is long, to crop safety.Prothioconazoles is mainly used in control cereal crop as the multiple diseases on wheat, barley, peanut, paddy rice and legume crop, almost all there is good control efficiency, as wheat powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease etc. to all wheat class diseases.The soil-borne disease of rape and peanut can also be prevented and treated, as stalk break, and main leaf diseases, as gray mold, black spot, brown spot, balck shank and rust etc.Using dosage is generally per hectare about active ingredient 200g, and under this dosage, its activity is better than or equals current conventional sterilization agent kind.
Tebuconazole (Tebuconazole), chemical name: 1-(4-chlorphenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-yl methyl) penta-3-alcohol, structural formula is as follows:
Tebuconazole belongs to triazole type low toxicity bactericide, it is sterol demethylation inhibitor, it is the efficient germicide of seed treatment for Important Economic crop or foliage spray, effectively can prevent and treat multiple rust, powdery mildew, net blotch, root rot, the head blight of cereal crop, smut and kind pass zonate spot etc.Tebuconazole has efficiently, wide spectrum, interior absorption, and have protection, treat, root out three zones, fungicidal spectrum is wide, the lasting period is long.This product is for preventing and treating sclerotinia rot of colza, and not only preventive effect is good, and has resistant to lodging, the features such as production-increasing function is obvious.
Triadimenol (triadimenol), chemical name: 1-(4-chlorophenoxy)-1-(1H-1,2,4-triazol-1-yl)-3,3-dimethyl-Ding-2-alcohol, structural formula is as follows:
Triadimenol is broad spectrum activity seed dressing bactericide, has interior absorption, can kill and invest the surface of the seed and inner pathogen.Its bactericidal action is the biosynthesis affecting fungi ergosterol.For preventing and treating powdery mildew and the smut of cereal crop.As prevented and treated loose smut of wheat, stinking smut, root rot, loose smut of barley, rust, leaf stripe, net blotch etc., to the loose kernel smut of spring barley, loose kernel smut along stripe disease, net blotch, root rot and winter wheat, stinking smut, snow mold and the leaf stripe of spring oats, the control efficiency 92% ~ 100% of loose kernel smut.Triadimenol is a kind of high-efficiency low-toxicity wide-spectrum bactericide.For preventing and treating the diseases such as wheat class, paddy rice rust, powdery mildew, banded sclerotial blight, there is obvious effect of increasing production.Also can be used as Cereal seed treatment and prevent and treat cereal head smut.
Triazole bactericidal agent is the series bactericidal agent that on current bactericide market, sales volume is maximum, also be the series bactericidal agent that the preparation variety that commercially occurs is maximum, the disease controls such as crops, vegetables, fruit tree, economic crops play very important effect.But at present, the resistance problem of triazole bactericidal agent just progressively manifests, especially vegetable disease.Being correlated with service life of kind to extend triazole bactericidal agent, selecting suitable composite developing to be a kind of important mode.Through overtesting find prochloraz nantokite and triazole bactericidal agent composite have significantly thank to synergetic, and there is no the composite report of three series bactericidal agents listed by prochloraz nantokite and the present invention up to now.
Summary of the invention
A kind of applied widely, the cost that the object of the invention is that the problems such as and pathogen resistance undesirable for current single dose effect provide low, effective containing prochloraz nantokite (A) and the one (B) in following triazole bactericidal agent: propiconazole, Difenoconazole, triticonazole, Cyproconazole, epoxiconazole, Fluquinconazole, Flutriafol, own azoles alcohol, plant the composition of bacterium azoles, metconazole, nitrile bacterium azoles, penconazole, prothioconazoles, Tebuconazole, Triadimenol, for control of plant disease.
A further object of the invention is to provide the application of this bactericidal composition on control Cereal, melon and fruit or vegetable crop fungal disease.
