CN115252448A

CN115252448A - Bacteriostatic personal cleaning composition and application thereof

Info

Publication number: CN115252448A
Application number: CN202210836522.XA
Authority: CN
Inventors: 宋银银; 江丹; 赵韬; 钟美; 李淑钰; 鹿桂乾; 张利萍
Original assignee: Guangzhou Liby Enterprise Group Co Ltd
Current assignee: Guangzhou Liby Enterprise Group Co Ltd
Priority date: 2022-07-15
Filing date: 2022-07-15
Publication date: 2022-11-01

Abstract

The invention discloses a bacteriostatic personal cleaning composition and application thereof, and relates to the technical field of personal cleaning. A bacteriostatic personal cleansing composition comprising the following ingredients: (a) 3% to 14% by weight of a fatty acid salt; (b) from 0.5% to 16% by weight of a fatty amido acid salt; (c) 0.01 to 0.5% by weight of a cationic quaternary ammonium surfactant; (d) a pH greater than 8.5; the fatty acid salt is fatty acid potassium salt or fatty acid sodium salt; the fatty acylamino acid salt is a potassium fatty acylamino acid salt or a sodium fatty acylamino acid salt. In the composition, the cationic quaternary ammonium salt surfactant can play a role in inhibiting bacteria in the combination of the fatty acid salt and the fatty acylamino acid salt, the inhibition rate to staphylococcus aureus and escherichia coli can reach more than 90% within 2 minutes in a short time, the same effect can be achieved after dilution, the composition has a broad-spectrum inhibition effect on bacteria, and is suitable for personal cleaning and nursing.

Description

Bacteriostatic personal cleaning composition and application thereof

Technical Field

The invention relates to the technical field of personal cleaning, in particular to a bacteriostatic personal cleaning composition and application thereof.

Background

The bacteriostatic cleanser is mainly in the form of a laureth sulfate (AES) system compound bactericide. The AES system bacteriostatic cleaning agent is limited by the difficult washability of AES, often has residual feeling in actual use, influences the use experience of consumers, can increase the residence time of the bactericide on the skin surface, and is easy to generate stimulation. The AES system has antagonistic action on the performance of a plurality of bactericides, and the bacteriostatic effect of part of the bactericides cannot be exerted in the system at all, such as cationic quaternary ammonium salt bactericides, part of the bactericides can exert better basic effect only by adding higher dosage, such as phenolic bactericides, and part of the bactericides can exert better bacteriostatic effect only by needing very low pH value, such as organic acid bactericides.

The cationic quaternary ammonium surfactant has good bacteriostatic or antibacterial effect when being used alone, has low dosage, does not have high requirement in the production process like an alcohol bactericide, is a bactericide component with broad-spectrum bacteriostatic and simple and convenient process, is limited by the special chemical property of the cationic quaternary ammonium surfactant, is mostly used in a no-wash type disinfection product, and is difficult to play bacteriostatic or antibacterial effect in a cleaning product with great market demand.

Patent document CN 109069422A discloses a topical composition comprising: a) 0.1 to 10 weight% nicotinamide or a derivative thereof; b) 0.01% to 5% by weight of a first quaternary ammonium salt comprising didecyl dimethyl ammonium chloride; c) 0.01 to 5 wt% of a second quaternary ammonium salt; and d) a cosmetically acceptable base. The composition has good antibacterial effect when staying on the surface of the action part. The patent still protects the antibacterial effect of the cation in the disposable product.

Patent document CN104736687a discloses a soap composition wherein the soap is capable of exerting a synergistic antimicrobial activity with other antimicrobial ingredients, essential oils and parachlorometaxylenol at a soap percentage of 15-80%. The invention finds that the high-content soap can be cooperated with other organic molecule bactericides to exert bactericidal activity, but the high-content soap is difficult to be added into the actual cleaning liquid product, so that the cost is high on one hand, and a liquid formula is difficult to form on the other hand.

The detergent product which is used on the skin surface and has the cleaning or bacteriostatic action has larger market demand, the cationic quaternary ammonium surfactant is also a stable and effective bactericide, and a system for the cationic quaternary ammonium surfactant to play the bacteriostatic action in the cleaning product is not researched in the prior art.

