CN110934759B - Application of cocamidopropyl PG-dimethyl ammonium chloride as bacteriostatic agent and application of cocamidopropyl PG-dimethyl ammonium chloride as bacteriostatic agent in daily chemical products - Google Patents
Application of cocamidopropyl PG-dimethyl ammonium chloride as bacteriostatic agent and application of cocamidopropyl PG-dimethyl ammonium chloride as bacteriostatic agent in daily chemical products Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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Abstract
The invention discloses application of cocamidopropyl PG-dimethyl ammonium chloride as a bacteriostatic agent and application of the cocamidopropyl PG-dimethyl ammonium chloride as the bacteriostatic agent in daily chemical products. Compared with the prior art, the invention provides the new application of the cocamidopropyl PG-dimethyl ammonium chloride as the bacteriostatic agent, and the cocamidopropyl PG-dimethyl ammonium chloride as the bacteriostatic agent can be applied to the field of daily chemical products and has good bacteriostatic effect.
Description
Technical Field
The invention relates to the technical field of bacteriostasis, in particular to application of cocamidopropyl PG-dimethyl ammonium chloride as a bacteriostat and application of the cocamidopropyl PG-dimethyl ammonium chloride as the bacteriostat in daily chemical products.
Background
The commonly used cocamidopropyl PG-dimethyl ammonium chloride phosphate in the market at present is a derivative of cocamidopropyl PG-dimethyl ammonium chloride, is also called natural bionic phospholipid, has good affinity with skin, has a certain repair function on damaged skin and hair, can supplement the phospholipid and grease lost by the skin, is a very mild amphoteric surfactant, and has data showing that the surfactant has broad-spectrum antibacterial property.
For example, patent application No. CN201811235175.5 (publication No. CN109172480A) discloses a mite-removing itching-relieving hair lotion and a preparation process thereof, which is characterized in that cocoamidopropyl PG-dimethyl ammonium chloride phosphate is added into the hair lotion, and the cocoamidopropyl PG-dimethyl ammonium chloride phosphate has a certain repair function on damaged hair, is a very mild amphoteric surfactant, and has excellent foamability and foam stability.
For example, the invention patent with patent application number CN201910433538.4 (publication number CN110184135A) discloses a propolis bacteriostatic detergent and a preparation method thereof, the surfactant in the liquid detergent is a composition consisting of sodium cocoamidopropyl PG-dimethyl ammonium chloride phosphate, sodium laureth sulfate, tea saponin, octyl glucoside and dodecyl glucoside, and indicates that cocoamidopropyl PG-dimethyl ammonium chloride sodium phosphate is a phospholipid compound, mainly consists of phosphodiester and triester with multiple long chain groups, is prepared from pure natural coconut oil, is completely compatible with natural lipid on the surface layer of skin, has extremely wide functional characteristics, has mild cleaning, low stimulation, skin softening and broad-spectrum antibacterial action, but the so-called broad-spectrum antibacterial action is not proved by data.
Cocamidopropyl PG-Dimonium Chloride (CAS number: 136920-08-6), which is known by its English name, has good antistatic performance and can improve the combing performance of hair.
Wherein, the invention patent with the patent application number of CN201710638891.7 (with the publication number of CN107296771A) discloses an anti-dandruff composition and a two-component multi-effect silicone oil-free shampoo, which contains DM-846, wherein DM-846 is a mixture of dichlorobenzyl alcohol, sodium isostearoyl lactylate, cocamidopropyl PG-dimethyl ammonium chloride and sodium lactate, has broad-spectrum high-efficiency bactericidal effect and strong bacteriostatic and bactericidal effects on fungi of scalp, but does not disclose the bactericidal property of the cocamidopropyl PG-dimethyl ammonium chloride and has no data to prove the specific effect of each component in DM-846, wherein among the components, the dichlorobenzyl alcohol is often used as a broad-spectrum antibacterial agent, the sodium isostearoyl lactylate is often used as an emulsifier, the cocamidopropyl PG-dimethyl ammonium chloride is often used as a conditioner for hair, sodium lactate has a strong water absorption capacity and is often used as a moisturizer, and therefore from the information provided in this document, dichlorobenzyl alcohol is generally considered to be bacteriostatic rather than cocamidopropyl PG-dimethyl ammonium chloride.
Disclosure of Invention
The first technical problem to be solved by the invention is to provide a new application of cocamidopropyl PG-dimethyl ammonium chloride aiming at the current situation of the prior art.
The invention aims to solve the second technical problem of providing a new application of the cocoamidopropyl PG-dimethyl ammonium chloride in daily chemical products.
The technical scheme adopted by the invention for solving the first technical problem is as follows: application of cocamidopropyl PG-dimethyl ammonium chloride as a bacteriostatic agent.
