CN111249337A - Microecological preparation for treating respiratory diseases of livestock and poultry and preparation method thereof - Google Patents
Microecological preparation for treating respiratory diseases of livestock and poultry and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a microecological preparation for treating respiratory diseases of livestock and poultry, which comprises the following components in parts by weight: 10-15 parts of mulberry leaf, 8-13 parts of moxibustion licorice, 10-15 parts of weeping forsythia leaf, 6-10 parts of scutellaria baicalensis, 1-2 parts of lactobacillus powder, 1-2 parts of sucrose and 1-2 parts of edible selenium. The microecological preparation has remarkable effects in preventing and treating respiratory diseases of livestock and poultry, reduces the difficulty of research and development of antibiotics, and improves the survival rate of livestock and poultry.
Description
Technical Field
The invention relates to the technical field of feed additive pharmaceutical compositions, in particular to a microecological preparation for treating respiratory diseases of livestock and poultry and a preparation method thereof.
Background
The feed additive is a small amount or trace substance added in the production, processing and using processes of feed, and the feed additive is small in dosage but remarkable in effect. The feed additive is a raw material inevitably used in modern feed industry, and has obvious effects on strengthening the nutritive value of basic feed, improving the production performance of animals, ensuring the health of the animals, saving the feed cost, improving the quality of animal products and the like. In the process of livestock and poultry breeding, the problems of breeding environment and livestock and poultry often cause the occurrence of some livestock and poultry viral diseases, and the livestock and poultry viral diseases cause great harm to the livestock and poultry viral diseases and bring great loss to the economy of farmers.
The respiratory diseases of livestock and poultry are syndromes caused by various pathogens, have the characteristics of high disease speed, rapid spread, long course of disease, high mortality, great control difficulty and the like, and are clinically manifested as respiratory symptoms such as asthma, cough, abdominal respiration and the like. Respiratory diseases of livestock and poultry are main diseases which affect the development of the breeding industry in China at present, and great economic loss is often caused to the breeding industry. The literature reports that the morbidity of respiratory diseases in large-scale pig farms is generally between 30 and 60 percent, and the mortality rate reaches 5 to 30 percent; the morbidity of respiratory diseases in chicken farms is generally between 20% and 80%, the mortality rate is 10-20%, and the mortality rate is 50-100% after mixed infection with other pathogens such as Newcastle disease and the like.
At present, only vaccines and antibiotics can be adopted for preventing and controlling respiratory diseases of livestock and poultry, and the preventing and treating effects are not obvious. Particularly, when antibiotic medicines are adopted for prevention and treatment, drug resistance and drug residues are easy to generate, so that the problem of drug resistance is increasingly serious, the treatment effect is increasingly reduced, and the difficulty in research and development of antibiotics is increased. In addition, viral respiratory diseases are often associated with bacterial diseases, and if simple vaccine immunization is used, immune failure can also occur.
Disclosure of Invention
Aiming at the problems mentioned in the background technology, the invention provides a microecological preparation for treating respiratory diseases of livestock and poultry and a preparation method thereof.
In order to achieve the aim, the invention provides a microecological preparation for treating respiratory diseases of livestock and poultry, which comprises the following components in parts by weight: 10-15 parts of mulberry leaf, 8-13 parts of moxibustion licorice, 10-15 parts of weeping forsythia leaf, 6-10 parts of scutellaria baicalensis, 1-2 parts of lactobacillus powder, 1-2 parts of sucrose and 1-2 parts of edible selenium.
A microecological preparation for treating respiratory diseases of livestock and poultry is characterized by comprising the following components in parts by weight: 12-14 parts of mulberry leaf, 10-12 parts of moxibustion licorice, 12-14 parts of weeping forsythia leaf, 7-9 parts of scutellaria baicalensis, 1.3-1.8 parts of lactobacillus powder, 1.3-1.8 parts of sucrose and 1.3-1.8 parts of edible selenium.
A microecological preparation for treating respiratory diseases of livestock and poultry is characterized by comprising the following components in parts by weight: 13 parts of mulberry leaf, 11 parts of moxibustion licorice, 13 parts of forsythia suspense leaf, 8 parts of scutellaria baicalensis, 1.5 parts of lactobacillus powder, 1.5 parts of sucrose and 1.5 parts of edible selenium.