Disclosure of Invention

In view of the above disadvantages of the prior art, the present inventors have found that in a suitable pH environment, a cationic quaternary ammonium surfactant can be well compatible with a fatty acid salt and a fatty acylamino acid salt, and the bacteriostatic effect of the cationic quaternary ammonium surfactant in a system containing an anionic surfactant can be released, and the bacteriostatic effect can be exhibited in a short time, such as 2 minutes, and is excellent.

Therefore, one purpose of the invention is to exert the bacteriostatic performance of the cationic quaternary ammonium salt surfactant in a cleaning system containing an anionic surfactant, so that the cationic quaternary ammonium salt bactericide has a wider application range.

It is another object of the present invention to provide a surfactant cleaning system which can exhibit bacteriostatic properties in a short time using a small amount of cationic quaternary ammonium salt surfactant.

The invention also aims to provide a composition, which is convenient to add other sterilization components, and can be cooperated with the composition to play a stronger bacteriostatic action.

In order to achieve the above purpose, the present invention provides the following technical solutions:

a bacteriostatic personal cleansing composition comprising the following ingredients:

a personal cleansing composition comprising the following ingredients:

(a) 3% to 14% by weight of a fatty acid salt;

(b) From 0.5% to 16% by weight of a fatty amido acid salt;

(c) 0.01 to 0.5% by weight of a cationic quaternary ammonium surfactant;

(d) The pH value is more than 8.5.

The fatty acid salt is fatty acid potassium salt or fatty acid sodium salt, and the fatty acid carbon chain is more than C12, belongs to an anionic surfactant, and has a good cleaning effect and excellent flushing property. The fatty acid salt is produced by neutralizing a fatty acid with a neutralizing agent at a temperature higher than the melting temperature of the fatty acid, usually at least about 80 to 90 ℃, and the neutralizing agent is sodium hydroxide or potassium hydroxide. The manufacture of the fatty acid salt requires a suitable reaction time at a suitable temperature and the end point of the neutralization can be controlled by testing the free fatty acid or the pH, e.g. by controlling the pH of a 10% aqueous solution at the end point of the fatty acid salt to be greater than 8.5.

The potassium salt of the fatty acid is at least one of potassium laurate, potassium myristate and potassium palmitate, and the sodium salt of the fatty acid is at least one of sodium laurate, sodium myristate and sodium palmitate. The fatty acid salt is preferably at least one of potassium laurate, potassium myristate and potassium palmitate, and more preferably at least one of potassium laurate and potassium myristate.

The fatty acylamino acid salt is fatty acylamino acid potassium salt or fatty acylamino acid sodium salt, the fatty acid carbon chain is more than C8, the fatty acylamino acid salt belongs to an anionic surfactant, and the fatty acylamino acid salt has a good cleaning effect and is mild to the skin.

The fatty acylamino acid potassium salt is at least one of potassium cocoyl glutamate, dipotassium cocoyl glutamate, potassium lauroyl glutamate, dipotassium lauroyl glutamate, potassium cocoyl glycinate, potassium lauroyl glycinate, potassium cocoyl alanate and potassium lauroyl alanate; the fatty acyl amino acid sodium salt is at least one of sodium cocoyl glutamate, disodium cocoyl glutamate, sodium lauroyl glutamate, disodium lauroyl glutamate, sodium cocoyl glycinate, sodium lauroyl glycinate, sodium cocoyl alanine and sodium lauroyl alanine.

The fatty acylamino acid salt is preferably at least one of potassium cocoyl glycinate, sodium cocoyl glycinate, disodium laurate glutamate, disodium cocoyl glutamate, sodium laurate glutamate and sodium cocoyl glutamate.

The cationic quaternary ammonium salt surfactant is preferably at least one of benzalkonium chloride, benzalkonium bromide, dodecyl dimethyl benzyl ammonium chloride, tetradecyl dimethyl benzyl ammonium chloride, dodecyl dimethyl benzyl ammonium bromide and tetradecyl dimethyl benzyl ammonium bromide.

