CN111248221A - Long-acting disinfectant stabilized by synergist - Google Patents
Long-acting disinfectant stabilized by synergist Download PDFInfo
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- CN111248221A CN111248221A CN202010090532.4A CN202010090532A CN111248221A CN 111248221 A CN111248221 A CN 111248221A CN 202010090532 A CN202010090532 A CN 202010090532A CN 111248221 A CN111248221 A CN 111248221A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/08—Amines; Quaternary ammonium compounds containing oxygen or sulfur
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Abstract
The invention provides a long-acting disinfectant stabilized by a synergist. Wherein the synergist mainly comprises polyethylene glycol long-chain alkylamine, benzalkonium chloride, polyhexamethylene monoguanidine hydrochloride, quaternary ammonium salt-73 and the like. Benzalkonium chloride, polyhexamethylene monoguanidine hydrochloride and quaternary ammonium salt-73, which have sterilizing capacity and can act with chlorine dioxide to disperse charges on oxygen atoms of the compounds, thereby stabilizing the chlorine dioxide. The polyethylene glycol long-chain alkylamine can effectively wrap active ingredients such as chlorine dioxide, benzalkonium chloride, polyhexamethylene guanidine hydrochloride, quaternary ammonium salt-73 and the like through the coordination of a plurality of oxygen atoms, and long-chain alkyl segments generate an isolation effect to reduce the degradation speed of the active ingredients, so that long-acting disinfection is realized.
Description
Technical Field
The invention relates to the fields of daily chemicals, personal cleaning, personal care, disinfection and the like, in particular to a long-acting disinfectant stabilized by a synergist. The synergistic agent in the disinfectant can effectively delay the decomposition of main disinfectant component chlorine dioxide, thereby enhancing the disinfection effect.
Background
Chlorine dioxide is favored for its excellent disinfection performance, but the concentration of chlorine dioxide in air exceeding a certain range is dangerous, and unsafe factors exist in use and storage, which all make the efficiency not fully exerted, cause waste of resources, and possibly even cause secondary pollution. Therefore, the synergist is added in the disinfectant formula, and a controllable chlorine dioxide release model is established, so that the release rate of chlorine dioxide can be effectively controlled, namely, the chlorine dioxide reaches a certain concentration at a certain rate in a certain time and a certain area, so that the disinfectant has generalization meaning and market operability, and has high market value and good quality and low price.
Currently, the main studies on the stabilization of chlorine dioxide are: 1. the stable chlorine dioxide solution mainly uses water-soluble inorganic salts such as sodium percarbonate, sodium perborate, chlorate, sulfite, acetic acid, citric acid, tartaric acid and the like to absorb chlorine dioxide, so that the chlorine dioxide solution has certain stability in an aqueous solution; 2. the adsorption type solid chlorine dioxide is prepared by adsorbing chlorine dioxide solution with activated solid carrier such as aluminosilicate, calcium alum, zeolite, silica fine powder, diatomite, active carbon, volcanic ash, hydrophilic resin, agar, high water absorption polyacrylic resin, carboxymethyl cellulose, etc. to obtain stable and sustained-release chlorine dioxide.
Although the above strategies may have some effect of stabilizing chlorine dioxide, the additives or stabilizers used have some biological safety or compatibility problems, and are not suitable for use in personal care/disinfection products, especially products that come into direct contact with the skin. The invention aims at the problems and provides a long-acting disinfectant stabilized by a synergist. The disinfectant takes chlorine dioxide as a main disinfecting component, and takes polyethylene glycol long-chain alkylamine, benzalkonium chloride, polyhexamethylene guanidine hydrochloride, quaternary ammonium salt-73 and the like as synergistic products, and the synergistic products have good biological safety and can effectively delay the decomposition of the main disinfecting component chlorine dioxide, thereby enhancing the disinfecting effect.
Disclosure of Invention
The invention provides a long-acting disinfectant stabilized by a synergist. The synergist mainly comprises polyethylene glycol long-chain alkylamine, benzalkonium chloride, polyhexamethylene monoguanidine hydrochloride, quaternary ammonium salt-73 and the like.
Wherein the polyethylene glycol long-chain alkylamine has the following structural characteristics:
in the structure, the Alkyl is selected from straight-chain or branched-chain Alkyl containing 6-30 carbons; n is the number of the repeated ethoxy units, namely the corresponding polyethylene glycol fragments with different molecular weights, generally, the polyethylene glycol fragment is selected from one or more mixtures of polyethylene glycols with the molecular weights of 200-1000, and is preferably selected from one or more mixtures of polyethylene glycols with the molecular weights of 200, 300, 400, 500, 600, 800 and 1000.
