CN111228164A - Plant extract soothing essence cream and preparation method thereof - Google Patents

Plant extract soothing essence cream and preparation method thereof Download PDF

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Publication number
CN111228164A
CN111228164A CN201911319595.6A CN201911319595A CN111228164A CN 111228164 A CN111228164 A CN 111228164A CN 201911319595 A CN201911319595 A CN 201911319595A CN 111228164 A CN111228164 A CN 111228164A
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parts
extract
liquid mixture
essence cream
plant extract
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卜睿臻
赵宇
白玉香
曲明
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TIANJIN DARENTANG JINGWANHONG PHARMACEUTICAL CO Ltd
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TIANJIN DARENTANG JINGWANHONG PHARMACEUTICAL CO Ltd
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Publication of CN111228164A publication Critical patent/CN111228164A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)

Abstract

The invention provides a plant extract soothing essence cream and a preparation method thereof, wherein the plant extract soothing essence cream comprises the following components in parts by weight: 2.16-4.70 parts of a relieving anti-inflammatory agent; 9.9-17.00 parts of an emollient; 10.34-14.23 parts of humectant; 0.6232-1.7932 parts of preservative; 2.82-3.92 parts of an emulsifier; 0.05-0.08 part of anti-aging agent; 0.03-0.05 part of chelating agent; 78.00 to 80.00 portions of water. The plant extract soothing essence cream can effectively solve the problems of sensitive skin such as redness and swelling of the skin, facial inflammation, acne and the like.

Description

Plant extract soothing essence cream and preparation method thereof
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a plant extract soothing essence cream and a preparation method thereof.
Background
The face of a human body is exposed in the air, dust, particles, harmful gas and various bacteria in the air can cause damage to the skin, so that inflammation is caused, and particularly, for the group in adolescence and with frequent facial acne, the generation of inflammation is further aggravated by substances such as dust in the air.
With the aggravation of environmental pollution and the increase of living pressure, more and more people with sensitive skin or skin allergic symptoms often occur; in addition, for another important reason, the skin care products in the market at present contain allergens, are easy to cause skin allergy, and cause allergic symptoms such as pruritus, desquamation, redness and swelling, so that the skin allergy is prevented, the skin allergy is not only far away from the allergens and the irritation is reduced, but also the skin barrier function is enhanced by using safe skin care products, so that the skin is kept in a healthy state. Therefore, the development of the soothing anti-inflammatory essence is an urgent technical problem to be solved in the field.
Disclosure of Invention
In view of the above, the invention aims to provide a plant extract soothing essence cream and a preparation method thereof, so as to solve the problems of sensitive skin such as redness and swelling of the skin, facial inflammation, acne and the like.
In order to achieve the purpose, the technical scheme of the invention is realized as follows:
the plant extract soothing essence cream comprises the following components in parts by weight:
2.16-4.70 parts of a relieving anti-inflammatory agent;
9.9-17.00 parts of an emollient;
10.34-14.23 parts of humectant;
0.6232-1.7932 parts of preservative;
2.82-3.92 parts of an emulsifier;
0.05-0.08 part of anti-aging agent;
0.03-0.05 part of chelating agent;
78.00 to 80.00 portions of water.
The relieving and anti-inflammatory agent comprises at least two or more of radix Sophorae Flavescentis extract, radix Glycyrrhizae Inflatae extract, radix Scutellariae extract, flos Lonicerae extract, radix Arnebiae extract, radix et rhizoma Rhei Palmati extract, and rhizoma Coptidis extract.
Further, the relieving anti-inflammatory agent comprises the following components in parts by weight:
0.50-1.00 part of sophora flavescens root extract;
0.20 to 1.00 portion of liquorice root extract of the fig;
1.00-1.20 parts of scutellaria root extract;
0.10-0.30 parts of honeysuckle flower extract;
0.01-0.10 parts of lithospermum extract;
0.05-0.10 part of rhubarb palmate extract;
0.30-1.00 part of coptis root extract.
