CN111228400B - 一种治疗多囊卵巢综合征的中药组合物及其应用 - Google Patents
一种治疗多囊卵巢综合征的中药组合物及其应用 Download PDFInfo
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Abstract
本发明公开了一种治疗多囊卵巢综合征的中药组合物,所述中药组合物是由以下重量份的原料药制成:熟地黄12‑30份,生地黄12‑30份,白芍9‑15份,麦冬9‑15份,知母9‑15份,黄柏9‑15份,黄精9‑30份,山茱萸15‑30份,夏枯草9‑15份,海藻9‑15份,石菖蒲9‑15份,当归6‑15份,陈皮6‑12份,皂角刺9‑15份,鳖甲6‑15份。本发明的中药组合物能够有效治疗多囊卵巢综合征且副作用小、复发率低。
Description
技术领域
本发明涉及中药组合物技术领域,具体涉及一种用于治疗多囊卵巢综合征的中药组合物及其应用。
背景技术
多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期女性常见的一种多因性、临床表现多态性、内分泌代谢紊乱性遗传异质性疾病,1935年首次由Stein和Leventhal提出,又称Stein-Leventhal综合征(S-L综合征),PCOS临床表现多样,如月经不调、稀发排卵、不孕、多毛、痤疮、肥胖等,并可引起多种近远期并发症,如妊娠综合征、代谢综合征以及心血管疾病、肿瘤等。其发病率占育龄期妇女的6~10%,占不排卵妇女的80~85%,严重困扰着育龄期女性的健康。
PCOS以高雄激素血症(Hyperandrogenism HA)和/或高胰岛素血症(Hyperinsulinism HI)为主要特征。现代医学研究显示,PCOS患者雄激素过度产生与PCOS患者胰岛素抵抗(肥胖)发生发展互为因果。PCOS患者体内增多的游离睾酮可增强α-肾上腺素的抗脂肪分解作用,从而导致脂肪积聚;另外,患者体内大量雄激素时,性激素结合球蛋白表达水平下降,增加的游离雄激素与脂肪组织中的雄激素受体相结合,使脂肪细胞分裂、脂肪生长、甘油三酯(TG)贮藏。而腹部和脏器脂肪的积聚也可进一步导致高雄激素血症的发生,两者相互作用,相互促进以致恶性循环,但PCOS疾病的确切发病机制目前尚不明确。
在治疗学方面,目前尚未形成一套理想的PCOS治疗方案。西医有腹腔镜下卵巢穿刺术、药物促排卵以及药物抗雄激素、增强胰岛素敏感性等治疗措施。然而这些治疗手段多是阶段性干预行为,且手术创伤大,药物治疗效果有限,对远期并发症的发生无积极的预防作用,此外还有副作用大,不能长期服用,停药后复发率高等弊端。因此不是PCOS患者的最佳选择。
中医药在治疗PCOS方面具有一定的优越性,不仅可以多途径、多靶点调节PCOS患者的内分泌水平,恢复卵巢功能,促进排卵,有利于妊娠,而且副作用小,无药物依赖性,安全性较好。目前尚无文献报道副作用小、停药后不容易复发的治疗多囊卵巢综合征的中药组合物。