The benzalkonium chloride has the chemical name of dimethyl benzyl ammonium chloride, is an important cationic quaternary ammonium salt surfactant, is widely used for products such as personal care, shampoo, hair conditioner and the like, has good antistatic, softening and antiseptic effects, and can also be used for industries such as sterilization, printing and dyeing auxiliaries, fabric washing and the like.
Polyhexamethylene guanidine hydrochloride, colorless, odorless; is nontoxic; non-inflammable, non-explosive, safe in use, broad in sterilization spectrum, low in effective concentration, fast in action speed, stable in property and easy to dissolve in water. It can be used at normal temperature, and has long-term antibacterial effect, no adverse side effect, and no corrosiveness.
The quaternary ammonium salt-73 is also called as proud, is a novel efficient acne-removing anti-inflammatory agent, and is yellow tasteless crystalline powder in appearance; acne, acne inhibitors with antibacterial activity; can be used as antiseptic, has strong killing effect on bacteria, staphylococcus, Escherichia coli, etc., has antiseptic property superior to that of parabens, and can inhibit melanin generation. In addition, it has high safety, good stability to heat and light, stability in ph range of 5.5-8.0, low dosage and high performance-price ratio.
Benzalkonium chloride, polyhexamethylene guanidine hydrochloride and quaternary ammonium salt-73, wherein the three compounds have a disinfection function, and when the three compounds are added into a disinfectant of chlorine dioxide, the disinfection effect can be enhanced; in addition, the three compounds belong to amine salt, and the nitrogen positive ion center of the amine salt can react with the oxygen atom of the chlorine dioxide to disperse the charge on the oxygen atom, thereby stabilizing the chlorine dioxide.
The polyethylene glycol long-chain alkylamine is formed by bridging polyethylene glycol and long-chain alkyl through amido. On one hand, the polyethylene glycol segment can effectively wrap active ingredients such as chlorine dioxide, benzalkonium chloride, polyhexamethylene guanidine hydrochloride, quaternary ammonium salt-73 and the like through the coordination of a plurality of oxygen atoms, and the long-chain alkyl segment has an isolation effect and reduces the degradation speed of the active ingredients, so that long-acting sterilization is realized; on the other hand, the polyethylene glycol long-chain alkylamine is used as an effective surfactant, can more effectively promote the dispersion of the disinfectant on the skin surface, and achieves a slow-release effect.
The purpose of the invention can be realized by the following technical scheme:
the long-acting disinfectant stabilized by the synergistic agent is characterized in that the disinfectant is prepared by taking chlorine dioxide as a main disinfecting component, pure water as a solvent, polyethylene glycol long-chain alkylamine, benzalkonium chloride, polyhexamethylene guanidine hydrochloride and quaternary ammonium salt-73 as the synergistic agent and adding a proper amount of auxiliary materials according to the dosage form of the disinfectant.
Further, the long-acting disinfectant stabilized by the synergist is characterized by being prepared from the following components in percentage by mass:
further, the long-acting disinfectant stabilized by the synergist is prepared by the following formula:
| serial number | Raw materials | Ratio of |
| 1 | Chlorine dioxide | 0.01-0.03％ |
| 2 | Polyethylene glycol long chain alkylamines | 0.5-1％ |
| 3 | Benzalkonium chloride | 0.1-0.3％ |
| 4 | Polyhexamethylene guanidine hydrochloride | 0.5-1％ |
| 5 | Quaternary ammonium salt-73 | 0.001-0.003％ |
| 6 | Propylene glycol | 1-3％ |
| 7 | Glycerol | 4-6％ |
| 8 | Trehalose | 0.5-1％ |
| 9 | Cocoamidopropyl betaine | 0.5-1％ |
| 10 | Lauryl glucoside | 0.2-0.5％ |
| 11 | Citric acid triethyl ester | 0.5-1％ |
| 12 | Ethylenediaminetetraacetic acid disodium salt | 0.1-0.5％ |
| 13 | Pure water | Balance of |
Further, the long-acting disinfectant stabilized by the synergist, a typical disinfectant spray formulation:
the invention has the beneficial effects that:
the invention provides a long-acting disinfectant stabilized by a synergist. Wherein the synergist mainly comprises polyethylene glycol long-chain alkylamine, benzalkonium chloride, polyhexamethylene monoguanidine hydrochloride, quaternary ammonium salt-73 and the like. Benzalkonium chloride, polyhexamethylene guanidine hydrochloride and quaternary ammonium salt-73, which have sterilizing capacity, and the nitrogen positive ion center of the three compounds can act with the oxygen atom of chlorine dioxide to disperse the charge on the oxygen atom, thereby stabilizing the chlorine dioxide. The polyethylene glycol long-chain alkylamine is formed by bridging polyethylene glycol and long-chain alkyl through amido. On one hand, the polyethylene glycol segment can effectively wrap active ingredients such as chlorine dioxide, benzalkonium chloride, polyhexamethylene guanidine hydrochloride, quaternary ammonium salt-73 and the like through the coordination of a plurality of oxygen atoms, and the long-chain alkyl segment has an isolation effect and reduces the degradation speed of the active ingredients, so that long-acting sterilization is realized; on the other hand, the polyethylene glycol long-chain alkylamine is used as an effective surfactant, can more effectively promote the dispersion of the disinfectant on the skin surface, and achieves a slow-release effect. The synergistic agents have good biological safety and can effectively delay the decomposition of the main disinfection component chlorine dioxide, thereby enhancing the disinfection effect and realizing long-acting disinfection.