Introduction of medicinal value of raw material components:
the mulberry leaves have the effects of dispelling wind and heat, clearing away lung-heat, moistening dryness, clearing liver and improving eyesight, have the effects of treating wind-heat type common cold, lung heat dryness cough, dizziness and headache, and conjunctival congestion and dim eyesight, have the effects of resisting bacteria and diminishing inflammation, clearing heat and removing toxicity, and can relax bowel, relieve constipation and effectively relieve toxin accumulation in vivo due to mineral substances contained in the mulberry leaves.
The prepared liquorice has the pharmacological actions of detoxifying, eliminating phlegm, relieving pain and relieving spasm to resist cancer and the like, and is used for tonifying spleen and qi, relieving cough and moistening lung, relieving urgency and detoxifying, harmonizing hundreds of medicines and mainly treating swollen sore throat, gastrointestinal ulcer, relieving drug toxicity, food poisoning and the like in traditional Chinese medicine.
Weeping forsythia leaves have the effects of detoxifying, relieving swelling, promoting blood circulation and stopping bleeding.
Baikal skullcap root and Baikal skullcap root are used for treating damp-warm fever, chest distress, thirst without desire for drink, damp-heat diarrhea, jaundice and the like, thereby having the efficacy of clearing heat and drying dampness. For fever due to damp-heat, it can be used in combination with pulvis Talci, fructus Amomi rotundus, and Poria; for dysentery and abdominal pain due to damp-heat, it is combined with Bai Shao, Ge Gen and gan Cao. For warm diseases, the special manifestations of warm diseases are acute onset, rapid change and many syndromes, and most of them have higher heat potential except fever. The disease condition can be relieved by taking the scutellaria baicalensis.
Further, the lactobacillus powder is derived from lactobacillus in healthy chickens.
Further, a preparation method of the microecological preparation for treating the respiratory diseases of the livestock and the poultry according to any one of claims 1 to 3, which is characterized by comprising the following steps:
(1) weighing folium Mori, radix Glycyrrhizae Preparata, folium forsythiae, and radix Scutellariae in proportion, pulverizing, and mixing to obtain Chinese medicinal composition;
(2) extracting the traditional Chinese medicine composition obtained in the step (1) by using a solvent to obtain a traditional Chinese medicine extract;
(3) pouring the traditional Chinese medicine extract obtained in the step (2) into a fermentation tank, adding lactobacillus powder, sucrose and edible selenium into the fermentation tank in proportion, adjusting pH to acidity, sealing and storing for 22-25 days, and extracting fermentation liquor to obtain the microecological preparation.
Further, the pH value is adjusted to be acidic by using wood vinegar in the step (3).
Further, the pH value in the step (3) is adjusted to 4.3-4.6.
Further, the fermentation tank is placed at 25-30 ℃ under the condition of shading for 8-10 hours before being sealed and stored in the step (3).
Further, in the step (3), the fermentation tank is wrapped by a plastic stretch film.
Furthermore, the application of the microecological preparation in preparing antiviral feed.
The technical principle of the invention is as follows: the traditional Chinese medicine composition provided by the invention is prepared by mixing folium mori, roasted liquorice, folium forsythia and radix scutellariae, the folium mori has the effects of resisting bacteria, diminishing inflammation, clearing heat and removing toxicity, and minerals contained in the folium mori have the effects of relaxing bowel, improving constipation and effectively relieving accumulation of toxins in bodies, so that the antibacterial and detoxifying effects of the preparation are improved, the immunity of livestock and poultry using the microbial preparation is higher, the radix glycyrrhizae preparata has the effects of tonifying spleen and qi, relieving cough and moistening lung, and relieving acute toxicity, the treatment effect of the microbial preparation on respiratory diseases of livestock and poultry is further improved, the added folium forsythia, radix scutellariae, folium mori and roasted liquorice are mixed to play a role in auxiliary reinforcement, and the prepared microbial preparation has a good treatment effect on the respiratory diseases of livestock and poultry through the synergistic effect among the components.