The object of the invention is to be realized by following measures:
A kind of bactericidal composition, it contains the one (B) in prochloraz nantokite (A) and following triazole bactericidal agent: propiconazole, Difenoconazole, triticonazole, Cyproconazole, epoxiconazole, Fluquinconazole, Flutriafol, own azoles alcohol, plant bacterium azoles, metconazole, nitrile bacterium azoles, penconazole, prothioconazoles, Tebuconazole, Triadimenol, wherein A and B weight ratio is 1 ~ 70:1 ~ 60, be preferably 1 ~ 50:1 ~ 50, more preferably 1 ~ 40:1 ~ 30, most preferably are 5 ~ 40:10 ~ 30.
Bactericidal composition of the present invention, the weight percentage that both A and B account for composition is 2 ~ 80%, is preferably 5 ~ 50%, most preferably 8 ~ 40%.
This bactericidal composition can become by A with B any one formulation that agricultural chemicals allows with known additive compound.
Described formulation is preferably processed into missible oil, pulvis, wetting powder, suspending agent, aqueous emulsion or water dispersion granule.
These known auxiliary agents have dispersant, diffusant, defoamer, wetting agent, disintegrant etc.Specifically fatty alcohol-polyoxyethylene ether can be adopted, alkylphenol polyoxyethylene, alkylphenol polyoxyethylene polyethenoxy ether aliphatic amine polyoxyethylene ether, castor oil polyoxyethylene ether, sorbitan fatty acid ester and APEO thereof, Ben-zylphenol Polyoxyethyl Ether, polyoxyethylene carboxylate, fatty acid glyceride and derivative thereof, bis-phenol polyethers, calcium dodecyl benzene sulfonate, alkylnaphthalene sulfonate, aliphatic alcohol sulfate, alkyl phosphate, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl naphthalene sulfonic acid formaldehyde condensation products sodium salt, the rare block compound of polyoxyethylene polyoxy third, polyoxyethylene nonylphenol ether cyclohexanone, dimethylbenzene, toluene, solvent naphtha (as agriculture breast 200#), methyl oleate, vegetable oil (as methylated soya oil), xanthans, polyvinyl alcohol, carboxymethyl cellulose, polyacrylate, aluminium-magnesium silicate, water (comprising deionized water), ethylene glycol, propane diols, one or more combinations in organosilicon etc.
Bactericidal composition of the present invention is at control Cereal, application on melon and fruit or vegetable crop fungal disease, preferably at preparation control rice blast, banded sclerotial blight, bacterial leaf-blight, black streak dwarf, false smut, bakanae disease, wheat powdery mildew, wheat rust, wheat sharp eyespot, take-all, wheat scab, cucumber downy mildew, cucurbits powdery mildew, melon anthracnose, gray mold, watermelon leaf pinta, early blight, late blight, the corn northern leaf blight, maize sheath blight, cotton seedling blight, alternaria leaf spot of apple, apple scab, pear scab, rust of pear, peach anthracnose, black spot, citrus scab, citrus anthracnose, citrus bacterial canker disease, Penicillium italicum, green mould, mango blossom-end rot, banana anthracnose, application on the germ killing drugs of banana freckle.
Compared with prior art, beneficial effect of the present invention:
1, the A prochloraz nantokite that the present invention is used plays bactericidal action by suppressing ergosterol biosynthesis, B is triazole type product, is sterol synthetic inhibitor, and action site is different, and the copper in prochloraz nantokite itself has certain bactericidal action, described composition activity is greater than the activity of independent component, can produce obvious synergistic function, expands control spectrum, sterilization speed is fast, the lasting period is long, can dosage be reduced when applying, reducing costs.
2, bactericidal composition of the present invention overcomes and has delayed pesticide resistance, inhibits the drug-fast generation of fungi, overcomes the deficiency of a certain composition of single use, the agricultural chemicals of alternative routine and easily generation resistance.
Embodiment
Prochloraz nantokite and propiconazole, Difenoconazole, triticonazole, Cyproconazole, epoxiconazole, Fluquinconazole, Flutriafol, own azoles alcohol, to plant any one in bacterium azoles, metconazole, nitrile bacterium azoles, penconazole, prothioconazoles, Tebuconazole, Triadimenol composite, two kinds of reactive compounds can be processed into any one formulation of permission, with specific embodiment, the preparation that two kinds of active ingredients are processed into is described below, but the preparation that these two kinds of active components can be processed be not limited only to following listed by.