中医学古籍中并没有多囊卵巢综合征这一病名的明确记载,根据其临床表现可以归属于“月经病”,“不孕症”以及“症瘕”等病症的某些症候范畴。中医学认为,肾为先天之本,主生殖,《傅青主女科》谓“经水出诸肾”,PCOS患者临床多表现为月经后期、量少,甚则闭经、不孕等症状,其主要病机应归咎于肾虚;肾气虚弱则血行迟滞而成瘀,肾阳不足则血寒而凝致瘀,肾阴亏损则血稠而滞成瘀,另《景岳全书·杂证谟》言“五脏之病,虽俱能生痰,然无不由乎脾肾,盖脾主湿,湿动则为痰;肾主水,水泛亦有痰。故痰之化,无不在脾;而痰之本,无不在肾。所以凡是痰证,非此即彼,必与二脏有涉”。故PCOS的基本病机是脾肾不足,痰瘀互阻,以肾精不足、脾气虚弱为本,瘀血阻滞、痰湿内停为标,据此补肾健脾、祛瘀豁痰为PCOS主要治疗原则。
发明内容
本发明的目的是提供一种副作用小、停药后不容易复发的治疗多囊卵巢综合征的中药组合物。
本发明的第二个目的是提供一种所述治疗多囊卵巢综合征的中药组合物在制备治疗多囊卵巢综合征的药物或保健食品中的应用。
为了实现上述目的,本发明采用的技术方案如下:
本发明人在长期的临床实践中发现,由熟地黄、生地黄、白芍、麦冬、知母、黄柏等药物组成的中药组合物重在补肾益精、理气活血化瘀,辅以豁痰祛湿,可明显调节PCOS患者的内分泌及代谢水平,显著改善其临床症状。进一步地,本发明人确认本发明的组方,通过多途径、多靶点降解脂肪,促使卵巢功能恢复,促进卵泡生长发育,诱发排卵,临床应用于治疗PCOS。
本发明的第一方面提供了一种治疗多囊卵巢综合征的中药组合物,所述中药组合物是由以下重量份的原料药制成:熟地黄12-30份,生地黄12-30份,白芍9-15份,麦冬9-15份,知母9-15份,黄柏9-15份,黄精9-30份,山茱萸15-30份,夏枯草9-15份,海藻9-15份,石菖蒲9-15份,当归6-15份,陈皮6-12份,皂角刺9-15份,鳖甲6-15份。
所述中药组合物是由以下重量份的原料药制成:熟地黄15份,生地黄15份,白芍15份,麦冬12份,知母9份,黄柏9份,黄精15份,山茱萸15份,夏枯草15份,海藻15份,石菖蒲15份,当归12份,陈皮9份,皂角刺15份,鳖甲9份。
本发明的第二方面还提供了一种药物制剂,所述药物制剂采用所述的治疗多囊卵巢综合征的中药组合物作为活性成分,该药物制剂是采用本领域常规制备方法制备成药剂学上的常用剂型。
所述药物制剂是水煎剂、颗粒剂、片剂、冲剂、散剂、胶囊剂、口服液或滴丸剂。
本发明的药物制剂可用以下方法制备得到:
(A)称取所述各药材组份,混合,获得混合物;
(B)在所述混合物中加入药学上可接受的载体,采用本领域常规制备方法制得。
本发明的第三方面提供了一种所述的治疗多囊卵巢综合征的中药组合物在制备治疗多囊卵巢综合征的药物或保健食品中的应用。
本发明的第四方面提供了一种所述的药物制剂在制备治疗多囊卵巢综合征的药物或保健食品中的应用。
本发明的给药量是治疗有效量,例如每天约2克/千克体-约5.5克/千克体重,较佳的剂量是约3克/千克体重-约4克/千克体重。一般用药时间为1-9月,较佳的为3-6月,更佳的为4-5月。当然,用药时间还要考虑给药途径、病人健康状况,这些都是熟练医师技能范围之内的。此外,本发明的中药组合物还可与其他治疗剂一起使用。
本发明所述的多囊卵巢综合征是现代医学病名,主要表现为月经不调、稀发排卵或无排卵、不孕、多毛、痤疮、肥胖等,并可引起多种近远期并发症,如妊娠综合征、代谢综合征以及心血管疾病、肿瘤等。祖国医学将其归属于“月经后期”、“月经过少”、“闭经”、“不孕症”、“崩漏”、“癥瘕”等妇科疾病范畴。其病位在下焦,小腹两侧,胞络为病,其病因病机复杂,历代医家多认为多囊卵巢综合征的病机多为脾肾不足,痰瘀互阻,故临床多以补肾健脾、活血化瘀、豁痰祛湿为主要治疗原则。本发明以此原则为依据,制备的中药组合物经长期临床实践证明可以显著改善患者的临床症状,且毒副作用小,复发率低,为多囊卵巢综合征患者提供一种更好的治疗方式。