The added lactobacillus powder is mainly used as probiotics for regulating the intestinal micro-ecological environment, after the lactobacillus powder is prepared into live bacteria in a non-culturable state, the probability of the bacteria contacting immune cells is increased due to the reduction of thalli, the difficulty of the bacteria moving to the immune cells and the vicinity of the immune cells is reduced, the non-culturable state lactobacillus can be acted on the immune cells of a host, the bacteriostatic activity of lysozyme or/and antibacterial peptide secreted by the action part of the host can be higher, the lysozyme or/and the antibacterial peptide can play a larger role, and the micro-ecological environment of the host digestive tract and other action parts can be improved more efficiently.
The lactobacillus powder is prepared from lactobacillus in healthy chicken, and the lactobacillus is modified by genetic engineering technology while exerting the advantages of microecological preparation of lactobacillus, so that the lactobacillus can express antiviral factors and immune antigens, and can secrete antiviral factors and specific antigen substances after administration through digestive tract, thereby inhibiting and killing pathogens, activating intestinal mucosa immune system, and improving the overall immunity of organism.
In summary, compared with the prior art, the invention has the following beneficial effects:
(1) the microbial preparation has high nutritive value and good prevention and treatment effects, and after the microbial preparation is eaten, the metabolites of livestock and poultry contain antiviral factors such as interferon, interleukin and the like, and in addition, lactic acid, acetic acid and various vitamins such as vitamin B1, vitamin B2, vitamin B6, nicotinic acid, calcium pantothenate and the like, so that the microbial preparation promotes the digestion and absorption of poultry organisms to protein, and has the functions of helping digestion, stimulating appetite, improving the utilization rate of calcium, phosphorus and iron and absorbing vitamin D.
(2) The microecological preparation of the invention can keep the body of livestock and poultry with lasting disease resistance, and the lactobacillus powder added in the raw material components can ensure that the microecological preparation colonizes in intestinal tract for a long time, continuously stimulates the body to generate immunity and secrete antiviral factors, induces specific and non-specific immune reaction, and eliminates the sub-health state.
(3) The preparation and the use of the microecological preparation are both convenient, and the raw material components in the microecological preparation are safe and have no toxic or side effect.
(4) The microecological preparation can eliminate immunosuppressive factors, and improve the uniformity of antibodies after vaccine immunization and the disease resistance of livestock and poultry.
Detailed Description
All features disclosed in this specification may be combined in any combination, except features and/or steps that are mutually exclusive.
In order to make those skilled in the art better understand the technical solution of the present invention, the following detailed description of the present invention is provided with reference to specific examples.
Example 1
A microecological preparation for treating respiratory diseases of livestock and poultry comprises the following components in parts by weight: 10 parts of mulberry leaf, 8 parts of moxibustion licorice, 10 parts of forsythia suspense leaf, 6 parts of scutellaria baicalensis, 1 part of lactobacillus powder, 1 part of sucrose and 1 part of edible selenium.
The preparation method of the microecological preparation specifically comprises the following steps:
(1) weighing folium Mori, radix Glycyrrhizae Preparata, folium forsythiae, and radix Scutellariae in proportion, pulverizing, and mixing to obtain Chinese medicinal composition;
(2) extracting the traditional Chinese medicine composition obtained in the step (1) by using a solvent to obtain a traditional Chinese medicine extract;
(3) pouring the traditional Chinese medicine extract obtained in the step (2) into a fermentation tank, adding lactobacillus powder, sucrose and edible selenium into the fermentation tank in proportion, adjusting the pH to 4.3 by using wood vinegar, placing the fermentation tank at 25 ℃ under a shading condition for 8 hours, wrapping the fermentation tank by using a plastic stretching film, sealing and storing for 22 days, and extracting fermentation liquor to obtain the microecological preparation.
Example 2
A microecological preparation for treating respiratory diseases of livestock and poultry comprises the following components in parts by weight: 15 parts of mulberry leaf, 13 parts of moxibustion licorice, 15 parts of forsythia suspense leaf, 10 parts of scutellaria baicalensis, 2 parts of lactobacillus powder, 2 parts of sucrose and 2 parts of edible selenium.