Preferably, the bacteriostatic agent is a product capable of inhibiting microorganisms.
Further, the microorganism is at least one of Staphylococcus aureus ATCC6538, Escherichia coli ATCC8739, Pseudomonas aeruginosa ATCC9027, Burkholderia cepacia ATCC25416, Enterobacter gourmentii ATCC33028, Candida albicans ATCC10231 and Aspergillus niger ATCC 16404.
The technical scheme adopted by the invention for solving the second technical problem is as follows: the application of cocamidopropyl PG-dimethyl ammonium chloride as a bacteriostatic agent in daily chemical products.
Preferably, the bacteriostatic agent is a product capable of inhibiting microorganisms.
Further, the microorganism is at least one of Staphylococcus aureus ATCC6538, Escherichia coli ATCC8739, Pseudomonas aeruginosa ATCC9027, Burkholderia cepacia ATCC25416, Enterobacter intergouans ATCC33028, Candida albicans ATCC10231 and Aspergillus niger ATCC 16404.
Preferably, the daily chemical product is a wet tissue or a cosmetic.
Preferably, the daily chemical product comprises a daily chemical product solution, wherein the daily chemical product solution comprises a cocamidopropyl PG-dimethyl ammonium chloride aqueous solution, and the addition amount of the cocamidopropyl PG-dimethyl ammonium chloride aqueous solution is 0.5-3 wt%.
Further, the concentration of the aqueous solution of the cocamidopropyl PG-dimethylammonium chloride is 33-37 wt%.
Further, the pH value of the daily chemical product solution is 4.6-6.5.
Compared with the prior art, the invention has the advantages that: the invention provides a new application of cocamidopropyl PG-dimethyl ammonium chloride as a bacteriostatic agent, and the cocamidopropyl PG-dimethyl ammonium chloride as the bacteriostatic agent can be applied to the field of daily chemical products to achieve a good bacteriostatic effect.
Detailed Description
The present invention will be described in further detail with reference to examples.
Example A:
the minimum inhibitory concentration of the aqueous solution of cocamidopropyl PG-dimethylammonium chloride was determined according to the minimum inhibitory concentration determination test (agar dilution method) of Disinfection Specification (2002 edition) 2.1.8.3, and the test microorganisms were Staphylococcus aureus ATCC6538, Escherichia coli ATCC8739, Pseudomonas aeruginosa ATCC9027, Burkholderia cepacia ATCC25416, Enterobacter rikoviae ATCC33028, Candida albicans ATCC10231, and Aspergillus niger ATCC 16404.
The method comprises the following specific steps: 5g of a sample to be detected is taken by aseptic technique and put into 45ml of sterilized PBS (0.03mol/L phosphate buffer solution), and the sample is fully shaken and dissolved to prepare a 10 percent evenly dispersed solution. Then diluted with PBSReleasing the test solution into test solutions with different concentrations, and placing the test solutions in a water bath at the temperature of 45-50 ℃ for standby at constant temperature. 10ml of serially diluted antimicrobial solution were added to the plate. 10ml of a double medium (MH agar for bacteria and Sabouraud's dextrose agar medium for fungi) in a water bath at 45 ℃ to 50 ℃ is added into a plate, and the plate is shaken while adding the medium, and is fully mixed. After the plate is solidified, taking 1-2 mul (the bacterial content is about 10)7cfu/ml, fungal content of about 106cfu/ml) is inoculated on a plate containing a bacteriostatic solution culture medium, and the diameter of a bacterium liquid ring formed after inoculation is about 5 mm-8 mm. Culture medium plates without bacteriostatic components were inoculated in the same manner as positive controls. And (3) placing the plate inoculated with the bacteria in an incubator at 36 +/-1 ℃, carrying out inverted culture for 18-24 h, and observing the result. And (3) placing the plate inoculated with the fungus in an incubator at 28 +/-1 ℃, culturing for 3-5d, and observing the result. The lowest bacteriostatic concentration of the completely inhibited colony growth is the MIC of the sample on the tested bacteria. Single colonies grew negligibly.
Comparative example a:
the minimum inhibitory concentration of the aqueous solution of sodium cocoamidopropyl PG-dimethylammonium chloride phosphate was determined according to the Sterilization specification (2002 edition) 2.1.8.3 minimum inhibitory concentration determination test (agar dilution method).
The test results of example a and comparative example a are detailed in table 1.