The pH value of the composition is more than 8.5, preferably the pH value is 8.5 to 10, the pH value of the composition can be adjusted by sodium hydroxide or potassium hydroxide serving as neutralizing agents, and can also be adjusted by fatty acid, and the fatty acid is preferably lauric acid, and can also be adjusted by citric acid or hydrochloric acid.

The composition also comprises 0.1 to 0.5 weight percent of other bactericides, wherein the other bactericides are at least one of p-chloro-m-dimethylphenol, o-phenylphenol and salts thereof, o-cymene-5-alcohol and piroctone olamine; the organic bactericide and the cationic quaternary ammonium salt surfactant are compounded for use, so that the bacteriostatic and even antibacterial effects can be better improved. According to the bacteriostatic or antibacterial requirements of the actual use of the cleaning product, other bactericide components can be added on the basis of the composition, the composition can be well compatible with other bactericides, the bacteriostatic or antibacterial performance of other bactericides can be fully exerted, the effect of other bactericides can be completely released, and the stability of the bacteriostatic or antibacterial performance is maintained.

The composition also includes water, preferably less than 96.5% by weight water, more preferably from 95% to 70% by weight water. The addition of water is convenient for the practical use of the composition, and the appropriate component is selected from the composition according to the actual dosage form requirement of the cleaning product, such as gel or liquid, such as liquid dosage form, preferably one of fatty acid potassium salt, gel type product, preferably fatty acid potassium salt or sodium salt, liquid dosage form, preferably lower content of fatty acid salt and fatty acylamino acid salt in the composition, and gel type product, preferably higher content of fatty acid salt and fatty acylamino acid salt in the composition

The invention also provides the bacteriostatic personal cleaning composition and application thereof in personal cleaning and nursing.

Has the advantages that:

(1) The composition is used for bacteriostasis, can exert the effect within 2 minutes in a short time, and can exert good bacteriostasis effect under the normal use concentration of cleaning products, such as the condition that the mass ratio of the composition to water is 1/0, 1/1 and 1/2. The antibacterial effect is tested according to GB15979-2002, the antibacterial rate of staphylococcus aureus (ATCC 6538) and escherichia coli (8099) is more than or equal to 90% within 2 minutes, the staphylococcus aureus and the escherichia coli are respectively representative of gram positive and gram negative, the staphylococcus aureus and the escherichia coli have good inhibition effects on the two strains, and the broad-spectrum inhibition effect on bacteria can be shown.

(2) In the compositions of the present invention, the cationic quaternary ammonium surfactant is capable of exerting bacteriostatic effects in the combination of the fatty acid salt and the fatty acylamino acid salt. Meanwhile, the composition of the invention can exert the antibacterial effect in a short time, is suitable for personal skin cleaning, can be preferably used for hand cleaning, can well ensure the cleaning effect and reduce the occurrence and spread of diseases caused by microorganism problems.

Detailed Description

In order to more fully understand the technical contents of the present invention, the technical solutions of the present invention will be further described and illustrated with reference to the following specific embodiments.

All percentages, fractions and ratios are calculated on the total mass of the composition of the invention, unless otherwise indicated. All qualities relating to the listed ingredients are given to the content of active substance, unless otherwise specified, and therefore they do not include solvents or by-products that may be contained in commercially available materials. The term "mass percent content" herein may be represented by the symbol "%".

All molecular weights herein are weight average molecular weights expressed in daltons, unless otherwise indicated.

All formulations and tests herein occur in a 25 ℃ environment unless otherwise indicated.

The use of "including," "comprising," "containing," "having," or other variations thereof herein, is meant to encompass the non-exclusive inclusion, as such terms are not to be construed. The term "comprising" means that other steps and ingredients can be added that do not affect the end result. The term "comprising" also includes the terms "consisting of …" and "consisting essentially of …". The compositions and methods/processes of the present invention comprise, consist of, and consist essentially of the essential elements and limitations described herein, as well as any of the additional or optional ingredients, components, steps, or limitations described herein. The terms "potency", "performance", "effect" and "efficacy" are not distinguished from one another herein.

Examples 1-18 were prepared according to table 1.