Further, the emollient comprises the following components in parts by weight:
2.12-2.78 parts of shea butter;
2.50-4.5 parts of caprylic/capric triglyceride;
3.00-5.0 parts of hydrogenated polyisobutene;
0.68-0.92 parts of cetearyl alcohol;
1.5-3.5 parts of oat kernel oil.
0.10-0.30 part of polydimethylsiloxane.
Further, the humectant comprises the following components in parts by weight:
6.00-8.00 parts of glycerol;
1.20-1.40 parts of betaine;
0.05-0.15 part of oat β -glucan;
0.42-0.85 part of tocopherol acetate;
0.03-0.05 part of sodium hyaluronate;
0.04-0.08 part of xanthan gum;
0.1-0.20 part of propylene glycol;
2.50-3.50 parts of butanediol.
Further, the preservative comprises the following components in parts by weight:
0.0032 parts of potassium sorbate;
0.13-0.43 part of methylparaben;
0.13-0.43 parts of propyl hydroxybenzoate;
0.35-0.85 part of phenoxyethanol;
0.01-0.08 part of ethylhexyl glycerol.
Further, the emulsifier comprises the following components in parts by weight: 1.22-1.62 parts of glycerol stearate, 1.00-1.50 parts of PEG-100 stearate and 0.60-0.80 part of cetearyl glucoside.
Further, the chelating agent is disodium EDTA.
Further, the anti-aging agent is artemia salina extract.
The preparation method of the plant extract soothing amino acid essence comprises the following steps:
s1, mixing a humectant, uniformly mixing with water, a chelating agent and a first preservative, and heating to 85 ℃ to obtain a first liquid mixture, wherein the first preservative is methyl hydroxybenzoate and propyl hydroxybenzoate;
s2, uniformly mixing the emollient and the emulsifier, and heating to 85 ℃ to obtain a second liquid mixture;
s3, mixing the first liquid mixture and the second liquid mixture to obtain a third liquid mixture, stirring and emulsifying uniformly, and cooling to 60 ℃;
s4, cooling the third liquid mixture to 45 ℃, adding a second preservative to obtain a fourth liquid mixture, and uniformly stirring, wherein the second preservative is potassium sorbate, phenoxyethanol and ethylhexylglycerin;
s5, adding the relieving and anti-inflammatory agent into the fourth liquid mixture which is uniformly stirred to obtain a fifth liquid mixture, and cooling to 45 ℃;
s6, uniformly mixing the anti-aging agents, adding the anti-aging agents into the fifth liquid mixture, uniformly stirring, cooling to 38 ℃, inspecting, and filtering to obtain the anti-aging liquid.
Compared with the prior art, the plant extract soothing essence cream and the preparation method thereof have the following advantages:
the soothing anti-inflammatory agent of the effective components in the essence disclosed by the invention completely adopts plant extract components, wherein the sophora flavescens root extract can balance the grease secretion of skin, dredge and astringe pores, remove endotoxin impurities in the skin, promote the growth and repair of damaged vascular nerve cells and restore the activity of subcutaneous capillary cells; the active substance in the extract of the root of Glycyrrhiza inflata L can resist aging and inhibit the generation of melanin; the Scutellariae radix extract has antiallergic effect, and can be used for relieving skin pruritus and skin allergy; caffeoylquinic acid contained in flos Lonicerae extract has strong antibacterial and skin aging preventing effects, and luteolin contained therein has antibacterial and antiinflammatory effects and can inhibit hyaluronidase activity; the radix Arnebiae extract has effects of relieving astringency, inhibiting bacteria, relieving inflammation, and resisting allergy; the Rheum palmatum extract contains components capable of inhibiting skin lipid peroxidation, and can prevent skin aging; the rhizoma Coptidis extract has antiinflammatory, antibacterial, acne inducing bacteria inhibiting, allergy inhibiting, skin whitening, and moisture keeping effects. The soothing anti-inflammatory agent is used in a matched manner, and can be used for synergistically conditioning the state of the skin to achieve the effects of relieving, resisting allergy, diminishing inflammation and repairing.