本发明的组方中熟地黄、生地黄、黄精、山茱萸、鳖甲组合成君药,白芍、当归、夏枯草、海藻、石菖蒲、皂角刺组合成臣药,麦冬、知母、黄柏、陈皮合成佐药。
本发明的组方中各项药物的性味、归经和功用,及常用重量如下:
熟地黄:为生地黄用黄酒拌闷、晒蒸的炮制加工品。味甘,性温,归肝、肾经。功效:补血滋润,益精填髓。主治:血虚萎黄;眩晕心悸;月经不调,崩漏不止;肝肾阴亏,潮热盗汗;遗精阳痿;不育不孕。常用量:6-30g。
生地黄:为玄参科植物地黄的新鲜或干燥块根。味甘、苦,性寒,归心、肝、肾经。功效:清热凉血,养阴生津。主治阴虚内热,津伤口渴,内热消渴,肠燥便秘,骨蒸劳热等肾精不足,肾阴亏虚之证。常用量:6-30g。
黄精:为百合科植物滇黄精或多花黄精的干燥根茎。味甘,性平,归脾、肺、肾经。功效:补脾益气,滋肾填精。主治:补脾胃之气、养脾胃之阴,善治脾虚之面黄倦怠,食少无力,或津亏之口干食少,舌红少苔;消渴;肾虚精亏之腰膝酸软,阳痿遗精,头晕耳鸣,目暗眼花,须发早白及小儿五迟、体虚羸瘦等。常用量:10-30g。
山茱萸:山茱萸科植物山茱萸的干燥成熟果肉。味酸、涩,微温,归肝、肾经。功效:补益肝肾,收敛固涩。主治:腰膝酸软,头晕耳鸣,阳痿,遗精滑精,遗尿尿频;崩漏,月经过多等。常用量:5-30g。
鳖甲:为鳖科动物鳖的背甲。味咸,性微寒,归肝、肾经。功效:滋阴潜阳,退热除蒸,软坚散结。主治:用于肾阴不足之阴虚发热、骨蒸劳热、阴虚阳亢、头晕目眩、虚风内动;肾精亏虚之经闭,癥瘕;久疟,疟母。常用量:6-24g。
白芍:为毛茛科植物芍药的干燥根。味苦、酸,性微寒,归肝、脾经。功效:养血敛阴,柔肝止痛,平抑肝阳。主治:肝血亏虚之月经不调;肝脾不和之胸胁脘腹疼痛,四肢挛急疼痛;肝阳上亢之头痛眩晕等。常用量:5-30g。
当归:为伞形科植物当归的干燥根。味甘、辛,性温,归肝、心、脾经。功效:补血活血,调经止痛,润肠通便。主治:血虚萎黄,月经不调,经闭痛经,虚寒腹痛,眩晕心悸,肠燥便秘,风湿痹痛,跌扑损伤,痈疽疮疡。酒当归活血通经,用于经闭痛经,风湿痹痛,跌扑损伤。常用量:6-30g。
夏枯草:为唇形科植物夏枯草的干燥果穗。夏季果穗呈棕红色时采收,除去杂质,晒干。味辛、苦,性寒,归肝、胆经。功效:清火,明目,散结,消肿。主治:用于目赤肿痛,目珠夜痛,头痛眩晕,瘰疬,瘿瘤,乳痈肿痛;甲状腺肿大,淋巴结结核,乳腺增生,高血压。常用量:9-30g。
海藻:为马尾藻科植物海蒿子或羊栖菜的干燥藻体。味苦、咸,性寒,归肝、胃、肾经。功效:软坚散结,消痰,利水。主治:瘿瘤,瘰疬;睾丸肿痛,痰饮水肿等痰结之症。常用量:6-30g。
石菖蒲:为天南星科植物石菖蒲的干燥根茎。味辛、苦,性温,归心、胃经。功效:化湿开胃,开窍豁痰,醒神益智。主治:脘痞不饥,噤口下痢,神昏癫病,健忘耳聋等痰蒙神窍之症。常用量:3-30g。
皂角刺:为豆科植物皂荚的干燥棘刺。味辛,性温,归肝、胃经。功效:消肿托毒,排脓,杀虫。主治:痈疽初起或脓成不溃;外治疥癣麻风。常用量:3-30g。外用适量,醋蒸取汁涂患处。