Examples B1 to B5:
the aqueous solution of cocamidopropyl PG-dimethylammonium chloride is added into wet tissue solutions with pH values of 4.6, 5.5 and 6.5 respectively to be used as a bacteriostatic agent, and a preservative challenge test is carried out according to a method of a microorganism preservative efficacy test of United states pharmacopoeia USP32 (51). The test microorganisms were staphylococcus aureus ATCC6538, escherichia coli ATCC8739, pseudomonas aeruginosa ATCC9027, enterobacter venenatus ATCC33028, candida albicans ATCC10231, aspergillus niger ATCC 16404. Enterobacter viviparum is a common pollution bacterium in daily chemical product factories in south China, so the Enterobacter viviparum is specially added in the experiment for testing. The concentration of the bacterial suspension is respectively adjusted to 108cfu/ml, wherein staphylococcus aureus, escherichia coli and pseudomonas aeruginosa are uniformly mixed into mixed bacteria in equal amount. MouldThe concentration of the suspension of the bacteria and the yeast bacteria is respectively adjusted to 107cfu/ml, equal amount of mould and yeast are mixed to form the mixed fungus. Taking 3 samples to be tested, wherein each sample is 50g, respectively adding 0.5ml of mixed bacteria, Enterobacter intergous and mixed fungi into 3 samples to ensure that the inoculation concentration of each bacteria in the samples is 106cfu/g, fungal 105cfu/g. And fully stirring and uniformly mixing the sample inoculated with the bacterial liquid by using a stirring rod. The mixed sample is placed at 22.5 +/-2.5 ℃. The microbial content was determined at 0h, 2, 7, 14, 21, 28d after inoculation and the log reduction of colony counts was calculated.
Comparative examples B1 to B3:
the wet towel solutions with pH of 4.6, 5.5, 6.5 were subjected to preservative challenge test according to the method of the USP32(51) microbial preservative efficacy test.
The wet wipe formulations and test results of examples B1-B5 and comparative examples B1-B3 are detailed in tables 2 and 3.
Example C:
adding a cocamidopropyl PG-dimethylammonium chloride aqueous solution into a wet tissue containing non-woven fabrics (the formula of the wet tissue solution is 654-078Y) to be used as a bacteriostatic agent, and carrying out a corrosion prevention challenge test according to a method for testing the microbial corrosion prevention efficacy of United states pharmacopoeia USP32 (51).
The wet wipe formulation and test results of example C are detailed in tables 4 and 5.
Example D:
the cationic emulsion was added with an aqueous solution of cocamidopropyl PG-dimethylammonium chloride for use as a bacteriostatic agent and tested for preservative challenge according to the method of the United states pharmacopoeia USP32(51) microbiological preservative efficacy test.
Comparative example D:
the preservative challenge test was performed in cationic emulsions according to the method of the USP32(51) microbial preservative efficacy test.
The cationic emulsion formulations and test results for example D and comparative example D are detailed in tables 6 and 7.
Example E:
the coconut amidopropyl PG-dimethyl ammonium chloride aqueous solution is added into the nonionic emulsion to be used as a bacteriostatic agent, and a preservative challenge test is carried out according to a method of a microorganism preservative efficacy test of United states pharmacopoeia USP32 (51).
Comparative example E:
preservative challenge tests were performed in nonionic emulsions according to the method of the USP32(51) microbial preservative efficacy test.
The nonionic emulsion formulations and test results for example E and comparative example E are detailed in tables 8 and 9.
Example F:
the cleansing foam was added with an aqueous solution of cocamidopropyl PG-dimethylammonium chloride for use as a bacteriostatic agent and tested for preservative challenge according to the United states pharmacopoeia USP32(51) microbiological preservative efficacy test.
Comparative example F:
the preservative challenge test was performed in a cleansing foam according to the method of the USP32(51) microbial preservative efficacy test.
The formulation of the cleansing foam and the test results of example F and comparative example F are detailed in tables 10 and 11.
Note: the aqueous solution of cocamidopropyl PG-dimethylammonium chloride is obtained from England chemical company of America under the trade name of LexquatTMC-PF with a concentration of 33-37 wt%;
the sodium cocoamidopropyl PG-dimethyl ammonium chloride phosphate aqueous solution is prepared from Phoenix Chemical, INC and is sold as PHOOENOTAINE C-35, and the concentration is 37-39 wt%.
As can be seen from tables 1 to 11:
(1) as can be seen from Table 1, the bacteriostatic activity of the aqueous solution of cocamidopropyl PG-dimethylammonium chloride on pseudomonas aeruginosa, burkholderia cepacia and enterobacter gourmet is obviously superior to that of the aqueous solution of sodium phosphate of cocamidopropyl PG-dimethylammonium chloride;
(2) as can be seen from tables 2 and 3, the wet tissue solutions with pH values of 4.6, 5.5 and 6.5 can pass the judgment standards of USP (United states pharmacopoeiｃA), PCPC (personal Care product Association) and EP-A (European pharmacopoeiｃA), and the aqueous solution of cocamidopropyl PG-dimethylammonium chloride has good antiseptic effect on bacteriｃA and fungi in the wet tissue solutions with different pH values, thereby playing ｃA broad-spectrum bacteriostatic role; and when the addition amount of the aqueous solution of the cocamidopropyl PG-dimethyl ammonium chloride is 0.5-1 wt%, the aqueous solution has a good anticorrosion effect.