The preparation method of the microecological preparation specifically comprises the following steps:
(1) weighing folium Mori, radix Glycyrrhizae Preparata, folium forsythiae, and radix Scutellariae in proportion, pulverizing, and mixing to obtain Chinese medicinal composition;
(2) extracting the traditional Chinese medicine composition obtained in the step (1) by using a solvent to obtain a traditional Chinese medicine extract;
(3) pouring the traditional Chinese medicine extract obtained in the step (2) into a fermentation tank, adding lactobacillus powder, sucrose and edible selenium into the fermentation tank in proportion, adjusting the pH to 4.3 by using wood vinegar, placing the fermentation tank at 25 ℃ under a shading condition for 8 hours, wrapping the fermentation tank by using a plastic stretching film, sealing and storing for 22 days, and extracting fermentation liquor to obtain the microecological preparation.
Example 3
A microecological preparation for treating respiratory diseases of livestock and poultry is characterized by comprising the following components in parts by weight: 14 parts of mulberry leaf, 12 parts of moxibustion licorice, 14 parts of forsythia suspense leaf, 9 parts of scutellaria baicalensis, 1.8 parts of lactobacillus powder, 1.8 parts of sucrose and 1.8 parts of edible selenium.
The preparation method of the microecological preparation specifically comprises the following steps:
(1) weighing folium Mori, radix Glycyrrhizae Preparata, folium forsythiae, and radix Scutellariae in proportion, pulverizing, and mixing to obtain Chinese medicinal composition;
(2) extracting the traditional Chinese medicine composition obtained in the step (1) by using a solvent to obtain a traditional Chinese medicine extract;
(3) pouring the traditional Chinese medicine extract obtained in the step (2) into a fermentation tank, adding lactobacillus powder, sucrose and edible selenium into the fermentation tank in proportion, adjusting the pH to 4.5 by using wood vinegar, placing the fermentation tank at 290 ℃ under a shading condition for 9.5 hours, wrapping the fermentation tank by using a plastic stretching film, sealing and storing for 24 days, and extracting fermentation liquor to obtain the microecological preparation.
Example 4
A microecological preparation for treating respiratory diseases of livestock and poultry comprises the following components in parts by weight: 14 parts of mulberry leaf, 12 parts of moxibustion licorice, 14 parts of forsythia suspense leaf, 9 parts of scutellaria baicalensis, 1.8 parts of lactobacillus powder, 1.8 parts of sucrose and 1.8 parts of edible selenium.
The preparation method of the microecological preparation specifically comprises the following steps:
(1) weighing folium Mori, radix Glycyrrhizae Preparata, folium forsythiae, and radix Scutellariae in proportion, pulverizing, and mixing to obtain Chinese medicinal composition;
(2) extracting the traditional Chinese medicine composition obtained in the step (1) by using a solvent to obtain a traditional Chinese medicine extract;
(3) pouring the traditional Chinese medicine extract obtained in the step (2) into a fermentation tank, adding lactobacillus powder, sucrose and edible selenium into the fermentation tank in proportion, adjusting the pH to 4.5 by using wood vinegar, placing the fermentation tank at 29 ℃ under a shading condition for 9.5 hours, wrapping the fermentation tank by using a plastic stretching film, sealing and storing for 24 days, and extracting fermentation liquor to obtain the microecological preparation.
Example 5
A microecological preparation for treating respiratory diseases of livestock and poultry is characterized by comprising the following components in parts by weight: 13 parts of mulberry leaf, 11 parts of moxibustion licorice, 13 parts of forsythia suspense leaf, 8 parts of scutellaria baicalensis, 1.5 parts of lactobacillus powder, 1.5 parts of sucrose and 1.5 parts of edible selenium.
The preparation method of the microecological preparation specifically comprises the following steps:
(1) weighing folium Mori, radix Glycyrrhizae Preparata, folium forsythiae, and radix Scutellariae in proportion, pulverizing, and mixing to obtain Chinese medicinal composition;
(2) extracting the traditional Chinese medicine composition obtained in the step (1) by using a solvent to obtain a traditional Chinese medicine extract;
(3) pouring the traditional Chinese medicine extract obtained in the step (2) into a fermentation tank, adding lactobacillus powder, sucrose and edible selenium into the fermentation tank in proportion, adjusting the pH to 4.6 by using wood vinegar, placing the fermentation tank at 30 ℃ under a shading condition for 10 hours, wrapping the fermentation tank by using a plastic stretching film, sealing and storing for 25 days, and extracting fermentation liquor to obtain the microecological preparation.