TABLE 1 examples

	Composition (%)	pH
			Example 1	3% potassium laurate, 2% potassium cocoyl glycinate and 0.02% benzalkonium chloride	9.0
Example 2	3.9% potassium laurate, 0.5% sodium cocoyl glycinate and 0.01% benzalkonium chloride	9.5
			Example 3	5.5% potassium laurate, 3% sodium lauroyl glutamate and 0.05% benzalkonium chloride	9.5
Example 4	5.5% potassium laurate, 10% sodium cocoyl glycinate and 0.05% benzalkonium chloride	8.5
			Example 5	6% potassium laurate, 3% sodium cocoyl glycinate and 0.06% benzalkonium chloride	9.5
Example 6	6% potassium laurate, 3% sodium cocoyl glycinate and 0.06% tetradecyldimethylbenzyl ammonium bromide	9.0
			Example 7	5.5% potassium laurate, 3% disodium cocoyl glutamate and 0.06% benzalkonium chloride	9.5
Example 8	8% potassium laurate, 2% potassium myristate, 7% sodium cocoyl glycinate, 0.2% benzalkonium chloride	10
			Example 9	12% potassium laurate, 2% sodium laurate, 10% potassium cocoyl glycinate and 0.4% benzalkonium chloride	10
Example 10	8% of potassium laurate, 2% of potassium myristate, 16% of sodium lauroyl glutamate and 0.5% of benzalkonium chloride	10
			Example 11	8% of potassium laurate, 16% of sodium lauroyl glutamate and 0.5% of benzalkonium chloride	10
Example 12	6% potassium laurate, 3% sodium cocoyl glycinate and 0.09% benzalkonium chloride	9.5
			Example 13	6% potassium laurate, 3% sodium cocoyl glycinate, 0.06% benzalkonium chloride and 0.1% p-chloro-m-dimethylphenol	9.5
Example 14	6% potassium laurate, 3% sodium cocoyl glycinate, 0.06% benzalkonium chloride and 0.2% p-chloro-m-dimethylphenol	9.5
			Example 15	6% Potassium laurate, 3% sodium cocoyl glycinate, 0.06% benzalkonium chloride and 0.2% piroctone olamine	9.5
Example 16	6% potassium laurate, 3% sodium cocoyl glycinate, 0.06% benzalkonium chloride and 0.5% o-phenylphenol	9.5
			Example 17	6% of potassium laurate, 3% of sodium cocoyl glutamate and 0.06% of tetradecyl dimethyl benzyl ammonium chloride	9.5
Example 18	6% of potassium laurate, 3% of sodium cocoyl glycinate, 0.06% of benzalkonium chloride and 0.1% of o-cymene-5-ol	9.5

Comparative examples 1 to 11, detailed in Table 2

TABLE 2 comparative examples

	Composition (%)	pH
			Comparative example 1	1% potassium laurate, 0.2% potassium cocoyl glycinate and 0.005% benzalkonium chloride	9.0
Comparative example 2	6% potassium laurate, 3% sodium cocoyl glycinate and 0.06% benzalkonium chloride	7.5
			Comparative example 3	9% of potassium laurate	9.5
Comparative example 4	9% Cocoyl Glycine Potassium	9.5
			Comparative example 5	6% potassium laurate +3% sodium cocoyl glycinate	9.5
Comparative example 6	9% Cocoylglutamic acid disodium salt	9.5
			Comparative example 7	9% Potassium laurate +0.06% benzalkonium chloride	9.5
Comparative example 8	9% of potassium cocoyl glycinate +0.06% of benzalkonium chloride	9.5
			Comparative example 9	9% sodium laureth sulfate +0.06% benzalkonium chloride	9.5
Comparative example 10	9% sodium lauryl sulfate +0.06% benzalkonium chloride	9.5
			Comparative example 11	6% Potassium laurate +3% sodium cocoyl glycinate+0.06% didecyl dimethyl ammonium chloride	9.5

Bacteriostatic effect

The examples and the comparative examples are tested for bacteriostasis according to GB15979-2002, the strains are selected from staphylococcus aureus (ATCC 6538) and escherichia coli (8099), the weight ratio of an acting concentration selected sample to pure water is 1/1 diluent, the dilution ratio is a common ratio of the cleaning products in the actual use process, the acting time is 2 minutes, the bacteriostasis results of the examples in Table 1 are detailed in Table 3, and the bacteriostasis results of the comparative example in Table 2 are detailed in Table 4.