Detailed Description
Unless defined otherwise, technical terms used in the following examples have the same meanings as commonly understood by one of ordinary skill in the art to which the present invention belongs. The test reagents used in the following examples, unless otherwise specified, are all conventional biochemical reagents; the experimental methods are conventional methods unless otherwise specified.
The present invention will be described in detail with reference to examples.
Example 1
The plant extract soothing essence cream comprises the following components in parts by weight:
the effective components are as follows: 0.50 part of sophora flavescens root extract; 0.20 part of glycyrrhiza inflata root extract; 1.00 part of scutellaria root extract; 0.20 part of honeysuckle flower extract; 0.01 part of lithospermum extract; 0.06 part of rhubarb palmate extract; 0.30 part of coptis root extract.
Other components:
2.20 parts of shea butter, 2.50 parts of caprylic/capric triglyceride, 3.00 parts of hydrogenated polyisobutene, 0.68 part of cetearyl alcohol, 0.60 part of cetearyl glucoside, 1.25 parts of glycerol stearate, 0.10 part of polydimethylsiloxane, 6.00 parts of glycerol, 1.20 parts of betaine, 0.05 part of oat β -glucan, 0.42 part of tocopherol acetate, 0.03 part of sodium hyaluronate, 0.04 part of xanthan gum, 0.10 part of propylene glycol, 2.50 parts of butanediol, 1.22 parts of glycerol stearate and 1.5 parts of oat kernel oil, 0.0032 part of potassium sorbate, 0.15 part of methyl hydroxybenzoate, 0.13 part of propyl hydroxybenzoate, 0.35 part of phenoxyethanol, 0.03 part of ethylhexyl glycerol, 1.22 parts of glycerol stearate, 1.00 part of PEG-100 stearate, 0.03 part of disodium EDTA and 0.05 part of artemia pest extract.
The preparation method of the plant extract soothing amino acid essence comprises the following steps:
s1, mixing a humectant, uniformly mixing with water, a chelating agent and a first preservative, and heating to 85 ℃ to obtain a first liquid mixture, wherein the first preservative is methyl hydroxybenzoate and propyl hydroxybenzoate;
s2, uniformly mixing the emollient and the emulsifier, and heating to 85 ℃ to obtain a second liquid mixture;
s3, mixing the first liquid mixture and the second liquid mixture to obtain a third liquid mixture, stirring and emulsifying uniformly, and cooling to 60 ℃;
s4, cooling the third liquid mixture to 45 ℃, adding a second preservative to obtain a fourth liquid mixture, and uniformly stirring, wherein the second preservative is potassium sorbate, phenoxyethanol and ethylhexylglycerin;
s5, adding the relieving and anti-inflammatory agent into the fourth liquid mixture which is uniformly stirred to obtain a fifth liquid mixture, and cooling to 45 ℃;
s6, uniformly mixing the anti-aging agents, adding the anti-aging agents into the fifth liquid mixture, uniformly stirring, cooling to 38 ℃, inspecting, and filtering to obtain the anti-aging liquid.
Example 2
The plant extract soothing essence cream comprises the following components in parts by weight:
the effective components are as follows: 0.80 part of sophora flavescens root extract; 0.50 part of glycyrrhiza inflata root extract; 1.00 part of scutellaria root extract; 0.20 part of honeysuckle flower extract; 0.05 part of lithospermum extract; 0.08 part of rhubarb palmate extract; 0.30 part of coptis root extract.
Other components:
2.60 parts of shea butter, 3.0 parts of caprylic/capric triglyceride, 3.00 parts of hydrogenated polyisobutene, 0.70 part of cetearyl alcohol, 0.60 part of cetearyl glucoside, 1.50 parts of glycerol stearate, 0.10 part of polydimethylsiloxane, 6.30 parts of glycerol, 1.20 parts of betaine, 0.12 part of oat β -glucan, 0.63 part of tocopherol acetate, 0.03 part of sodium hyaluronate, 0.04 part of xanthan gum, 0.15 part of propylene glycol, 2.50 parts of butanediol, 1.40 parts of glycerol stearate, 1.50 parts of oat kernel oil, potassium sorbate, and the like
0.0032 parts; 0.25 part of methylparaben; 0.20 part of propyl hydroxybenzoate; 0.45 part of phenoxyethanol; 0.06 part of ethylhexyl glycerol; 1.61 parts of glycerol stearic acid; 1.00 part of PEG-100 stearate; 0.04 part of EDTA disodium and 0.06 part of artemia salina extract.