The technical principle of examples 1 to 5 is:
the traditional Chinese medicine composition provided by the invention is prepared by mixing folium mori, roasted liquorice, folium forsythia and radix scutellariae, the folium mori has the effects of resisting bacteria, diminishing inflammation, clearing heat and removing toxicity, and minerals contained in the folium mori have the effects of relaxing bowel, improving constipation and effectively relieving accumulation of toxins in bodies, so that the antibacterial and detoxifying effects of the preparation are improved, the immunity of livestock and poultry using the microbial preparation is higher, the radix glycyrrhizae preparata has the effects of tonifying spleen and qi, relieving cough and moistening lung, and relieving acute toxicity, the treatment effect of the microbial preparation on respiratory diseases of livestock and poultry is further improved, the added folium forsythia, radix scutellariae, folium mori and roasted liquorice are mixed to play a role in auxiliary reinforcement, and the prepared microbial preparation has a good treatment effect on the respiratory diseases of livestock and poultry through the synergistic effect among the components.
The added lactobacillus powder is mainly used as probiotics for regulating the intestinal micro-ecological environment, after the lactobacillus powder is prepared into live bacteria in a non-culturable state, the probability of the bacteria contacting immune cells is increased due to the reduction of thalli, the difficulty of the bacteria moving to the immune cells and the vicinity of the immune cells is reduced, the non-culturable state lactobacillus can be acted on the immune cells of a host, the bacteriostatic activity of lysozyme or/and antibacterial peptide secreted by the action part of the host can be higher, the lysozyme or/and the antibacterial peptide can play a larger role, and the micro-ecological environment of the host digestive tract and other action parts can be improved more efficiently.
The lactobacillus powder is prepared from lactobacillus in healthy chicken, and the lactobacillus is modified by genetic engineering technology while exerting the advantages of microecological preparation of lactobacillus, so that the lactobacillus can express antiviral factors and immune antigens, and can secrete antiviral factors and specific antigen substances after administration through digestive tract, thereby inhibiting and killing pathogens, activating intestinal mucosa immune system, and improving the overall immunity of organism.
Test detection
Test materials: microbial preparations prepared in examples 1 to 5 of the present invention
Test animals: naturally-occurring sick chicken
And (3) disease diagnosis: the chickens with natural onset are selected to be cough, tracheal rales and sneeze, and the dead chickens are dissected to find the swollen and pale kidney, renal tubule and ureter urate deposition.
The medication method comprises the following steps: 200g of the medicine/ton of the feed is uniformly mixed into the feed for oral administration; the control group was a normal diet, and was used for 5 days.
And (3) judging the curative effect: continuously taking the medicine for 5 days, observing the overall situation of the chicken group every day during the medicine taking period, continuously observing for 2 days after the medicine taking period is finished, recording the observation result every day, comparing the observation result with the recorded result before the medicine taking, and judging the curative effect of the medicine in the disease prevention and treatment according to the comparison result. During the experimental administration treatment and observation period, the chicken is judged to be effective if the symptoms are obviously relieved after the chicken is cured or administered; during treatment and observation with experimental dosing, the typical symptoms of bronchitis in chickens appeared and died, with a characteristic lesion determined to be dead at necropsy.
And (3) clinical trials: the natural-onset chickens with typical clinical symptoms are selected, randomly grouped into 6 groups, each group comprises 100 chickens, 5 sample groups (examples 1-5) of the drug treatment group are selected, a blank control group (normally fed with feed) is arranged, and statistical treatment results are observed under the condition that feeding management conditions are consistent.