(3) As can be seen from tables 4 and 5, the wet tissue 654-078Y can pass the judgment standards of USP (USP), PCPC (personal Care product Association) and EP-A (European pharmacopoeiｃA), and the aqueous solution of the cocamidopropyl PG-dimethylammonium chloride still has good broad-spectrum bacteriostasis in the wet tissue containing the non-woven fabric;
(4) as can be seen from tables 6 and 7, compared with the emulsion 654-079D without adding the aqueous solution of cocamidopropyl PG-dimethylammonium chloride, the emulsion 654-079C with the aqueous solution of 1.0 percent of cocamidopropyl PG-dimethylammonium chloride has better antiseptic effect on bacteria and fungi, which indicates that the aqueous solution of cocamidopropyl PG-dimethylammonium chloride has good bacteriostatic action in the cationic emulsion;
(5) as can be seen from tables 8 and 9, the nonionic emulsion 654-103B added with the 0.5% aqueous solution of cocamidopropyl PG-dimethylammonium chloride can pass the judgment standards of USP and EP-B, which shows that the aqueous solution of cocamidopropyl PG-dimethylammonium chloride has good broad-spectrum bacteriostasis in the nonionic emulsion.
(6) As can be seen from tables 10 and 11, the cleansing foam 654-081C added with the 3.0% aqueous solution of cocamidopropyl PG-dimethylammonium chloride can pass the judgment standards of USP, PCPC and EP-B, indicating that the aqueous solution of cocamidopropyl PG-dimethylammonium chloride has good broad-spectrum bacteriostatic action in the cleansing foam.
TABLE 1 test results for example A and comparative example A
TABLE 2 Wet towel formulations of examples B1-B5 and comparative examples B1-B3
TABLE 3 test results of examples B1-B3 and comparative examples B1-B3
Table 4 wet wipe formulation of example C
TABLE 5 test results for example C
TABLE 6 cationic emulsion formulations of example D and comparative example D
TABLE 7 test results of example D and comparative example D
TABLE 8 nonionic emulsion formulations of example E and comparative example E
TABLE 9 test results of example E and comparative example E
TABLE 10 cleansing foam formulations of example F and comparative example F
TABLE 11 test results of example F and comparative example F
Claims (7)
1. The application of cocamidopropyl PG-dimethyl ammonium chloride as a bacteriostatic agent refers to a product which has an inhibitory effect on microorganisms, wherein the microorganisms are at least one of pseudomonas aeruginosa ATCC9027, burkholderia cepacia ATCC25416, enterobacter interdonae ATCC33028 and candida albicans ATCC 10231.
2. The application of cocamidopropyl PG-dimethyl ammonium chloride as a bacteriostatic agent in daily chemical products, wherein the bacteriostatic agent refers to a product which has a bacteriostatic effect on microorganisms, and the microorganisms are at least one of pseudomonas aeruginosa ATCC9027, Burkholderia cepacia ATCC25416, Enterobacter gourmentii ATCC33028 and Candida albicans ATCC 10231.
3. Use according to claim 2, characterized in that: the daily chemical product is a wet tissue.
4. Use according to claim 2, characterized in that: the daily chemical product is a cosmetic.
5. Use according to claim 2, characterized in that: the daily chemical product comprises a daily chemical product solution, wherein the daily chemical product solution comprises a cocoamidopropyl PG-dimethyl ammonium chloride aqueous solution, and the addition amount of the cocoamidopropyl PG-dimethyl ammonium chloride aqueous solution is 0.5-3 wt%.
6. Use according to claim 5, characterized in that: the concentration of the aqueous solution of the cocamidopropyl PG-dimethylammonium chloride is 33-37 wt%.
7. Use according to claim 5, characterized in that: the pH value of the daily chemical product solution is 4.6-6.5.
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| CN112932991A (en) * | 2020-12-31 | 2021-06-11 | 广州增城潮徽生物技术有限公司 | Phospholipid composition, preparation method thereof and scalp care solution containing same |
| CN113999732A (en) * | 2021-12-06 | 2022-02-01 | 李晓娜 | Mite-removing and bacteriostatic laundry detergent and preparation method thereof |
| CN114306096B (en) * | 2021-12-30 | 2023-08-15 | 福建恒安集团有限公司 | Influenza virus resistant wet tissue and preparation method thereof |
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