The preparation method of the plant extract soothing amino acid essence cream is the same as that in example 1.
Example 3
The plant extract soothing essence cream comprises the following components in parts by weight:
the effective components are as follows: 0.80 part of sophora flavescens root extract; 0.75 part of glycyrrhiza inflate extract and 1.05 parts of scutellaria baicalensis root extract; 0.19 part of honeysuckle flower extract; 0.07 part of lithospermum extract; 0.06 part of rhubarb palmate extract; 0.80 part of coptis root extract.
Other components:
2.60 parts of shea butter, 3.50 parts of caprylic/capric triglyceride, 5.0 parts of hydrogenated polyisobutene, 0.85 part of cetearyl alcohol, 0.60 part of cetearyl glucoside, 1.40 parts of glycerol stearate, 0.10 part of polydimethylsiloxane, 6.00 parts of glycerol, 1.20 parts of betaine, 0.05 part of oat β -glucan, 0.63 part of tocopherol acetate, 0.03 part of sodium hyaluronate, 0.06 part of xanthan gum, 0.10 part of propylene glycol, 2.50 parts of butanediol, 1.55 parts of glycerol stearate, 2.0 parts of oat kernel oil, 0.0032 part of potassium sorbate, 0.20 part of methyl hydroxybenzoate, 0.20 part of propyl hydroxybenzoate, 0.35 part of phenoxyethanol, 0.06 part of ethylhexyl glycerol, 1.45 parts of glycerol stearate, 1.00 part of PEG-100 stearate, 0.03 part of disodium EDTA and 0.05 part of artemia pest extract.
The preparation method of the plant extract soothing amino acid essence cream is the same as that in example 1.
Example 4
The plant extract soothing essence cream comprises the following components in parts by weight:
the effective components are as follows: 1.00 part of sophora flavescens root extract; 0.80 part of glycyrrhiza inflata root extract; 1.10 parts of scutellaria root extract; 0.25 part of honeysuckle flower extract; 0.08 part of lithospermum extract; 0.10 part of rhubarb palmate extract; 1.00 part of coptis root extract.
Other components:
2.70 parts of shea butter, 4.30 parts of caprylic/capric triglyceride, 5.0 parts of hydrogenated polyisobutene, 0.80 part of cetearyl alcohol, 0.80 part of cetearyl glucoside, 1.55 parts of glyceryl stearate, 0.30 part of polydimethylsiloxane, 7.50 parts of glycerol, 1.30 parts of betaine, 0.05-0.15 part of oat β -glucan, 0.85 part of tocopherol acetate, 0.05 part of sodium hyaluronate, 0.06 part of xanthan gum, 0.20 part of propylene glycol, 3.50 parts of butanediol, 1.60 parts of glyceryl stearate, 3.20 parts of oat kernel oil, 0.0032 part of potassium sorbate, 0.40 part of methyl hydroxybenzoate, 0.40 part of propyl hydroxybenzoate, 0.80 part of phenoxyethanol, 0.06 part of ethylhexyl glycerol, 1.60 parts of glyceryl stearate, 1.30 parts of PEG-100 stearate, 0.05 part of disodium EDTA and 0.08 part of artemia extract.
The preparation method of the plant extract soothing amino acid essence cream is the same as that in example 1.
Example 5
The plant extract soothing essence cream comprises the following components in parts by weight:
the effective components are as follows: 1.00 part of sophora flavescens root extract; 1.00 part of liquorice root extract of the fig, 1.20 parts of radix scutellariae extract; 0.25 part of honeysuckle flower extract; 0.08 part of lithospermum extract; 0.10 part of rhubarb palmate extract; 1.00 part of coptis root extract.