Embodiment 1
By prochloraz nantokite 5g, propiconazole 10g, detergent LS(to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin adds to 100g, mixture carries out air-flow crushing, and obtained principle active component weight percentage is 15% wetting powder.
Embodiment 2
By prochloraz nantokite 10g, Difenoconazole 2g, detergent LS3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g, and mixture carries out air-flow crushing, and obtained principle active component weight percentage is 12% wetting powder.
Embodiment 3
By prochloraz nantokite 4g, triticonazole 0.2g, detergent LS3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g, and mixture carries out air-flow crushing, and obtained principle active component weight percentage is 4.2% wetting powder.
Embodiment 4
Take prochloraz nantokite 5g, Cyproconazole 0.1g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, 100# solvent naphtha 13g, add water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making principle active component weight percentage is 5.1% aqueous emulsion.
Embodiment 5
Take prochloraz nantokite 26g, epoxiconazole 5g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, 100# solvent naphtha 13g, add water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making principle active component weight percentage is 31% aqueous emulsion.
Embodiment 6
Take prochloraz nantokite 50g, Fluquinconazole 5g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, 100# solvent naphtha 13g, add water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making principle active component weight percentage is 55% aqueous emulsion.
Embodiment 7
Take prochloraz nantokite 20g, Flutriafol 2g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 22% suspending agent.
Embodiment 8
Take prochloraz nantokite 20g, plant bacterium azoles 2g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 22% suspending agent.
Embodiment 9
Take prochloraz nantokite 20g, own azoles alcohol 2g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 22% suspending agent.
Embodiment 10
Take prochloraz nantokite 20g, metconazole 2g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 22% suspending agent.
Embodiment 11
Take prochloraz nantokite 15g, nitrile bacterium azoles 1g, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, add water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making principle active component weight percentage is 16% microemulsion.
Embodiment 12
Take prochloraz nantokite 50g, penconazole 10g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 60% suspending agent.
Embodiment 13
Take prochloraz nantokite 15g, prothioconazoles 5g, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite complements to 100g, it is 20% water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 14
Take prochloraz nantokite 15g, Tebuconazole 2g, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite complements to 100g, and it is 17% water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 15
Take prochloraz nantokite 5g, Triadimenol 1g, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite complements to 100g, it is 6% water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 16
Take prochloraz nantokite 5g, Flutriafol 0.1g, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite complements to 100g, it is 5.1% water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 17
Take prochloraz nantokite 25g, triticonazole 10g, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite complements to 100g, it is 35% water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 18
Take 10g prochloraz nantokite, 1g Cyproconazole, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 11% suspending agent.
Embodiment 19
Take prochloraz nantokite 30g, Tebuconazole 12g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 32% suspending agent.
Embodiment 20
Take prochloraz nantokite 25g, penconazole 5g, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite complements to 100g, it is 30% water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 21
Take prochloraz nantokite 40g, metconazole 1g, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite complements to 100g, it is 41% water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 22
Take prochloraz nantokite 10g, prothioconazoles 2g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 12% suspending agent.
Indoor biometrics test example
Indoor biometrics test is main adopts mycelial growth rate method or spore germination method (test method reference People's Republic of China (PRC) agricultural industry criteria: NY/T1156.1-2006; NY/T1156.2-2006; NY/T1156.4-2006; NY/T1156.6-2006; NY/T1156.8-2006; NY/T1156.15-2006), complex composition bactericide is measured to the EC of different strains
50value.
The calculating of co-toxicity coefficient (CTC) adopts the co-toxicity coefficient computational methods of the abundant introduction of Sun Yun, and the computational process of CTC is as follows:
With single dose a certain in mixture for standard agent (selects EC usually
50junior),
Single dose toxicity index=standard agent EC
50/ single dose EC
50× 100,
Toxicity index × B single dose proportion in mixture of toxicity index × A single dose proportion+B single dose in mixture of theoretical toxicity index=A single dose
The EC of actual measurement toxicity index=standard single dose
50the EC of value/mixture
50value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
According to classification rule: CTC is greater than 120 and shows that mixture has significant synergetic, and CTC is less than 80 and shows to show antagonism between mixture, CTC shows to be summation action between mixture between 80-120.