Detailed Description
Example 1
Preparation of polyethylene glycol long-chain alkylamine (polyethylene glycol 1000 octadecylamine):
the preparation method of the polyethylene glycol long-chain alkylamine with alkyl chain containing 18 carbon atoms and polyethylene glycol fragment molecular weight of 1000 comprises the following steps: 100 g (0.1mol) of polyethylene glycol monomethyl ether (mPEG1000) having a molecular weight of 1000, 3 g (0.05mol) of silica, 10 g (0.1mol) of alumina, and 27 g (0.1mol) of octadecylamine were sequentially added to a 500ml autoclave, and after reacting at 180 ℃ for 36 hours, the mixture was extracted three times with water and ethyl acetate to remove the water layer, and the organic layer was dried over anhydrous sodium sulfate. Removing solvent with rotary evaporator, extracting product with dichloromethane, and evaporating solvent to obtain 111 g polyethylene glycol octadecyl amine (1) with yield of 89%
Example 2
Preparation of polyethylene glycol long-chain alkylamine (polyethylene glycol 500 hexadecylamine):
the preparation method of the polyethylene glycol long-chain alkylamine with an alkyl chain containing 16 carbon atoms and a polyethylene glycol fragment molecular weight of 500 comprises the following steps: 50 g (0.1mol) of polyethylene glycol monomethyl ether (mPEG500) having a molecular weight of 500, 3 g (0.05mol) of silica, 10 g (0.1mol) of alumina, and 26 g (0.1mol) of hexadecylamine were sequentially added to a 500ml autoclave, and after reacting at 180 ℃ for 36 hours, the mixture was extracted three times with water and ethyl acetate to remove the water layer, and the organic layer was dried over anhydrous sodium sulfate. The solvent was removed by a rotary evaporator, the product was extracted with dichloromethane and the solvent was evaporated to yield 65 g of polyethylene glycol hexadecylamine (2) in 88% yield
Example 3 (disinfectant formulation 1)
Example 4 (disinfectant formulation 2)
Example 5 (disinfectant formulation 3)
Example 6 (formulation of foam disinfectant):
example 7 (formulation of disinfectant spray):
example 8 (stability test of disinfectant):
the disinfectant prepared in the embodiment is stored in a constant temperature box at 37 ℃ for 90 days, and the appearance of the disinfectant is unchanged and is colorless and transparent.
The content of the effective components in the disinfectant is changed (mass percentage):
| active ingredient | Before preservation | After preservation | Rate of decline |
| Chlorine dioxide in foam disinfectant of Baojiashu (example 6) | 0.02％ | 0.0195 | 2.5％ |
| Chlorine dioxide in a disinfectant spray of Baojiashu (example 7) | 0.02％ | 0.0196 | 2％ |
The experimental result shows that the product is stored for 90 days at 37 ℃, the reduction rate of the main components is lower than 3 percent, and the product meets the standard that the effective period is 2 years.
Example 9 (Sterilization Effect test)
The disinfectant prepared in the example was subjected to a quantitative sterilization test using a suspension according to the requirements of the test method "technical specification for disinfection" (2002 edition), and the test results are shown in the following table, taking the disinfectant spray "baobaoshu" prepared in example 7 as an example:
| type of microorganism | Time of action | Killing logarithm value | Rate of killing |
| Colon bacillus 8099 | 1 minute | >5 | 100％ |
| Pseudomonas aeruginosa ATCC15442 | 1 minute | >5 | 100％ |
| Staphylococcus aureus ATCC6538 | 1 minute | >5 | 100％ |
| Hemolytic streptococcus | 1 minute | >5 | 100％ |
The product quality index is as follows:
| microorganisms | Index (I) |
| Total bacterial colony count cfu/mL | ≤200 |
| Total number of fungal colonies cfu/mL | ≤100 |
| Coliform group bacteria | Cannot be detected |
| Pathogenic purulent bacteria | Cannot be detected |
The results show that the product can achieve 100 percent of killing rate in a short time (1min) for killing common bacteria, and achieves the effect of quick sterilization.
Claims (7)
1. A long-acting disinfectant stabilized by synergistic agent is characterized by that said disinfectant is made up by using chlorine dioxide as main disinfecting component, using pure water as solvent, using polyethylene glycol long-chain alkylamine, benzalkonium chloride, polyhexamethylene guanidine hydrochloride and quaternary ammonium salt-73 as synergistic agent and adding proper quantity of auxiliary material according to the dosage form of said product.