Other components:
2.70 parts of shea butter, 4.5 parts of caprylic/capric triglyceride, 5.0 parts of hydrogenated polyisobutene, 0.90 part of cetearyl alcohol, 0.80 part of cetearyl glucoside, 1.60 parts of glyceryl stearate, 0.30 part of polydimethylsiloxane, 8.00 parts of glycerol, 1.40 parts of betaine, 0.12 part of oat β -glucan, 0.80 part of tocopherol acetate, 0.05 part of sodium hyaluronate, 0.08 part of xanthan gum, 0.20 part of propylene glycol, 3.50 parts of butanediol, 1.62 parts of glyceryl stearate and 3.5 parts of oat kernel oil, 0.0032 part of potassium sorbate, 0.43 part of methyl hydroxybenzoate, 0.43 part of propyl hydroxybenzoate, 0.80 part of phenoxyethanol, 0.08 part of ethylhexyl glycerol, 1.62 parts of glyceryl stearate, 1.50 parts of PEG-100 stearate, 0.05 part of disodium EDTA and 0.08 part of artemia pest extract.
The preparation method of the plant extract soothing amino acid essence cream is the same as that in example 1.
Comparative example 1
The same formulation and preparation as in example 1, except that: the effective component is 0.01 part of ectoin.
Comparative example 2
The same formulation and preparation as in example 1, except that: the effective component is 0.01 part of dipotassium glycyrrhizinate.
Test example 1
The plant extract soothing essence cream prepared in example 1 of the invention is subjected to heavy metal content measurement according to the "hygienic chemistry inspection method" in technical safety standards for cosmetics (2015), and the results are shown in the following table:
inspection item Test results (mg/kg) Index (I)
Mercury <0.6 ≤1mg/kg
Lead (II) <7 ≤10mg/kg
Arsenic (As) <1.0 ≤2mg/kg
Cadmium (Cd) <2 ≤5mg/kg
Test example 2
The plant extract soothing essence cream prepared in example 1 of the invention is subjected to microorganism content measurement according to the microorganism inspection method in technical standards for cosmetic safety (2015 edition), and the results are shown in the following table:
inspection item The result of the detection Index (I)
Total number of colonies <600CFU/g ≤1000CFU/g
Total number of mold and yeast <65CFU/g ≤100CFU/g
Heat-resistant coliform group Not detected out No detectable value/g
Staphylococcus aureus Not detected out No detectable value/g
Pseudomonas aeruginosa Not detected out No detectable value/g
Test example 3
The plant extract soothing essence cream prepared in example 2 of the present invention is subjected to skin irritation measurement according to the "skin irritation experimental method" in technical safety standards of cosmetics (2015 th), and the specific operations and results are as follows:
the product of example 2 was applied to the skin on the back of a depilated skin (depilated range was 3cm × 3cm, application area was 2.5cm × 2.5cm) according to the requirements of "cosmetic hygiene code", the other side skin was used as a control, the application was continued for 10 hours, after the experiment was completed, the skin was washed with clear water, and the skin reaction at the application site was observed for 1, 24, 48, and 72 hours after washing, and no erythema or edema appeared in any of the 6 white rabbits, demonstrating that the product of the present invention has no skin irritation.
Test example 4
Mouse anti-inflammatory assay (mouse ear swelling assay):
(1) subjects and groups:
60 KM male mice, weighing 18-22g, were randomly divided into 6 groups. The anti-inflammatory efficacy was compared using the clear water group as a blank group, the effective ingredients in comparative examples 1 and 2 as control groups 1-2, and the effective ingredients in examples 1-5 as experimental groups 1-5.