麦冬:为百合科沿阶草属多年生常绿草本植物。甘、微苦,微寒,归心、肺、胃经。功效:养阴润肺、益胃生津、清心除烦。主治:用于肺燥干咳,阴虚痨嗽,喉痹咽痛,津伤口渴,内热消渴,心烦失眠,肠燥便秘。常用量:6-12g。
知母:为百合科植物知母的干燥根茎。味苦、甘,寒,归肺、胃、肾经。功效:清热泻火,滋阴润燥。主治:热病烦渴,肺热燥咳;骨蒸潮热;内热消渴;肠燥便秘。常用量:6-12g。
黄柏:为芸香科植物黄皮树的干燥树皮。味苦,寒,归肾、膀胱、大肠经。功效:清热燥湿,泻火解毒,除骨蒸功效。主治:湿热带下,热淋涩痛,湿热泻痢,黄疸,湿热脚气,瘘证,骨蒸劳热,盗汗,遗精,疮疡肿毒,湿疹瘙痒。常用量:3-12g。
陈皮:为芸香科植物橘及其栽培变种的干燥成熟果皮。味辛、苦,温,归脾、肺经。功效:理气健脾,燥湿化痰。主治:脾胃气滞,呕吐、呃逆;湿痰、寒痰之咳嗽;胸痹等。常用量:3-10g。
由于采用上述技术方案,本发明具有以下优点和有益效果:
本发明提供的用于治疗多囊卵巢综合征的中药组合物,所用原料价廉,制备简便,使用方便,副作用小,可长期服用,经多年临床应用和药理研究,对治疗多囊卵巢综合征具有较好的疗效。鉴于多囊卵巢综合征患病人群数量较大,目前临床激素治疗效果欠佳,本发明提供的中药复方制剂具有良好的应用前景。
本发明的中药组合物能够有效治疗多囊卵巢综合征且副作用小、复发率低。
具体实施方式
为了更清楚地说明本发明,下面结合优选实施例对本发明做进一步的说明。本领域技术人员应当理解,下面所具体描述的内容是说明性的而非限制性的,不应以此限制本发明的保护范围。
下列实施例中未注明具体条件的实验方法,通常按照常规条件,或按照制造厂商所建议的条件。本发明实施例所用药材除另有注明,均可以从中药材销售公司获得。所获得的药材除另有注明,均为中药材饮片。饮片既可以从销售公司获得,也可以是获得后经加工而成。
实施例1
本发明的治疗多囊卵巢综合征的中药组合物的汤剂制备:
称取熟地黄15g,生地黄15g,白芍15g,麦冬12g,知母9g,黄柏9g,黄精15g,山茱萸15g,夏枯草15g,海藻15g,石菖蒲15g,当归12g,陈皮9g,皂角刺15g,鳖甲9g。
用水冲洗上述药材后于容器内浸泡2小时以上,以砂锅、瓦罐为最佳,搪瓷罐次之,忌铁铜等金属锅具,水质清洁新鲜为好,水量没过药材2cm为宜,本组方药物以补益药物为主,宜先用武火煮沸,继用文火煎煮30~60分钟。后滤出药液,得到本发明中药组合物的水煎剂。
实施例2
本发明的治疗多囊卵巢综合征的中药组合物的颗粒剂制备:
称取熟地黄15g,生地黄15g,白芍15g,麦冬12g,知母9g,黄柏9g,黄精15g,山茱萸15g,夏枯草15g,海藻15g,石菖蒲15g,当归12g,陈皮9g,皂角刺15g,鳖甲9g。
遵照实施例1煎煮方法获得水煎剂,得到本发明中药组合物的水提取物,浓缩后加糊精,糖粉,混匀,以适量70%乙醇制软材,过1号筛制粒,50℃干燥2小时,干燥颗粒过12~14目筛整粒,分装,即得。
实施例3
本发明的治疗多囊卵巢综合征的中药组合物的片剂制备:
称取熟地黄15g,生地黄15g,白芍15g,麦冬12g,知母9g,黄柏9g,黄精15g,山茱萸15g,夏枯草15g,海藻15g,石菖蒲15g,当归12g,陈皮9g,皂角刺15g,鳖甲9g。
遵照实施例1煎煮方法获得水煎剂,得到本发明中药组合物的水提取物,加微晶纤维素、淀粉混匀,加入适量70%乙醇制软材,过1号筛制粒,50℃干燥2小时,干燥颗粒过12~14目筛整粒,加入硬脂酸镁,混匀,压片,即得。