Table 3 example bacteriostatic results

Table 4 comparative example bacteriostatic results

	Inhibition of E.coli/%)	Inhibition of Staphylococcus aureus/%)
			Comparative example 1	42.94	31.29
Comparative example 2	21.43	80.96
			Comparative example 3	99.16	17.39
Comparative example 4	80.63	37.04
			Comparative example 5	92.94	39.29
Comparative example 6	45.26	33.33
			Comparative example 7	99.78	78.73
Comparative example 8	81.83	52.76
			Comparative example 9	8.51	32.50
Comparative example 10	6.38	35.00
			Comparative example 11	89.73	28.54

As can be seen from the data in Table 3, when the dilution ratio of the composition to pure water is 1:1, the composition has excellent inhibition effect on Escherichia coli, can completely inhibit growth within 2 minutes of action, and finally has no colony residue; meanwhile, the composition has excellent bacteriostatic effect on staphylococcus aureus, the inhibition rate of the composition can reach more than 90%, and examples 5, 6, 9, 12, 13, 14, 15, 16 and 18 can completely inhibit the growth of staphylococcus aureus within 2 minutes, so that no colony residue exists finally. Therefore, the composition has excellent bacteriostatic effect on escherichia coli and staphylococcus aureus, and has broad-spectrum inhibitory effect on bacteria.

Comparing the data in table 3 and table 4, the composition of the present invention exerts the synergistic effect of the components well and releases the bacteriostatic property of the cationic quaternary ammonium surfactant to the maximum. The content of each component in the comparative example 1 is low, and a good antibacterial effect cannot be achieved; in comparative example 2, the pH is lower than the range of the present claims, and although it has a certain inhibitory effect on staphylococcus aureus, it is difficult to exert the bacteriostatic action of the components; comparative example 3 using potassium laurate alone can only preserve potassium laurate itself for better bacteriostatic effect on escherichia coli, and hardly has bacteriostatic effect on staphylococcus aureus; comparative example 4 and comparative example 6 are fatty acylamino acid salts alone, and potassium cocoyl glycinate also has a certain effect of inhibiting escherichia coli under alkaline conditions, but the effect of disodium cocoyl glutamate on two microorganisms is not ideal, and the effect of the two comparative examples cannot be compared with the composition of the invention.

Compared with the comparative example 5, the potassium laurate and the sodium cocoyl glycinate are compounded, so that the antibacterial effect is much poorer than that of the comparative example 5, and no synergistic effect exists compared with the comparative example 3 and the comparative example 4; after the potassium laurate is compounded with the benzalkonium chloride in the comparative example 7, the inhibition rate of staphylococcus aureus is improved compared with that of the potassium laurate alone in the comparative example 3, but the result is still not ideal compared with that of the example 5; in comparative example 8, after the potassium cocoyl glycinate and benzalkonium chloride were compounded, the inhibition effect of the two strains was not changed compared with that of comparative example 4 in which the potassium cocoyl glycinate was used alone, and both of the inhibition effects were weaker than those of example 5.

Compared with the comparative examples 9 and 10, the common anionic surfactant sulfate is used, and from the bacteriostatic result, the inhibition rates of the sodium laureth sulfate and the sodium laureth sulfate to two strains after being compounded with benzalkonium chloride are poor, and the effect is almost not achieved, and the bacteriostatic activity of the benzalkonium chloride in the surfactant is completely inhibited.

Comparative example 11 uses a cationic quaternary ammonium surfactant outside the limitations of the present invention, which is incompatible with other ingredients in the composition and does not mutually promote and act synergistically, resulting in unsatisfactory inhibitory effects on both microorganisms.

The composition can exert the antibacterial performance of the cationic quaternary ammonium salt surfactant in a cleaning system containing the anionic surfactant, so that the cationic quaternary ammonium salt bactericide has a wider application range. The composition can exert bacteriostatic performance within 2 minutes by using a small amount of cationic quaternary ammonium salt surfactant in an anionic surfactant cleaning system.