(2) Experimental procedure
Dipping 20 mul of liquid medicine of the experimental group and the control group of the drug on the front and back surfaces of the right ear of each mouse by a cotton swab, coating distilled water (20 mul/mouse) on the front and back surfaces of the right ear of each mouse in the blank group, dipping 20 mul of xylene with the cotton swab with the volume of about 100 percent on the front and back surfaces of the right ear of each mouse, uniformly and rapidly coating the xylene with the cotton swab on the front and back surfaces of the right ear of each mouse, recording the drug coating and sensitization time of each mouse, and repeatedly using the drug 0.5 h, 1.5 h and 2.5h after inflammation. Killing the animals 4h after inflammation, cutting two ears along the base line of auricle, punching the ears of the two ears by using a trephine with diameter of 6mm, measuring the thickness of the two ears, and taking the difference of the thicknesses of the two ears as swelling degree (mm); the swelling inhibition (%) was calculated as the difference in thickness (mm) between the two ear pieces, and the calculation formula was as follows:
swelling degree (mm) ═ right ear thickness (mm) -left ear thickness (mm)
The swelling inhibition ratio (%) - (blank group ear thickness difference (mg) — sample group ear thickness difference (mg))/blank group ear thickness difference (mg) × 100%.
The results of the mouse anti-inflammatory efficacy test are shown in the following table:
group of samples Swelling degree (mm) Swelling inhibition ratio (%)
Example 1 0.207±0.050 81.38
Example 2 0.189±0.043 83.00
Example 3 0.139±0.071 87.50
Example 4 0.133±0.069 88.04
Example 5 0.110±0.055 90.10
Comparative example 1 0.890±0.036 19.96
Comparative example 2 0.834±0.088 25.00
Blank group 1.112±0.061 /
As can be seen from the experimental results, the difference in ear thickness and swelling degree of the mice in examples 1 to 5 were significantly smaller than those of the control group and the blank group, indicating that the effective ingredient can improve the anti-inflammatory effect, with the anti-inflammatory effect of example 5 being the best example.
Test example 5
Human body trial test
Human body trial test
And (3) testing a product: the plant extract soothing essence cream obtained from example 5.
Test objects: 30 face skins have symptoms of discomfort, itching, desquamation and the like, particularly, after cosmetics are used, a series of volunteers with sensitive symptoms appear, and the age span is 18-35 years old. Patients with severe allergy, systemic allergy and other diseases with medical signs were excluded.
The therapeutic effect judgment standard is as follows: (1) and (3) curing: disappearance of clinical symptoms and resolution of sensitive symptoms; (2) the method has the following advantages: reduction of clinical symptoms, resolution or disappearance, reduction or reduction of sensitive symptoms; (3) and (4) invalidation: the clinical symptoms and the sensitive symptoms are not improved.
The test method comprises the following steps: the volunteers who were asked to try use the plant extract soothing essence prepared in example 3 after cleaning the face in the morning and evening, continuously using for one month, and making a return visit of the product effect at day 30, and the test results: the effective rate of the essence cream using example 3 was 88.9%, the effective rate of the essence cream using example 4 was 86.3%, the effective rate of the essence cream using example 2 was 89.0%, the effective rate of the essence cream using comparative example 1 was 43.1%, and the effective rate of the essence cream using comparative example 2 was 40.3%.
In particular, the manifestations of specific symptoms and effects are shown in the following table:
symptoms and signs Total number of symptoms Cure of disease Is effective Invalidation
Itching (pruritus) 30 28 5 0
Peeling off 28 27 0 1
Stabbing pain 29 27 2 0
Glow and glow 30 24 6 0
Erythema 27 24 3 1
According to the use evaluation of a human body, the plant extract soothing essence cream has good soothing and anti-inflammatory effects, has an obvious skin care effect, and can promote the skin to moisturize and diminish inflammation, so that the skin is healthier.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (9)

1. The plant extract soothing essence cream is characterized in that: the composition comprises the following components in parts by weight:
2.16-4.70 parts of a relieving anti-inflammatory agent;
9.9-17.00 parts of an emollient;
10.34-14.23 parts of humectant;
0.6232-1.7932 parts of preservative;
2.82-3.92 parts of an emulsifier;
0.05-0.08 part of anti-aging agent;
0.03-0.05 part of chelating agent;
78.00 to 80.00 portions of water.