实施例4
本发明的临床观察:
病例来源:病例收集自2018年10月至2019年10月间,以月经不调(月经后期、淋漓不净或闭经)、不孕等就诊于第二军医大学附属长海医院中医科门诊的PCOS患者。
诊断标准:2003年鹿特丹会议修正的欧洲人类生殖胚胎学会与美国生殖医学会(ESHRE/ASRM)的诊断标准:(1)稀发排卵或无排卵(2)临床和(或)生化的高雄激素症(3)B超多囊卵巢:表现为每侧卵巢可见直径2-9mm的卵泡≥10~12个,和(或)卵巢体积≥10ml。
纳入标准:1)所有病例均须符合PCOS西医诊断标准及肝经湿热诊断标准;2)自愿参加本实验,并签署知情同意书;3)未曾西药治疗或曾用西药治疗但已停药3个月。
排除标准:经内分泌科医生会诊,排除其他原因引起的月经异常、高雄激素症及胰岛素抵抗,如生殖器官器质性病变;先天性肾上腺皮质醇增多症、分泌雄激素的肿瘤、特发性多毛症;高泌乳素血症、卵巢早衰、库兴综合征、甲状腺功能异常;原发性糖尿病和内分泌紊乱性疾病。
剔除标准:1)未曾用药或者间断用药者;2)由于使用某种禁用药物,以致无法评价疗效。
脱落标准:未如期完成临床方案的入组病例应视为脱落,包括:1)病人自行退出;2)病人失访;3)研究者令其退出(依从性差;出现不适合继续治疗的疾病;严重违背方案)。
疗效观察:对按上述标准纳入的患者采用本发明实施例1中的中药组合物汤剂施治,予患者每日1剂,水煎服,约500ml分早、晚两次服用,28天为一疗程,连续服用3个疗程。对治疗前后病人的临床症状进行观察,并就各项实验室指标进行检测(见表1-4),采取治疗前后对照方式判断诊治效果。
BMI(kg/m<sup>2</sup>) | 多毛 | 痤疮 | 黑棘皮症 | |
治疗前 | 23.00±3.71 | 9.65±3.21 | 1.35±0.99 | 0.40±0.50 |
治疗后 | 23.27±3.85 | 7.55±2.56** | 0.20±0.41** | 0.25±0.44 |
注:与治疗前相比较*P<0.05,**P<0.01。
LH(IU/L) | FSH(IU/L) | LH/FSH | T(ug/L) | DHEA-S(ug/dl) | |
治疗前 | 11.92±5.47 | 6.44±1.76 | 1.94±0.95 | 0.55±0.16 | 255.8±107.6 |
治疗后 | 4.17±2.27** | 5.58±1.71 | 0.76±0.40** | 0.39±0.14** | 202.5±87.2** |
注:与治疗前相比较*P<0.05,**P<0.01。
(mmol/L) | 0min | 30min | 60min | 120min | 180min |
治疗前 | 10.00±4.69 | 101.99±70.56 | 109.76±84.92 | 79.54±48.59 | 33.55±33.74 |
治疗后 | 8.62±3.78 | 101.02±62.97 | 61.38±33.81** | 74.36±35.58 | 23.43±21.74 |
注:与治疗前相比较*P<0.05,**P<0.01。
注:与治疗前相比较*P<0.05,**P<0.01。