2. A long acting disinfectant stabilized by a synergist according to claim 1 wherein said polyethylene glycol long chain alkyl amine has the following structural features:
wherein the Alkyl is selected from straight-chain or branched-chain Alkyl containing 6-30 carbons; n is the number of the repeated ethoxy units, namely the corresponding polyethylene glycol fragments with different molecular weights, generally, the polyethylene glycol fragment is selected from one or more mixtures of polyethylene glycols with the molecular weights of 200-1000, and is preferably selected from one or more mixtures of polyethylene glycols with the molecular weights of 200, 300, 400, 500, 600, 800 and 1000.
3. The long-acting disinfectant stabilized by the synergistic agent as claimed in claims 1-2, which is prepared from the following components in percentage by mass:
4. a long-acting disinfectant stabilized by a synergist according to claims 1-2, wherein a typical foam disinfectant formulation:
5. a long-acting disinfectant stabilised by means of synergists according to claims 1-2, characterised in that a typical disinfectant spray formulation:
6. A long-acting disinfectant stabilized by synergists according to claims 1-2, wherein a commercial foam disinfectant formulation:
7. a long acting disinfectant stabilised by synergists according to claims 1 to 2 characterised in that a commercial disinfectant spray is formulated as:
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111944139A (en) * | 2020-06-30 | 2020-11-17 | 名畔科技(镇江)有限公司 | Surfactant, and synthesis method and application thereof |
| CN113116809A (en) * | 2021-03-02 | 2021-07-16 | 泰州市第二人民医院 | External-use type delivery analgesic composition and application thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1631770A (en) * | 2003-12-23 | 2005-06-29 | 王汉道 | Method for preparing activation-free stable chlorine dioxide |
| CN1644488A (en) * | 2004-12-08 | 2005-07-27 | 龙膺厚 | Long-effective instant aqueous chlorine solution |
| US20050196370A1 (en) * | 2003-03-18 | 2005-09-08 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
| CN1759679A (en) * | 2005-11-01 | 2006-04-19 | 济南营养源食品科技有限公司 | Controlled release formulation of solid chlorine dioxide |
| CN101036471A (en) * | 2007-04-28 | 2007-09-19 | 穆超碧 | Disinfecting agent and its preparing method |
| CN101669518A (en) * | 2009-09-30 | 2010-03-17 | 北京欧凯纳斯科技有限公司 | Germicidal antiviral composite containing chlorine dioxide |
| CN101766186A (en) * | 2010-01-15 | 2010-07-07 | 北京欧凯纳斯科技有限公司 | Composition capable of slowly-releasing chlorine dioxide and application thereof |
| CN107347910A (en) * | 2017-06-23 | 2017-11-17 | 四川奥恒环保科技有限公司 | A kind of Biocidal algae-killing agent and preparation method thereof |
-
2020
- 2020-02-13 CN CN202010090532.4A patent/CN111248221A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050196370A1 (en) * | 2003-03-18 | 2005-09-08 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
| CN1631770A (en) * | 2003-12-23 | 2005-06-29 | 王汉道 | Method for preparing activation-free stable chlorine dioxide |
| CN1644488A (en) * | 2004-12-08 | 2005-07-27 | 龙膺厚 | Long-effective instant aqueous chlorine solution |
| CN1759679A (en) * | 2005-11-01 | 2006-04-19 | 济南营养源食品科技有限公司 | Controlled release formulation of solid chlorine dioxide |
| CN101036471A (en) * | 2007-04-28 | 2007-09-19 | 穆超碧 | Disinfecting agent and its preparing method |
| CN101669518A (en) * | 2009-09-30 | 2010-03-17 | 北京欧凯纳斯科技有限公司 | Germicidal antiviral composite containing chlorine dioxide |
| CN101766186A (en) * | 2010-01-15 | 2010-07-07 | 北京欧凯纳斯科技有限公司 | Composition capable of slowly-releasing chlorine dioxide and application thereof |
| CN107347910A (en) * | 2017-06-23 | 2017-11-17 | 四川奥恒环保科技有限公司 | A kind of Biocidal algae-killing agent and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111944139A (en) * | 2020-06-30 | 2020-11-17 | 名畔科技(镇江)有限公司 | Surfactant, and synthesis method and application thereof |
| CN111944139B (en) * | 2020-06-30 | 2023-06-06 | 名畔科技(镇江)有限公司 | Surfactant, synthetic method and application of surfactant |
| CN113116809A (en) * | 2021-03-02 | 2021-07-16 | 泰州市第二人民医院 | External-use type delivery analgesic composition and application thereof |
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Application publication date: 20200609 |