According to above laboratory test and the method calculating co-toxicity coefficient, determine prochloraz nantokite+propiconazole, prochloraz nantokite+Difenoconazole, prochloraz nantokite+triticonazole, prochloraz nantokite+Cyproconazole, prochloraz nantokite+epoxiconazole, prochloraz nantokite+Fluquinconazole, prochloraz nantokite+Flutriafol, prochloraz nantokite+own azoles alcohol, prochloraz nantokite+kind of bacterium azoles, prochloraz nantokite+metconazole, prochloraz nantokite+nitrile bacterium azoles, prochloraz nantokite+penconazole, prochloraz nantokite+prothioconazoles, prochloraz nantokite+Tebuconazole, the synergism of the several different ratio of prochloraz nantokite+Triadimenol, result of the test in table 1 to table 16.
Table 1: prochloraz nantokite-propiconazole different ratio is to the indoor biometrics result of wheat powdery mildew
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=2.7920X+2.9436 | 5.4515 | - |
| Propiconazole (B) | Y=3.9926X+4.6127 | 1.2503 | - |
| A：B=10:1 | Y=1.2103X+4.4884 | 2.6465 | 157.5 |
| A：B=5:1 | Y=8.0937X+2.5208 | 2.0245 | 171.6 |
| A：B=2.5:1 | Y=2.2651X+4.7393 | 1.3035 | 213.2 |
| A：B=1:1 | Y=2.6987X+4.4108 | 1.6532 | 124.0 |
| A：B=1:3 | Y=5.1099X+4.5402 | 1.2302 | 125.5 |
As can be seen from Table 1, the microbicide compositions of prochloraz nantokite-propiconazole, has comparatively significantly synergetic to wheat powdery mildew.
Table 2: prochloraz nantokite-Difenoconazole different ratio is to the indoor biometrics result of watermelon leaf spot fungi
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=5.4551X+4.3414 | 1.3205 | - |
| Difenoconazole (B) | Y=4.5584X+1.3727 | 6.2481 | - |
| A：B=1:10 | Y=3.5758X+3.1881 | 3.2114 | 146.9 |
| A：B=1:5 | Y=2.5177X+4.2074 | 2.0644 | 188.1 |
| A：B=1:3 | Y=2.168X+4.8829 | 1.1324 | 284.4 |
| A：B=1:1 | Y=1.5470X+4.9042 | 1.1532 | 187.7 |
| A：B=3:1 | Y=3.6267X+4.5199 | 1.3564 | 121.7 |
As can be seen from Table 2, the microbicide compositions of prochloraz nantokite-Difenoconazole, has comparatively significantly synergetic when preventing and treating watermelon leaf spot fungi.
Table 3: prochloraz nantokite-triticonazole different ratio is to the indoor biometrics result of rust of pear germ
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=2.9028X+2.1947 | 9.2554 | - |
| Triticonazole (B) | Y=1.2307X+3.4896 | 16.8744 | - |
| A：B=10:1 | Y=3.9887X+1.6262 | 7.0121 | 137.5 |
| A：B=5:1 | Y=4.7091X+1.1574 | 6.5464 | 153.7 |
| A：B=2.5:1 | Y=1.3977X+3.9139 | 5.9851 | 177.8 |
| A：B=1:1 | Y=4.7576X+1.2894 | 6.0245 | 199.6 |
| A：B=1:3 | Y=3.4814X+1.9234 | 7.6513 | 183.3 |
As can be seen from Table 3, the microbicide compositions of prochloraz nantokite-triticonazole, have comparatively significantly synergism to rust of pear germ, effect is better than the control efficiency of unitary agent.