The relieving and anti-inflammatory agent comprises at least two or more of radix Sophorae Flavescentis extract, radix Glycyrrhizae Inflatae extract, radix Scutellariae extract, flos Lonicerae extract, radix Arnebiae extract, radix et rhizoma Rhei Palmati extract, and rhizoma Coptidis extract.
2. The plant extract soothing essence cream according to claim 1, characterized in that: the relieving anti-inflammatory agent comprises the following components in parts by weight:
0.50-1.00 part of sophora flavescens root extract;
0.20 to 1.00 portion of liquorice root extract of the fig;
1.00-1.20 parts of scutellaria root extract;
0.10-0.30 parts of honeysuckle flower extract;
0.01-0.10 parts of lithospermum extract;
0.05-0.10 part of rhubarb palmate extract;
0.30-1.00 part of coptis root extract.
3. The plant extract soothing essence cream according to claim 1, characterized in that: the emollient comprises the following components in parts by weight:
2.12-2.78 parts of shea butter;
2.50-4.5 parts of caprylic/capric triglyceride;
3.00-5.0 parts of hydrogenated polyisobutene;
0.68-0.92 parts of cetearyl alcohol;
1.50-3.50 parts of oat kernel oil.
0.10-0.30 part of polydimethylsiloxane.
4. The plant extract soothing essence cream according to claim 1, characterized in that: the humectant comprises the following components in parts by weight:
6.00-8.00 parts of glycerol;
1.20-1.40 parts of betaine;
0.05-0.15 part of oat β -glucan;
0.42-0.85 part of tocopherol acetate;
0.03-0.05 part of sodium hyaluronate;
0.04-0.08 part of xanthan gum;
0.1-0.20 part of propylene glycol;
2.50-3.50 parts of butanediol.
5. The plant extract soothing essence cream according to claim 1, characterized in that: the preservative comprises the following components in parts by weight:
0.0032 parts of potassium sorbate;
0.13-0.43 part of methylparaben;
0.13-0.43 parts of propyl hydroxybenzoate;
0.35-0.85 part of phenoxyethanol;
0.01-0.08 part of ethylhexyl glycerol.
6. The plant extract soothing essence cream according to claim 1, characterized in that: the emulsifier comprises the following components in parts by weight: 1.22-1.62 parts of glycerol stearate, 1.00-1.50 parts of PEG-100 stearate and 0.60-0.80 part of cetearyl glucoside.
7. The plant extract soothing essence cream according to claim 1, characterized in that: the chelating agent is disodium EDTA.
8. The plant extract soothing essence cream according to claim 1, characterized in that: the anti-aging agent is artemia salina extract.
9. The method of preparing a plant extract soothing essence cream according to any one of claims 1 to 8, wherein the method comprises the steps of: the method comprises the following steps:
s1, mixing a humectant, uniformly mixing with water, a chelating agent and a first preservative, and heating to 85 ℃ to obtain a first liquid mixture, wherein the first preservative is methyl hydroxybenzoate and propyl hydroxybenzoate;
s2, uniformly mixing the emollient and the emulsifier, and heating to 85 ℃ to obtain a second liquid mixture;
s3, mixing the first liquid mixture and the second liquid mixture to obtain a third liquid mixture, stirring and emulsifying uniformly, and cooling to 60 ℃;
s4, cooling the third liquid mixture to 45 ℃, adding a second preservative to obtain a fourth liquid mixture, and uniformly stirring, wherein the second preservative is potassium sorbate, phenoxyethanol and ethylhexylglycerin;
s5, adding the relieving and anti-inflammatory agent into the fourth liquid mixture which is uniformly stirred to obtain a fifth liquid mixture, and cooling to 45 ℃;
s6, uniformly mixing the anti-aging agents, adding the anti-aging agents into the fifth liquid mixture, uniformly stirring, cooling to 38 ℃, inspecting, and filtering to obtain the anti-aging liquid.
CN201911319595.6A 2019-12-19 2019-12-19 Plant extract soothing essence cream and preparation method thereof Pending CN111228164A (en)

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