临床疗效观察显示,本发明中药组合物干预后,PCOS患者多毛、痤疮明显缓解(P<0.01);血清性激素LH、LH/FSH、T、DHEAS水平明显下降(P<0.01);血清代谢指标FPG及胰岛素抵抗指标INS60min明显下降(P<0.01),ISI值(P<0.05)上升,统计学差异显著。提示本发明中药组合物对PCOS患者具有一定的治疗作用。
实施例5
王**,女,初诊时间:2019.02.03,初诊年龄:32岁,主诉:月经稀发10年余,月经周期滞后,1.5-月来潮一次。患者身高160cm,体重73kg,体重指数BMI=28.52kg/m2(≥25kg/m2),黑棘皮症(++),BBT单向,内分泌检查结果回报:FSH:4.73mIU/ml,LH:14.00mIU/ml,E2:31pmol/L,T:0.77nmol/L,DHEAS:335.6ng/ml。胰岛素释放试验:空腹:10.25mU/L,30’:131.83mU/L,60’:183.25mU/L,120’:188.23mU/L,180’:91.84mU/L。患者形体肥胖,头发油腻,面色晦暗,舌红伴齿痕,苔薄黄,自诉口干,渴不欲饮,平素腰酸明显,带下量多,大便溏结不调,失眠多梦。
以本发明实施例1中的中药组合物汤剂为基础辩证施治,予患者每日1剂,水煎服,约500ml,分早、晚两次服用。连续治疗半年后,月经周期基本恢复,6~7天/30~33天,于2019-08-21复查性激素FSH:6.73mIU/ml,LH:7.26mIU/ml,E2:46pmol/L,T:0.58nmol/L,DHEAS:295.6ng/ml;胰岛素释放试验检测:空腹:7.12mU/L,30’:36.28mU/L,60’:49.81mU/L,120’:62.46mU/L,180’:28.30mU/L。该患者复测体重64kg,计算体重指数BMI=25.00kg/m2(较治疗前明显降低),BBT双向,其临床表现黑棘皮症、头发油腻、口干、腰酸、带下量多、失眠多梦症状均较前明显好转。
实施例6
马**,女,初诊时间:2018.06.18,初诊年龄:29岁,主诉:月经周期紊乱半年,7~10天/15~150天。患者身高164cm,体重65kg,体重指数BMI=24.17kg/m2,腰围90cm,臀围100cm,腰臀比WHR=0.9,黑棘皮症(-),内分泌检查结果回报:FSH:6.76mIU/ml,LH:11.84mIU/ml,E2:60pmol/L,T:0.72nmol/L,DHEAS:317.6ng/ml。胰岛素释放试验:空腹:12.44mU/L,30’:142.89mU/L,60’:96.95mU/L,90’:127.66mU/L,120’:267.57mU/L,180’:50.07mU/L。患者既往月经规则,近半年因工作压力较大,体重增加近15斤,月经周期出现紊乱,面色晦暗不清,舌苔厚腻伴裂纹,消谷善饥,口干口苦,疲劳乏力,心烦易躁,大便干结。
以本发明实施例1中的中药组合物汤剂为基础辩证施治,予患者每日1剂,水煎服,约500ml,分早、晚两次服用。连续治疗三月后,该患者月经周期基本恢复,5~7天/28~35天。患者身高164cm,该患者体重62kg,体重指数BMI=23.05kg/m2,腰围86cm,臀围96cm,腰臀比WHR=0.89。2018.10.28复查内分泌:FSH:5.23mIU/ml,LH:11.52mIU/ml,E2:37pmol/L,T:0.54nmol/L,DHEAS:305.5ng/ml。胰岛素释放试验:空腹:13.2mU/L,30’:109.6mU/L,60’:141.8mU/L,90’:211.5mU/L,120’:100.1mU/L,180’:10.5mU/L。患者精神状态较前明显好转。