Table 4: prochloraz nantokite-Cyproconazole different ratio is to the indoor biometrics result of wheat powdery mildew
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=2.7920X+2.9436 | 5.4515 | - |
| Cyproconazole (B) | Y=4.0252X+3.5428 | 2.3015 | - |
| A：B=20:1 | Y=7.5421X+1.3451 | 3.0521 | 166.9 |
| A：B=5:1 | Y=3.1662X+4.0386 | 2.0121 | 220.3 |
| A：B=1:1 | Y=2.6748X+4.2323 | 1.9365 | 267.6 |
| A：B=1:8 | Y=2.2982X+4.8856 | 1.1214 | 219.0 |
| A：B=1:20 | Y=2.9891X+4.6058 | 1.3548 | 175.0 |
As can be seen from Table 4, the microbicide compositions of prochloraz nantokite-Cyproconazole, has comparatively significantly synergetic to wheat powdery mildew.
Table 5: prochloraz nantokite-epoxiconazole different ratio is to the indoor biometrics result of bunt of wheat bacterium
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=4.7645X+1.1001 | 6.5848 | - |
| Epoxiconazole (B) | Y=2.5741X+2.4686 | 9.6254 | - |
| A：B=30:1 | Y=2.9130X+2.9528 | 5.0441 | 131.9 |
| A：B=10:1 | Y=2.2602X+3.6092 | 4.1244 | 164.6 |
| A：B=1:1 | Y=2.6328X+3.5373 | 3.5941 | 218.2 |
| A：B=1:10 | Y=3.3553X+2.7756 | 4.6021 | 201.5 |
| A：B=1:30 | Y=4.1598X+2.0027 | 5.2545 | 181.6 |
As can be seen from Table 5, the microbicide compositions of prochloraz nantokite-epoxiconazole, has comparatively significantly synergetic to bunt of wheat bacterium.
Table 6: prochloraz nantokite-Fluquinconazole different ratio is to the indoor biometrics result of wheat powdery mildew
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=2.7920X+2.9436 | 5.4515 | - |
| Fluquinconazole (B) | Y=2.1401X+2.4149 | 16.1412 | - |
| A：B=30:1 | Y=2.2116X+3.8965 | 3.1545 | 176.3 |
| A：B=10:1 | Y=2.9935X+4.0718 | 2.0421 | 284.0 |
| A：B=1:1 | Y=1.5564X+4.1937 | 3.2965 | 246.8 |
| A：B=1:5 | Y=2.892X+2.9909 | 4.9512 | 244.7 |
| A：B=1:10 | Y=1.7093X+3.5634 | 6.9254 | 196.8 |
As can be seen from Table 6, the microbicide compositions of prochloraz nantokite-Fluquinconazole, has comparatively significantly synergetic to wheat powdery mildew.
Table 7: prochloraz nantokite-Flutriafol different ratio is to the indoor biometrics result of watermelon leaf spot fungi
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=5.4551X+4.3414 | 1.3205 | - |
| Flutriafol (B) | Y=1.3918X+3.3529 | 15.2546 | - |
| A：B=40:1 | Y=7.3341X+4.9322 | 1.0215 | 131.9 |
| A：B=20:1 | Y=3.1243X+4.8681 | 1.1021 | 124.8 |
| A：B=5:1 | Y=2.9595X+4.7545 | 1.2105 | 128.3 |
| A：B=1:10 | Y=3.8715X+2.2801 | 5.0412 | 154.1 |
| A：B=1:30 | Y=2.1435X+3.2993 | 6.2151 | 177.1 |
As can be seen from Table 7, the microbicide compositions of prochloraz nantokite-Flutriafol, has comparatively significantly synergetic to watermelon leaf spot fungi.
Table 8: prochloraz nantokite-own azoles alcohol different ratio is to the indoor biometrics result of rust of pear bacterium
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=2.9028X+2.1947 | 9.2554 | - |
| Own azoles alcohol (B) | Y=2.8446X+1.2015 | 21.6444 | - |
| A：B=30:1 | Y=3.8542X+1.9855 | 6.0554 | 156.0 |
| A：B=10:1 | Y=4.8152X+1.5482 | 5.2103 | 187.0 |
| A：B=1:1 | Y=3.1114X+2.8194 | 5.0214 | 259.6 |
| A：B=1:10 | Y=2.1983X+2.9887 | 8.2214 | 234.5 |
| A：B=1:30 | Y=2.575X+2.5425 | 9.0024 | 228.5 |
As can be seen from Table 8, the microbicide compositions of prochloraz nantokite-own azoles alcohol, has comparatively significantly synergetic to rust of pear bacterium.