Test results
| Group of | Name of disease | Number of cases | Effective number | High efficiency | Number of deaths | Mortality rate |
| Example 1 | Bronchitis | 100 | 95 | 95％ | 5 | 5％ |
| Example 2 | Bronchitis | 100 | 96 | 96％ | 4 | 4％ |
| Example 3 | Bronchitis | 100 | 95 | 95％ | 5 | 5％ |
| Example 4 | Bronchitis | 100 | 98 | 98％ | 2 | 2％ |
| Example 5 | Bronchitis | 100 | 97 | 97％ | 3 | 3％ |
| Control group | Bronchitis | 100 | 10 | 10％ | 90 | 90％ |
According to the data detected in the table, the microecological preparation for treating the respiratory diseases of the livestock and poultry, which is prepared by the invention, has a good treatment effect, and the survival rate is improved. The microecological preparation can maintain the body of livestock and poultry with persistent disease resistance, and the lactobacillus powder added in the raw material components can ensure that the microecological preparation colonizes in intestinal tract for a long time, continuously stimulate the body to generate immunity and secrete antiviral factors, induce specific and nonspecific immunoreaction, and eliminate sub-health state. Meanwhile, the preparation and the use of the microecological preparation are both convenient, and the raw material components in the microecological preparation are safe and have no toxic or side effect.
The above-mentioned embodiments only express the specific embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present application. It should be noted that, for those skilled in the art, without departing from the technical idea of the present application, several changes and modifications can be made, which are all within the protection scope of the present application.
Claims (10)
1. A microecological preparation for treating respiratory diseases of livestock and poultry is characterized by comprising the following components in parts by weight: 10-15 parts of mulberry leaf, 8-13 parts of moxibustion licorice, 10-15 parts of weeping forsythia leaf, 6-10 parts of scutellaria baicalensis, 1-2 parts of lactobacillus powder, 1-2 parts of sucrose and 1-2 parts of edible selenium.
2. The microecological preparation for treating the respiratory diseases of livestock and poultry according to claim 1, which comprises the following components in parts by weight: 12-14 parts of mulberry leaf, 10-12 parts of moxibustion licorice, 12-14 parts of weeping forsythia leaf, 7-9 parts of scutellaria baicalensis, 1.3-1.8 parts of lactobacillus powder, 1.3-1.8 parts of sucrose and 1.3-1.8 parts of edible selenium.
3. The microecological preparation for treating the respiratory diseases of livestock and poultry according to claim 1, which comprises the following components in parts by weight: 13 parts of mulberry leaf, 11 parts of moxibustion licorice, 13 parts of forsythia suspense leaf, 8 parts of scutellaria baicalensis, 1.5 parts of lactobacillus powder, 1.5 parts of sucrose and 1.5 parts of edible selenium.
4. The microecological agent for treating respiratory diseases in livestock and poultry according to any one of claims 1 to 3, wherein the lactic acid bacteria powder is derived from lactic acid bacteria in healthy chickens.
5. A preparation method of the microecological preparation for treating the respiratory diseases of the livestock and the poultry according to any one of claims 1 to 3, which is characterized by comprising the following steps:
(1) weighing folium Mori, radix Glycyrrhizae Preparata, folium forsythiae, and radix Scutellariae in proportion, pulverizing, and mixing to obtain Chinese medicinal composition;
(2) extracting the traditional Chinese medicine composition obtained in the step (1) by using a solvent to obtain a traditional Chinese medicine extract;
(3) pouring the traditional Chinese medicine extract obtained in the step (2) into a fermentation tank, adding lactobacillus powder, sucrose and edible selenium into the fermentation tank in proportion, adjusting pH to acidity, sealing and storing for 22-25 days, and extracting fermentation liquor to obtain the microecological preparation.
6. The preparation method of the microecological agent for treating the respiratory diseases of livestock and poultry according to claim 4, wherein the pH value is adjusted to be acidic by using wood vinegar in the step (3).
7. The method for preparing a microecological agent for treating respiratory diseases in livestock and poultry according to claim 4 or 5, wherein the pH in the step (3) is adjusted to 4.3 to 4.6.
8. The preparation method of the microecological agent for treating the respiratory diseases of livestock and poultry according to claim 4, wherein the fermentation tank is placed at 25-30 ℃ under a shading condition for 8-10 hours before being hermetically stored in the step (3).
9. The preparation method of the microecological agent for treating the respiratory diseases of livestock and poultry according to claim 4, wherein the fermentation tank is coated with a plastic stretch film in the step (3).
10. The use of the microecological agent for the treatment of respiratory diseases in livestock and poultry according to any one of claims 1 to 3, wherein the microecological agent is used for preparing an antiviral feed.
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