实施例7
周*,女,初诊时间:2018.03.15,初诊年龄:34岁,主诉:未避孕不孕3年。患者15岁初潮,既往月经规则,5~6天/26~28天,月经量可,色鲜红,无血块,痛经(-)。5年前无明显诱因月经量较前减少,1~3天/26~28天,量少,色暗,有血块,经前及经前偶有下腹胀痛,热敷后少有好转,遂未予明显重视。31岁结婚,婚后未采取任何避孕措施,3年未孕,丈夫精液常规正常。患者月经周期第2天内分泌检查(2018.3.6)结果示:FSH:7.56mIU/ml,LH:15.67mIU/ml,E2:45pmol/L,T:0.52nmol/L,DHEAS:310.5ng/ml。月经周期结束后第3天阴道超声(2018.3.10)提示:子宫形态正常,双侧卵巢多囊样改变。患者身高165cm,体重58kg,体重指数BMI=21.30kg/m2,中等身材,面色萎黄,舌暗有瘀点,舌尖稍红,苔薄,平素手脚心发热,偶有腰酸,余未见明显异常。
以本发明实施例1中的中药组合物汤剂为基础辩证施治,予患者每日1剂,水煎服,约500ml,分早、晚两次服用。连续治疗半年,服药期间患者月经经期延长持续5~6天,月经量明显增加,色鲜红,血块明显减少,无痛经,继续以本发明中药组合物汤剂为基础方治疗,患者于2018年10月自然妊娠。
以上所述仅是本发明的较佳实施例而已,并非对本发明作任何形式上的限制,虽然本发明已以较佳实施例揭露如上,然而并非用以限定本发明,任何熟悉本专利的技术人员在不脱离本发明技术方案范围内,当可利用上述提示的技术内容作出些许更动或修饰为等同变化的等效实施例,但凡是未脱离本发明技术方案的内容,依据本发明的技术实质对以上实施例所作的任何简单修改、等同变化与修饰,均仍属于本发明方案的范围内。
Claims (6)
1.一种治疗多囊卵巢综合征的中药组合物,其特征在于,所述中药组合物是由以下重量份的原料药制成:熟地黄12-30份,生地黄12-30份,白芍9-15份,麦冬9-15份,知母9-15份,黄柏9-15份,黄精9-30份,山茱萸15-30份,夏枯草9-15份,海藻9-15份,石菖蒲9-15份,当归6-15份,陈皮6-12份,皂角刺9-15份,鳖甲6-15份。
2.根据权利要求1所述的治疗多囊卵巢综合征的中药组合物,其特征在于,所述中药组合物是由以下重量份的原料药制成:熟地黄15份,生地黄15份,白芍15份,麦冬12份,知母9份,黄柏9份,黄精15份,山茱萸15份,夏枯草15份,海藻15份,石菖蒲15份,当归12份,陈皮9份,皂角刺15份,鳖甲9份。
3.一种药物制剂,其特征在于,所述药物制剂采用权利要求1或2所述的治疗多囊卵巢综合征的中药组合物作为活性成分。
4.根据权利要求3所述的药物制剂,其特征在于,所述药物制剂是水煎剂、颗粒剂、片剂、散剂、胶囊剂、口服液或滴丸剂。
5.一种权利要求1或2所述的治疗多囊卵巢综合征的中药组合物在制备治疗多囊卵巢综合征的药物中的应用。
6.一种权利要求3或4所述的药物制剂在制备治疗多囊卵巢综合征的药物中的应用。
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