Table 9: prochloraz nantokite-kind of bacterium azoles different ratio is to the indoor biometrics result of rice blast fungus
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=1.3201X+3.6121 | 11.2561 | - |
| Plant bacterium azoles (B) | Y=3.7883X+1.9066 | 6.5548 | - |
| A：B=25:1 | Y=3.5545X+1.7667 | 8.1211 | 134.7 |
| A：B=10:1 | Y=2.4952X+3.1884 | 5.3215 | 197.7 |
| A：B=1:1 | Y=3.9503X+2.1169 | 5.3685 | 154.2 |
| A：B=1:10 | Y=3.1233X+2.9238 | 4.6211 | 147.6 |
| A：B=1:25 | Y=2.4955X+3.5356 | 3.8621 | 172.5 |
As can be seen from Table 9, the microbicide compositions of prochloraz nantokite-kind of bacterium azoles, has comparatively significantly synergetic to rice blast fungus.
Table 10: prochloraz nantokite-metconazole different ratio is to the indoor biometrics result of wheat powdery mildew
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=2.7920X+2.9436 | 5.4515 | - |
| Metconazole (B) | Y=2.1386X+2.2825 | 18.6512 | - |
| A：B=40:1 | Y=2.1654X+3.8881 | 3.2621 | 170.5 |
| A：B=15:1 | Y=1.9265X+4.0805 | 3.0011 | 189.2 |
| A：B=2:1 | Y=4.7654X+2.7589 | 2.9531 | 242.9 |
| A：B=1:10 | Y=4.2062X+1.5446 | 6.6298 | 228.4 |
| A：B=1:20 | Y=4.2741X+1.1601 | 7.9141 | 208.7 |
As can be seen from Table 10, the microbicide compositions of prochloraz nantokite-metconazole, has comparatively significantly synergetic to wheat powdery mildew.
Table 11: prochloraz nantokite-nitrile bacterium azoles different ratio is to the indoor biometrics result of cucumber powdery mildew's pathogen
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=2.7920X+2.9436 | 5.4515 | - |
| Nitrile bacterium azoles (B) | Y=2.6928X+1.9782 | 13.2481 | - |
| A：B=40:1 | Y=3.9676X+2.4766 | 4.3251 | 127.3 |
| A：B=20:1 | Y=4.7471X+2.7177 | 3.0254 | 185.8 |
| A：B=5:1 | Y=3.0844X+3.5903 | 2.8645 | 211.5 |
| A：B=1:2 | Y=2.2135X+3.3807 | 5.3894 | 165.8 |
| A：B=1:15 | Y=2.7539X+2.5641 | 7.6654 | 158.1 |
As can be seen from Table 11, the microbicide compositions of prochloraz nantokite-nitrile bacterium azoles, has comparatively significantly synergetic to cucumber powdery mildew's pathogen.
Table 12: prochloraz nantokite-penconazole different ratio is to the indoor biometrics result of Phyllosticta musarum
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=2.0343X+2.9434 | 10.2564 | - |
| Penconazole (B) | Y=1.3972X+3.5105 | 11.6428 | - |
| A：B=30:1 | Y=3.6714X+1.8945 | 7.0121 | 146.3 |
| A：B=10:1 | Y=4.7753X+1.5291 | 5.3316 | 194.3 |
| A：B=1:1 | Y=2.3408X+3.3215 | 5.2127 | 209.3 |
| A：B=1:10 | Y=4.9421X+1.2226 | 5.8121 | 198.3 |
| A：B=1:30 | Y=4.5509X+1.3585 | 6.3121 | 184.7 |
As can be seen from Table 12, the microbicide compositions of prochloraz nantokite-penconazole, has comparatively significantly synergetic to Phyllosticta musarum.