The composition disclosed by the invention is also convenient to add other sterilization components, and can be used for synergistic interaction with the composition to exert a stronger antibacterial demand, for example, in the embodiments 13, 14, 15, 16 and 18 disclosed by the invention, the composition is compounded with other antibacterial agents, the antibacterial rate of the composition on escherichia coli and staphylococcus aureus reaches more than 99.99%, and the composition has remarkable antibacterial and bacteriostatic effects.

Table 5 compares the bacteriostatic effect of the compositions of examples 5, 12, 13, 14, 15 and 16 after dilution with a weight ratio of 1/1 of sample to pure water and dilution with a weight ratio of 1/2 of sample to pure water.

TABLE 5 bacteriostatic effect of different dilution concentration examples

When the active ingredients are diluted, namely the active concentration is reduced, the excellent antibacterial effect can be continuously maintained, which shows that the composition can effectively release the antibacterial performance of various bactericides; meanwhile, after the action concentration is reduced, the antibacterial effect can be further improved by increasing the bactericide component or improving the content of the effective component.

In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes performed by the present invention or directly or indirectly applied to other related technical fields are included in the scope of the present invention.

Claims

1. A bacteriostatic personal cleansing composition comprising the following ingredients:

(a) 3% to 14% by weight of a fatty acid salt;

(b) From 0.5% to 16% by weight of a fatty amido acid salt;

(c) 0.01 to 0.5% by weight of a cationic quaternary ammonium surfactant;

(d) The pH value is more than 8.5;

the fatty acid salt is fatty acid potassium salt or fatty acid sodium salt;

the fatty acylamino acid salt is a potassium fatty acylamino acid salt or a sodium fatty acylamino acid salt.

2. The bacteriostatic personal cleansing composition according to claim 1, wherein said potassium salt of a fatty acid is selected from at least one of potassium laurate, potassium myristate, and potassium palmitate, and said sodium salt of a fatty acid is selected from at least one of sodium laurate, sodium myristate, and sodium palmitate.

3. A bacteriostatic personal cleansing composition according to claim 2 wherein the potassium salt of a fatty acyl amino acid is selected from at least one of potassium cocoyl glutamate, dipotassium cocoyl glutamate, potassium lauroyl glutamate, dipotassium lauroyl glutamate, potassium cocoyl glycinate, potassium lauroyl glycinate, potassium cocoyl alanate, potassium lauroyl alanate.

4. A bacteriostatic personal cleansing composition according to claim 3 wherein said sodium salt of a fatty acyl amino acid is selected from at least one of sodium cocoyl glutamate, disodium cocoyl glutamate, sodium lauroyl glutamate, disodium lauroyl glutamate, sodium cocoyl glycinate, sodium lauroyl glycinate, sodium cocoyl alaninate, sodium lauroyl alaninate.

5. A bacteriostatic personal cleansing composition according to claim 4 wherein the fatty amido acid salt is selected from at least one of potassium cocoyl glycinate, sodium cocoyl glycinate, disodium laurate glutamate, disodium cocoyl glutamate, sodium laurate glutamate and sodium cocoyl glutamate.

6. The bacteriostatic personal cleansing composition according to claim 5, wherein the cationic quaternary ammonium salt surfactant is selected from at least one of benzalkonium chloride, benzalkonium bromide, dodecyldimethylbenzyl ammonium chloride, tetradecyldimethylbenzyl ammonium chloride, dodecyldimethylbenzyl ammonium bromide, tetradecyldimethylbenzyl ammonium bromide.

7. The bacteriostatic personal cleansing composition according to claim 6, wherein the pH is 8.5-10.

8. A bacteriostatic personal cleansing composition according to any one of claims 1 to 7 further comprising from 0.1% to 0.5% by weight of a bactericide selected from at least one of p-chloro-m-dimethylphenol, o-phenylphenol and salts thereof, o-cymene-5-ol, piroctone olamine.

9. The bacteriostatic personal cleansing composition according to claim 8, further comprising water, wherein the weight of the water is less than 96.5%.

10. Bacteriostatic personal cleansing composition according to claim 1 for use in personal cleansing care.