Table 13: prochloraz nantokite-prothioconazoles different ratio is to the indoor biometrics result of rust of pear bacterium
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=2.9028X+2.1947 | 9.2554 | - |
| Prothioconazoles (B) | Y=3.0756X+3.1999 | 3.8484 | - |
| A：B=20:1 | Y=2.0694X+3.4101 | 5.8654 | 147.5 |
| A：B=10:1 | Y=1.9497X+3.7607 | 4.3214 | 189.5 |
| A：B=1:1 | Y=3.8194X+3.3788 | 2.6574 | 204.9 |
| A：B=1:10 | Y=3.8798X+3.3474 | 2.6665 | 152.2 |
| A：B=1:25 | Y=2.6362X+4.0229 | 2.3477 | 167.8 |
As can be seen from Table 13, the microbicide compositions of prochloraz nantokite-prothioconazoles, has comparatively significantly synergetic to rust of pear bacterium.
Table 14: prochloraz nantokite-Tebuconazole different ratio is to the indoor biometrics result of Ustilago tritici
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=2.4684X+2.4049 | 11.2545 | - |
| Tebuconazole (B) | Y=2.5575X+3.7028 | 3.2154 | - |
| A：B=30:1 | Y=2.0669X+3.2125 | 7.3251 | 142.3 |
| A：B=10:1 | Y=3.8597X+2.4497 | 4.5789 | 200.0 |
| A：B=1:1 | Y=3.5625X+3.6384 | 2.4111 | 207.5 |
| A：B=1:10 | Y=3.8481X+3.8406 | 2.0012 | 172.0 |
| A：B=1:30 | Y=3.0437X+4.1144 | 1.9541 | 168.4 |
As can be seen from Table 14, the microbicide compositions of prochloraz nantokite-Tebuconazole, has comparatively significantly synergetic to ustilago.
Table 15: prochloraz nantokite-Triadimenol different ratio is to the indoor biometrics result of rust of pear bacterium
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| Prochloraz nantokite (A) | Y=2.9028X+2.1947 | 9.2554 | - |
| Triadimenol (B) | Y=1.9451X+2.6217 | 16.6989 | - |
| A：B=40:1 | Y=2.4474X+3.0918 | 6.0211 | 155.3 |
| A：B=20:1 | Y=2.4210X+3.4612 | 4.3215 | 218.6 |
| A：B=2:1 | Y=2.2149X+3.3311 | 5.6688 | 192.1 |
| A：B=1:5 | Y=3.5791X+1.6453 | 8.6555 | 169.7 |
| A：B=1:15 | Y=3.2601X+1.8888 | 9.0021 | 177.3 |
As can be seen from Table 15, the microbicide compositions of prochloraz nantokite-Triadimenol, has comparatively significantly synergetic to rust of pear bacterium.
Field control effectiveness test embodiment
The obtained pesticidal preparations of section Example is selected to carry out the test of control crop powdery mildew, rust, leaf spot and scab.
1, test process: this test medicine is indoor employing conventional pesticide processing mode and is processed into test medicine, consumption establishes three concentration for the treatment of respectively according to the difference of each composition, and contrast medicament is self-control agricultural chemicals 50% prochloraz nantokite WP and commercially available agricultural chemicals and blank clean water experiment respectively.
2, test method: each plot area is 66.7m
2, repeat 3 times; Inspection drug effect method before dispenser after Investigation and Prevention is: in test treatment region, random sampling 5 point (gets 2m at often
2), check controlling disease occurrence degree.
3, field trial the results are shown in Table 17-21:
Table 16: prochloraz nantokite-propiconazole is with the field test results of proportioning to wheat powdery mildew
Table 17: prochloraz nantokite-Difenoconazole different ratio is to the field test results of watermelon leaf pinta
table 18: prochloraz nantokite-triticonazole different ratio is to the field test results of rust of pear
Table 19: prochloraz nantokite (A)-penconazole (B) different ratio is to the indoor biometrics result of banana freckle
As can be seen from table 16-19, prochloraz nantokite is composite with propiconazole, Difenoconazole, triticonazole, penconazole respectively, and the control efficiency of composition is excellent, and sterilization speed is fast, the lasting period is long, and control efficiency is all better than single dose kind.
Claims (10)
1. a bactericidal composition, it is characterized in that containing the one (B) in prochloraz nantokite (A) and following triazole bactericidal agent: propiconazole, Difenoconazole, triticonazole, Cyproconazole, epoxiconazole, Fluquinconazole, Flutriafol, own azoles alcohol, plant bacterium azoles, metconazole, nitrile bacterium azoles, penconazole, prothioconazoles, Tebuconazole, Triadimenol, wherein the weight ratio of A and B is 1 ~ 70:1 ~ 60.
2. bactericidal composition according to claim 1, is characterized in that the weight ratio of described A and B is 1 ~ 50:1 ~ 50.
3. bactericidal composition according to claim 2, is characterized in that the weight ratio of described A and B is 1 ~ 40:1 ~ 30.
4. bactericidal composition according to claim 3, is characterized in that the weight ratio of described A and B is 5 ~ 40:10 ~ 30.
5. bactericidal composition according to claim 1, is characterized in that the weight percentage that both described A and B account for composition is 2 ~ 80%.
6. bactericidal composition according to claim 5, is characterized in that the weight percentage that described A and B accounts for composition is 5 ~ 50%.
7. bactericidal composition according to claim 6, is characterized in that the weight percentage that described A and B accounts for composition is 8 ~ 40%.
8. bactericidal composition according to claim 1, it is characterized in that can being re-dubbed with known auxiliary agent any one formulation that agricultural chemicals allows by A and B, described formulation is missible oil, pulvis, wetting powder, suspending agent, aqueous emulsion or water dispersion granule.
9. the application of bactericidal composition according to claim 1 on control Cereal, melon and fruit or vegetable crop fungal disease.
10. bactericidal composition according to claim 1 is at preparation control rice blast, banded sclerotial blight, bacterial leaf-blight, black streak dwarf, false smut, bakanae disease, wheat powdery mildew, wheat rust, wheat sharp eyespot, take-all, wheat scab, cucumber downy mildew, cucumber anthracnose, gray mold, watermelon leaf pinta, early blight, late blight, the corn northern leaf blight, maize sheath blight, cotton seedling blight, alternaria leaf spot of apple, apple scab, pear scab, rust of pear, peach anthracnose, black spot, citrus scab, citrus anthracnose, citrus bacterial canker disease, Penicillium italicum, green mould, mango blossom-end rot, banana anthracnose, application on the germ killing drugs of banana freckle.
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| CN (1) | CN104604920A (en) |
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| CN105961436A (en) * | 2016-04-29 | 2016-09-28 | 安徽农业大学 | Medicine for preventing and controlling hickory nut canker, and use method thereof |
| CN106538601A (en) * | 2015-09-18 | 2017-03-29 | 南京华洲药业有限公司 | The bactericidal composition and its application of a kind of 2-cyano-3-amino-3-phenylancryic acetate-containing and prochloraz nantokite |
| CN108684661A (en) * | 2018-04-20 | 2018-10-23 | 江苏辉丰生物农业股份有限公司 | A kind of suspending agent of prevention rice disease |
| WO2018211383A1 (en) * | 2017-05-18 | 2018-11-22 | Upl Ltd | Stable liquid formulations of prothioconazole |
| CN114158564A (en) * | 2021-12-13 | 2022-03-11 | 宁波市农业技术推广总站 | Method for controlling content of vomitoxin aiming at diseased wheat |
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| CN105961436A (en) * | 2016-04-29 | 2016-09-28 | 安徽农业大学 | Medicine for preventing and controlling hickory nut canker, and use method thereof |
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| CN108684661A (en) * | 2018-04-20 | 2018-10-23 | 江苏辉丰生物农业股份有限公司 | A kind of suspending agent of prevention rice disease |
| CN114698637A (en) * | 2021-12-10 | 2022-07-05 | 上海生农生化制品股份有限公司 | Poaceae plant sterilization composition and preparation method and application thereof |
| CN114158564A (en) * | 2021-12-13 | 2022-03-11 | 宁波市农业技术推广总站 | Method for controlling content of vomitoxin aiming at diseased wheat |
| CN114514935A (en) * | 2022-03-07 | 2022-05-20 | 安徽农业大学 | Bactericidal composition for preventing and treating corynespora leaf spot disease of tobacco and application thereof |
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